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Volumn 2, Issue 1, 2007, Pages 71-77

The risks and benefits of therapy with aldosterone receptor antagonist therapy

Author keywords

Aldosterone receptor antagonism; Eplerenone; Heart failure; Hyperkalemia; Resistant hypertension; Spironolactone

Indexed keywords

ALDOSTERONE; ALDOSTERONE ANTAGONIST; ANGIOTENSIN RECEPTOR ANTAGONIST; CANRENONE; CYTOCHROME P450 3A4; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENALAPRIL; EPLERENONE; ERYTHROMYCIN; FLUCONAZOLE; ITRACONAZOLE; KETOCONAZOLE; LOSARTAN; MINERALOCORTICOID; PLACEBO; POTASSIUM ION; SAQUINAVIR; SODIUM ION; SPIRONOLACTONE; THIAZIDE DIURETIC AGENT; VERAPAMIL;

EID: 34248217670     PISSN: 15748863     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488607779315499     Document Type: Review
Times cited : (15)

References (64)
  • 1
    • 21244485815 scopus 로고    scopus 로고
    • Mineralocorticoid receptors: Distribution and activation
    • Funder JW. Mineralocorticoid receptors: distribution and activation. Heart Fail Rev 2005; 10: 15-22.
    • (2005) Heart Fail Rev , vol.10 , pp. 15-22
    • Funder, J.W.1
  • 2
    • 33645412965 scopus 로고    scopus 로고
    • Nongenomic actions of aldosterone: Physiological or pathophysiological role?
    • Mihailidou AS. Nongenomic actions of aldosterone: physiological or pathophysiological role? Steroids 2006; 71: 277-280.
    • (2006) Steroids , vol.71 , pp. 277-280
    • Mihailidou, A.S.1
  • 5
    • 0015912489 scopus 로고
    • Adverse reactions to spironolactone. A report from the Boston Collaborative Drug Surveillance Program
    • Greenblatt DJ, Koch-Weser J. Adverse reactions to spironolactone. A report from the Boston Collaborative Drug Surveillance Program. JAMA 1973; 225: 40-43.
    • (1973) JAMA , vol.225 , pp. 40-43
    • Greenblatt, D.J.1    Koch-Weser, J.2
  • 7
    • 2342511545 scopus 로고    scopus 로고
    • The 45-year story of the development of an anti-aldosterone more specific than spironolactone
    • Menard J. The 45-year story of the development of an anti-aldosterone more specific than spironolactone. Mol Cell Endocrinol 2004; 217: 45-52.
    • (2004) Mol Cell Endocrinol , vol.217 , pp. 45-52
    • Menard, J.1
  • 8
    • 0023117413 scopus 로고
    • Three new epoxy-spirolactone derivatives: Characterization in vivo and in vitro
    • deGasparo M, Joss U, Ramjoue HP, et al. Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. J Pharm Exp Ther 1987; 240: 650-656.
    • (1987) J Pharm Exp Ther , vol.240 , pp. 650-656
    • deGasparo, M.1    Joss, U.2    Ramjoue, H.P.3
  • 9
    • 21044433173 scopus 로고    scopus 로고
    • Pharmacokinetics of eplerenone after single and multiple dosing in subjects with and without renal impairment
    • Ravis WR, Reid S, Sica DA, Tolbert DS. Pharmacokinetics of eplerenone after single and multiple dosing in subjects with and without renal impairment. J Clin Pharmacol 2005; 45: 810-821.
    • (2005) J Clin Pharmacol , vol.45 , pp. 810-821
    • Ravis, W.R.1    Reid, S.2    Sica, D.A.3    Tolbert, D.S.4
  • 10
    • 21244485814 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of mineralocorticoid blocking agents and their effects on potassium homeostasis
    • Sica DA. Pharmacokinetics and pharmacodynamics of mineralocorticoid blocking agents and their effects on potassium homeostasis. Heart Fail Rev 2005; 10: 23-29.
    • (2005) Heart Fail Rev , vol.10 , pp. 23-29
    • Sica, D.A.1
  • 11
    • 0036893488 scopus 로고    scopus 로고
    • Involvement of CYP3A in the metabolism of eplerenone in humans and dogs: Differential metabolism by CYP3A4 and CYP3A5
    • Cook CS, Berry LM, Kim DH, et al. Involvement of CYP3A in the metabolism of eplerenone in humans and dogs: differential metabolism by CYP3A4 and CYP3A5. Drug Met Dispos 2002; 30: 1344-1351.
    • (2002) Drug Met Dispos , vol.30 , pp. 1344-1351
    • Cook, C.S.1    Berry, L.M.2    Kim, D.H.3
  • 12
    • 0141997157 scopus 로고    scopus 로고
    • Pharmacokinetics of eplerenone coadministered with other medications
    • Tolbert DS, Reid SE, Roniker B. Pharmacokinetics of eplerenone coadministered with other medications. Pharmacotherapy 2002; 22: 1331.
    • (2002) Pharmacotherapy , vol.22 , pp. 1331
    • Tolbert, D.S.1    Reid, S.E.2    Roniker, B.3
  • 13
    • 1842779162 scopus 로고    scopus 로고
    • Prediction of in vivo drug interactions with eplerenone in man from in vitro metabolic inhibition data
    • Cook CS, Berry LM, Burton E. Prediction of in vivo drug interactions with eplerenone in man from in vitro metabolic inhibition data. Xenobiotica 2004; 34: 215-228.
    • (2004) Xenobiotica , vol.34 , pp. 215-228
    • Cook, C.S.1    Berry, L.M.2    Burton, E.3
  • 14
    • 0028860490 scopus 로고
    • Effects of adding spironolactone to an angiotensin-converting enzyme inhibitor in chronic congestive heart failure secondary to coronary artery disease
    • Barr CS, Lang CC, Hanson J, et al. Effects of adding spironolactone to an angiotensin-converting enzyme inhibitor in chronic congestive heart failure secondary to coronary artery disease. Am J Cardiol 1995; 76: 1259-1265.
    • (1995) Am J Cardiol , vol.76 , pp. 1259-1265
    • Barr, C.S.1    Lang, C.C.2    Hanson, J.3
  • 15
    • 10744226690 scopus 로고    scopus 로고
    • Spironolactone alone or in combination with furosemide in the treatment of moderate ascites in nonazotemic cirrhosis. A randomized comparative study of efficacy and safety
    • Santos J, Planas R, Pardo A, et al. Spironolactone alone or in combination with furosemide in the treatment of moderate ascites in nonazotemic cirrhosis. A randomized comparative study of efficacy and safety. J Hepatol 2003; 39: 187-192.
    • (2003) J Hepatol , vol.39 , pp. 187-192
    • Santos, J.1    Planas, R.2    Pardo, A.3
  • 16
    • 0031954433 scopus 로고    scopus 로고
    • Predictive factors influencing the therapeutic response to diuretic treatment of ascites in nonazotemic cirrhotic patients
    • Ljubicic N, Kujundzic M, Banic M, Vrkljan M. Predictive factors influencing the therapeutic response to diuretic treatment of ascites in nonazotemic cirrhotic patients. Scand J Gastroenterol 1998; 33: 441-447.
    • (1998) Scand J Gastroenterol , vol.33 , pp. 441-447
    • Ljubicic, N.1    Kujundzic, M.2    Banic, M.3    Vrkljan, M.4
  • 17
    • 0018348588 scopus 로고
    • Hydrochlorothiazide and spironolactone in hypertension
    • Schrijver G, Weinberger MH. Hydrochlorothiazide and spironolactone in hypertension. Clin Pharmacol Ther 1979; 25: 33-42.
    • (1979) Clin Pharmacol Ther , vol.25 , pp. 33-42
    • Schrijver, G.1    Weinberger, M.H.2
  • 18
    • 0018819754 scopus 로고
    • Amiloride, spironolactone, and potassium chloride in thiazide-treated hypertensive patients
    • Ramsay LE, Hettiarachchi J, Fraser R, Morton JJ. Amiloride, spironolactone, and potassium chloride in thiazide-treated hypertensive patients. Clin Pharmacol Ther 1980; 27: 533-543.
    • (1980) Clin Pharmacol Ther , vol.27 , pp. 533-543
    • Ramsay, L.E.1    Hettiarachchi, J.2    Fraser, R.3    Morton, J.J.4
  • 19
    • 34248156800 scopus 로고
    • Single versus divided dose bioavailability of spironolactone in hypertensive patients
    • edited by Addison GM, Wirenfeldt Asmussen N, Corvol P. Kloppenborg PWC, Norman N, Schroder R, Robertson JIS, Excerpta Medica, Amsterdam
    • Henningsen NC. Single versus divided dose bioavailability of spironolactone in hypertensive patients. In Aldosterone Antagonists in Clinical Medicine, edited by Addison GM, Wirenfeldt Asmussen N, Corvol P. Kloppenborg PWC, Norman N, Schroder R, Robertson JIS, Excerpta Medica, Amsterdam, 1978, 227.
    • (1978) Aldosterone Antagonists in Clinical Medicine , pp. 227
    • Henningsen, N.C.1
  • 20
    • 5444227854 scopus 로고    scopus 로고
    • The use of selective aldosterone antagonists
    • Weinberger MH. The use of selective aldosterone antagonists. Curr Hypertens Rep 2004; 6: 342-345.
    • (2004) Curr Hypertens Rep , vol.6 , pp. 342-345
    • Weinberger, M.H.1
  • 21
    • 0036330671 scopus 로고    scopus 로고
    • Efficacy of eplerenone added to renin-angiotensin blockade in hypertensive patients
    • Krum H, Nolly H, Workman D, et al. Efficacy of eplerenone added to renin-angiotensin blockade in hypertensive patients. Hypertension 2002; 40: 117-123.
    • (2002) Hypertension , vol.40 , pp. 117-123
    • Krum, H.1    Nolly, H.2    Workman, D.3
  • 22
    • 24944492935 scopus 로고    scopus 로고
    • Effects of eplerenone versus losartan in patients with low-renin hypertension
    • Weinberger MH, White WB, Ruilope LM, et al. Effects of eplerenone versus losartan in patients with low-renin hypertension. Am Heart J 2005; 150: 426-433.
    • (2005) Am Heart J , vol.150 , pp. 426-433
    • Weinberger, M.H.1    White, W.B.2    Ruilope, L.M.3
  • 23
    • 0035997359 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension
    • Weinberger MH, Roniker B, Krause SL, Weiss RJ. Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension. Am J Hypertens 2002; 15: 709-716.
    • (2002) Am J Hypertens , vol.15 , pp. 709-716
    • Weinberger, M.H.1    Roniker, B.2    Krause, S.L.3    Weiss, R.J.4
  • 25
    • 20544445158 scopus 로고    scopus 로고
    • Effect of spironolactone on blood pressure and the renin-angiotensin-aldosterone system in oligo-anuric hemodialysis patients
    • Gross E, Rothstein M, Dombek S, Juknis HI. Effect of spironolactone on blood pressure and the renin-angiotensin-aldosterone system in oligo-anuric hemodialysis patients. Am J Kidney Dis 2005; 46: 94-101.
    • (2005) Am J Kidney Dis , vol.46 , pp. 94-101
    • Gross, E.1    Rothstein, M.2    Dombek, S.3    Juknis, H.I.4
  • 26
    • 4344642203 scopus 로고    scopus 로고
    • Aldosterone-receptor antagonism and end-stage renal disease
    • McLaughlin N, Gehr TW, Sica DA. Aldosterone-receptor antagonism and end-stage renal disease. Curr Hypertens Rep 2004; 6: 327-330.
    • (2004) Curr Hypertens Rep , vol.6 , pp. 327-330
    • McLaughlin, N.1    Gehr, T.W.2    Sica, D.A.3
  • 27
    • 0142231538 scopus 로고    scopus 로고
    • Efficacy of low-dose spironolactone in subjects with resistant hypertension
    • Nishizaka MK, Zaman MA, Calhoun DA. Efficacy of low-dose spironolactone in subjects with resistant hypertension. Am J Hypertens 2003; 16: 925-930.
    • (2003) Am J Hypertens , vol.16 , pp. 925-930
    • Nishizaka, M.K.1    Zaman, M.A.2    Calhoun, D.A.3
  • 28
    • 0036110762 scopus 로고    scopus 로고
    • The role of spironolactone in the treatment of patients with refractory hypertension
    • Ouzan J, Perault C, Lincoff AM, et al. The role of spironolactone in the treatment of patients with refractory hypertension. Am J Hypertens 2002; 15: 333-339.
    • (2002) Am J Hypertens , vol.15 , pp. 333-339
    • Ouzan, J.1    Perault, C.2    Lincoff, A.M.3
  • 30
    • 25444446626 scopus 로고    scopus 로고
    • Improvement in blood pressure with inhibition of the epithelial sodium channel in blacks with hypertension
    • Saha C, Eckert GJ, Ambrosius WT, et al. Improvement in blood pressure with inhibition of the epithelial sodium channel in blacks with hypertension. Hypertension 2005; 46: 481-487.
    • (2005) Hypertension , vol.46 , pp. 481-487
    • Saha, C.1    Eckert, G.J.2    Ambrosius, W.T.3
  • 31
    • 0142085752 scopus 로고    scopus 로고
    • Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: The 4E-left ventricular hypertrophy study
    • Pitt B, Reichek N, Willenbrock R, et al. Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study. Circulation 2003; 108: 1831-1838.
    • (2003) Circulation , vol.108 , pp. 1831-1838
    • Pitt, B.1    Reichek, N.2    Willenbrock, R.3
  • 32
    • 0001847493 scopus 로고    scopus 로고
    • Antiproteinuric efficacy of eplerenone, enalapril, and eplerenone/enalapril combination in diabetic hypertensives with microalbuminuria
    • Epstein M, Buckalew V, Martinez F, et al. Antiproteinuric efficacy of eplerenone, enalapril, and eplerenone/enalapril combination in diabetic hypertensives with microalbuminuria. Am J Hypertens 2002; 15(Suppl 1): A24.
    • (2002) Am J Hypertens , vol.15 , Issue.SUPPL. 1
    • Epstein, M.1    Buckalew, V.2    Martinez, F.3
  • 33
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure
    • Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 1999; 341: 709-717.
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3
  • 34
    • 0037417252 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    • Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003; 348: 1309-1321.
    • (2003) N Engl J Med , vol.348 , pp. 1309-1321
    • Pitt, B.1    Remme, W.2    Zannad, F.3
  • 35
    • 2342559832 scopus 로고    scopus 로고
    • The effect of spironolactone, cilazapril and their combination on albuminuria in patients with hypertension and diabetic nephropathy is independent of blood pressure reduction: A randomized controlled study
    • Rachmani R, Slavachevsky I, Amit M, et al. The effect of spironolactone, cilazapril and their combination on albuminuria in patients with hypertension and diabetic nephropathy is independent of blood pressure reduction: a randomized controlled study. Diabet Med 2004; 21: 471-475.
    • (2004) Diabet Med , vol.21 , pp. 471-475
    • Rachmani, R.1    Slavachevsky, I.2    Amit, M.3
  • 36
    • 13244298395 scopus 로고    scopus 로고
    • Antiproteinuric effects of mineralocorticoid receptor blockade in patients with chronic renal disease
    • Sato A, Hayashi K, Saruta T. Antiproteinuric effects of mineralocorticoid receptor blockade in patients with chronic renal disease. Am J Hypertens 2005; 18: 44-49.
    • (2005) Am J Hypertens , vol.18 , pp. 44-49
    • Sato, A.1    Hayashi, K.2    Saruta, T.3
  • 37
    • 33746566456 scopus 로고    scopus 로고
    • Beneficial impact of spironolactone on nephrotic range albuminuria in diabetic nephropathy
    • Jun 14 [epub ahead of print
    • Schjoedt KJ, Rossing K, Juhl TR, et al. Beneficial impact of spironolactone on nephrotic range albuminuria in diabetic nephropathy. Kidney Int 2006 Jun 14 [epub ahead of print].
    • (2006) Kidney Int
    • Schjoedt, K.J.1    Rossing, K.2    Juhl, T.R.3
  • 38
    • 33745209933 scopus 로고    scopus 로고
    • Spironolactone further reduces urinary albumin excretion and plasma B-type natriuretic peptide levels in hypertensive type II diabetes treated with angiotensin-converting enzyme inhibitor
    • Ogawa S, Takeuchi K, Mori T, Nako K, Ito S. Spironolactone further reduces urinary albumin excretion and plasma B-type natriuretic peptide levels in hypertensive type II diabetes treated with angiotensin-converting enzyme inhibitor. Clin Exp Pharmacol Physiol 2006; 33: 477-479.
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , pp. 477-479
    • Ogawa, S.1    Takeuchi, K.2    Mori, T.3    Nako, K.4    Ito, S.5
  • 39
    • 32844467281 scopus 로고    scopus 로고
    • Beneficial impact of spironolactone in diabetic nephropathy
    • Schjoedt KJ, Rossing K, Juhl TR, et al. Beneficial impact of spironolactone in diabetic nephropathy. Kidney Int 2005; 68: 2829-2836.
    • (2005) Kidney Int , vol.68 , pp. 2829-2836
    • Schjoedt, K.J.1    Rossing, K.2    Juhl, T.R.3
  • 40
    • 20544465842 scopus 로고    scopus 로고
    • Antagonists of aldosterone and proteinuria in patients with CKD: An uncontrolled pilot study
    • Bianchi S, Bigazzi R, Campese VM. Antagonists of aldosterone and proteinuria in patients with CKD: an uncontrolled pilot study. Am J Kidney Dis 2005; 46: 45-51.
    • (2005) Am J Kidney Dis , vol.46 , pp. 45-51
    • Bianchi, S.1    Bigazzi, R.2    Campese, V.M.3
  • 41
    • 0036867985 scopus 로고    scopus 로고
    • Relative long-term effects of spironolactone in conjunction with an angiotensin-converting enzyme inhibitor on left ventricular mass and diastolic function in patients with essential hypertension
    • Sato A, Hayashi M, Saruta T. Relative long-term effects of spironolactone in conjunction with an angiotensin-converting enzyme inhibitor on left ventricular mass and diastolic function in patients with essential hypertension. Hypertens Res 2002; 25: 837-842.
    • (2002) Hypertens Res , vol.25 , pp. 837-842
    • Sato, A.1    Hayashi, M.2    Saruta, T.3
  • 42
    • 33645508990 scopus 로고    scopus 로고
    • Aldosterone receptor antagonists for heart failure: Current status, future indications
    • Pitt B, Rajagopalan S. Aldosterone receptor antagonists for heart failure: current status, future indications. Cleve Clin J Med 2006; 73: 257-60, 264-8.
    • (2006) Cleve Clin J Med , vol.73
    • Pitt, B.1    Rajagopalan, S.2
  • 43
    • 22844437062 scopus 로고    scopus 로고
    • Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure
    • Pitt B, White H, Nicolau J, et al. Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure. J Am Coll Cardiol 2005; 46: 425-431.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 425-431
    • Pitt, B.1    White, H.2    Nicolau, J.3
  • 44
    • 33646371453 scopus 로고    scopus 로고
    • Pitt B, Gheorghiade M, Zannad F, et al. Evaluation of eplerenone in the subgroup of EPHESUS patients with baseline left ventricular ejection fraction
    • Pitt B, Gheorghiade M, Zannad F, et al. Evaluation of eplerenone in the subgroup of EPHESUS patients with baseline left ventricular ejection fraction
  • 45
    • 29144495925 scopus 로고    scopus 로고
    • Are beta-blockers needed in patients receiving spironolactone for severe chronic heart failure? An analysis of the COPERNICUS study
    • Krum H, Mohacsi P, Katus HA, et al. Are beta-blockers needed in patients receiving spironolactone for severe chronic heart failure? An analysis of the COPERNICUS study. Am Heart J 2006; 151: 55-61.
    • (2006) Am Heart J , vol.151 , pp. 55-61
    • Krum, H.1    Mohacsi, P.2    Katus, H.A.3
  • 46
    • 21844459736 scopus 로고    scopus 로고
    • Adoption of spironolactone therapy for older patients with heart failure and left ventricular systolic dysfunction in the United States, 1998-2001
    • Masoudi FA, Gross CP, Wang Y, et al. Adoption of spironolactone therapy for older patients with heart failure and left ventricular systolic dysfunction in the United States, 1998-2001. Circulation 2005; 112: 39-47.
    • (2005) Circulation , vol.112 , pp. 39-47
    • Masoudi, F.A.1    Gross, C.P.2    Wang, Y.3
  • 47
    • 0023620145 scopus 로고
    • Efficacy and tolerance of spironolactone in essential hypertension
    • Jeunemaitre X, Chatellier G, Kreft-Jais C, et al. Efficacy and tolerance of spironolactone in essential hypertension. Am J Cardiol 1987; 60: 820-825.
    • (1987) Am J Cardiol , vol.60 , pp. 820-825
    • Jeunemaitre, X.1    Chatellier, G.2    Kreft-Jais, C.3
  • 48
    • 0017670467 scopus 로고
    • Pathophysiology of spironolactone-induced gynecomastia
    • Rose K, Underwood RH, Newmark SR, et al. Pathophysiology of spironolactone-induced gynecomastia. Ann Int Med 1977; 87: 398-403.
    • (1977) Ann Int Med , vol.87 , pp. 398-403
    • Rose, K.1    Underwood, R.H.2    Newmark, S.R.3
  • 49
    • 0024502383 scopus 로고
    • Antialdosterones: Incidence and prevention of sexual side-effects
    • deGasparo M, Whitebread SE, Preiswerk G, et al. Antialdosterones: incidence and prevention of sexual side-effects. J Steroid Biochem 1989; 32: 223-227.
    • (1989) J Steroid Biochem , vol.32 , pp. 223-227
    • deGasparo, M.1    Whitebread, S.E.2    Preiswerk, G.3
  • 50
    • 33645824752 scopus 로고    scopus 로고
    • Use and side-effect profile of spironolactone in a private cardiologist's practice
    • Williams EM, Katholi RE, Karambelas MR. Use and side-effect profile of spironolactone in a private cardiologist's practice. Clin Cardiol 2006; 29: 149-53.
    • (2006) Clin Cardiol , vol.29 , pp. 149-153
    • Williams, E.M.1    Katholi, R.E.2    Karambelas, M.R.3
  • 51
    • 9144220832 scopus 로고    scopus 로고
    • Tolerability of spironolactone in patients with chronic heart failure - a cautionary message
    • Witham MD, Gillespie ND, Struthers AD. Tolerability of spironolactone in patients with chronic heart failure - a cautionary message. Br J Clin Pharmacol 2004; 58: 554-557.
    • (2004) Br J Clin Pharmacol , vol.58 , pp. 554-557
    • Witham, M.D.1    Gillespie, N.D.2    Struthers, A.D.3
  • 52
    • 33747617316 scopus 로고    scopus 로고
    • Spironolactone and risk of upper gastrointestinal events: Population based case-control study
    • Verhamme K, Mosis G, Dieleman J, Stricker B, Sturkenboom M. Spironolactone and risk of upper gastrointestinal events: population based case-control study. BMJ 2006; 333(7563): 330.
    • (2006) BMJ , vol.333 , Issue.7563 , pp. 330
    • Verhamme, K.1    Mosis, G.2    Dieleman, J.3    Stricker, B.4    Sturkenboom, M.5
  • 53
    • 0027427220 scopus 로고
    • Type IV renal tubular acidosis and spironolactone therapy in the elderly
    • O'Connell JE, Colledge NR. Type IV renal tubular acidosis and spironolactone therapy in the elderly. Postgrad Med J 1993; 69: 887-889.
    • (1993) Postgrad Med J , vol.69 , pp. 887-889
    • O'Connell, J.E.1    Colledge, N.R.2
  • 54
    • 4344600703 scopus 로고    scopus 로고
    • Usefulness of spironolactone in a specialized heart failure clinic
    • Sligl W, McAlister FA, Ezekowitz J, Armstrong PW. Usefulness of spironolactone in a specialized heart failure clinic. Am J Cardiol 2004; 94: 443-447.
    • (2004) Am J Cardiol , vol.94 , pp. 443-447
    • Sligl, W.1    McAlister, F.A.2    Ezekowitz, J.3    Armstrong, P.W.4
  • 55
    • 0030587794 scopus 로고    scopus 로고
    • Effectiveness of spironolactone added to an angiotensin-converting enzyme inhibitor and a loop diuretic for severe chronic congestive heart failure (The Randomized Aldactone Evaluation Study [RALES])
    • The RALES Investigators
    • The RALES Investigators. Effectiveness of spironolactone added to an angiotensin-converting enzyme inhibitor and a loop diuretic for severe chronic congestive heart failure (The Randomized Aldactone Evaluation Study [RALES]). Am J Cardiol 1996; 78: 902-907.
    • (1996) Am J Cardiol , vol.78 , pp. 902-907
  • 56
    • 4243509443 scopus 로고    scopus 로고
    • Eplerenone and serum potassium change - relationship to renal function
    • Sica DA. Eplerenone and serum potassium change - relationship to renal function. Am J Hypertens 2003: 16(Suppl 1): A100.
    • (2003) Am J Hypertens , vol.16 , Issue.SUPPL. 1
    • Sica, D.A.1
  • 57
    • 3442886513 scopus 로고    scopus 로고
    • Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study
    • Juurlink DN, Mamdani MM, Lee DS, et al. Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study. N Engl J Med 2004; 351: 543-551.
    • (2004) N Engl J Med , vol.351 , pp. 543-551
    • Juurlink, D.N.1    Mamdani, M.M.2    Lee, D.S.3
  • 58
    • 16644365016 scopus 로고    scopus 로고
    • Aldosterone receptor antagonism: Interface with hyperkalemia in heart failure
    • Sica DA, Hess M. Aldosterone receptor antagonism: interface with hyperkalemia in heart failure. Cong Heart Fail 2004; 10: 259-264.
    • (2004) Cong Heart Fail , vol.10 , pp. 259-264
    • Sica, D.A.1    Hess, M.2
  • 59
    • 10644242516 scopus 로고    scopus 로고
    • Spironolactone-induced renal insufficiency and hyperkalemia in patients with heart failure
    • Tamarisa KP, Aaronson KD, Koelling TM. Spironolactone-induced renal insufficiency and hyperkalemia in patients with heart failure. Am Heart J 2004; 148: 971-978.
    • (2004) Am Heart J , vol.148 , pp. 971-978
    • Tamarisa, K.P.1    Aaronson, K.D.2    Koelling, T.M.3
  • 60
    • 0037107014 scopus 로고    scopus 로고
    • Estimation of glomerular filtration rate to prevent life-threatening hyperkalemia due to combined therapy with spironolactone and angiotensin-converting enzyme inhibition or angiotensin receptor blockade
    • Blaustein DA, Babu K, Reddy A, et al. Estimation of glomerular filtration rate to prevent life-threatening hyperkalemia due to combined therapy with spironolactone and angiotensin-converting enzyme inhibition or angiotensin receptor blockade. Am J Cardiol 2002; 90: 662-663.
    • (2002) Am J Cardiol , vol.90 , pp. 662-663
    • Blaustein, D.A.1    Babu, K.2    Reddy, A.3
  • 61
    • 4143062592 scopus 로고    scopus 로고
    • How prevalent is hyperkalemia and renal dysfunction during treatment with spironolactone in patients with congestive heart failure?
    • Svensson M, Gustafsson F, Galatius S, et al. How prevalent is hyperkalemia and renal dysfunction during treatment with spironolactone in patients with congestive heart failure? J Card Fail 2004; 10: 297-303.
    • (2004) J Card Fail , vol.10 , pp. 297-303
    • Svensson, M.1    Gustafsson, F.2    Galatius, S.3
  • 62
    • 33646484997 scopus 로고    scopus 로고
    • Appropriateness of spironolactone prescribing in heart failure patients: A population-based study
    • Ko DT, Juurlink DN, Mamdani MM, et al. Appropriateness of spironolactone prescribing in heart failure patients: a population-based study. J Card Fail 2006; 12: 205-210.
    • (2006) J Card Fail , vol.12 , pp. 205-210
    • Ko, D.T.1    Juurlink, D.N.2    Mamdani, M.M.3
  • 63
    • 24044466543 scopus 로고    scopus 로고
    • The adequacy of laboratory monitoring in patients treated with spironolactone for congestive heart failure
    • Shah KB, Rao K, Sawyer R, Gottlieb SS. The adequacy of laboratory monitoring in patients treated with spironolactone for congestive heart failure. J Am Coll Cardiol 2005; 46: 845-849.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 845-849
    • Shah, K.B.1    Rao, K.2    Sawyer, R.3    Gottlieb, S.S.4
  • 64
    • 0037438820 scopus 로고    scopus 로고
    • Complications of inappropriate use of spironolactone in heart failure: When an old medicine spirals out of new guidelines
    • Bozkurt B, Agoston I, Knowlton AA. Complications of inappropriate use of spironolactone in heart failure: when an old medicine spirals out of new guidelines. J Am Coll Cardiol 2003; 41: 211-214.
    • (2003) J Am Coll Cardiol , vol.41 , pp. 211-214
    • Bozkurt, B.1    Agoston, I.2    Knowlton, A.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.