The ends of a conundrum [1]

Journal of Cell Science

Volumn 120, Issue 7, 2007, Pages 1145-1146

  Paramio, Jesús M ^a   Santos, Mixentru ^a   Lorcano, José L ^a  

^a CIEMAT   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

KERATIN; RAS PROTEIN; 7,12 DIMETHYLBENZ[A]ANTHRACENE; CARCINOGEN; CYTOKERATIN 10; CYTOKERATIN 14; CYTOKERATIN 5; PHORBOL 13 ACETATE 12 MYRISTATE;

APOPTOSIS; BASAL CELL; CANCER SUSCEPTIBILITY; CELL ACTIVITY; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CELL ULTRASTRUCTURE; EPITHELIUM CELL; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENETIC CODE; GENETIC SUSCEPTIBILITY; HYPOPLASIA; KERATINOCYTE; LETTER; MUTATIONAL ANALYSIS; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SKIN CANCER; SKIN CARCINOGENESIS; ANIMAL; BAGG ALBINO MOUSE; BINDING SITE; C57BL MOUSE; CELL CULTURE; CHEMISTRY; CYTOLOGY; DBA MOUSE; DISEASE PREDISPOSITION; EPIDERMIS; GENETICS; INTERMEDIATE FILAMENT; METABOLISM; MOUSE; MOUSE MUTANT; NOTE; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SKIN TUMOR; TRANSGENIC MOUSE;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; APOPTOSIS; BINDING SITES; CARCINOGENS; CELL PROLIFERATION; CELLS, CULTURED; DISEASE SUSCEPTIBILITY; EPIDERMIS; INTERMEDIATE FILAMENTS; KERATIN-10; KERATIN-14; KERATIN-5; KERATINOCYTES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; MICE, TRANSGENIC; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE;

EID: 34248214599     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.005348     Document Type: Letter

References (20)

1. Chen, J., Cheng, X., Merched-Sauvage, M., Caulin, C., Roop, D. R. and Koch, P. J. (2006). An unexpected role for keratin 10 end domains in susceptibility to skin cancer. J. Cell Sci. 119, 5067-5076.
2. Kim, S., Wong, P. and Coulombe, P. A. (2006). A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature 441, 362-365.
3. Koch, P. J. and Roop, D. R. (2004). The role of keratins in epidermal development and homeostasis - going beyond the obvious. J. Invest. Dermatol. 123, x-xi.
4. Koster, M. I. and Roop, D. R. (2004). Genetic pathways required for epidermal morphogenesis. Eur. J. Cell Biol. 83, 625-629.
5. Koster, M. I., Huntzinger, K. A. and Roop, D. R. (2002). Epidermal differentiation: transgenic/knockout mouse models reveal genes involved in stem cell fate decisions and commitment to differentiation. J. Investig. Dermatol. Symp. Proc. 7, 41-45.
6. Lefort, K. and Dotto, G. P. (2004). Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression. Semin. Cancer Biol. 14, 374-386.
7. Paramio, J. M. (1999). A role for phosphorylation in the dynamics of keratin intermediate filaments.Eur. J. Cell Biol. 78, 33-43.
8. Paramio, J. M. and Jorcano, J. L. (2002). Beyond structure: do intermediate filaments modulate cell signalling? BioEssays 24, 836-844.
9. Paramio, J. M., Casanova, M. L., Alonso, A. and Jorcano, J. L. (1997). Keratin intermediate filament dynamics in cell heterokaryons reveals diverse behaviour of different keratins. J. Cell Sci. 110, 1099-1111.
10. Paramio, J. M., Casanova, M. L., Segrelles, C., Mittnacht, S., Lane, E. B. and Jorcano, J. L. (1999). Modulation of cell proliferation by cytokeratins K10 and K16. Mol. Cell. Biol. 19, 3086-3094.
11. Paramio, J. M., Segrelles, C., Ruiz, S. and Jorcano, J. L. (2001). Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest. Mol. Cell. Biol. 21, 7449-7459.
12. Reichelt, J. and Maging T. M. (2002). Hyperproliferation, induction of c-Myc and 14-3-3sigma, but no cell fragility in keratin-10-null mice. J. Cell Sci. 115, 2639-2650.
13. Reichelt, J., Furstenberger, G. and Magin, T. M. (2004). Loss of keratin 10 leads to mitogen-activated protein kinase (MAPK) activation, increased keratinocyte turnover, and decreased tumor formation in mice. J. Invest. Dermatol. 123, 973-981.
14. Ruiz, S., Santos, M., Segrelles, C., Leis, H., Jorcano, J. L., Berns, A., Paramio, J. M. and Vooijs, M. (2004). Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis. Development 131, 2737-2748.
15. Santos, M., Paramio, J. M., Bravo, A., Ramirez, A. and Jorcano, J. L. (2002). The expression of keratin k10 in the basal layer of the epidermis inhibits cell proliferation and prevents skin tumorigenesis. J. Biol. Chem. 277, 19122-19130.
16. Santos, M., Perez, P., Segrelles, C., Ruiz, S., Jorcano, J. L. and Paramio, J. M. (2003). Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha in transgenic mice expressing keratin K10 in the basal layer of the epidermis. J. Biol. Chem. 278, 13422-13430.
17. Santos, M., Rio, P., Ruiz, S., Martinez-Palacio, J., Segrelles, C. Lara, M. F., Segovia, J. C. and Paramio, J. M. (2005). Altered T cell differentiation and Notch signaling induced by the ectopic expression of keratin K10 in the epithelial cells of the thymus. J. Cell. Biochem. 95, 543-558.
18. Segrelles, C., Ruiz, S., Perez, P., Murga, C., Santos, M., Budunova, I. V., Martinez, J., Larcher, F., Slaga, T. J., Gutkind, J. S. et al. (2002). Functional roles of Akt signaling in mouse skin tumorigenesis. Oncogene 21, 53-64.
19. Tong, X. and Coulombe, P. A. (2006). Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion. Genes Dev. 20, 1353-1364.
20. Yoneda, K., Furukawa, T., Zheng, Y. J., Momoi, T., Izawa, I., Inagaki, M., Manabe, M. and Inagaki, N. (2004). An autocrine/ paracrine loop linking keratin 14 aggregates to tumor necrosis factor alpha-mediated cytotoxicity in a keratinocyte model of epidermolysis bullosa simplex. J. Biol. Chem. 279, 7296-7303.