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Volumn 48, Issue 4, 2007, Pages 182-205

Toxicity of local anaesthetics - Have recommended maximal doses any relevance?;Lokalanästhetikatoxizität - Relevanz empfohlener maximaldosen?

Author keywords

Local anaesthetics; Maximum recommended doses; Pharmacokinetics; Toxicity

Indexed keywords

ADRENALIN; LIDOCAINE; LOCAL ANESTHETIC AGENT; METHEMOGLOBIN; PRILOCAINE;

EID: 34248211188     PISSN: 01705334     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (16)

References (69)
  • 1
    • 0036854808 scopus 로고    scopus 로고
    • Systemic toxicity and cardiotoxicity from local anesthetics: Incidence and preventive measures
    • Mulroy MF. Systemic toxicity and cardiotoxicity from local anesthetics: incidence and preventive measures. Reg Anesth Pain Med 2002;27:556-561.
    • (2002) Reg Anesth Pain Med , vol.27 , pp. 556-561
    • Mulroy, M.F.1
  • 2
    • 28644447060 scopus 로고    scopus 로고
    • Acute toxicity of local anesthetics: Underlying pharmacokinetic and pharmacodynamic concepts
    • Mather LE, Copeland SE, Ladd LA. Acute toxicity of local anesthetics: underlying pharmacokinetic and pharmacodynamic concepts. Reg Anaesth Pain Med 2005;30:553-566.
    • (2005) Reg Anaesth Pain Med , vol.30 , pp. 553-566
    • Mather, L.E.1    Copeland, S.E.2    Ladd, L.A.3
  • 3
    • 20244368048 scopus 로고    scopus 로고
    • Critical Incidents during regional anesthesia in Japanese Society of Anesthesiologists-certified training hospitals: An analysis of responses to the annual survey conducted between 1999 and 2002 by the Japanese Society of Anesthesiologists
    • Irita K, Kawashima Y, Morita K. Critical Incidents during regional anesthesia in Japanese Society of Anesthesiologists-certified training hospitals: an analysis of responses to the annual survey conducted between 1999 and 2002 by the Japanese Society of Anesthesiologists. Masui 2005;54:440-449.
    • (2005) Masui , vol.54 , pp. 440-449
    • Irita, K.1    Kawashima, Y.2    Morita, K.3
  • 5
    • 11144291440 scopus 로고    scopus 로고
    • Interscalene brachial plexus anesthesia with ropivacaine 5 mg/mL and bupivacaine 5 mg/mL: Effects on electrocardiogram
    • Borgeat A, Ekatodramis G, Blumenthal S. Interscalene brachial plexus anesthesia with ropivacaine 5 mg/mL and bupivacaine 5 mg/mL: effects on electrocardiogram. Reg Anesth Pain Med 2004;29:557-563.
    • (2004) Reg Anesth Pain Med , vol.29 , pp. 557-563
    • Borgeat, A.1    Ekatodramis, G.2    Blumenthal, S.3
  • 6
    • 11144346156 scopus 로고    scopus 로고
    • Let's abandon blanket maximum recommended doses of local anesthetics
    • Heavner JE. Let's abandon blanket maximum recommended doses of local anesthetics. Reg Anesth Pain Med 2004;29:524.
    • (2004) Reg Anesth Pain Med , vol.29 , pp. 524
    • Heavner, J.E.1
  • 7
    • 0024422828 scopus 로고
    • Maximum recommended doses of local anaesthetic drugs
    • Scott DB. "Maximum recommended doses" of local anaesthetic drugs. Br J Anaesth 1989;63:373-374.
    • (1989) Br J Anaesth , vol.63 , pp. 373-374
    • Scott, D.B.1
  • 8
    • 11144320679 scopus 로고    scopus 로고
    • Maximum recommended doses of local anesthetics: A multifactorial concept
    • Rosenberg PH, Veering BT, Urmey WF. Maximum recommended doses of local anesthetics: a multifactorial concept. Reg Anesth Pain Med 2004;29:564-575.
    • (2004) Reg Anesth Pain Med , vol.29 , pp. 564-575
    • Rosenberg, P.H.1    Veering, B.T.2    Urmey, W.F.3
  • 9
    • 0030440344 scopus 로고    scopus 로고
    • Tumescent anesthesia with a lidocaine dose of 55 mg/kg is safe for liposuction
    • Ostad A, Kageyama N, Moy RL. Tumescent anesthesia with a lidocaine dose of 55 mg/kg is safe for liposuction. Dermatol Surg 1996;22:921-927.
    • (1996) Dermatol Surg , vol.22 , pp. 921-927
    • Ostad, A.1    Kageyama, N.2    Moy, R.L.3
  • 10
    • 17844386065 scopus 로고    scopus 로고
    • The pharmacokinetics of ropivacaine in hepatic and renal insufficiency
    • Jokinen MJ. The pharmacokinetics of ropivacaine in hepatic and renal insufficiency. Best Pract Res Clin Anaesthesiol 2005;19:269-274.
    • (2005) Best Pract Res Clin Anaesthesiol , vol.19 , pp. 269-274
    • Jokinen, M.J.1
  • 11
    • 0037302028 scopus 로고    scopus 로고
    • Pharmacokinetics of ropivacaine in uremic and nonuremic patients after axillary brachial plexus block
    • Pere P, Salonen M, Jokinen M, et al. Pharmacokinetics of ropivacaine in uremic and nonuremic patients after axillary brachial plexus block. Anesth Analg 2003;96:563-569.
    • (2003) Anesth Analg , vol.96 , pp. 563-569
    • Pere, P.1    Salonen, M.2    Jokinen, M.3
  • 12
    • 0025236887 scopus 로고
    • Die Bedeutung des Entnahmeortes bei der Bestimmung von Lokalanästhetikakonzentrationen im Plasma am Beispiel von Bupivacain 0,75%. Reg
    • Bachmann-Menennga B, Biscoping J, Adams HA, Menges T, Krumholz W, Hempelmann G. Die Bedeutung des Entnahmeortes bei der Bestimmung von Lokalanästhetikakonzentrationen im Plasma am Beispiel von Bupivacain 0,75%. Reg Anaesth 1990;13:16-20.
    • (1990) Anaesth , vol.13 , pp. 16-20
    • Bachmann-Menennga, B.1    Biscoping, J.2    Adams, H.A.3    Menges, T.4    Krumholz, W.5    Hempelmann, G.6
  • 13
    • 0026057219 scopus 로고
    • Plasma concentrations of bupivacaine and two of its metabolites during continuous interscalene brachial plexus block
    • Rosenberg PH, Pere P, Hekali R, Tuominen M. Plasma concentrations of bupivacaine and two of its metabolites during continuous interscalene brachial plexus block. Br J Anaesth 1991;66:25-30.
    • (1991) Br J Anaesth , vol.66 , pp. 25-30
    • Rosenberg, P.H.1    Pere, P.2    Hekali, R.3    Tuominen, M.4
  • 14
    • 0030625932 scopus 로고    scopus 로고
    • Lokalanästhetika - empfohlene Grenzdosen
    • Niesel HC. Lokalanästhetika - empfohlene Grenzdosen. Anaesthesiol Reanim 1997;22:60-62.
    • (1997) Anaesthesiol Reanim , vol.22 , pp. 60-62
    • Niesel, H.C.1
  • 16
    • 0015411243 scopus 로고
    • Factors affecting plasma levels of lignocaine and prilocaine
    • Scott DB, Jebson PJ, Braid DP, et al. Factors affecting plasma levels of lignocaine and prilocaine. Br J Anaesth 1972;44:1040-1049.
    • (1972) Br J Anaesth , vol.44 , pp. 1040-1049
    • Scott, D.B.1    Jebson, P.J.2    Braid, D.P.3
  • 17
    • 0000030068 scopus 로고
    • The Systemic Absorption of Local Analgesic Drugs
    • Braid DP, Scott DB. The Systemic Absorption of Local Analgesic Drugs. Br J Anaesth 1965;37:394-404.
    • (1965) Br J Anaesth , vol.37 , pp. 394-404
    • Braid, D.P.1    Scott, D.B.2
  • 18
    • 0030744773 scopus 로고    scopus 로고
    • Serum bupivacaine concentrations and transplacental transfer following repeated epidural administrations in term parturients during labour
    • Decocq G, Brazier M, Hary L, et al. Serum bupivacaine concentrations and transplacental transfer following repeated epidural administrations in term parturients during labour. Fundam Clin Pharmacol 1997;11:365-370.
    • (1997) Fundam Clin Pharmacol , vol.11 , pp. 365-370
    • Decocq, G.1    Brazier, M.2    Hary, L.3
  • 19
    • 10644271784 scopus 로고    scopus 로고
    • Benefit-risk assessment of ropivacaine in the management of postoperative pain
    • Zink W, Graf BM. Benefit-risk assessment of ropivacaine in the management of postoperative pain. Drug Saf 2004;27:1093-1114.
    • (2004) Drug Saf , vol.27 , pp. 1093-1114
    • Zink, W.1    Graf, B.M.2
  • 20
    • 0024367128 scopus 로고
    • Effects of local anesthesia on nerve blood flow: Studies using lidocaine with and without epinephrine
    • Myers RR, Heckman HM. Effects of local anesthesia on nerve blood flow: studies using lidocaine with and without epinephrine. Anesthesiology 1989;71:757-762.
    • (1989) Anesthesiology , vol.71 , pp. 757-762
    • Myers, R.R.1    Heckman, H.M.2
  • 21
    • 0026046807 scopus 로고
    • The effects of local anesthetics and epinephrine on rat sciatic nerve blood flow
    • Partridge BL. The effects of local anesthetics and epinephrine on rat sciatic nerve blood flow. Anesthesiology 1991;75:243-250.
    • (1991) Anesthesiology , vol.75 , pp. 243-250
    • Partridge, B.L.1
  • 22
    • 0024353985 scopus 로고
    • Effect of ropivacaine on cutaneous capillary blood flow in pigs
    • Kopacz DJ, Carpenter RL, Mackey DC. Effect of ropivacaine on cutaneous capillary blood flow in pigs. Anesthesiology 1989;71:69-74.
    • (1989) Anesthesiology , vol.71 , pp. 69-74
    • Kopacz, D.J.1    Carpenter, R.L.2    Mackey, D.C.3
  • 23
    • 0027086456 scopus 로고
    • Effect of local anesthetic concentration on capillary blood flow in human skin
    • Guinard JP, Carpenter RL, Morell RC. Effect of local anesthetic concentration on capillary blood flow in human skin. Reg Anesth 1992;17:317-321.
    • (1992) Reg Anesth , vol.17 , pp. 317-321
    • Guinard, J.P.1    Carpenter, R.L.2    Morell, R.C.3
  • 24
    • 0036828410 scopus 로고    scopus 로고
    • The effect of the addition of epinephrine on early systemic absorption of epidural ropivacaine in humans
    • Lee BB, Ngan Kee WD, Plummer JL, et al. The effect of the addition of epinephrine on early systemic absorption of epidural ropivacaine in humans. Anesth Analg 2002;95:1402-1407.
    • (2002) Anesth Analg , vol.95 , pp. 1402-1407
    • Lee, B.B.1    Ngan Kee, W.D.2    Plummer, J.L.3
  • 25
    • 0024336994 scopus 로고
    • Clinical pharmacokinetics of epidural and spinal anaesthesia
    • Burm AG. Clinical pharmacokinetics of epidural and spinal anaesthesia. Clin Pharmacokinet 1989;16:283-311.
    • (1989) Clin Pharmacokinet , vol.16 , pp. 283-311
    • Burm, A.G.1
  • 26
    • 0017089195 scopus 로고
    • The effects of adding adrenaline to etidocaine and lignocaine in extradural anaesthesia II: Pharmacokinetics
    • Mather LE, Tucker GT, Murphy TM, et al. The effects of adding adrenaline to etidocaine and lignocaine in extradural anaesthesia II: Pharmacokinetics. Br J Anaesth 1976;48:989-994.
    • (1976) Br J Anaesth , vol.48 , pp. 989-994
    • Mather, L.E.1    Tucker, G.T.2    Murphy, T.M.3
  • 28
    • 0018072676 scopus 로고
    • Bupivacaine binding to plasma protein fractions
    • Mather LE, Thomas J. Bupivacaine binding to plasma protein fractions. J Pharm Pharmacol 1978;30:653-654.
    • (1978) J Pharm Pharmacol , vol.30 , pp. 653-654
    • Mather, L.E.1    Thomas, J.2
  • 29
    • 0031937088 scopus 로고    scopus 로고
    • Pharmacokinetics of the enantiomers of bupivacaine and mepivacaine after epidural administration of the racemates
    • Groen K, Mantel M, Zeijlmans PW, et al. Pharmacokinetics of the enantiomers of bupivacaine and mepivacaine after epidural administration of the racemates. Anesth Analg 1998;86:361-366.
    • (1998) Anesth Analg , vol.86 , pp. 361-366
    • Groen, K.1    Mantel, M.2    Zeijlmans, P.W.3
  • 30
    • 0029161456 scopus 로고
    • Transpulmonary disposition of prilocaine, mepivacaine, and bupivacaine in humans in the course of epidural anaesthesia
    • Kietzmann D, Foth H, Geng WP, et al. Transpulmonary disposition of prilocaine, mepivacaine, and bupivacaine in humans in the course of epidural anaesthesia. Acta Anaesthesiol Scand 1995;39:885-890.
    • (1995) Acta Anaesthesiol Scand , vol.39 , pp. 885-890
    • Kietzmann, D.1    Foth, H.2    Geng, W.P.3
  • 31
    • 0031976547 scopus 로고    scopus 로고
    • Adverse effects and drug interactions associated with local and regional anaesthesia
    • Naguib M, Magboul MM, Samarkandi AH, Attia M. Adverse effects and drug interactions associated with local and regional anaesthesia. Drug Saf 1998;18:221-250.
    • (1998) Drug Saf , vol.18 , pp. 221-250
    • Naguib, M.1    Magboul, M.M.2    Samarkandi, A.H.3    Attia, M.4
  • 32
    • 0013865517 scopus 로고
    • Prilocaine. An experimental study in man of a new local anaesthetic with special regard to efficacy, toxicity and excretion
    • Eriksson E. Prilocaine. An experimental study in man of a new local anaesthetic with special regard to efficacy, toxicity and excretion. Acta Chir Scand Suppl 1966;358:1-82.
    • (1966) Acta Chir Scand Suppl , vol.358 , pp. 1-82
    • Eriksson, E.1
  • 33
    • 0025259083 scopus 로고
    • Plasma concentrations of bupivacaine after intercostal nerve block in patients after orthotopic liver transplantation
    • Bodenham A, Park GR. Plasma concentrations of bupivacaine after intercostal nerve block in patients after orthotopic liver transplantation. Br J Anaesth 1990;64:436-441.
    • (1990) Br J Anaesth , vol.64 , pp. 436-441
    • Bodenham, A.1    Park, G.R.2
  • 34
    • 0025946965 scopus 로고
    • Cumulation of bupivacaine, desbutylbupivacaine and 4-hydroxybupivacaine during and after continuous interscalene brachial plexus block
    • Pere P, Tuominen M, Rosenberg PH. Cumulation of bupivacaine, desbutylbupivacaine and 4-hydroxybupivacaine during and after continuous interscalene brachial plexus block. Acta Anaesthesiol Scand 1991;35:647-650.
    • (1991) Acta Anaesthesiol Scand , vol.35 , pp. 647-650
    • Pere, P.1    Tuominen, M.2    Rosenberg, P.H.3
  • 36
    • 0035093848 scopus 로고    scopus 로고
    • Caudal ropivacaine in infants: Population pharmacokinetics and plasma concentrations
    • Hansen TG, Ilett KF, Reid C, et al. Caudal ropivacaine in infants: population pharmacokinetics and plasma concentrations. Anesthesiology 2001;94:579-584.
    • (2001) Anesthesiology , vol.94 , pp. 579-584
    • Hansen, T.G.1    Ilett, K.F.2    Reid, C.3
  • 37
    • 0023841683 scopus 로고
    • The effect of age on plasma clearance of epidural lidocaine and bupivacaine
    • Bowdle TA, Freund PR. The effect of age on plasma clearance of epidural lidocaine and bupivacaine. Anesth Analg 1988;67:299.
    • (1988) Anesth Analg , vol.67 , pp. 299
    • Bowdle, T.A.1    Freund, P.R.2
  • 39
    • 0023836046 scopus 로고
    • Spinal anaesthesia with hyperbaric bupivacaine. Effects of age on neural blockade and pharmacokinetics
    • Veering BT, Burm AG, Spierdijk J. Spinal anaesthesia with hyperbaric bupivacaine. Effects of age on neural blockade and pharmacokinetics. Br J Anaesth 1988;60:187-194.
    • (1988) Br J Anaesth , vol.60 , pp. 187-194
    • Veering, B.T.1    Burm, A.G.2    Spierdijk, J.3
  • 40
    • 33845951574 scopus 로고    scopus 로고
    • Pharmacokinetics of Ropivacaine in Patients with Chronic End-stage Liver Disease
    • Jokinen MJ, Neuvonen PJ, Lindgren L, et al. Pharmacokinetics of Ropivacaine in Patients with Chronic End-stage Liver Disease. Anesthesiology 2007;106:43-55.
    • (2007) Anesthesiology , vol.106 , pp. 43-55
    • Jokinen, M.J.1    Neuvonen, P.J.2    Lindgren, L.3
  • 41
    • 0028909146 scopus 로고
    • Bupivacaine enantiomer pharmacokinetics after intercostal neural blockade in liver transplantation patients
    • Mather LE, McCall P, McNicol PL. Bupivacaine enantiomer pharmacokinetics after intercostal neural blockade in liver transplantation patients. Anesth Analg 1995;80:328-335.
    • (1995) Anesth Analg , vol.80 , pp. 328-335
    • Mather, L.E.1    McCall, P.2    McNicol, P.L.3
  • 42
    • 0015121532 scopus 로고
    • The influence of heart failure, liver disease, and renal failure on the disposition of lidocaine in man
    • Thomson PD, Rowland M, Melmon KL. The influence of heart failure, liver disease, and renal failure on the disposition of lidocaine in man. Am Heart J 1971;82:417-421.
    • (1971) Am Heart J , vol.82 , pp. 417-421
    • Thomson, P.D.1    Rowland, M.2    Melmon, K.L.3
  • 43
    • 0015610111 scopus 로고
    • Lidocaine pharmacokinetics in advanced heart failure, liver disease, and renal failure in humans
    • Thomson PD, Melmon KL, Richardson JA, et al. Lidocaine pharmacokinetics in advanced heart failure, liver disease, and renal failure in humans. Ann Intern Med 1973;78:499-508.
    • (1973) Ann Intern Med , vol.78 , pp. 499-508
    • Thomson, P.D.1    Melmon, K.L.2    Richardson, J.A.3
  • 44
    • 0021848382 scopus 로고
    • Vergleichende Untersuchungen zur Dosisanpassung der intraoperativen Lidocain-Therapie bei herzinsuffizienten Patienten
    • Biscoping J, Kling D, von Bormann B, et al. Vergleichende Untersuchungen zur Dosisanpassung der intraoperativen Lidocain-Therapie bei herzinsuffizienten Patienten. Anaesth Intensivther Notfallmed 1985;20:136-138.
    • (1985) Anaesth Intensivther Notfallmed , vol.20 , pp. 136-138
    • Biscoping, J.1    Kling, D.2    von Bormann, B.3
  • 45
    • 0032983947 scopus 로고    scopus 로고
    • Clinical effects and maternal and fetal plasma concentrations of 0.5% epidural levobupivacaine versus bupivacaine for cesarean delivery
    • Bader AM, Tsen LC, Camann WR, et al. Clinical effects and maternal and fetal plasma concentrations of 0.5% epidural levobupivacaine versus bupivacaine for cesarean delivery. Anesthesiology 1999;90:1596-1601.
    • (1999) Anesthesiology , vol.90 , pp. 1596-1601
    • Bader, A.M.1    Tsen, L.C.2    Camann, W.R.3
  • 46
    • 0025364363 scopus 로고
    • Pregnancy increases median nerve susceptibility to lidocaine
    • Butterworth JFt, Walker FO, Lysak SZ. Pregnancy increases median nerve susceptibility to lidocaine. Anesthesiology 1990;72:962-965.
    • (1990) Anesthesiology , vol.72 , pp. 962-965
    • Butterworth, J.F.1    Walker, F.O.2    Lysak, S.Z.3
  • 47
    • 0032837619 scopus 로고    scopus 로고
    • Effect of itraconazole on the pharmacokinetics of bupivacaine enantiomers in healthy volunteers
    • Palkama VJ, Neuvonen PJ, Olkkola KT. Effect of itraconazole on the pharmacokinetics of bupivacaine enantiomers in healthy volunteers. Br J Anaesth 1999;83:659-661.
    • (1999) Br J Anaesth , vol.83 , pp. 659-661
    • Palkama, V.J.1    Neuvonen, P.J.2    Olkkola, K.T.3
  • 48
    • 0031793525 scopus 로고    scopus 로고
    • Effect of erythromycin and itraconazole on the pharmacokinetics of intravenous lignocaine
    • Isohanni MH, Neuvonen PJ, Palkama VJ, Olkkola KT. Effect of erythromycin and itraconazole on the pharmacokinetics of intravenous lignocaine. Eur J Clin Pharmacol 1998;54:561-565.
    • (1998) Eur J Clin Pharmacol , vol.54 , pp. 561-565
    • Isohanni, M.H.1    Neuvonen, P.J.2    Palkama, V.J.3    Olkkola, K.T.4
  • 50
    • 0027981249 scopus 로고
    • Pharmacokinetics of the enantiomers of bupivacaine following intravenous administration of the racemate
    • Burm AG, van der Meer AD, van Kleef JW, et al. Pharmacokinetics of the enantiomers of bupivacaine following intravenous administration of the racemate. Br J Clin Pharmacol 1994;38:125-129.
    • (1994) Br J Clin Pharmacol , vol.38 , pp. 125-129
    • Burm, A.G.1    van der Meer, A.D.2    van Kleef, J.W.3
  • 51
    • 0033762586 scopus 로고    scopus 로고
    • The effect of erythromycin, fluvoxamine, and their combination on the pharmacokinetics of ropivacaine
    • Jokinen MJ, Ahonen J, Neuvonen PJ, Olkkola KT. The effect of erythromycin, fluvoxamine, and their combination on the pharmacokinetics of ropivacaine. Anesth Analg, 2000:1207-1212.
    • (2000) Anesth Analg , pp. 1207-1212
    • Jokinen, M.J.1    Ahonen, J.2    Neuvonen, P.J.3    Olkkola, K.T.4
  • 53
    • 0035044033 scopus 로고    scopus 로고
    • Effect of clarithromycin and itraconazole on the pharmacokinetics of ropivacaine
    • Jokinen MJ, Ahonen J, Neuvonen PJ, Olkkola KT. Effect of clarithromycin and itraconazole on the pharmacokinetics of ropivacaine. Pharmacol Toxicol 2001;88:187-191.
    • (2001) Pharmacol Toxicol , vol.88 , pp. 187-191
    • Jokinen, M.J.1    Ahonen, J.2    Neuvonen, P.J.3    Olkkola, K.T.4
  • 54
    • 3242876818 scopus 로고    scopus 로고
    • Local anesthetic myotoxicity
    • Zink W, Graf BM. Local anesthetic myotoxicity. Reg Anesth Pain Med 2004;29:333-340.
    • (2004) Reg Anesth Pain Med , vol.29 , pp. 333-340
    • Zink, W.1    Graf, B.M.2
  • 55
    • 0002464509 scopus 로고
    • Methaemoglobinaemia due to prilocaine
    • Scott DB, Owen JA, Richmond J. Methaemoglobinaemia due to prilocaine. Lancet 1964;171:728-729.
    • (1964) Lancet , vol.171 , pp. 728-729
    • Scott, D.B.1    Owen, J.A.2    Richmond, J.3
  • 56
    • 0031711689 scopus 로고    scopus 로고
    • Toxic methemoglobinemia: A rare but serious complication of transesophageal echocardiography
    • Fisher MA, Henry D, Gillam L, Chen C. Toxic methemoglobinemia: a rare but serious complication of transesophageal echocardiography. Can J Cardiol 1998;14:1157-1160.
    • (1998) Can J Cardiol , vol.14 , pp. 1157-1160
    • Fisher, M.A.1    Henry, D.2    Gillam, L.3    Chen, C.4
  • 57
    • 27844602338 scopus 로고    scopus 로고
    • Death of an infant involving benzocaine
    • Logan BK, Gordon AM. Death of an infant involving benzocaine. J Forensic Sci 2005;50:1486-1488.
    • (2005) J Forensic Sci , vol.50 , pp. 1486-1488
    • Logan, B.K.1    Gordon, A.M.2
  • 58
    • 0742307186 scopus 로고    scopus 로고
    • EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity
    • Hahn IH, Hoffman RS, Nelson LS. EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity. J Emerg Med 2004;26:85-88.
    • (2004) J Emerg Med , vol.26 , pp. 85-88
    • Hahn, I.H.1    Hoffman, R.S.2    Nelson, L.S.3
  • 59
    • 0036394854 scopus 로고    scopus 로고
    • Benefit and risks of local anesthetics in infants and children
    • Gunter JB. Benefit and risks of local anesthetics in infants and children. Paediatr Drugs 2002;4:649-672.
    • (2002) Paediatr Drugs , vol.4 , pp. 649-672
    • Gunter, J.B.1
  • 60
    • 0023992925 scopus 로고
    • Effect of age on maximum circulating local anesthetic concentrations during epidural anesthesia
    • Bowdle TA, Freund PR. Effect of age on maximum circulating local anesthetic concentrations during epidural anesthesia. Anesth Analg 1988;67:419-421.
    • (1988) Anesth Analg , vol.67 , pp. 419-421
    • Bowdle, T.A.1    Freund, P.R.2
  • 61
    • 5444266748 scopus 로고    scopus 로고
    • Effect of age on the clinical profile and systemic absorption and disposition of levobupivacaine after epidural administration
    • Simon MJ, Veering BT, Stienstra R, et al. Effect of age on the clinical profile and systemic absorption and disposition of levobupivacaine after epidural administration. Br J Anaesth 2004;93:512-520.
    • (2004) Br J Anaesth , vol.93 , pp. 512-520
    • Simon, M.J.1    Veering, B.T.2    Stienstra, R.3
  • 62
    • 0016371131 scopus 로고
    • Alteration in pharmacologic response induced by cardiovascular disease
    • Thomson PD. Alteration in pharmacologic response induced by cardiovascular disease. Cardiovasc Clin 1974;6:55-61.
    • (1974) Cardiovasc Clin , vol.6 , pp. 55-61
    • Thomson, P.D.1
  • 63
    • 0027520371 scopus 로고
    • Epinephrine in local anesthetics does indeed produce hypokalemia and ECG changes
    • Kubota Y, Toyoda Y, Kubota H, Asada A. Epinephrine in local anesthetics does indeed produce hypokalemia and ECG changes. Anesth Analg 1993;77:867-868.
    • (1993) Anesth Analg , vol.77 , pp. 867-868
    • Kubota, Y.1    Toyoda, Y.2    Kubota, H.3    Asada, A.4
  • 64
    • 0023116859 scopus 로고
    • Effect of pregnancy on bupivacaine-induced conduction blockade in the isolated rabbit vagus nerve
    • Flanagan HL, Datta S, Lambert DH, et al. Effect of pregnancy on bupivacaine-induced conduction blockade in the isolated rabbit vagus nerve. Anesth Analg 1987;66:123-126.
    • (1987) Anesth Analg , vol.66 , pp. 123-126
    • Flanagan, H.L.1    Datta, S.2    Lambert, D.H.3
  • 65
    • 0033762586 scopus 로고    scopus 로고
    • The effect of erythromycin, fluvoxamine, and their combination on the pharmacokinetics of ropivacaine
    • Jokinen MJ, Ahonen J, Neuvonen PJ, Olkkola KT. The effect of erythromycin, fluvoxamine, and their combination on the pharmacokinetics of ropivacaine. Anesth Analg 2000;91:1207-1212.
    • (2000) Anesth Analg , vol.91 , pp. 1207-1212
    • Jokinen, M.J.1    Ahonen, J.2    Neuvonen, P.J.3    Olkkola, K.T.4
  • 66
    • 0035064687 scopus 로고    scopus 로고
    • Cardiotoxicity with modern local anaesthetics: Is there a safer choice?
    • Mather LE, Chang DH. Cardiotoxicity with modern local anaesthetics: is there a safer choice? Drugs 2001;61:333-342.
    • (2001) Drugs , vol.61 , pp. 333-342
    • Mather, L.E.1    Chang, D.H.2
  • 67
    • 0035436975 scopus 로고    scopus 로고
    • The cardiotoxicity of local anesthetics: The place of ropivacaine
    • Graf BM. The cardiotoxicity of local anesthetics: the place of ropivacaine. Curr Top Med Chem 2001;1:207-214.
    • (2001) Curr Top Med Chem , vol.1 , pp. 207-214
    • Graf, B.M.1
  • 68
    • 28644436121 scopus 로고    scopus 로고
    • Local anesthetics: Helpful science, but don't forget the basic clinical safety steps
    • Mulroy MF. Local anesthetics: helpful science, but don't forget the basic clinical safety steps. Reg Anesth Pain Med 2005:30:513-515.
    • (2005) Reg Anesth Pain Med , vol.30 , pp. 513-515
    • Mulroy, M.F.1
  • 69
    • 0031981986 scopus 로고    scopus 로고
    • The epinephrine test dose in obstetrics: Note the limitations
    • Mulroy M, Glosten B. The epinephrine test dose in obstetrics: note the limitations. Anesth Analg 1998;86:923-925.
    • (1998) Anesth Analg , vol.86 , pp. 923-925
    • Mulroy, M.1    Glosten, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.