The effect of the addition of epinephrine on early systemic absorption of epidural ropivacaine in humans

Anesthesia and Analgesia

Volumn 95, Issue 5, 2002, Pages 1402-1407

  Lee, Bee B ^a   Ngan Kee, Warwick D ^a   Plummer, John L ^a   Karmakar, Manoj K ^a   Wong, April S Y ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ROPIVACAINE;

ABDOMINAL HYSTERECTOMY; ADULT; AGED; ARTERIAL BLOOD; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; EPIDURAL ANESTHESIA; FEMALE; HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VASOCONSTRICTION; VENOUS BLOOD;

EID: 0036828410     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-200211000-00055     Document Type: Article

References (26)

1. Akerman B, Hellberg IB, Trossvik C. Primary evaluation of the local anaesthetic properties of the amino amide agent ropivacaine (LEA 103). Acta Anaesthesiol Scand 1988;32:571-8.
2. Kopacz DJ, Carpenter RL, Mackey DC. Effect of ropivacaine on cutaneous capillary blood flow in pigs. Anesthesiology 1989;71: 69-74.
3. Guinard JP, Carpenter RL, Owens BD, Nadir B. Comparison between ropivacaine and bupivacaine after subcutaneous injection in pigs: Cutaneous blood flow and surgical bleeding. Reg Anesth 1991;16:268-71.
4. Nakamura K, Toda H, Kakuyama M, et al. Direct vascular effect of ropivacaine in femoral artery and vein of the dog. Acta Anaesthesiol Scand 1993;37:269-73.
5. Gherardini G, Samuelson U, Jernbeck J, et al. Comparison of vascular effects of ropivacaine and lidocaine on isolated rings of human arteries. Acta Anaesthesiol Scand 1995;39:765-8.
6. Cederholm I, Evers H, Lofstrom JB. Skin blood flow after intradermal injection of ropivacaine in various concentrations with and without epinephrine evaluated by laser Doppler flowmetry. Reg Anesth 1992;17:322-8.
7. Dahl JB, Simonsen L, Mogensen T, et al. The effect of 0.5% ropivacaine on epidural blood flow. Acta Anaesthesiol Scand 1990;34:308-10.
8. Emanuelsson BM, Persson J, Alm C, et al. Systemic absorption and block after epidural injection of ropivacaine in healthy volunteers. Anesthesiology 1997;87:1309-17.
9. Winer BJ. Statistical Principles in Experimental Design. 2nd ed. New York: McGraw-Hill, 1971.
10. Diggle PJ, Liang KY, Zeger SL. Analysis of Longitudinal Data. Oxford: Oxford University Press, 1994.
11. Tucker GT, Mather LE. Clinical pharmacokinetics of local anaesthetics. Clin Pharmacokinet 1979;4:241-78.
12. Burm AG, van Kleef JW, Gladines MP, et al. Epidural anesthesia with lidocaine and bupivacaine: Effects of epinephrine on the plasma concentration profiles. Anesth Analg 1986;65:1281-4.
13. Cederholm I, Akerman B, Evers H. Local analgesic and vascular effects of intradermal ropivacaine and bupivacaine in various concentrations with and without addition of adrenaline in man. Acta Anaesthesiol Scand 1994;38:322-7.
14. Hickey R, Blanchard J, Hoffman J, et al. Plasma concentrations of ropivacaine given with or without epinephrine for brachial plexus block. Can J Anaesth 1990;37:878-82.
15. Arthur GR, Feldman HS, Covino BG. Comparative pharmacokinetics of bupivacaine and ropivacaine, a new amide local anesthetic. Anesth Analg 1988;67:1053-8.
16. Hurley RJ, Feldman HS, Latka C, et al. The effects of epinephrine on the anesthetic and hemodynamic properties of ropivacaine and bupivacaine after epidural administration in the dog. Reg Anesth 1991;16:303-8.
17. Cederholm I, Anskar S, Bengtsson M. Sensory, motor, and sympathetic block during epidural analgesia with 0.5% and 0.75% ropivacaine with and without epinephrine. Reg Anesth 1994;19: 18-33.
18. Liddle AM, Hall AP, Arrowsmith J, Smith G. Effect of infiltration with ropivacaine on blood loss during reduction mammoplasty. Br J Anaesth 1998;81:974-5.
19. Leonard SA, Flynn R, Kelleher N, Shorten GD. The effect of the addition of epinephrine to ropivacaine for labour epidural analgesia on efficacy, systemic absorption and neonatal outcome. Eur J Anaesthesiol 2000;17:A519 (suppl 19).
20. Roelants FA, Veyckemans F, Verbeeck RK, Van Obbergh LJ. Pharmacokinetics of caudal ropivacaine with or without epinephrine in children. Anesthesiology 2000;3A:A1269.
21. Sandler AN, Arlander E, Finucane BT, et al. Pharmacokinetics of three doses of epidural ropivacaine during hysterectomy and comparison with bupivacaine. Can J Anaesth 1998;45:843-9.
22. Chiou WL. The phenomenon and rationale of marked dependence of drug concentration on blood sampling site: Implications in pharmacokinetics, pharmacodynamics, toxicology and therapeutics (Part I). Clin Pharmacokinet 1989;17:175-99.
23. Chiou WL. The phenomenon and rationale of marked dependence of drug concentration on blood sampling site: Implications in pharmacokinetics, pharmacodynamics, toxicology and therapeutics (Part II). Clin Pharmacokinet 1989;17:275-90.
24. Moore DC, Mather LE, Bridenbaugh PO, et al. Arterial and venous plasma levels of bupivacaine following epidural and intercostal nerve blocks. Anesthesiology 1976;45:39-45.
25. Bachmann-M B, Biscoping J, Adams HA, et al. The significance of the sampling site in the determination of plasma levels of local anesthetics using 0.75% bupivacaine as an example. Reg Anesth 1990;13:16-20.
26. Eyres RL, Bishop W, Oppenheim RC, Brown TC. Plasma bupivacaine concentrations in children during caudal epidural analgesia. Anaesth Intensive Care 1983;11:20-2.