Evaluation of Herpes Simplex Virus 1 thymidine kinase-mediated trapping of 131I FIAU and prodrug activation of ganciclovir as a synergistic cancer radio/chemotherapy

Molecular Imaging and Biology

Volumn 9, Issue 3, 2007, Pages 110-116

  Schipper, Meike L ^a   Goris, Michael L ^a   Gambhir, Sanjiv S ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Gene therapy; Prodrug activation; Radioisotope therapy

Indexed keywords

FIALURIDINE I 131; GANCICLOVIR; HERPES SIMPLEX VIRUS 1 THYMIDINE KINASE; PRODRUG; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; VIRUS ENZYME;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GENE THERAPY; CANCER INHIBITION; CONTROLLED STUDY; DRUG ACTIVATION; DRUG EFFICACY; DRUG EXPOSURE; DRUG POTENTIATION; DRUG SCREENING; DRUG SYNTHESIS; DRUG UPTAKE; ISOTOPE LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT;

ANIMALS; ARABINOFURANOSYLURACIL; CELL DIVISION; CELL LINE, TUMOR; COMBINED MODALITY THERAPY; DOSE-RESPONSE RELATIONSHIP, RADIATION; GANCICLOVIR; GENE EXPRESSION; HERPESVIRUS 1, HUMAN; IODINE RADIOISOTOPES; NEOPLASMS; PRODRUGS; RADIOPHARMACEUTICALS; RATS; THYMIDINE KINASE;

HUMAN HERPESVIRUS 1;

EID: 34248202673     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-007-0078-3     Document Type: Article

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