Cell surface expression of melanocortin-1 receptor on HaCaT keratinocytes and α-melanocortin stimulation do not affect the formation and repair of UVB-induced DNA photoproducts

Photochemical and Photobiological Sciences

Volumn 6, Issue 5, 2007, Pages 585-593

  Garcin, Geneviève ^a   Douki, Thierry ^b   Stoebner, Pierre Emmanuel ^a,c   Guesnet, Joëlle ^d   Guezennec, Anne ^d   Martinez, Jean ^a   Cadet, Jean ^b   Meunier, Laurent ^a,c  

^a UNIVERSITÉ DE MONTPELLIER   (France)

^b CEA GRENOBLE   (France)

^c DEPARTMENT OF NEUROLOGY   (France)

^d YSL Beauté Recherche et Développement   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYGUANOSINE DERIVATIVE; DNA; MELANOCORTIN; MELANOCORTIN 1 RECEPTOR; PYRIMIDINE DERIVATIVE;

ARTICLE; CELL STIMULATION; CELL SURFACE; CONTROLLED STUDY; DNA DAMAGE; GENETIC TRANSFECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; KERATINOCYTE; MELANOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TANDEM MASS SPECTROMETRY; ULTRAVIOLET B RADIATION; WILD TYPE;

EID: 34248202163     PISSN: 1474905X     EISSN: 14749092     Source Type: Journal    
DOI: 10.1039/b615656h     Document Type: Article

References (51)

1. Z. Abdel-Malek M. C. Scott I. Suzuki A. Tada S. Im L. Lamoreux S. Ito G. Barsh V. J. Hearing The melanocortin-1 receptor is a key regulator of human cutaneous pigmentation Pigment Cell Res. 2000 13 Suppl. 8 156 162
2. M. C. Scott I. Suzuki Z. A. Abdel-Malek Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors and by ultraviolet radiation Pigment Cell Res. 2002 15 433 439
3. J. C. Garcia-Borron B. L. Sanchez-Laorden C. Jimenez-Cervantes Melanocortin-1 receptor structure and functional regulation Pigment Cell Res. 2005 18 393 410
4. A. J. Stratigos G. Dimisianos V. Nikolaou M. Poulou V. Sypsa I. Stefanaki O. Papadopoulos D. Polydorou M. Plaka E. Christofidou H. Gogas D. Tsoutsos O. Kastana C. Antoniou A. Hatzakis E. Kanavakis A. D. Katsambas Melanocortin receptor-1 gene polymorphisms and the risk of cutaneous melanoma in a low-risk southern European population J. Invest. Dermatol. 2006 126 1842 1849
5. M. Liboutet M. Portela G. Delestaing C. Vilmer N. Dupin I. Gorin P. Saiag C. Lebbe D. Kerob L. Dubertret B. Grandchamp N. Basset-Seguin N. Soufir MC1R and PTCH gene polymorphism in French patients with basal cell carcinomas J. Invest. Dermatol. 2006 126 1510 1517
6. M. C. Scott K. Wakamatsu S. Ito A. L. Kadekaro N. Kobayashi J. Groden R. Kavanagh T. Takakuwa V. Virador V. J. Hearing Z. A. Abdel-Malek Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation J. Cell. Sci. 2002 115 2349 2355
7. M. T. Landi J. Bauer R. M. Pfeiffer D. E. Elder B. Hulley P. Minghetti D. Calista P. A. Kanetsky D. Pinkel B. C. Bastian MC1R germline variants confer risk for BRAF-mutant melanoma Science 2006 313 521 522
8. J. A. D'Orazio T. Nobuhisa R. Cui M. Arya M. Spry K. Wakamatsu V. Igras T. Kunisada S. R. Granter E. K. Nishimura S. Ito D. E. Fisher Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning Nature 2006 443 340 344
9. A. Chakraborty A. Slominski G. Ermak J. Hwang J. Pawelek Ultraviolet B and melanocyte-stimulating hormone (MSH) stimulate mRNA production for alpha MSH receptors and proopiomelanocortin-derived peptides in mouse melanoma cells and transformed keratinocytes J. Invest. Dermatol. 1995 105 655 659
10. F. Rouzaud A. L. Kadekaro Z. A. Abdel-Malek V. J. Hearing MC1R and the response of melanocytes to ultraviolet radiation Mutat. Res. 2005 571 133 152
11. A. K. Chakraborty Y. Funasaka J. M. Pawelek M. Nagahama A. Ito M. Ichihashi Enhanced expression of melanocortin-1 receptor (MC1-R) in normal human keratinocytes during differentiation: evidence for increased expression of POMC peptides near suprabasal layer of epidermis J. Invest. Dermatol. 1999 112 853 860
12. D. W. Roberts R. A. Newton K. A. Beaumont J. Helen Leonard R. A. Sturm Quantitative analysis of MC1R gene expression in human skin cell cultures Pigment Cell Res. 2006 19 76 89
13. M. Schiller T. Brzoska M. Bohm D. Metze T. E. Scholzen A. Rougier T. A. Luger Solar-simulated ultraviolet radiation-induced upregulation of the melanocortin-1 receptor, proopiomelanocortin, and alpha-melanocyte-stimulating hormone in human epidermis in vivo J. Invest. Dermatol. 2004 122 468 476
14. M. Bohm I. Wolff T. E. Scholzen S. J. Robinson E. Healy T. A. Luger T. Schwarz A. Schwarz alpha-Melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage J. Biol. Chem. 2005 280 5795 5802
15. J. L. Ravanat T. Douki P. Duez E. Gremaud K. Herbert T. Hofer L. Lasserre C. Saint-Pierre A. Favier J. Cadet Cellular background level of 8-oxo-7,8-dihydro-2′-deoxyguanosine: an isotope based method to evaluate artefactual oxidation of DNA during its extraction and subsequent work-up Carcinogenesis 2002 23 1911 1918
16. T. Douki J. Cadet Individual determination of the yield of the main UV-induced dimeric pyrimidine photoproducts in DNA suggests a high mutagenicity of CC photolesions Biochemistry 2001 40 2495 2501
17. V. Chhajlani J. E. Wikberg Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA FEBS Lett. 1992 309 417 420
18. R. J. Elliott M. Szabo M. J. Wagner E. H. Kemp S. MacNeil J. W. Haycock alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells J. Invest. Dermatol. 2004 122 1010 1019
19. J. Sanchez-Mas C. Hahmann I. Gerritsen J. C. Garcia-Borron C. Jimenez-Cervantes Agonist-independent, high constitutive activity of the human melanocortin 1 receptor Pigment Cell Res. 2004 17 386 395
20. T. Douki D. Perdiz P. Grof Z. Kuluncsics E. Moustacchi J. Cadet E. Sage Oxidation of guanine in cellular DNA by solar UV radiation: biological role Photochem. Photobiol. 1999 70 184 190
21. C. Kielbassa L. Roza B. Epe Wavelength dependence of oxidative DNA damage induced by UV and visible light Carcinogenesis 1997 18 811 816
22. S. Courdavault C. Baudouin M. Charveron B. Canguilhem A. Favier J. Cadet T. Douki Repair of the three main types of bipyrimidine DNA photoproducts in human keratinocytes exposed to UVB and UVA radiations DNA Repair (Amst) 2005 4 836 844
23. A. L. Kadekaro R. Kavanagh H. Kanto S. Terzieva J. Hauser N. Kobayashi S. Schwemberger J. Cornelius G. Babcock H. G. Shertzer G. Scott Z. A. Abdel-Malek alpha-Melanocortin and endothelin-1 activate antiapoptotic pathways and reduce DNA damage in human melanocytes Cancer Res. 2005 65 4292 4299
24. J. Cadet E. Sage T. Douki Ultraviolet radiation-mediated damage to cellular DNA Mutat. Res. 2005 571 3 17
25. J. Cadet S. Bellon M. Berger A. G. Bourdat T. Douki V. Duarte S. Frelon D. Gasparutto E. Muller J. L. Ravanat S. Sauvaigo Recent aspects of oxidative DNA damage: guanine lesions, measurement and substrate specificity of DNA repair glycosylases Biol. Chem. 2002 383 933 943
26. J. Cadet T. Douki D. Gasparutto J. L. Ravanat Oxidative damage to DNA: formation, measurement and biochemical features Mutat. Res. 2003 531 5 23
27. M. D'Errico M. Teson A. Calcagnile T. Nardo N. De Luca C. Lazzari S. Soddu G. Zambruno M. Stefanini E. Dogliotti Differential role of transcription-coupled repair in UVB-induced response of human fibroblasts and keratinocytes Cancer Res. 2005 65 432 438
28. A. R. Young C. S. Potten O. Nikaido P. G. Parsons J. Boenders J. M. Ramsden C. A. Chadwick Human melanocytes and keratinocytes exposed to UVB or UVA in vivo show comparable levels of thymine dimers J. Invest. Dermatol. 1998 111 936 940
29. S. Frelon T. Douki J. L. Ravanat J. P. Pouget C. Tornabene J. Cadet High-performance liquid chromatography-tandem mass spectrometry measurement of radiation-induced base damage to isolated and cellular DNA Chem. Res. Toxicol. 2000 13 1002 1010
30. T. Douki M. Court S. Sauvaigo F. Odin J. Cadet Formation of the main UV-induced thymine dimeric lesions within isolated and cellular DNA as measured by high performance liquid chromatography-tandem mass spectrometry J. Biol. Chem. 2000 275 11678 11685
31. S. Mouret C. Baudouin M. Charveron A. Favier J. Cadet T. Douki Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation Proc. Natl. Acad. Sci. USA 2006 103 13765 13770
32. J. Cadet T. Douki S. Frelon S. Sauvaigo J. P. Pouget J. L. Ravanat Assessment of oxidative base damage to isolated and cellular DNA by HPLC-MS/MS measurement Free Radical Biol. Med. 2002 33 441 449
33. R. Greinert O. Boguhn D. Harder E. W. Breitbart D. L. Mitchell B. Volkmer The dose dependence of cyclobutane dimer induction and repair in UVB-irradiated human keratinocytes Photochem. Photobiol. 2000 72 701 708
34. Z. A. Abdel-Malek A. L. Kadekaro R. J. Kavanagh A. Todorovic L. N. Koikov J. C. McNulty P. J. Jackson G. L. Millhauser S. Schwemberger G. Babcock C. Haskell-Luevano J. J. Knittel Melanoma prevention strategy based on using tetrapeptide alpha-MSH analogs that protect human melanocytes from UV-induced DNA damage and cytotoxicity FASEB J. 2006 20 1561 1563
35. R. T. Dorr G. Ertl N. Levine C. Brooks J. L. Bangert M. B. Powell S. Humphrey D. S. Alberts Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers Arch. Dermatol. 2004 140 827 835
36. L. M. Fitzgerald J. L. Fryer T. Dwyer S. M. Humphrey Effect of MELANOTAN, [Nle(4),d-Phe(7)]-alpha-MSH, on melanin synthesis in humans with MC1R variant alleles Peptides 2006 27 388 394
37. R. S. Barnetson T. K. Ooi L. Zhuang G. M. Halliday C. M. Reid P. C. Walker S. M. Humphrey M. J. Kleinig [Nle4-d-Phe7]-alpha-melanocyte-stimulating hormone significantly increased pigmentation and decreased UV damage in fair-skinned Caucasian volunteers J. Invest. Dermatol. 2006 126 1869 1878
38. J. E. Hauser A. L. Kadekaro R. J. Kavanagh K. Wakamatsu S. Terzieva S. Schwemberger G. Babcock M. B. Rao S. Ito Z. A. Abdel-Malek Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human melanocytes Pigment Cell Res. 2006 19 303 314
39. N. E. Fusenig P. Boukamp Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes Mol. Carcinog. 1998 23 144 158
40. J. Z. Qin V. Chaturvedi M. F. Denning D. Choubey M. O. Diaz B. J. Nickoloff Role of NF-kappaB in the apoptotic-resistant phenotype of keratinocytes J. Biol. Chem. 1999 274 37957 37964
41. V. Chaturvedi J. Z. Qin M. F. Denning D. Choubey M. O. Diaz B. J. Nickoloff Apoptosis in proliferating, senescent, and immortalized keratinocytes J. Biol. Chem. 1999 274 23358 23367
42. D. A. Lewis S. F. Hengeltraub F. C. Gao M. A. Leivant D. F. Spandau Aberrant NF-κB activity in HaCaT cells alters their response to UVB signaling J. Invest. Dermatol. 2006 126 1885 1892
43. M. Bohm T. A. Luger D. J. Tobin J. C. Garcia-Borron Melanocortin receptor ligands: new horizons for skin biology and clinical dermatology J. Invest. Dermatol. 2006 126 1966 1975
44. H. Aoki O. Moro Involvement of microphthalmia-associated transcription factor (MITF) in expression of human melanocortin-1 receptor (MC1R) Life Sci. 2002 71 2171 2179
45. S. Pavey B. Gabrielli Alpha-melanocyte stimulating hormone potentiates p16/CDKN2A expression in human skin after ultraviolet irradiation Cancer Res. 2002 62 875 880
46. P. Sarkar-Agrawal I. Vergilis N. E. Sharpless R. A. DePinho T. M. Runger Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF J. Natl. Cancer Inst. 2004 96 1790 1793
47. J. M. Ford P. C. Hanawalt Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts J. Biol. Chem. 1997 272 28073 28080
48. G. Mathonnet C. Leger J. Desnoyers R. Drouin J. P. Therrien E. A. Drobetsky UV wavelength-dependent regulation of transcription-coupled nucleotide excision repair in p53-deficient human cells Proc. Natl. Acad. Sci. USA 2003 100 7219 7224
49. D. H. Oh K. Yeh Differentiating human keratinocytes are deficient in p53 but retain global nucleotide excision repair following ultraviolet radiation DNA Repair (Amst) 2005 4 1149 1159
50. B. E. Ferguson D. H. Oh Proficient global nucleotide excision repair in human keratinocytes but not in fibroblasts deficient in p53 Cancer Res. 2005 65 8723 8729
51. P. J. Rochette N. Bastien J. Lavoie S. L. Guerin R. Drouin SW480, a p53 double-mutant cell line retains proficiency for some p53 functions J. Mol. Biol. 2005 352 44 57