When to add supplemental rectal paracetamol for postoperative analgesia with caudal bupivacaine in children? A prospective, double-blind, randomized study

Paediatric Anaesthesia

Volumn 17, Issue 6, 2007, Pages 547-551

  Mercan, Arzu ^b,c   Murat Sayin, M ^a   Saydam, Sibel ^b   Ozmert, Sengul ^b   Tiryaki, Tugrul ^b  

^a SSK Ankara Training Hospital   (Turkey)

^b SSK Ankara Diskapi Hospital   (Turkey)

^c YEDITEPE UNIVERSITY   (Turkey)

Author keywords

Bupivacaine; Caudal; Children; Paracetamol; Rectal

Indexed keywords

BUPIVACAINE; MIDAZOLAM; PARACETAMOL; PETHIDINE; SEVOFLURANE;

ARTICLE; CHILD; CIRCUMCISION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; DOUBLE BLIND PROCEDURE; EPIDURAL ANESTHESIA; FEMALE; HERNIOPLASTY; HUMAN; MAJOR CLINICAL STUDY; MALE; OPERATION DURATION; ORCHIDOPEXY; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; UNSPECIFIED SIDE EFFECT; UROLOGIC SURGERY; VISUAL ANALOG SCALE;

ACETAMINOPHEN; ADMINISTRATION, RECTAL; ANALGESIA; ANALGESICS, NON-NARCOTIC; ANESTHESIA, CAUDAL; ANESTHETICS, LOCAL; BUPIVACAINE; CHILD; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; FEMALE; HERNIA, INGUINAL; HUMANS; INFANT; MALE; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PROSPECTIVE STUDIES; TIME FACTORS;

EID: 34248201560     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/j.1460-9592.2006.02141.x     Document Type: Article

References (20)

1. Ozbek H, Bilen A, Ozcengiz D et al. The comparison of caudal ketamine, alfentanil and ketamine plus alfentanil administration for postoperative analgesia in children. Paediatr Anaesth 2002 12 : 610 616.
2. Tsui BCH, Berde CB. Caudal analgesia and anaesthesia techniques in children. Curr Opin Anaesthesiol 2005 18 : 283 288.
3. Samuel M, Hampson-Evans DH, Cunnington P. Prospective to a randomized double-blind controlled trial to assess efficacy of double caudal analgesia in hypospadias repair. J Pediatr Surg 2002 37 : 168 174.
4. Ozcengiz D, Gunduz M, Ozbek H et al. Comparison of caudal morphine and tramadol for postoperative pain control in children undergoing inguinal herniography. Paediatr Anaesth 2001 11 : 459 464.
5. Ansermino M, Basu R, Vandebeek C et al. Nonopioid additives to local anaesthetics for caudal blockade in children: a systematic review. Paediatr Anaesth 2003 13 : 561 573.
6. Ozkan S, Pocan S, Bahar A et al. The effect of caudal bupivacaine versus tramadol in postoperative analgesia for paediatric patients. J Int Med Res 2003 31 : 467 502.
7. Anderson BJ. What we don't know about paracetamol in children. Paediatr Anaesth 1998 8 : 451 460.
8. Ozyuvaci E, Altan A, Yucel M et al. Evaluation of adding preoperative or postoperative rectal paracetamol to caudal bupivacaine for postoperative analgesia in children. Pediatr Anesth 2004 14 : 661 665.
9. Birmingham PK, Tobin MJ, Fisher DM et al. Initial and subsequent dosing of rectal acetaminophen in children. Anesthesiology 2001 94 : 385 389.
10. Levy G. Pharmacokinetic analysis and analgesic effect of a single dose of acetaminophen in humans. J Pharm Sci 1987 76 : 88 89.
11. Gazzard BG, Ford-Hutchinson AW, Smith MJ et al. The binding of paracetamol to plasma proteins of man and pig. J Pharm Pharmacol 1973 25 : 964 967.
12. Hahn TW, Henneberg SW, Holm-Knudsen RJ et al. Pharmacokinetics of rectal paracetamol after repeated dosing in children. Br J Anaesth 2000 85 : 512 519.
13. Montgomery CJ, McCormack JP, Reichert CC et al. Plasma concentrations after high-dose (45 mg·kg-1) rectal acetaminophen in children. Can J Anaesth 1995 42 : 982 986.
14. Hansen T, O'Brian K, Morton NS et al. Plasma paracetamol concentrations and pharmacokinetics following rectal administration in neonates and young infants. Acta Anaesthesiol Scand 1999 43 : 855 859.
15. Lin YC, Susman HH, Benitz WE. Plasma concentrations after rectal administration of acetaminophen in preterm neonates. Paediatr Anaesth 1997 7 : 457 459.
16. Birmingham PK, Tobin MJ, Henthorn TK et al. Twenty-four hour pharmacokinetics of rectal acetaminophen in children. An old drug with new recommendations. Anesthesiology 1997 87 : 244 252.
17. Anderson BJ, Woollard GA, Holford NHG. Pharmacokinetics of rectal paracetamol after major surgery in children. Paediatr Anaesth 1995 5 : 237 242.
18. Anderson BJ, Holford NHG, Woollard GA. Paracetamol kinetics in neonates. Anaesth Intensive Care 1997 25 : 721 722.
19. Hahn TW, Mogensen T, Lund C et al. High dose rectal and oral acetaminophen in postoperative patients-serum saliva concentrations. Acta Anaesthesiol Scand 2000 44 : 302 306.
20. Warth H, Astfalk W, Walz GU. Pain control with paracetamol following inguinal herniorrhaphy or orchidopexy in childhood. Anaesthesiol Intensivmed Notfallmed Schmerzther 1994 29 : 90 95.