Preparation and evaluation of modified release ibuprofen microspheres with acrylic polymers (Eudragit®) by quasiemulsion solvent diffusion method: Effect of variables

Acta Poloniae Pharmaceutica - Drug Research

Volumn 63, Issue 6, 2006, Pages 521-534

  Devrim, Burcu ^a   Canefe, Kandemir ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

Eudragit ; Ibuprofen; Microspheres; Modified release; Quasi emulsion solvent diffusion method

Indexed keywords

EUDRAGIT; EUDRAGIT RS; IBUPROFEN; MICROSPHERE; POLYVINYL ALCOHOL; METHYLMETHACRYLATE METHACRYLIC ACID COPOLYMER; METHYLMETHACRYLATE-METHACRYLIC ACID COPOLYMER; POLYMETHACRYLIC ACID DERIVATIVE; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; BULK DENSITY; DIFFUSION; DRUG FORMULATION; DRUG RELEASE; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION; CHEMISTRY; EMULSION; SOLUBILITY;

DIFFUSION; EMULSIONS; IBUPROFEN; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; POLYMETHACRYLIC ACIDS; SOLUBILITY; SOLVENTS;

EID: 34248200909     PISSN: 00016837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Adams S.S., Buckler J.W.: Ibuprofen and Flurbiprofen. in: E.C. Huskisson (Ed.), Anti-Rheumatic Drugs, p. 244, Praeger, West Port, CT 1983.
2. th ed., Royal Pharmaceutical Society, London 2005.
3. Gallardo A., Eguiburu J.L., Berridi M.J.F., Roman J.S.: J. Controlled Rel. 55, 171 (1998).
4. Jbilou M., Ettabia A., Guyot-Hermann A.-M., Guyot J.-C.: Drug Dev. Ind. Pharm. 25(3), 297 (1999).
5. Leo E., Forni F., Bernabei M.T.: Int. J. Pharm. 196, 1 (2000).
6. Maheshwari M., Ketkar A.R., Chauhan B., Patil V.B., Paradkar A.R.: Int. J. Pharm. 261, 57 (2003).
7. Davis S.S., Illum L.: Biomaterials 9, 111 (1988).
8. Ritschel W.A.: Drug Dev. Ind. Pharm. 15, 1073 (1989).
9. Follonier N., Doelker E.: S.T.P. Pharma Sciences 2, 141 (1992).
10. Kawashima Y., Niwa T., Handa T., Takeuchi H., Iwamoto T., Itoh K.: J. Pharm. Sci. 78, 68 (1989).
11. Ré M.I., Biscans B.: Powder Technology 101, 120 (1999).
12. Khanfar M., Salem M., Najib N., Pillai G.: Acta Pharm. Hung. 67, 235 (1997)
13. Jovanovic M., Jovicic G., Djuric Z., Agbaba D., Karljikovic-Rajic K., Nikolic L.: Acta Pharm. Hung. 67, 229 (1997).
14. Zaghloul A.A., Vaithiyalingam S.R., Faltinek J., Reddy I.K., Khan M.A.: J. Microencapsul. 18, 651 (2001).
15. Yang M., Cui F., You B., Fan Y., Wang L., Yue P., Yang H.: Int. J. Pharm. 259, 103 (2003).
16. Mateovic-Rojinik T., Frlan R., Bogataj M., Bukovec P., Mrhar A.: Chem. Pharm. Bull. 53, 143 (2005).
17. Eudragit RS and Eudragit RL data sheets, Röhm Pharma GmbH, Darmstadt 1991.
18. Pignatello R., Bucolo C., Ferrara P., Maltese A., Puleo A., Puglisi G.: Eur. J. Pharm. Sci. 16, 53 (2002).
19. Dortunç B., Haznedar S.: Int. J. Pharm. 269, 131 (2004).
20. Devrim B., Canefe K.: Proceedings of the 8th European Congress of Pharmaceutical Sciences, Brussels, Belgium; Eur. J. Pharm. Sci. 23 (Suppl. 1), S40 (2004).
21. Canefe K., Ateşoǧlu-Göçmez S.: Boll. Chim. Farmac. 141, 423 (2002).
22. You J., Cui F., Han X., Wang Y., Yang L., Yu Y., Li Q.: Colloids and Surfaces B: Biointerfaces 48, 35 (2006).
23. Khan M.A., Bolton S., Kislalioǧlu M.S.: Int. J. Pharm. 102, 185 (1994). 24. Kachrimanis K., Ktistis G., Malamataris S.: Int. J. Pharm. 173, 61 (1998).
24. th ed., United States Pharmacopoeial Convention Inc., National Publishing Philadelphia, PA 2000.