Preparation of sustained-release nitrendipine microspheres with Eudragit RS and Aerosil using quasi-emulsion solvent diffusion method

International Journal of Pharmaceutics

Volumn 259, Issue 1-2, 2003, Pages 103-113

  Yang, Ming Shi ^a   Cui, Fu De ^a   You, Ben Gang ^a   Fan, Yu Ling ^a   Wang, Liang ^a   Yue, Peng ^a   Yang, He ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Aerosil; Eudragit RS; Nitrendipine; Quasi emulsion solvent diffusion method; Solvent deposition system; Sustained release microsphere

Indexed keywords

AEROSIL; DODECYL SULFATE SODIUM; EUDRAGIT RS; MICROSPHERE; NITRENDIPINE; SOLVENT;

ANALYTIC METHOD; ARTICLE; BULK DENSITY; CRYSTAL; DISPERSION; DRUG SOLUBILITY; EMULSION; LIQUID; OBSERVATION; PARTICLE SIZE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE PREPARATION; X RAY DIFFRACTION;

EID: 0037685276     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(03)00209-6     Document Type: Article

References (13)

1. Akbuga J. Preparation and evaluation of controlled release furosemide microspheres by spherical crystallization. Int. J. Pharm. 53:1989;99-105.
2. Akbuga J. Furosemide-loaded ethyl cellulose microspheres prepared by spherical crystallization technique: morphology and release characteristics. Int. J. Pharm. 76:1991;193-198.
3. Cui F.-D., Kawashima Y., Takeuchi H., Niwa T., Hino T. Preparation of controlled releasing acrylic polymer microspheres of acebutolol hydrochloride and those powder coated microspheres with sodium alginate in a polymeric spherical crystallization system. Chem. Pharm. Bull. 44:1996;837-842.
4. Cui, F.-D., Wang, X., Yang, M.-S., Pang, X.J., 2001. Studies on the preparation of sustained-release microspheres by spherical crystallization technique. In: The 18th Symposium on Particulate Preparations and Designs, Japan. pp. 209-214.
5. Johansen H., Møller N. Solvent deposition method for enhancement of dissolution rate: importance of drug-to-excipient ratio. J. Pharm. Sci. 67:1978;134-136.
6. Kawashima Y., Niwa T., Handa T., Takeushi H., Iwamoto T., Itoh K. Preparation of controlled-released microspheres of ibuprofen with acrylic polymers by a novel quasi-emulsion solvent diffusion method. J. Pharm Sci. 78:1989a;68-72.
7. Kawashima Y., Niwa T., Handa T., Takeuchi H., Iwamoto T., Itoh Y. Perparation of prolonged-release spherical micro-matrix of ibuprofen with acrylic polymer by the emulsion-solvent diffusion method for improving bioavailability. Chem. Pharm. Bull. 37:1989b;425-429.
8. Law S.L., Chiang C.H. Improve dissolution rates of griseofulvin by deposition on disintegrants. Drug Dev. Ind. Pharm. 16:1990;137-147.
9. Liao C.-H., Jarowski C.I. Dissolution rates of corticoid solutions dispersed on silicas. J. Pharm. Sci. 72:1984;401-403.
10. Monkhouse D.C., Lach J.L. Use of adsorbents in enhancement of drug dissolution I. J. Pharm. Sci. 61:1972;1430-1435.
11. Mikus G., Eichelbaum M. Pharmacokinetics, bioavailability, metabolism, and hemodynamic effects of the calcium channel antagonist nitrendipine. J. Cardiovasc. Pharmacol. 9:1987;S140-S141.
12. Niwa T., Takeuchi H., Hino T., Kunou N., Kawashima Y. Preparation of biodegradable nanospheres of water-soluble and insoluble drugs with DL-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method and the drug release behavior. J. Control. Release. 25:1993;89-98.
13. Sheth A., Jarowski C.I. Use of powdered solutions to improve the dissolution rate of polythiazide tablets. Drug Dev. Ind. Pharm. 16:1990;769-777.