Analysis of internal motions of interleukin-13 variant associated with severe bronchial asthma using 15N NMR relaxation measurements

Biochemical and Biophysical Research Communications

Volumn 358, Issue 1, 2007, Pages 292-297

  Yoshida, Yuichiro ^a   Ohkuri, Takatoshi ^a   Takeda, Chika ^a   Kuroki, Ryota ^b   Izuhara, Kenji ^c   Imoto, Taiji ^d   Ueda, Tadashi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b JAPAN ATOMIC ENERGY AGENCY   (Japan)

^c Center for Comprehensive Community Medicine   (Japan)

^d SOJO UNIVERSITY   (Japan)

Author keywords

Interleukin 13; Interleukin 13 receptor; Internal motion; NMR

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR ALPHA2;

ARTICLE; ASTHMA; BINDING AFFINITY; CONTROLLED STUDY; DISEASE SEVERITY; HUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PURIFICATION; PROTEIN VARIANT;

ASTHMA; HUMANS; INTERLEUKIN-13; INTERLEUKIN-13 RECEPTOR ALPHA2 SUBUNIT; MODELS, MOLECULAR; MOTION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN CONFORMATION;

EID: 34248179165     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.04.128     Document Type: Article

References (30)

1. McKenzie A.N., Culpepper J.A., de Waal Malefyt R., Briere F., Punnonen J., Aversa G., Sato A., Dang W., Cocks B.G., Menon S., et al. Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function. Proc. Natl. Acad. Sci. USA 90 (1993) 3735-3739
2. Minty A., Chalon P., Derocq J.M., Dumont X., Guillemot J.C., Kaghad M., Labit C., Leplatois P., Liauzun P., Miloux B., et al. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature 362 (1993) 248-250
3. Zurawski G., and de Vries J.E. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol Today 15 (1994) 19-26
4. Punnonen J., Cocks B.G., Carballido J.M., Bennett B., Peterson D., Aversa G., and de Vries J.E. Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes. J. Exp. Med. 185 (1997) 993-1004
5. Kajiwara K., Shinazawa M., Morishima H., and Yanagihara Y. Differential effect of IL-4 and IL-13 on the expression of recombination-activating genes in mature B cells from human peripheral blood. Cell Immunol. 227 (2004) 121-128
6. Bousquet J., Jeffery P.K., Busse W.W., Johnson M., and Vignola A.M. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am. J. Respir. Crit. Care Med. 161 (2000) 1720-1745
7. Kuperman D.A., Huang X., Koth L.L., Chang G.H., Dolganov G.M., Zhu Z., Elias J.A., Sheppard D., and Erle D.J. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat. Med. 8 (2002) 885-889
8. Aman M.J., Tayebi N., Obiri N.I., Puri R.K., Modi W.S., and Leonard W.J. cDNA cloning and characterization of the human interleukin 13 receptor alpha chain. J. Biol. Chem. 271 (1996) 29265-29270
9. Hilton D.J., Zhang J.G., Metcalf D., Alexander W.S., Nicola N.A., and Willson T.A. Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc. Natl. Acad. Sci. USA 93 (1996) 497-501
10. Donaldson D.D., Whitters M.J., Fitz L.J., Neben T.Y., Finnerty H., Henderson S.L., O'Hara Jr. R.M., Beier D.R., Turner K.J., Wood C.R., and Collins M. The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1. J. Immunol. 161 (1998) 2317-2324
11. Zheng T., Zhu Z., Liu W., Lee C.G., Chen Q., Homer R.J., and Elias J.A. Cytokine regulation of IL-13Ralpha2 and IL-13Ralpha1 in vivo and in vitro. J. Allergy Clin. Immunol. 111 (2003) 720-728
12. Kawakami K., Taguchi J., Murata T., and Puri R.K. The interleukin-13 receptor alpha2 chain: an essential component for binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway. Blood 97 (2001) 2673-2679
13. van der Pouw Kraan T.C., van Veen A., Boeije L.C., van Tuyl S.A., de Groot E.R., Stapel S.O., Bakker A., Verweij C.L., Aarden L.A., and van der Zee J.S. An IL-13 promoter polymorphism associated with increased risk of allergic asthma. Genes Immun. 1 (1999) 61-65
14. Graves P.E., Kabesch M., Halonen M., Holberg C.J., Baldini M., Fritzsch C., Weiland S.K., Erickson R.P., von Mutius E., and Martinez F.D. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J. Allergy Clin. Immunol. 105 (2000) 506-513
15. Heinzmann A., Mao X.Q., Akaiwa M., Kreomer R.T., Gao P.S., Ohshima K., Umeshita R., Abe Y., Braun S., Yamashita T., Roberts M.H., Sugimoto R., Arima K., Arinobu Y., Yu B., Kruse S., Enomoto T., Dake Y., Kawai M., Shimazu S., Sasaki S., Adra C.N., Kitaichi M., Inoue H., Yamauchi K., Tomichi N., Kurimoto F., Hamasaki N., Hopkin J.M., Izuhara K., Shirakawa T., and Deichmann K.A. Genetic variants of IL-13 signalling and human asthma and atopy. Hum. Mol. Genet. 9 (2000) 549-559
16. Leung T.F., Tang N.L., Chan I.H., Li A.M., Ha G., and Lam C.W. A polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in Chinese children. Clin. Exp. Allergy 31 (2001) 1515-1521
17. Tsunemi Y., Saeki H., Nakamura K., Sekiya T., Hirai K., Kakinuma T., Fujita H., Asano N., Tanida Y., Wakugawa M., Torii H., and Tamaki K. Interleukin-13 gene polymorphism G4257A is associated with atopic dermatitis in Japanese patients. J. Dermatol. Sci. 30 (2002) 100-107
18. Arima K., Umeshita-Suyama R., Sakata Y., Akaiwa M., Mao X.Q., Enomoto T., Dake Y., Shimazu S., Yamashita T., Sugawara N., Brodeur S., Geha R., Puri R.K., Sayegh M.H., Adra C.N., Hamasaki N., Hopkin J.M., Shirakawa T., and Izuhara K. Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma. J. Allergy Clin. Immunol. 109 (2002) 980-987
19. Madhankumar A.B., Mintz A., and Debinski W. Alanine-scanning mutagenesis of alpha-helix D segment of interleukin-13 reveals new functionally important residues of the cytokine. J. Biol. Chem. 277 (2002) 43194-43205
20. Zidek L., Novotny M.V., and Stone M.J. Increased protein backbone conformational entropy upon hydrophobic ligand binding. Nat. Struct. Biol. 6 (1999) 1118-1121
21. Mittag T., Schaffhausen B., and Gunther U.L. Direct observation of protein-ligand interaction kinetics. Biochemistry 42 (2003) 11128-11136
22. Fesik S.W., Zuiderweg E.R., Olejniczak E.T., and Gampe Jr. R.T. NMR methods for determining the structures of enzyme/inhibitor complexes as an aid in drug design. Biochem. Pharmacol. 40 (1990) 161-167
23. 15N Hartmann-Hahn-multiple quantum coherence and nuclear Overhauser-multiple quantum coherence spectroscopy: application to interleukin 1 beta. Biochemistry 28 (1989) 6150-6156
24. Delaglio F., Grzesiek S., Vuister G.W., Zhu G., Pfeifer J., and Bax A. NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J. Biomol. NMR 6 (1995) 277-293
25. 15N inverse detected heteronuclear NMR spectroscopy: application to staphylococcal nuclease. Biochemistry 28 (1989) 8972-8979
26. Kordel J., Skelton N.J., Akke M., Palmer III A.G., and Chazin W.J. Backbone dynamics of calcium-loaded calbindin D9k studied by two-dimensional proton-detected 15N NMR spectroscopy. Biochemistry 31 (1992) 4856-4866
27. Mandel A.M., Akke M., and Palmer III A.G. Backbone dynamics of Escherichia coli ribonuclease HI: correlations with structure and function in an active enzyme. J. Mol. Biol. 246 (1995) 144-163
28. Eisenmesser E.Z., Kapust R.B., Nawrocki J.P., Mazzulla M.J., Pannell L.K., Waugh D.S., and Byrd R.A. Expression, purification, refolding, and characterization of recombinant human interleukin-13: utilization of intracellular processing. Protein Expr. Purif. 20 (2000) 186-195
29. Akke M. NMR methods for characterizing microsecond to millisecond dynamics in recognition and catalysis. Curr. Opin. Struct. Biol. 12 (2002) 642-647
30. Eisenmesser E.Z., Horita D.A., Altieri A.S., and Byrd R.A. Solution structure of interleukin-13 and insights into receptor engagement. J. Mol. Biol. 310 (2001) 231-241