메뉴 건너뛰기




Volumn 7, Issue 5, 2007, Pages 651-663

Haemophilia therapies

Author keywords

Bypassing agents; FIX; FVIII; Gene therapy; Global haemostasis tests; Haemophilia

Indexed keywords

ACTIVATED PROTHROMBIN COMPLEX; ADENOVIRUS VECTOR; BETAFACT; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 8 CONCENTRATE; BLOOD CLOTTING FACTOR 8 INHIBITOR; BLOOD CLOTTING FACTOR 9; BLOOD CLOTTING FACTOR 9 CONCENTRATE; CD20 ANTIBODY; EMOCLOT DI; FACTANE; FANHDI; HELIXATE FS; KOATE DVI; NOVIX; OCTANATE; OCTANINE; PROTHROMBIN COMPLEX; RECOMBINANT BLOOD CLOTTING FACTOR 7A; RECOMBINANT BLOOD CLOTTING FACTOR 8; RECOMBINANT BLOOD CLOTTING FACTOR 9; RETROVIRUS VECTOR; UNCLASSIFIED DRUG;

EID: 34248176342     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.7.5.651     Document Type: Review
Times cited : (10)

References (143)
  • 1
    • 0035822038 scopus 로고    scopus 로고
    • The hemophilias-from royal genes to gene therapy
    • MANNUCCI PM, TUDDENHAM EG: The hemophilias-from royal genes to gene therapy. N. Engl. J. Med. (2001) 344:1773-1780.
    • (2001) N. Engl. J. Med , vol.344 , pp. 1773-1780
    • MANNUCCI, P.M.1    TUDDENHAM, E.G.2
  • 2
    • 0014499005 scopus 로고
    • Haemophilia in the Talmud and rabbinic writings
    • ROSNER F: Haemophilia in the Talmud and rabbinic writings. Ann. Intern. Med. (1969) 70:833-837.
    • (1969) Ann. Intern. Med , vol.70 , pp. 833-837
    • ROSNER, F.1
  • 3
    • 0001556240 scopus 로고
    • Haemorrhagid diarhesis. Successful transfusion of blood
    • LANE S: Haemorrhagid diarhesis. Successful transfusion of blood. Lancet (1840) 1:185-188.
    • (1840) Lancet , vol.1 , pp. 185-188
    • LANE, S.1
  • 4
    • 0008722340 scopus 로고
    • Haemostatic therapy in haemophilia
    • PAYNE WW, STEEN RE: Haemostatic therapy in haemophilia. Br. Med. J. (1929) 29(1):1150-1152.
    • (1929) Br. Med. J , vol.29 , Issue.1 , pp. 1150-1152
    • PAYNE, W.W.1    STEEN, R.E.2
  • 5
    • 0000010301 scopus 로고
    • A study of the clotting defect in hemophilia : The delayed formation of thrombin
    • BRINKHOUS KM: A study of the clotting defect in hemophilia : the delayed formation of thrombin. Am. J. Med. Sci. (1939) 198:509-516.
    • (1939) Am. J. Med. Sci , vol.198 , pp. 509-516
    • BRINKHOUS, K.M.1
  • 7
    • 77951380017 scopus 로고
    • Two cases of hereditary hemophilia due to a deficiency of a new clotting factor (Christmas factor)
    • CRAMER R, FLÜCKIGER P, GASSER C, KOLLER F, LOELIGER A, MATTER M: Two cases of hereditary hemophilia due to a deficiency of a new clotting factor (Christmas factor). Acta Haematol. (1953) 10:65-76.
    • (1953) Acta Haematol , vol.10 , pp. 65-76
    • CRAMER, R.1    FLÜCKIGER, P.2    GASSER, C.3    KOLLER, F.4    LOELIGER, A.5    MATTER, M.6
  • 8
    • 3042704579 scopus 로고    scopus 로고
    • MANNUCCI PM: AIDS, hepatitis and hemophilia in the 1980s: memoirs from an insider. J. Thromb. Haemost. (2003) 1:2065-2069. •• An excellent review of the infectious complications in haemophilia patients.
    • MANNUCCI PM: AIDS, hepatitis and hemophilia in the 1980s: memoirs from an insider. J. Thromb. Haemost. (2003) 1:2065-2069. •• An excellent review of the infectious complications in haemophilia patients.
  • 10
    • 0036207230 scopus 로고    scopus 로고
    • Quality of life differences between prophylactic and on-demand factor replacement therapy in European haemophilia patients
    • ROYAL S, SCHRAMM W, BERNTORP E et al.: Quality of life differences between prophylactic and on-demand factor replacement therapy in European haemophilia patients. Haemophilia (2002) 8:44-50.
    • (2002) Haemophilia , vol.8 , pp. 44-50
    • ROYAL, S.1    SCHRAMM, W.2    BERNTORP, E.3
  • 11
    • 0141832940 scopus 로고    scopus 로고
    • MANNUCCI PM: Haemophilia:treatment options in the twenty-first century. J. Thromb. Haemost. (2003) 1:1349-1355. •• An excellent comprehensive review on haemophilia treatment.
    • MANNUCCI PM: Haemophilia:treatment options in the twenty-first century. J. Thromb. Haemost. (2003) 1:1349-1355. •• An excellent comprehensive review on haemophilia treatment.
  • 12
    • 0037276210 scopus 로고    scopus 로고
    • Nanofiltration of plasma derived biopharmaceutical products
    • BURNOUF T, RADOSEVICH M: Nanofiltration of plasma derived biopharmaceutical products. Haemophilia (2003) 9:24-37.
    • (2003) Haemophilia , vol.9 , pp. 24-37
    • BURNOUF, T.1    RADOSEVICH, M.2
  • 13
    • 0034133532 scopus 로고    scopus 로고
    • Commitee report. Nucleic acid testing of blood donors for transfusion- transmitted infectious diseases: Report of the Interorganizational task force on nucleic acis amplification testing of blood donors
    • BUSCH MP, KLEINMAN SH, JACKSON B, STRAMER SL, HEWLETT I, PRESTON S: Commitee report. Nucleic acid testing of blood donors for transfusion- transmitted infectious diseases: report of the Interorganizational task force on nucleic acis amplification testing of blood donors. Transfusion (2000) 40:143-159.
    • (2000) Transfusion , vol.40 , pp. 143-159
    • BUSCH, M.P.1    KLEINMAN, S.H.2    JACKSON, B.3    STRAMER, S.L.4    HEWLETT, I.5    PRESTON, S.6
  • 14
    • 30344434999 scopus 로고    scopus 로고
    • Influence of the type of Factor VIII concentrate on the incidence of Factor VIII inhibitors in previously untreated patients with severe hemophilia A. FVIII-LFB and Recombinant FVIII Study Groups
    • GOUDEMAND J, ROTSCHILD C, DEMIGUEL V et al.: Influence of the type of Factor VIII concentrate on the incidence of Factor VIII inhibitors in previously untreated patients with severe hemophilia A. FVIII-LFB and Recombinant FVIII Study Groups. Blood (2006) 107:46-51.
    • (2006) Blood , vol.107 , pp. 46-51
    • GOUDEMAND, J.1    ROTSCHILD, C.2    DEMIGUEL, V.3
  • 15
    • 0036332175 scopus 로고    scopus 로고
    • Von Willebrand factor modulates Factor VIII immunogenicity: Comparative study of different Factor VIII concentrates in a haemophilia A mouse model
    • BEHRMANN M, PASI J, SAINT-REMY JM et al.: Von Willebrand factor modulates Factor VIII immunogenicity: comparative study of different Factor VIII concentrates in a haemophilia A mouse model. Thromb. Haemost. (2002) 88:221-229.
    • (2002) Thromb. Haemost , vol.88 , pp. 221-229
    • BEHRMANN, M.1    PASI, J.2    SAINT-REMY, J.M.3
  • 17
    • 0141673367 scopus 로고    scopus 로고
    • Treatment of haemophilia: Recombinant factors only? Yes
    • GIANGRANDE PLF: Treatment of haemophilia: recombinant factors only? Yes. J. Thromb. Haemost. (2003) 1:214-215.
    • (2003) J. Thromb. Haemost , vol.1 , pp. 214-215
    • GIANGRANDE, P.L.F.1
  • 18
    • 0021750055 scopus 로고
    • Characterization of the human Factor VIII gene
    • GITSCHIER J, WOOD WI, GORALKA TM et al.: Characterization of the human Factor VIII gene. Nature (1984) 312:326-330.
    • (1984) Nature , vol.312 , pp. 326-330
    • GITSCHIER, J.1    WOOD, W.I.2    GORALKA, T.M.3
  • 19
    • 0021715169 scopus 로고
    • Molecular cloning of a cDNA encoding human anti-haemophilic factor
    • TOOLE JT, KNOPF JL, WOZNEY JM et al.: Molecular cloning of a cDNA encoding human anti-haemophilic factor. Nature (1984) 312:342-347.
    • (1984) Nature , vol.312 , pp. 342-347
    • TOOLE, J.T.1    KNOPF, J.L.2    WOZNEY, J.M.3
  • 20
    • 0025644310 scopus 로고
    • Human recombinant DNA-derived antihaemophilic factor (Factor VIII) in the treatment of haemophilia A
    • SCHWARTZ RS, ABILDGAARD CF, ALEDORT LM et al.: Human recombinant DNA-derived antihaemophilic factor (Factor VIII) in the treatment of haemophilia A. N. Engl J. Med. (1990) 323:1800-1805.
    • (1990) N. Engl J. Med , vol.323 , pp. 1800-1805
    • SCHWARTZ, R.S.1    ABILDGAARD, C.F.2    ALEDORT, L.M.3
  • 21
    • 0034869020 scopus 로고    scopus 로고
    • Production processes of licensed recombinant factor FVIII preparations
    • BOEDEKER BG: Production processes of licensed recombinant factor FVIII preparations. Semin. Thromb. Haemost. (2001) 274:385-394.
    • (2001) Semin. Thromb. Haemost , vol.274 , pp. 385-394
    • BOEDEKER, B.G.1
  • 22
    • 0036017366 scopus 로고    scopus 로고
    • Preclinical pharmacology of albumin-free B domain deleted recombinant Factor VIII
    • BRINKHOUS K, SANDBERG H, WIDLUND L et al.: Preclinical pharmacology of albumin-free B domain deleted recombinant Factor VIII. Semin. Thromb. Haemost. (2002) 28:269-272.
    • (2002) Semin. Thromb. Haemost , vol.28 , pp. 269-272
    • BRINKHOUS, K.1    SANDBERG, H.2    WIDLUND, L.3
  • 23
    • 34248219684 scopus 로고
    • A large region (=95kDa) of human Factor VIII is dispensable for in vitro procoagulant activity
    • TOOLE JT, PITTMAN DD, ORR EC et al.: A large region (=95kDa) of human Factor VIII is dispensable for in vitro procoagulant activity. Proc. Natl. Acad. Sci. USA (1986) 83:5839-5842.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 5839-5842
    • TOOLE, J.T.1    PITTMAN, D.D.2    ORR, E.C.3
  • 24
    • 0037276262 scopus 로고    scopus 로고
    • The safety and efficacy of B domain deleted recombinant Factor VIII concentrate in patients with severe haemopihilia A. For the REFACTO 3 Study Group
    • LUSHER JM, LEE CA, KESSLER CM, BEDROSIAN CL: The safety and efficacy of B domain deleted recombinant Factor VIII concentrate in patients with severe haemopihilia A. For the REFACTO 3 Study Group. Haemophilia (2003) 9:38-49.
    • (2003) Haemophilia , vol.9 , pp. 38-49
    • LUSHER, J.M.1    LEE, C.A.2    KESSLER, C.M.3    BEDROSIAN, C.L.4
  • 25
    • 4844231460 scopus 로고    scopus 로고
    • Increased breaktrough bleeding during prophylaxis with B-domain deleted Factor VIII - a robust meta-analytic finding
    • GRUPPO RA
    • GRUPPO RA, BROWN D, WILKES MM, NAVICKIS RJ: Increased breaktrough bleeding during prophylaxis with B-domain deleted Factor VIII - a robust meta-analytic finding. Haemophilia (2004) 10:449-451.
    • (2004) Haemophilia , vol.10 , pp. 449-451
    • BROWN, D.1    WILKES, M.M.2    NAVICKIS, R.J.3
  • 26
    • 34248195245 scopus 로고    scopus 로고
    • Recombinant Factor VIII manufactured without the use of animal/human derived substances (rAHF-PFM)
    • Abstract
    • MITTERER A, KALIWODA M, KUMAR HP, KASHI RS: Recombinant Factor VIII manufactured without the use of animal/human derived substances (rAHF-PFM). Blood (2002) 100:92b (Abstract).
    • (2002) Blood , vol.100
    • MITTERER, A.1    KALIWODA, M.2    KUMAR, H.P.3    KASHI, R.S.4
  • 27
    • 0019957533 scopus 로고
    • Molecular cloning of the gene for human anti-haemophilic Facror IX
    • CHOO KH, GOULD KG, REES DJ, BROWNLEE GG: Molecular cloning of the gene for human anti-haemophilic Facror IX. Nature (1982) 299(5879):178- 180.
    • (1982) Nature , vol.299 , Issue.5879 , pp. 178-180
    • CHOO, K.H.1    GOULD, K.G.2    REES, D.J.3    BROWNLEE, G.G.4
  • 28
    • 0021435842 scopus 로고
    • The gene structure of human anti-haemophilic Factor IX
    • ANSON DS, CHOO KH, REES DJ et al.: The gene structure of human anti-haemophilic Factor IX. EMBO J. (1984) 3:1053-1060.
    • (1984) EMBO J , vol.3 , pp. 1053-1060
    • ANSON, D.S.1    CHOO, K.H.2    REES, D.J.3
  • 29
    • 85102663590 scopus 로고    scopus 로고
    • Human recombinant Factor IX: Safety and efficacy studies in haemophilia B patients previously treated with plasma derived Factor IX concentrates
    • 4242; author reply 4242-4243
    • HAASE M: Human recombinant Factor IX: safety and efficacy studies in haemophilia B patients previously treated with plasma derived Factor IX concentrates. Blood (2002) 100:4242; author reply 4242-4243.
    • (2002) Blood , vol.100
    • HAASE, M.1
  • 30
    • 0031977163 scopus 로고    scopus 로고
    • Clinical evaluation of recombinant Factor IX
    • WHITE G, SHAPIRO A, RAGNI M et al.: Clinical evaluation of recombinant Factor IX. Semin. Hematol. (1998) 35(Suppl. 2):33-38.
    • (1998) Semin. Hematol , vol.35 , Issue.SUPPL. 2 , pp. 33-38
    • WHITE, G.1    SHAPIRO, A.2    RAGNI, M.3
  • 31
    • 0030942094 scopus 로고    scopus 로고
    • A multicentre study of recombinant Factor VIII (Recombinate) in previously treated patients with hemophilia A
    • WHITE GC II, COURTER S, BRAY GL, LEE M, GOMPERTS ED: A multicentre study of recombinant Factor VIII (Recombinate) in previously treated patients with hemophilia A. Thromb. Haemost. (1997) 77:660-667.
    • (1997) Thromb. Haemost , vol.77 , pp. 660-667
    • WHITE II, G.C.1    COURTER, S.2    BRAY, G.L.3    LEE, M.4    GOMPERTS, E.D.5
  • 32
    • 0032787813 scopus 로고    scopus 로고
    • Incidence of inhibitors in haemophilia A patients-a review of recent studies of recombinant and plasma-derived FVIII concentrates
    • SCHARRER I, BRAY GL, NEUTZLING O: Incidence of inhibitors in haemophilia A patients-a review of recent studies of recombinant and plasma-derived FVIII concentrates. Haemophilia (1999) 5:145-154.
    • (1999) Haemophilia , vol.5 , pp. 145-154
    • SCHARRER, I.1    BRAY, G.L.2    NEUTZLING, O.3
  • 33
    • 0028266130 scopus 로고
    • A multicentre study of recombinant Factor VIII (Recombinate): Safety, efficacy and inhibitor risk in perviously untreated patients with haemophilia A
    • BRAY GL, GOMPERTS ED, COURTER S et al.: A multicentre study of recombinant Factor VIII (Recombinate): safety, efficacy and inhibitor risk in perviously untreated patients with haemophilia A. Blood (1994) 83:2428-2435.
    • (1994) Blood , vol.83 , pp. 2428-2435
    • BRAY, G.L.1    GOMPERTS, E.D.2    COURTER, S.3
  • 34
    • 0027473752 scopus 로고
    • Kogenate previously untreated patient study group. Recombinant afctor VIII for the treatment of previously untreated patients with haemophilia A: Safety, efficacy and development of inhibitors
    • LUSHER JM, ARKIN S, ABILGAARD CF: Kogenate previously untreated patient study group. Recombinant afctor VIII for the treatment of previously untreated patients with haemophilia A: safety, efficacy and development of inhibitors. N. Engl. J. Med. (1993) 328:453-459.
    • (1993) N. Engl. J. Med , vol.328 , pp. 453-459
    • LUSHER, J.M.1    ARKIN, S.2    ABILGAARD, C.F.3
  • 35
    • 0026548917 scopus 로고
    • Incidence of development of factor FVIII and FIX inhibitors in haemophiliacs
    • EHRENFORTH S, KREUZ W, SCHARRER I et al.: Incidence of development of factor FVIII and FIX inhibitors in haemophiliacs. Lancet (1992) 339:594-598.
    • (1992) Lancet , vol.339 , pp. 594-598
    • EHRENFORTH, S.1    KREUZ, W.2    SCHARRER, I.3
  • 36
    • 0037247721 scopus 로고    scopus 로고
    • RODRIGUEZ-MERCHAN EC: Orthopedic surgery in persons with haemophilia. Thromb. Haemost. (2003) 89:34-42. •• An excellent discussion on the issues regarding the orthopaedic problems of haemophilia patients.
    • RODRIGUEZ-MERCHAN EC: Orthopedic surgery in persons with haemophilia. Thromb. Haemost. (2003) 89:34-42. •• An excellent discussion on the issues regarding the orthopaedic problems of haemophilia patients.
  • 37
    • 0037810806 scopus 로고    scopus 로고
    • Prophylaxis for severe hamophilia: Clinical and economical issues
    • FISCHER K, VAN DER BERG M: Prophylaxis for severe hamophilia: clinical and economical issues. Haemophilia (2003) 9:376-381.
    • (2003) Haemophilia , vol.9 , pp. 376-381
    • FISCHER, K.1    VAN DER, B.M.2
  • 39
  • 40
    • 85046914303 scopus 로고    scopus 로고
    • Prophylactic versus on demand treatment strategies for severe haemophilia: A comparison of costs and long term outcome
    • FISCHER K, VAN DER BOM M, NEGRIER C et al.: Prophylactic versus on demand treatment strategies for severe haemophilia: a comparison of costs and long term outcome. Haemophilia (2002) 8:1365-2516.
    • (2002) Haemophilia , vol.8 , pp. 1365-2516
    • FISCHER, K.1    VAN DER, B.M.2    NEGRIER, C.3
  • 41
    • 0031856486 scopus 로고    scopus 로고
    • Prophylactic treatment in Sweden - overtreatment or optimal model?
    • LJUNG RC: Prophylactic treatment in Sweden - overtreatment or optimal model? Haemophilia (1998) 4:409-412.
    • (1998) Haemophilia , vol.4 , pp. 409-412
    • LJUNG, R.C.1
  • 43
    • 0031697705 scopus 로고    scopus 로고
    • Port-A-Cath usage in children with haemophilia: Experience of 53 cases
    • LJUNG R, VAN DER BERG M, PETRINI P et al.: Port-A-Cath usage in children with haemophilia: experience of 53 cases. Acta Pediatr. (1998) 87:1051-1054.
    • (1998) Acta Pediatr , vol.87 , pp. 1051-1054
    • LJUNG, R.1    VAN DER, B.M.2    PETRINI, P.3
  • 44
    • 1842842526 scopus 로고    scopus 로고
    • Prophylaxis in developed and in emerging countries
    • TUSELL J, PEREZ-BIANCO R: Prophylaxis in developed and in emerging countries. Haemophilia (2002) 8:183-188.
    • (2002) Haemophilia , vol.8 , pp. 183-188
    • TUSELL, J.1    PEREZ-BIANCO, R.2
  • 45
    • 0000895004 scopus 로고    scopus 로고
    • Preliminary results from the Canadian hemophilia prophylaxis trial
    • FELDMAN BM, RIVARD G, ISRAELIS S et al.: Preliminary results from the Canadian hemophilia prophylaxis trial. Haemophilia (2000) 6:272.
    • (2000) Haemophilia , vol.6 , pp. 272
    • FELDMAN, B.M.1    RIVARD, G.2    ISRAELIS, S.3
  • 46
    • 0344924804 scopus 로고    scopus 로고
    • Why thrombin generation? From bench to bedside
    • ALEDORT LM: Why thrombin generation? From bench to bedside. Pathophysiol. Haemost. Thromb. (2003) 33:2-3.
    • (2003) Pathophysiol. Haemost. Thromb , vol.33 , pp. 2-3
    • ALEDORT, L.M.1
  • 47
    • 34248200195 scopus 로고    scopus 로고
    • THE MEDICAL AND SCIENTIFIC ADVISORY COUNCIL (MASAC): MASAC Recommendations Concerning Prophylaxis. MASAC Document #170. 22 April 2006, and adopted by the National Hemophilia Foundation Board of Directors on 3 June 2006 (2006).
    • THE MEDICAL AND SCIENTIFIC ADVISORY COUNCIL (MASAC): MASAC Recommendations Concerning Prophylaxis. MASAC Document #170. 22 April 2006, and adopted by the National Hemophilia Foundation Board of Directors on 3 June 2006 (2006).
  • 48
    • 33645995723 scopus 로고    scopus 로고
    • Unresolved issues in diagnosis and management of inherited bleeding disorders in the perinatal period: A white paper of the Perinatal Task Force of THE Medical and Scientific Advisory Council of the National Hemophilia Foundation, USA
    • KULKARNI R, PONDER KP, JAMES AH et al.: Unresolved issues in diagnosis and management of inherited bleeding disorders in the perinatal period: a white paper of the Perinatal Task Force of THE Medical and Scientific Advisory Council of the National Hemophilia Foundation, USA. Haemophilia (2006) 12:205-211.
    • (2006) Haemophilia , vol.12 , pp. 205-211
    • KULKARNI, R.1    PONDER, K.P.2    JAMES, A.H.3
  • 50
    • 0033056524 scopus 로고    scopus 로고
    • Central venous catheter associated thrombosis in severe haemophilia
    • VIDLER V, RICHARDS M, VORA A: Central venous catheter associated thrombosis in severe haemophilia. Br. J. Haematol. (1999) 104:461-464.
    • (1999) Br. J. Haematol , vol.104 , pp. 461-464
    • VIDLER, V.1    RICHARDS, M.2    VORA, A.3
  • 51
    • 0003350106 scopus 로고    scopus 로고
    • High risk of central venous line-associated thrombosis in boys wirh hemophilia
    • Abstract
    • BLANCHETTE VS, AL-TRABOLSI H, STAIN AM: High risk of central venous line-associated thrombosis in boys wirh hemophilia. Blood (1999) 94:818a (Abstract).
    • (1999) Blood , vol.94
    • BLANCHETTE, V.S.1    AL-TRABOLSI, H.2    STAIN, A.M.3
  • 53
    • 0038779219 scopus 로고    scopus 로고
    • Central venous lines in haemophilia
    • LJUNG R: Central venous lines in haemophilia. Haemophilia (2003) 9(Suppl. 1):88-93.
    • (2003) Haemophilia , vol.9 , Issue.SUPPL. 1 , pp. 88-93
    • LJUNG, R.1
  • 55
    • 0038383605 scopus 로고    scopus 로고
    • The epidemiology of inhibitors in haemophilia A: A systemic review
    • WIGHT J, PAISLEY S: The epidemiology of inhibitors in haemophilia A: a systemic review. Haemophilia (2003) 9:418-435.
    • (2003) Haemophilia , vol.9 , pp. 418-435
    • WIGHT, J.1    PAISLEY, S.2
  • 56
    • 33646140127 scopus 로고    scopus 로고
    • Why do inhibitors develop? Principles of and factors influencing the risk for inhibitor development in haemophilia
    • ASTERMARK J: Why do inhibitors develop? Principles of and factors influencing the risk for inhibitor development in haemophilia. Haemophilia (2006) 12(Suppl. 3):52-60.
    • (2006) Haemophilia , vol.12 , Issue.SUPPL. 3 , pp. 52-60
    • ASTERMARK, J.1
  • 57
    • 11144219711 scopus 로고    scopus 로고
    • Inhibitors in mhaemophilia: Pathophysiology
    • SAINT REMY JM, LACROIX DESMAZES S, OLDENBURG J: Inhibitors in mhaemophilia: pathophysiology. Haemophilia (2004) 10(Suppl. 4):146-151.
    • (2004) Haemophilia , vol.10 , Issue.SUPPL. 4 , pp. 146-151
    • SAINT REMY JM, L.D.S.1    OLDENBURG, J.2
  • 58
    • 28344447401 scopus 로고    scopus 로고
    • WHITE GC II, KEMPTON CL, GRIMSLEY A, NIELSEN B, ROBERTS R: Cellular immune responses in haemophilia: why do inhibitors develop in some, but not all haemophiliacs? J. Thromb. Haemost. (2005) 3:1676-1681. • An excellent discussion of inhibitors.
    • WHITE GC II, KEMPTON CL, GRIMSLEY A, NIELSEN B, ROBERTS R: Cellular immune responses in haemophilia: why do inhibitors develop in some, but not all haemophiliacs? J. Thromb. Haemost. (2005) 3:1676-1681. • An excellent discussion of inhibitors.
  • 59
    • 4644334185 scopus 로고    scopus 로고
    • Prevention of bleeds in hemophilia patients with inhibitors:emerging data and clinical direction
    • LEISSINGER CA: Prevention of bleeds in hemophilia patients with inhibitors:emerging data and clinical direction. Am. J. Hematol. (2004) 77:187-193.
    • (2004) Am. J. Hematol , vol.77 , pp. 187-193
    • LEISSINGER, C.A.1
  • 60
    • 0019135948 scopus 로고
    • Anti inhibitor coagulant complex (Autoplex) for treatment of Factor VIII inhibitors in haemophilia
    • ABILDGAARD CF, PENNER JA, WATSON-WILLIAMS EJ: Anti inhibitor coagulant complex (Autoplex) for treatment of Factor VIII inhibitors in haemophilia. Blood (1980) 56:978-984.
    • (1980) Blood , vol.56 , pp. 978-984
    • ABILDGAARD, C.F.1    PENNER, J.A.2    WATSON-WILLIAMS, E.J.3
  • 61
    • 0021067681 scopus 로고
    • Autoplex versus Proplex: A controlled, double-blind study of effectiveness in acute haemarthroses in haemophiliacs with inhibitors to Factor VIII
    • LUSHER JM, BLATT PM, PENNER JA et al.: Autoplex versus Proplex: a controlled, double-blind study of effectiveness in acute haemarthroses in haemophiliacs with inhibitors to Factor VIII. Blood (1983) 62:1135-1138.
    • (1983) Blood , vol.62 , pp. 1135-1138
    • LUSHER, J.M.1    BLATT, P.M.2    PENNER, J.A.3
  • 62
    • 24744463959 scopus 로고    scopus 로고
    • Activated prothrombin complex concentrates induce haemostasis by a balanced effect at multiple sites of the coagulation pathway
    • Abstract
    • TURECEK PL, VARADI K, GRITSCH H, SCHWARZ HP: Activated prothrombin complex concentrates induce haemostasis by a balanced effect at multiple sites of the coagulation pathway. Haemophilia (1998) 4:168 (Abstract).
    • (1998) Haemophilia , vol.4 , pp. 168
    • TURECEK, P.L.1    VARADI, K.2    GRITSCH, H.3    SCHWARZ, H.P.4
  • 63
    • 27744458341 scopus 로고    scopus 로고
    • Managing acute bleeds in the patient with haemophilia and inhibitors: Options, efficacy and safety
    • VON DEPKA M: Managing acute bleeds in the patient with haemophilia and inhibitors: options, efficacy and safety. Haemophilia (2005) 11(Suppl. 1):18-23.
    • (2005) Haemophilia , vol.11 , Issue.SUPPL. 1 , pp. 18-23
    • VON DEPKA, M.1
  • 64
    • 0347552464 scopus 로고    scopus 로고
    • Evidence for the use of activated prothrombin complex concentrates (aPCCs) in the treatment of patients with haemophilia and inhibitors
    • WILDE JT: Evidence for the use of activated prothrombin complex concentrates (aPCCs) in the treatment of patients with haemophilia and inhibitors. Pathophysiol. Haemost. Thromb. (2002) 32(Suppl. 1):9-12.
    • (2002) Pathophysiol. Haemost. Thromb , vol.32 , Issue.SUPPL. 1 , pp. 9-12
    • WILDE, J.T.1
  • 65
    • 0019426632 scopus 로고
    • The effect of activated prothrombin complex concentrate (FEIBA) on joint and muscle bleeding in patients with haemophilia A and antibodies to FVIII. A double blind clinical trial
    • SJAMSOEDIN LJ, HEIJNEN L, MAUSER-BUNSCHOTEN EP et al.: The effect of activated prothrombin complex concentrate (FEIBA) on joint and muscle bleeding in patients with haemophilia A and antibodies to FVIII. A double blind clinical trial. N. Engl. J. Med. (1981) 305:717-721
    • (1981) N. Engl. J. Med , vol.305 , pp. 717-721
    • SJAMSOEDIN, L.J.1    HEIJNEN, L.2    MAUSER-BUNSCHOTEN, E.P.3
  • 66
    • 0020662181 scopus 로고
    • The use of factor eight inhibitor by-passing activity (FEIBA immuno) product for treatment of bleeding episodes in haemophiliacs with inhibitors
    • HILGARTNER MW, KNATTERUD GL: The use of factor eight inhibitor by-passing activity (FEIBA immuno) product for treatment of bleeding episodes in haemophiliacs with inhibitors. Blood (1983) 61:36-40.
    • (1983) Blood , vol.61 , pp. 36-40
    • HILGARTNER, M.W.1    KNATTERUD, G.L.2
  • 67
    • 0025180213 scopus 로고
    • Efficacy ans safety of vapour heated anti-inhibitor coagulant complex in haemophilia patients. FEIBA study group
    • HILGARTNER M, ALEDORT L, ANDES A, GILL J: Efficacy ans safety of vapour heated anti-inhibitor coagulant complex in haemophilia patients. FEIBA study group. Transfusion (1990) 30:626-630.
    • (1990) Transfusion , vol.30 , pp. 626-630
    • HILGARTNER, M.1    ALEDORT, L.2    ANDES, A.3    GILL, J.4
  • 68
    • 0030837755 scopus 로고    scopus 로고
    • NEGRIER C, GOUDEMAND J, SULTAN Y, BERTRAND M, ROTHSCHILD C, LAUROUA P: Multicentre retrospective study on the utilization of FEIBA in France in patients with Factor VIII and Factor IX inhibitors. French FEIBA study Group. Factor Eight Bypassing Activity. Thromb. Haemost. (1997) 77:1113-1119. • An important article discussing the use of FEIBA.
    • NEGRIER C, GOUDEMAND J, SULTAN Y, BERTRAND M, ROTHSCHILD C, LAUROUA P: Multicentre retrospective study on the utilization of FEIBA in France in patients with Factor VIII and Factor IX inhibitors. French FEIBA study Group. Factor Eight Bypassing Activity. Thromb. Haemost. (1997) 77:1113-1119. • An important article discussing the use of FEIBA.
  • 69
    • 0033768130 scopus 로고    scopus 로고
    • The diagnosis and management of Factor VIII and IX inhibitors: A guideline from the UK Haemophilia Centre Doctors' Organization (UKHCDO)
    • HAY CR, BAGLIN TP, COLLINS PW et al.: The diagnosis and management of Factor VIII and IX inhibitors: a guideline from the UK Haemophilia Centre Doctors' Organization (UKHCDO). Br. J. Haematol. (2000) 111:78-90.
    • (2000) Br. J. Haematol , vol.111 , pp. 78-90
    • HAY, C.R.1    BAGLIN, T.P.2    COLLINS, P.W.3
  • 70
    • 0036489638 scopus 로고    scopus 로고
    • Safety of FVIII inhibitor bypass activity (FEIBA): 10-year compilation of thrombotic adverse events
    • EHRLICH HJ, HENZL M, GOMPERTS ED: Safety of FVIII inhibitor bypass activity (FEIBA): 10-year compilation of thrombotic adverse events. Haemophilia (2002) 8:83-90.
    • (2002) Haemophilia , vol.8 , pp. 83-90
    • EHRLICH, H.J.1    HENZL, M.2    GOMPERTS, E.D.3
  • 71
    • 0033768130 scopus 로고    scopus 로고
    • The diagnosis and management of Factor VIII and Factor IX inhibitors: A guideline from UK haemophilia center Doctors' organisation (UKHCDO)
    • HAY CR, BAGLIN TP, COLLINS PW, HILL FG, KEELING DM: The diagnosis and management of Factor VIII and Factor IX inhibitors: a guideline from UK haemophilia center Doctors' organisation (UKHCDO). Br. J. Haematol. (2000) 111:78-90.
    • (2000) Br. J. Haematol , vol.111 , pp. 78-90
    • HAY, C.R.1    BAGLIN, T.P.2    COLLINS, P.W.3    HILL, F.G.4    KEELING, D.M.5
  • 72
    • 0032731206 scopus 로고    scopus 로고
    • Efficacy of viral clearance methods used in the manufacture of activated prothrombin complexe concentrates: Focus on Autoplex T
    • HORWITH G, REVIE DR: Efficacy of viral clearance methods used in the manufacture of activated prothrombin complexe concentrates: focus on Autoplex T. Haemophilia (1999) 5(Suppl. 3):19-23.
    • (1999) Haemophilia , vol.5 , Issue.SUPPL. 3 , pp. 19-23
    • HORWITH, G.1    REVIE, D.R.2
  • 73
    • 0019426632 scopus 로고
    • The effect of activated prothrombin complex concentrate (FEIBA) on joint and muscle bleeding in patients with haemophilia A and antibodies to Factor VIII
    • SJAMSOEDIN LJ, HEIJNEN L, MAUSER-BUNSCHOTEN EP et al.: The effect of activated prothrombin complex concentrate (FEIBA) on joint and muscle bleeding in patients with haemophilia A and antibodies to Factor VIII. N. Engl. J. Med. (1981) 305:717-721.
    • (1981) N. Engl. J. Med , vol.305 , pp. 717-721
    • SJAMSOEDIN, L.J.1    HEIJNEN, L.2    MAUSER-BUNSCHOTEN, E.P.3
  • 74
    • 3242737794 scopus 로고    scopus 로고
    • Monitoring the bioavailability of FEIBA with a thrombin generation assay
    • VARADI K, NEGRIER C, BERNTORP E et al.: Monitoring the bioavailability of FEIBA with a thrombin generation assay. J. Thromb. Haemost. (2003) 1:2374-2380.
    • (2003) J. Thromb. Haemost , vol.1 , pp. 2374-2380
    • VARADI, K.1    NEGRIER, C.2    BERNTORP, E.3
  • 75
    • 24644460532 scopus 로고    scopus 로고
    • Major surgery in a severe haemophilia A patient with high titre inhibitor: Use of the thrombin generation test in the therapeutic decision
    • DARGAUD Y, LIENHART A, MEUNIER S et al.: Major surgery in a severe haemophilia A patient with high titre inhibitor: use of the thrombin generation test in the therapeutic decision. Haemophilia (2005) 11(5):552-558.
    • (2005) Haemophilia , vol.11 , Issue.5 , pp. 552-558
    • DARGAUD, Y.1    LIENHART, A.2    MEUNIER, S.3
  • 76
    • 33750690191 scopus 로고    scopus 로고
    • Individualization of bypassing agent treatment for hemophilic patients with inhibitors utilizing thromboelastography
    • YOUNG G, BLAIN R, NAKAGAWA P, NUGERT DJ: Individualization of bypassing agent treatment for hemophilic patients with inhibitors utilizing thromboelastography. Haemophilia (2006) 12:598-604.
    • (2006) Haemophilia , vol.12 , pp. 598-604
    • YOUNG, G.1    BLAIN, R.2    NAKAGAWA, P.3    NUGERT, D.J.4
  • 77
    • 0030695063 scopus 로고    scopus 로고
    • Platelet activity of high dose Factor VIIa is independent of tissue afctor
    • MONROE DM, HOFFMAN M, OLIVER JA et al.: Platelet activity of high dose Factor VIIa is independent of tissue afctor. Br. J. Haematol. (1997) 99:542-547.
    • (1997) Br. J. Haematol , vol.99 , pp. 542-547
    • MONROE, D.M.1    HOFFMAN, M.2    OLIVER, J.A.3
  • 78
    • 20444452505 scopus 로고    scopus 로고
    • FRANCHINI M, ZAFFANELLO M, VENERI D: Recombinnat FVIIa. Thromb. Haemost. (2005) 93:1027-1035.
    • FRANCHINI M, ZAFFANELLO M, VENERI D: Recombinnat FVIIa. Thromb. Haemost. (2005) 93:1027-1035.
  • 79
    • 0034651933 scopus 로고    scopus 로고
    • Inhibition of thrombin generation by the zymogen Factor VII: Implications for the treatment of hemophilia A by Factor VIIa
    • VAN'T VEER C, GOLDEN NJ, MANN KG: Inhibition of thrombin generation by the zymogen Factor VII: implications for the treatment of hemophilia A by Factor VIIa. Blood (2000) 95:1330-1335.
    • (2000) Blood , vol.95 , pp. 1330-1335
    • VAN'T VEER, C.1    GOLDEN, N.J.2    MANN, K.G.3
  • 80
    • 0242299079 scopus 로고    scopus 로고
    • A cell based model of haemostasis
    • HOFFMAN M: A cell based model of haemostasis. Blood Rev. (2003) 17:S1-S5.
    • (2003) Blood Rev , vol.17
    • HOFFMAN, M.1
  • 81
    • 0036090268 scopus 로고    scopus 로고
    • Inhibition of fibrinolysis by recombinant Factor VIIa in plasma from patients with severe haemophilia A
    • LISMAN T, MOSNIER LO, LAMBERT T et al.: Inhibition of fibrinolysis by recombinant Factor VIIa in plasma from patients with severe haemophilia A. Blood (2002) 99:175-179.
    • (2002) Blood , vol.99 , pp. 175-179
    • LISMAN, T.1    MOSNIER, L.O.2    LAMBERT, T.3
  • 82
    • 0031743504 scopus 로고    scopus 로고
    • Prospective randomised trial of two doses of rFVIIa (Novoseven) in haemophilia patients with inhibitors undergoing surgery
    • SHAPIRO A, GILCHRIST GS, HOOTS WK, COOPER HA, GASTINEAU DA: Prospective randomised trial of two doses of rFVIIa (Novoseven) in haemophilia patients with inhibitors undergoing surgery. Thromb. Haemost. (1998) 80:773-778.
    • (1998) Thromb. Haemost , vol.80 , pp. 773-778
    • SHAPIRO, A.1    GILCHRIST, G.S.2    HOOTS, W.K.3    COOPER, H.A.4    GASTINEAU, D.A.5
  • 84
    • 0032884251 scopus 로고    scopus 로고
    • Recombinate Factor VIIa for patients with inhibitors to Factor VIII or IX or Factor VII deficiency
    • SCHARRER I: Recombinate Factor VIIa for patients with inhibitors to Factor VIII or IX or Factor VII deficiency. Haemophilia (1999) 5:253-259.
    • (1999) Haemophilia , vol.5 , pp. 253-259
    • SCHARRER, I.1
  • 85
    • 0033758876 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant Factor VIIa in the prophylaxis of bleeding in various surgical procedures in hemophilia patients with Factor VIII and Factor IX inhibitors
    • INGERSLEV J: Efficacy and safety of recombinant Factor VIIa in the prophylaxis of bleeding in various surgical procedures in hemophilia patients with Factor VIII and Factor IX inhibitors. Semin. Thromb. Haemost. (2000) 26:425-432.
    • (2000) Semin. Thromb. Haemost , vol.26 , pp. 425-432
    • INGERSLEV, J.1
  • 86
    • 0027522777 scopus 로고
    • Recombinant activated Factor VII in the treatment of bleeding episodes in patients with inherited and acquired bleeding disorders
    • HEDNER U, GLAZER S, FALCH J: Recombinant activated Factor VII in the treatment of bleeding episodes in patients with inherited and acquired bleeding disorders. Transfus. Med. Rev. (1993) 7:78-83.
    • (1993) Transfus. Med. Rev , vol.7 , pp. 78-83
    • HEDNER, U.1    GLAZER, S.2    FALCH, J.3
  • 87
    • 0032950164 scopus 로고    scopus 로고
    • Home treatment with recombinant activated Factor VII in patients with Factor VIII inhibitors: The advantages of early intervention
    • SANTAGOSTINO E, GRINGERI A, MANNUCCI PM: Home treatment with recombinant activated Factor VII in patients with Factor VIII inhibitors: the advantages of early intervention. Br. J. Haematol. (1999) 104:22-26.
    • (1999) Br. J. Haematol , vol.104 , pp. 22-26
    • SANTAGOSTINO, E.1    GRINGERI, A.2    MANNUCCI, P.M.3
  • 88
    • 0001610906 scopus 로고    scopus 로고
    • Use of recombinant activated Factor VII as first line therapy for bleeding episodes in haemophilaics with Factor VIII or IX inhibitors (NOSEPAC study)
    • LAURIAN Y, GOUDEMAND J, NEGRIER C et al.: Use of recombinant activated Factor VII as first line therapy for bleeding episodes in haemophilaics with Factor VIII or IX inhibitors (NOSEPAC study). Blood Coagul. Fibrinolysis (1998) 9:S107-S110.
    • (1998) Blood Coagul. Fibrinolysis , vol.9
    • LAURIAN, Y.1    GOUDEMAND, J.2    NEGRIER, C.3
  • 89
    • 17144437423 scopus 로고    scopus 로고
    • Home treatment of mild to moderate bleeding episodes using recombinant activated Factor VII (Novoseven) in haemophiliacs with inhibitors
    • KEY NS, ALEDORT LM, BEARDSLEY D et al.: Home treatment of mild to moderate bleeding episodes using recombinant activated Factor VII (Novoseven) in haemophiliacs with inhibitors. Thromb. Haemost. (1998) 80:912-918.
    • (1998) Thromb. Haemost , vol.80 , pp. 912-918
    • KEY, N.S.1    ALEDORT, L.M.2    BEARDSLEY, D.3
  • 90
    • 0038383602 scopus 로고    scopus 로고
    • Control of bleeding in patients with haemophilia A with inhibitors:a systematic review
    • LLOYDS-JONES M, WIGHT J, PAISLEY S, KNIGHT C: Control of bleeding in patients with haemophilia A with inhibitors:a systematic review. Haemophilia (2003) 9:464-520.
    • (2003) Haemophilia , vol.9 , pp. 464-520
    • LLOYDS-JONES, M.1    WIGHT, J.2    PAISLEY, S.3    KNIGHT, C.4
  • 91
    • 17944368846 scopus 로고    scopus 로고
    • JURLANDER B, THIM L, KLAUSEN NK et al.: Recombinant activated Factor VII (rFVIIa): characterization, manufacturing and clinical development. Semin. Thromb. Haemost. (2001) 27:373-383. • A review on the mechanism of action and the clinical use of rFVIIa.
    • JURLANDER B, THIM L, KLAUSEN NK et al.: Recombinant activated Factor VII (rFVIIa): characterization, manufacturing and clinical development. Semin. Thromb. Haemost. (2001) 27:373-383. • A review on the mechanism of action and the clinical use of rFVIIa.
  • 92
    • 20544455655 scopus 로고    scopus 로고
    • Recombinant Factor VIIa (eptacog alfa). A review of its use in congenital or acquired haemophilia and other congenital bleeding disorders
    • SIDDIQUI MA, SCOTT LJ: Recombinant Factor VIIa (eptacog alfa). A review of its use in congenital or acquired haemophilia and other congenital bleeding disorders. Drugs (2005) 65:1161-1177.
    • (2005) Drugs , vol.65 , pp. 1161-1177
    • SIDDIQUI, M.A.1    SCOTT, L.J.2
  • 93
    • 0642372623 scopus 로고    scopus 로고
    • A new approach to treatment of bleeding episodes in young hemophilia patients: A single bolus megadose of recombinant activated Factor VII (Novoseven)
    • KENET G, LUBETSKY A, LUBOSHITZ J et al.: A new approach to treatment of bleeding episodes in young hemophilia patients: a single bolus megadose of recombinant activated Factor VII (Novoseven). J. Thromb. Haemost. (2003) 1:450-455.
    • (2003) J. Thromb. Haemost , vol.1 , pp. 450-455
    • KENET, G.1    LUBETSKY, A.2    LUBOSHITZ, J.3
  • 94
    • 20144389671 scopus 로고    scopus 로고
    • Dose effect and efficacy of rFVIIa in the treatment of haemophilia patients with inhibitors: Analysis from the hemophilia and thrombosis research society. HTRS Registry Investigators
    • PARAMESWARAN R, SHAPIRO AD, GILL JC, KESSLER CM: Dose effect and efficacy of rFVIIa in the treatment of haemophilia patients with inhibitors: analysis from the hemophilia and thrombosis research society. HTRS Registry Investigators. Haemophilia (2005) 11:100-106.
    • (2005) Haemophilia , vol.11 , pp. 100-106
    • PARAMESWARAN, R.1    SHAPIRO, A.D.2    GILL, J.C.3    KESSLER, C.M.4
  • 95
    • 33645750469 scopus 로고    scopus 로고
    • Home treatment of haemarthroses using a single dose regimen of recombinant activated afctor VII in patients with haemophilia and inhibitors. A multi-centre, randomised, double-blind, cross-over trial. NovoSeven Trial (F7 HEAM-510) Investigators
    • KAVAKLI K, MAKRIS M, ZULFIKAR B, ERHARDTSEN E, ABRAMS ZS, KENETT G: Home treatment of haemarthroses using a single dose regimen of recombinant activated afctor VII in patients with haemophilia and inhibitors. A multi-centre, randomised, double-blind, cross-over trial. NovoSeven Trial (F7 HEAM-510) Investigators. Thromb. Haemost. (2006) 95:600-605.
    • (2006) Thromb. Haemost , vol.95 , pp. 600-605
    • KAVAKLI, K.1    MAKRIS, M.2    ZULFIKAR, B.3    ERHARDTSEN, E.4    ABRAMS, Z.S.5    KENETT, G.6
  • 96
    • 9044249714 scopus 로고    scopus 로고
    • Feasibility of using recombinant Factor VIIa in continuous infusion
    • SCHULMAN S, BECH-JENSEN M, VARON D et al.: Feasibility of using recombinant Factor VIIa in continuous infusion. Thromb. Haemost. (1996) 75:432-436.
    • (1996) Thromb. Haemost , vol.75 , pp. 432-436
    • SCHULMAN, S.1    BECH-JENSEN, M.2    VARON, D.3
  • 97
    • 0344406183 scopus 로고    scopus 로고
    • A prospective study of recombinant activated Factor VII administered by continuous infusion to inhibitor patients undergoing elective major otrhopaedic surgery: A pharmacokinetic and efficacy evaluation
    • LUDLAM CA, SMITH MP, MORFINI M et al.: A prospective study of recombinant activated Factor VII administered by continuous infusion to inhibitor patients undergoing elective major otrhopaedic surgery: a pharmacokinetic and efficacy evaluation. Br. J. Haematol. (2003) 120:808-813.
    • (2003) Br. J. Haematol , vol.120 , pp. 808-813
    • LUDLAM, C.A.1    SMITH, M.P.2    MORFINI, M.3
  • 98
    • 0034769034 scopus 로고    scopus 로고
    • Relationship between Factor VII activity and clinical efficacy of recombinant afctor VIIa given by continuous infusion to patients with Factor VIII inhibitors
    • SANTAGOSTINO E, MORFINI M, ROCINO A et al.: Relationship between Factor VII activity and clinical efficacy of recombinant afctor VIIa given by continuous infusion to patients with Factor VIII inhibitors. Thromb. Haemost. (2001) 86:954-958.
    • (2001) Thromb. Haemost , vol.86 , pp. 954-958
    • SANTAGOSTINO, E.1    MORFINI, M.2    ROCINO, A.3
  • 99
    • 4444376084 scopus 로고    scopus 로고
    • Whole blood clot formation phenotypes in haemophilia A and rare coagulation disorders. Patterns of response to recombinant Factor VIIa
    • SORENSEN B, INGERSLEV J: Whole blood clot formation phenotypes in haemophilia A and rare coagulation disorders. Patterns of response to recombinant Factor VIIa. J. Thromb. Haemost. (2004) 2:102-110.
    • (2004) J. Thromb. Haemost , vol.2 , pp. 102-110
    • SORENSEN, B.1    INGERSLEV, J.2
  • 100
    • 33749355621 scopus 로고    scopus 로고
    • A case of Glanzmann's thrombasthenia successfully treated with recombinant FVIIa during a surgical procedure: Observations on the monitoring and the mechanismof action of this drug
    • DARGAUD Y, BORDET JC, TRZECIAK MC, VINCIGUERRA C, NEGRIER C: A case of Glanzmann's thrombasthenia successfully treated with recombinant FVIIa during a surgical procedure: observations on the monitoring and the mechanismof action of this drug. Haematologica (2006) 91(1):17-20.
    • (2006) Haematologica , vol.91 , Issue.1 , pp. 17-20
    • DARGAUD, Y.1    BORDET, J.C.2    TRZECIAK, M.C.3    VINCIGUERRA, C.4    NEGRIER, C.5
  • 101
    • 0023274159 scopus 로고
    • FVIII inhibitor IgG subclass and FVIII polypeptide specificity determined by immunoblotting
    • FULCHER CA, DE GRAAF MAHONEY S, ZIMMERMANN TS et al.: FVIII inhibitor IgG subclass and FVIII polypeptide specificity determined by immunoblotting. Blood (1987) 69:1475-1480.
    • (1987) Blood , vol.69 , pp. 1475-1480
    • FULCHER, C.A.1    DE GRAAF MAHONEY, S.2    ZIMMERMANN, T.S.3
  • 102
    • 13544277095 scopus 로고    scopus 로고
    • FREEDMAN J, GARVEY MB: Immunoadsorption of Factor VIII inhibitors. Curr. Opin. Hematol. (2004) 11:327-333. • A discussion on the use of the immunoabsorption of FVIII inhibitors.
    • FREEDMAN J, GARVEY MB: Immunoadsorption of Factor VIII inhibitors. Curr. Opin. Hematol. (2004) 11:327-333. • A discussion on the use of the immunoabsorption of FVIII inhibitors.
  • 103
    • 1842833281 scopus 로고    scopus 로고
    • Use of protein A column and porcine Factor VIII
    • RIVARD GE: Use of protein A column and porcine Factor VIII. Haemophilai (2002) 8(Suppl. 1):20-23.
    • (2002) Haemophilai , vol.8 , Issue.SUPPL. 1 , pp. 20-23
    • RIVARD, G.E.1
  • 104
    • 0017785868 scopus 로고
    • Massive Factor VIII infusion in haemophiliac with Factor VIII inhibitor, high responder
    • BRACKMANN HH, GORMSEN J: Massive Factor VIII infusion in haemophiliac with Factor VIII inhibitor, high responder. Lancet (1977) 2(8044):933.
    • (1977) Lancet , vol.2 , Issue.8044 , pp. 933
    • BRACKMANN, H.H.1    GORMSEN, J.2
  • 105
    • 0025847974 scopus 로고
    • The design and analysis of half-life and recovery studies for Factor VIII and Factor IX. Facror VIII/Facror IX Scientific and Standardization Commitee of the International Society for Thrombosis and Haemostasis
    • MORFINI M, LEE M, MESSORI A: The design and analysis of half-life and recovery studies for Factor VIII and Factor IX. Facror VIII/Facror IX Scientific and Standardization Commitee of the International Society for Thrombosis and Haemostasis. Thromb. Haemost. (1991) 66:384-386.
    • (1991) Thromb. Haemost , vol.66 , pp. 384-386
    • MORFINI, M.1    LEE, M.2    MESSORI, A.3
  • 106
    • 0036147943 scopus 로고    scopus 로고
    • DIMICHELE DM, KRONER B; THE NORTH AMERICAN IMMUE TOLERANCE STUDY GROUP: The North American Immue Tolerance Registry: practices, outcomes, outcome predictors. Thromb. Haemost. (2002) 87:52-57. • A report on the immune tolerance practices and outcomes in haemophilia patients.
    • DIMICHELE DM, KRONER B; THE NORTH AMERICAN IMMUE TOLERANCE STUDY GROUP: The North American Immue Tolerance Registry: practices, outcomes, outcome predictors. Thromb. Haemost. (2002) 87:52-57. • A report on the immune tolerance practices and outcomes in haemophilia patients.
  • 108
    • 34248220822 scopus 로고    scopus 로고
    • Current European practice in immune tolerance induction therapy in patients with haemophilia and inhibitors
    • ASTERMARK J, MORADO M, ROCINO A et al.: Current European practice in immune tolerance induction therapy in patients with haemophilia and inhibitors. Haemophilia (2006) 12:363-371.
    • (2006) Haemophilia , vol.12 , pp. 363-371
    • ASTERMARK, J.1    MORADO, M.2    ROCINO, A.3
  • 109
    • 0035133958 scopus 로고    scopus 로고
    • Immune tolerance induction: Recombinant versus human-derived product
    • BERNTORP E: Immune tolerance induction: recombinant versus human-derived product. Haemophilia (2001) 7:109-113.
    • (2001) Haemophilia , vol.7 , pp. 109-113
    • BERNTORP, E.1
  • 110
    • 0036282373 scopus 로고    scopus 로고
    • Inhibitor development in previously untreated patients with haemophila A: A prospective long-term follow-up comparing plasma derived and recombinant products
    • KREUZ W, ETTINGSHAUSEN CE, ZYSCHKA A et al.: Inhibitor development in previously untreated patients with haemophila A: a prospective long-term follow-up comparing plasma derived and recombinant products. Semin. Thromb. Haemost. (2002) 28:285-290.
    • (2002) Semin. Thromb. Haemost , vol.28 , pp. 285-290
    • KREUZ, W.1    ETTINGSHAUSEN, C.E.2    ZYSCHKA, A.3
  • 111
    • 27744516149 scopus 로고    scopus 로고
    • Italian guidelines for the diagnosis and treatment of patients with haemophilia and inhibitors. For Italian Association of Haemophilia Centres
    • GRINGERI A, MANNUCCI PM: Italian guidelines for the diagnosis and treatment of patients with haemophilia and inhibitors. For Italian Association of Haemophilia Centres. Thromb. Haemost. (2005) 11:611-619.
    • (2005) Thromb. Haemost , vol.11 , pp. 611-619
    • GRINGERI, A.1    MANNUCCI, P.M.2
  • 112
    • 2942591961 scopus 로고    scopus 로고
    • Selective B cell depletion with rituximab for the treatment of patients with acquired hemophilia
    • STASI R, BRUNETTI M, STIPA E, AMADORI S: Selective B cell depletion with rituximab for the treatment of patients with acquired hemophilia. Blood (2004) 103:4424-4428.
    • (2004) Blood , vol.103 , pp. 4424-4428
    • STASI, R.1    BRUNETTI, M.2    STIPA, E.3    AMADORI, S.4
  • 113
    • 33645981947 scopus 로고    scopus 로고
    • Rituximab for congenital haemophiliacs with inhibitors: A Canadian experience. On behalf of the Inhibitor Subcommittee of the Association of Haemophilia Clinic Directors of Canada
    • CARCAO M, ST LOUIS J, POON MC et al.: Rituximab for congenital haemophiliacs with inhibitors: a Canadian experience. On behalf of the Inhibitor Subcommittee of the Association of Haemophilia Clinic Directors of Canada. Haemophilia (2006) 12:7-18.
    • (2006) Haemophilia , vol.12 , pp. 7-18
    • CARCAO, M.1    ST LOUIS, J.2    POON, M.C.3
  • 114
    • 2442472195 scopus 로고    scopus 로고
    • Rituximab in the treatment of alloimmune Factor VIII and IX antibodies in two children with severe haemophilia
    • MATHIAS M, KHAIR K, HANN I et al.: Rituximab in the treatment of alloimmune Factor VIII and IX antibodies in two children with severe haemophilia. Br. J. Haematol. (2004) 125:366-368.
    • (2004) Br. J. Haematol , vol.125 , pp. 366-368
    • MATHIAS, M.1    KHAIR, K.2    HANN, I.3
  • 115
    • 28244484911 scopus 로고    scopus 로고
    • The promise and challenges of bioengineered recombinant clotting factors
    • PIPE SW: The promise and challenges of bioengineered recombinant clotting factors. J. Thromb. Haemost. (2005) 3:1692-701.
    • (2005) J. Thromb. Haemost , vol.3 , pp. 1692-1701
    • PIPE, S.W.1
  • 116
    • 1942521325 scopus 로고    scopus 로고
    • Bioengineering of coagulant FVIII for improved secretion
    • MIAO HZ, SIRANCHAINAN N, PALMER L et al.: Bioengineering of coagulant FVIII for improved secretion. Blood (2004) 103:3412- 3419.
    • (2004) Blood , vol.103 , pp. 3412-3419
    • MIAO, H.Z.1    SIRANCHAINAN, N.2    PALMER, L.3
  • 117
    • 33646147385 scopus 로고    scopus 로고
    • SAENKO EL, PIPE SW: Strategies towards a longer acting Factor VIII. Haemophilia (2006) 12(Suppl. 3):42-51. • A nice discussion of the bioengineering of FVIII and FIX.
    • SAENKO EL, PIPE SW: Strategies towards a longer acting Factor VIII. Haemophilia (2006) 12(Suppl. 3):42-51. • A nice discussion of the bioengineering of FVIII and FIX.
  • 118
    • 0043261498 scopus 로고    scopus 로고
    • Pegylation: Engineering improved biopharmaceuticals for oncology
    • MOLINEUX G: Pegylation: engineering improved biopharmaceuticals for oncology. Pharmacotherapy (2003) 23:3S-8S.
    • (2003) Pharmacotherapy , vol.23
    • MOLINEUX, G.1
  • 119
    • 20444503381 scopus 로고    scopus 로고
    • Factor VIII efficient and specific non-covalent binding to PEGylated liposomes enables prolongation of its circulation time and haemostatic efficacy
    • BARU M, CARMEL-GOREN L, BARENHOLZ Y et al.: Factor VIII efficient and specific non-covalent binding to PEGylated liposomes enables prolongation of its circulation time and haemostatic efficacy. Thromb. Haemost. (2005) 93:1061-1068.
    • (2005) Thromb. Haemost , vol.93 , pp. 1061-1068
    • BARU, M.1    CARMEL-GOREN, L.2    BARENHOLZ, Y.3
  • 120
    • 0030664471 scopus 로고    scopus 로고
    • Characterization of a genetically engineered inactivation resistant coagulation Factor VIIIa
    • PIPE SW, KAUFMAN RJ: Characterization of a genetically engineered inactivation resistant coagulation Factor VIIIa. Proc. Natl. Acad. Sci USA (1997) 94:11851-6.
    • (1997) Proc. Natl. Acad. Sci USA , vol.94 , pp. 11851-11856
    • PIPE, S.W.1    KAUFMAN, R.J.2
  • 121
    • 0033621486 scopus 로고    scopus 로고
    • Role of the low density lipoprotein-related protein receptor in mediation of Factor VIII catabolism
    • SAENKO EL, YAKHYAEV AV, MIKHAILENKO I et al.: Role of the low density lipoprotein-related protein receptor in mediation of Factor VIII catabolism. J. Biol. Chem. (1999) 274:37685-92.
    • (1999) J. Biol. Chem , vol.274 , pp. 37685-37692
    • SAENKO, E.L.1    YAKHYAEV, A.V.2    MIKHAILENKO, I.3
  • 122
    • 23044478501 scopus 로고    scopus 로고
    • LDL receptor cooperates with LDL receptor related protein in regulating plasma levels of coagulation Factor VIII in vivo
    • BOVENSCHEN N, MERTENS K, HU L et al.: LDL receptor cooperates with LDL receptor related protein in regulating plasma levels of coagulation Factor VIII in vivo. Blood (2005) 106:906-912.
    • (2005) Blood , vol.106 , pp. 906-912
    • BOVENSCHEN, N.1    MERTENS, K.2    HU, L.3
  • 123
    • 0030807719 scopus 로고    scopus 로고
    • Analysis of the human Factor VIII A2 inhibitor epitope by alanine scanning mutagenesis
    • LUBIN IM, HEALEY JF, BARROW RT, SCANDELLA D, LOLLAR P: Analysis of the human Factor VIII A2 inhibitor epitope by alanine scanning mutagenesis. J. Biol. Chem. (1997) 272:30191-30195.
    • (1997) J. Biol. Chem , vol.272 , pp. 30191-30195
    • LUBIN, I.M.1    HEALEY, J.F.2    BARROW, R.T.3    SCANDELLA, D.4    LOLLAR, P.5
  • 124
    • 0034651022 scopus 로고    scopus 로고
    • Reduction of antigenicity of FVIII toward complex inhibitory antibody plasmas using multiply-substituted hybrid human/porcine Factor VIII molecules
    • BARROW RT, HEALEY JF, GAILANI D, SCANDELLA D, LOLLAR P: Reduction of antigenicity of FVIII toward complex inhibitory antibody plasmas using multiply-substituted hybrid human/porcine Factor VIII molecules. Blood (2000) 95:564-568.
    • (2000) Blood , vol.95 , pp. 564-568
    • BARROW, R.T.1    HEALEY, J.F.2    GAILANI, D.3    SCANDELLA, D.4    LOLLAR, P.5
  • 127
    • 33646121524 scopus 로고    scopus 로고
    • LILLICRAP D, VANDENDRIESSCHE T, HIGH K: Cellular and genetic therapies for haemophilia. Haemophilia (2006) 12(Suppl. 3):36-41. •• An excellent review of cellular and gene therapy for haemophilia.
    • LILLICRAP D, VANDENDRIESSCHE T, HIGH K: Cellular and genetic therapies for haemophilia. Haemophilia (2006) 12(Suppl. 3):36-41. •• An excellent review of cellular and gene therapy for haemophilia.
  • 128
    • 4043057757 scopus 로고    scopus 로고
    • Immune responses to AAV and to FIX in a Phase I study of AAV mediated, liver directed gene transfer for hemophilia B
    • HIGH KA, MANNO CS, SABATINO DE et al.: Immune responses to AAV and to FIX in a Phase I study of AAV mediated, liver directed gene transfer for hemophilia B. Blood (2003) 102:154a.
    • (2003) Blood , vol.102
    • HIGH, K.A.1    MANNO, C.S.2    SABATINO, D.E.3
  • 129
    • 0032989268 scopus 로고    scopus 로고
    • KAZAZIAN HH JR: An estimated frequency of endogenous insertional mutations in humans. Nat. Genet. (1999) 22:130.
    • KAZAZIAN HH JR: An estimated frequency of endogenous insertional mutations in humans. Nat. Genet. (1999) 22:130.
  • 130
    • 0036592086 scopus 로고    scopus 로고
    • A new adenoviral helper dependent vector results in long term therapeutic levels of human coagulation Factor IX at low doses in vivo
    • EHRHARDT A, KAY MA: A new adenoviral helper dependent vector results in long term therapeutic levels of human coagulation Factor IX at low doses in vivo. Blood (2002) 99:3923-3930.
    • (2002) Blood , vol.99 , pp. 3923-3930
    • EHRHARDT, A.1    KAY, M.A.2
  • 131
    • 0142084745 scopus 로고    scopus 로고
    • LMO2 associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    • HACEIN BEY ABINA S, VON KALLE C, SCHMIDT M et al.: LMO2 associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science (2003) 302:415-419.
    • (2003) Science , vol.302 , pp. 415-419
    • HACEIN, B.E.Y.1    ABINA, S.2    VON KALLE, C.3    SCHMIDT, M.4
  • 132
    • 0842342531 scopus 로고    scopus 로고
    • Thromboelastography and recombinant Factor VIIa hemophilia and beyond
    • SORENSEN B, INGERSLEV J: Thromboelastography and recombinant Factor VIIa hemophilia and beyond. Semin. Hematol. (2004) 41(Suppl. 1):140-144.
    • (2004) Semin. Hematol , vol.41 , Issue.SUPPL. 1 , pp. 140-144
    • SORENSEN, B.1    INGERSLEV, J.2
  • 133
    • 27744533650 scopus 로고    scopus 로고
    • Tailoring haemostatic treatment to patient requirements - an update on monitoring haemostatic response using thromboelastography
    • SORENSEN B, INGERSLEV J: Tailoring haemostatic treatment to patient requirements - an update on monitoring haemostatic response using thromboelastography. Haemophilia (2005) 11:1-6.
    • (2005) Haemophilia , vol.11 , pp. 1-6
    • SORENSEN, B.1    INGERSLEV, J.2
  • 134
    • 0242575183 scopus 로고    scopus 로고
    • Thrombin generation in severe haemophilia A and B: The endogenous thrombin potential in platelet-rich plasma
    • SIEGEMUND T, PETROS S, SIEGEMUND A et al.: Thrombin generation in severe haemophilia A and B: the endogenous thrombin potential in platelet-rich plasma. Thromb. Haemost. (2003) 90(5):781-786.
    • (2003) Thromb. Haemost , vol.90 , Issue.5 , pp. 781-786
    • SIEGEMUND, T.1    PETROS, S.2    SIEGEMUND, A.3
  • 135
    • 0242401773 scopus 로고    scopus 로고
    • Calibrated automated thrombin generation measurement in clotting plasma
    • HEMKER HC, GIESEN P, AL DIERI R et al.: Calibrated automated thrombin generation measurement in clotting plasma. Pathophysiol. Haemost. Thromb. (2003) 33:4-15.
    • (2003) Pathophysiol. Haemost. Thromb , vol.33 , pp. 4-15
    • HEMKER, H.C.1    GIESEN, P.2    AL DIERI, R.3
  • 136
    • 15344343052 scopus 로고    scopus 로고
    • Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B
    • DARGAUD Y, BEGUIN S, LIENHART A et al.: Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B. Thromb. Haemost. (2005) 93:475-480.
    • (2005) Thromb. Haemost , vol.93 , pp. 475-480
    • DARGAUD, Y.1    BEGUIN, S.2    LIENHART, A.3
  • 137
    • 34248182747 scopus 로고    scopus 로고
    • Monitoring of FVIII-FIX by-passing agents by calibrated automated thrombin generation test
    • Abstract PO 376
    • DARGAUD Y, BORDET JC, BAGLIN T et al.: Monitoring of FVIII-FIX by-passing agents by calibrated automated thrombin generation test. Haematologica (2006) 12(Suppl. 2):14 (Abstract PO 376).
    • (2006) Haematologica , vol.12 , Issue.SUPPL. 2 , pp. 14
    • DARGAUD, Y.1    BORDET, J.C.2    BAGLIN, T.3
  • 138
    • 0034050904 scopus 로고    scopus 로고
    • Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector
    • KAY MA, MANNO CS, RAGNI MV et al.: Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector. Nat. Genet. (2000) 24(3):257-261.
    • (2000) Nat. Genet , vol.24 , Issue.3 , pp. 257-261
    • KAY, M.A.1    MANNO, C.S.2    RAGNI, M.V.3
  • 139
    • 0035822005 scopus 로고    scopus 로고
    • ROTH DA, TAWA NE JR, O'BRIEN JM et al.: Nonviral transfer of the gene encoding coagulation factor VIII in patients with severe hemophilia A. Factor VIII Transkaryotic Therapy Study Group. N. Engl. J. Med. (2001) 344:1735-1742.
    • ROTH DA, TAWA NE JR, O'BRIEN JM et al.: Nonviral transfer of the gene encoding coagulation factor VIII in patients with severe hemophilia A. Factor VIII Transkaryotic Therapy Study Group. N. Engl. J. Med. (2001) 344:1735-1742.
  • 140
    • 0141679053 scopus 로고    scopus 로고
    • Phase 1 trial of FVIII gene transfer for severe hemophilia A using a retroviral construct administered by peripheral intravenous infusion
    • POWELL JS, RAGNI MV, WHITE GC 2ND et al.: Phase 1 trial of FVIII gene transfer for severe hemophilia A using a retroviral construct administered by peripheral intravenous infusion. Blood (2003) 102:2038-2045.
    • (2003) Blood , vol.102 , pp. 2038-2045
    • POWELL, J.S.1    RAGNI, M.V.2    WHITE 2ND, G.C.3
  • 141
    • 33644820684 scopus 로고    scopus 로고
    • Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
    • MANNO CS, MANNO CS, ARRUDA VR et al.: Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat. Med. (2006) 12:342-347.
    • (2006) Nat. Med , vol.12 , pp. 342-347
    • MANNO, C.S.1    MANNO, C.S.2    ARRUDA, V.R.3
  • 142
    • 33746909909 scopus 로고    scopus 로고
    • Evidence of multiyear factor IX expression by AAV-mediated gene transfer to skeletal muscle in an individual with severe hemophilia B
    • JIANG H, PIERCE GF, OZELO MC et al.: Evidence of multiyear factor IX expression by AAV-mediated gene transfer to skeletal muscle in an individual with severe hemophilia B. Mol. Ther. (2006) 14:452-455.
    • (2006) Mol. Ther , vol.14 , pp. 452-455
    • JIANG, H.1    PIERCE, G.F.2    OZELO, M.C.3
  • 143
    • 43949163969 scopus 로고
    • Stage I clinical trial of gene therapy for hemophilia B
    • LU DR, ZHOU JM, ZHENG B et al.: Stage I clinical trial of gene therapy for hemophilia B. Sci. China B (1993) 36:1342-1351.
    • (1993) Sci. China B , vol.36 , pp. 1342-1351
    • LU, D.R.1    ZHOU, J.M.2    ZHENG, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.