St. John's wort (Hypericum perforatum L.): Challenges and strategies for production of chemically consistent plants

Canadian Journal of Plant Science

Volumn 86, Issue 3, 2006, Pages 765-771

  Murch, Susan J ^a   Saxena, Praveen K ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF GUELPH   (Canada)

Author keywords

Chemical consistency; Controlled environment systems; Hyperforin, melatonin; St. John's wort

Indexed keywords

CLONAL GROWTH; CULTIVAR; DICOTYLEDON; MEDICINAL PLANT; PLANT EXTRACT; SELECTIVE BREEDING;

CANADA; NORTH AMERICA;

HYPERICUM PERFORATUM;

EID: 34248148536     PISSN: 00084220     EISSN: None     Source Type: Journal    
DOI: 10.4141/P05-179     Document Type: Conference Paper

References (41)

1. American Botanical Council. 1997. St. John's wort monograph. American Herbal Pharmacoepea and Therapeutic Compendium HerbalGram. 40: 37-45.
2. Bais, H. P., Walker, T. S., McGrew, J. J. and Vivanco, J. M. 2002. Factors affecting growth of cell suspension cultures of Hypericum perforatum L. (St. John's wort) and production of hypericin. In Vitro Cell. Dev. Biol. Plant. 38: 58-65.
3. Barnes, P. M., Powell-Griner, E., McFann, K. and Nahin, R. I. 2004. Complementary and alternative medicine use among adults: United States 2002, Adv. Data. 343: 1-19.
4. Briskin, D. P. and Gawienowski, M. C. 2001. Differential effects of light and nitrogen on production of hypericins and leaf glands in Hypericum perforatum. Plant Physiol. Biochem. 39: 1075-1081.
5. Buter, B., Orlacchio, C., Soldati, A. and Berger, K. 1998. Significance of genetic and environmental aspects in the field cultivation of Hypericum perforatum. Planta Med. 64: 431-437.
6. Čellárová, E., Daxnerova, Z., Kimakova, K. and Haluskova, J. 1994. The variability of the hypericin content in the regenerants of Hypericum perforatum. Acta Biotechnol. 14: 267-274.
7. Čellárová, E. 2003. Culture and biotechnology of Hypericum. Pages 65-76 in E. Ernst, ed. Hypericum: The Genus Hypericum. Taylor & Francis, London, UK.
8. Dias, A. C. P. 2003. The potential of in vitro cultures of Hypericum perforatum and of Hypericum androsaemum to produce interesting pharmaceutical compounds. Pages 137-154 in E. Ernst, ed. Hypericum: The Genus Hypericum. Taylor & Francis, London, UK.
9. Draves, A. H. and Walker, S. E. 2003. Analysis of the hypericin and pseudohypericin content of commercially available St. John's wort preparations. Can. J. Clin. Pharmacol. 10: 114-118.
10. Ellgehausen, K., Schaffner, W. and Berger Buter, K. 1998. Isolierung, kultivierung und regeneration aus Protoplaten oberer sprossabschnitte von Hypericum perforatum. Vortr. Pflanzenzuchtg. 42:148-186.
11. Ernst, E 2003. Hypericum: The genus Hypericum. Taylor & Francis, London, UK.
12. Fava, M., Alpert, J., Nierenberg, A. A., Mischoulon, D., Otto, M. W., Zajecka, J., Murck, H. and Rosenbaum, J. F. 2005. A double-blind, randomized trial of St. John's wort, fluoxetine, and placebo in major depressive disorder. J. Clin. Psychopharmacol. 25: 441-447.
13. Gaedcke, F. 2003. St John's wort herb extracts: Manufacturing, standardization and characterization Pages 49-64 in E. Ernst, ed. Hypericum: The genus Hypericum. Taylor & Francis, London, UK.
14. Gamborg, O. L., Miller, R. A. and Ojima, K. 1968. Nutrient requirement of suspension cultures of soybean root cells. Exp. Cell Res. 50: 150-158.
15. Health Canada. 1998. Natural health products: A new vision. Standing Committee on Health. Final Report.
16. Health Canada. 2003. Natural health products regulations. Canada Gazette Part II 137: 1532-1607.
17. Kirakosyan, A., Sirvent, T. M., Gibson, D. M. and Kaufman, P. B. 2004. The production of hypericins and hyperforin by in vitro cultures of St. John's wort (Hypericum perforatum). Biotech. Appl. Biochem. 39: 71-81.
18. Linde, K., Berner, M., Egger, M. and Mulrow, C. 2005. St. John's wort for depression. Br. J. Psychol. 186: 99-107.
19. McCoy, J. A. and Camper, N. D. 2002. Development of a micropropagation protocol for St. John's Wort (Hypericum perforatum L.). HortScience 37: 978-980.
20. Michelitsch, A., Likussar, W., Schubert-Zsilavecz, M. and Wurglics, M. 2003. Determination of hypericins and hyperforin in herbal medicinal products. Pages 94-99 in E. Ernst, ed. Hypericum: The Genus Hypericum. Taylor & Francis, London, UK.
21. Murashige, T. and Skoog, F. 1962. A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol. Plant. 15: 473-497.
22. Murch, S. J. and Saxena, P. K. 2006. A melatonin-rich germplasm line of St. John's wort (Hypericum perforatum L.). J. Pineal Res. (in press).
23. Murch, S. J., Choffe, K. L., Victor, J. M. R., Slimmon, T. Y., KrishnaRaj, S. and Saxena P. K. 2000c. Thidiazuron-induced regeneration from hypocotyl cultures of St. John's wort (Hypericum perforatum cv. Anthos). Plant Cell Rep. 19: 576-581.
24. Murch, S. J., KrishnaRaj, S. and Saxena, P. K. 2000a. Phytopharmaceuticals: Problems, limitations and solutions. Scientific Reviews of Alternate Medicine 4: 33-38.
25. Murch, S. J., KrishnaRaj, S. and Saxena P. K. 2000b. Tryptophan is a precursor for melatonin and serotonin biosynthesis in in vitro regenerated St. John's wort (Hypericum perforatum L. cv. Anthos) plants. Plant Cell Rep. 19: 698-704.
26. Murch, S. J., Rupasinghe, H. P. V. and Saxena, P. K. 2002. An in vitro and hydroponic growing system for hypericin, pseudohypericin, and hyperforin production of St. John's wort (Hypericum perforatum cv. new stem). Planta Med. 68: 1108-1112.
27. Murch, S. J., Rupasinghe, H. P. V., Goodenowe, D. and Saxena, P. K. 2004. A metabolomic analysis of medicinal diversity in Huang-qin (Scutellaria baicalensis Georgi) genotypes: discovery of novel compounds. Plant Cell Rep. 23: 419-425.
28. Murch, S. J., Simmons, C. B. and Saxena, P. K. 1997. Melatonin in feverfew and other medicinal plants. Lancet 350: 1598-1599.
29. Pan, Z. G., Liu, C. Z., Murch, S. J. and Saxena, P. K. 2005. Optimized chemodiversity in protoplast-derived lines of St. John's wort (Hypericum perforatum L.). In Vitro Cell. Dev. Biol. 41: 226-232.
30. Pank, F., Matzk, F., Kastner, U., Bluthner, W. D., Foltys de Garcia, E., Meister, A., Ryschka, U. and Schumann, G. 2003. Reproductive diversity and strategies for breeding in St. John's wort (Hypericum perforatum L.). Euphytica 134: 77-84.
31. Pasqua, G., Avato, P., Monacelli, B., Santamaria, A. R. and Argentieri, M. P. 2003. Metabolites in cell suspension cultures, calli, and in vitro regenerated organs of Hypericum perforatum cv. Topas. Plant Sci. 165: 977-982.
32. Roscetti, G., Franzese, O., Comandini, A. and Bonmassar, E. 2004. Cytotoxic activity of Hypericum perforatum L. on K562 erythroleukemic cells: Differential effects between methanolic extract and hypericin Phytother. Res. 18: 66-72.
33. Seidler-Lożykowska, K. 2003. Secondary metabolites content of Hypericum sp. in different stages and plant parts. Pages 100-105 in E. Ernst, ed. Hypericum: The genus Hypericum. Taylor & Francis, London, UK.
34. Sirvent, T. M., Krasnoff, S. B. and Gibson, D. M. 2003. Induction of hypericins and hyperforins in Hypericum perforatum in response to damage by herbivores. J. Chem. Ecol. 29: 2667-2681.
35. Szegedi, A., Kohnen, R., Dienel, A. and Kieser, M. 2005. Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St. John's wort): randomized controlled double blind non-inferiority trial versus paroxetine. Br. Med J. 330: 503-508.
36. United States Pharmacopeia. 2004. The official compendia of standards. 27: 2032-2034.
37. Urbanová, M., Čellárová, E. and Kimáková, K. 2002. Chromosome number stability and mitotic activity of cryopreserved Hypericum perforatum L. meristems. Plant Cell Rep. 20: 1082-1086.
38. Williams, J. W. and Holsinger, T. 2005. St. John's for depression, worts and all. Br. Med J. 330: 350-351.
39. Zobayed, S. M. A. and Saxena, P. K. 2003. In vitro-grown roots: a superior explant for prolific shoot regeneration of St. John's wort (Hypericum perforatum L. cv. 'New Stem') in a temporary immersion bioreactor. Plant Sci. 165: 463-470.
40. Zobayed, S. M. A., Murch, S. J., Rupasinghe, H. P. V. and Saxena, P. K. 2004. In vitro production and chemical characterization of St. John's wort (Hypericum perforatum L. cv 'New Stem'). Plant Sci. 166: 333-340.
41. Zobayed, S. M. A. and Saxena, P. K. 2004. Production of St. John's wort plants under controlled environment for maximizing biomass and secondary metabolites. In Vitro Cell. Dev. Biol. Plant 40: 108-114.