An in vitro and hydroponic growing system for hypericin, pseudohypericin, and hyperforin production of St. John's wort (Hypericum perforatum CV new stem)

Planta Medica

Volumn 68, Issue 12, 2002, Pages 1108-1112

  Murch, Susan J ^a   Vasantha Rupasinghe, H P ^a   Saxena, Praveen K ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

Clusiaceae; Greenhouse hydroponics; Hyperforin; Hypericins; Hypericum perforatum; St. John's wort

Indexed keywords

HYPERFORIN; HYPERICIN; PSEUDOHYPERICIN;

ACCLIMATIZATION; ARTICLE; GREENHOUSE; HYDROPONICS; HYPERICUM PERFORATUM; IN VITRO STUDY; MEDICINAL PLANT; NONHUMAN; PLANT GROWTH; PLANT STEM; QUANTITATIVE ANALYSIS; TECHNIQUE;

BICYCLO COMPOUNDS; CULTURE TECHNIQUES; ENVIRONMENT, CONTROLLED; HYDROPONICS; HYPERICUM; PERYLENE; PHLOROGLUCINOL; PLANT EXTRACTS; TERPENES;

CLUSIACEAE; HYPERICUM; HYPERICUM PERFORATUM;

EID: 0036970454     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2002-36352     Document Type: Article

References (22)

1. Perovic S, Muller WEG. Pharmacological profile of Hypericum extract: Effect of serotonin uptake by postsynaptic receptors. Arzneimittel-Forsch 1995; 45: 1145-8
2. Butterweck V, Petereit F, Winterhoff H, Nahrstedt A. Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test. Planta Med 1998; 64: 291-4
3. Caputi P. Interleukin-6 involvement in antidepressant action of Hypericum perforatum. Pharmacopsych 2001; 34: S8-10
4. Chatterjee SS, Noldner M, Koch E, Erdelmeier C. Antidepressant activity of Hypericum perforatum and hyperforin: The neglected possibility. Pharmacopsychiat 1998; 31: 7-15
5. Orth HC, Rentel C, Schmidt PC. Isolation, purity analysis and stability of hyperforin as a standard material from Hypericum perforatum L. J Pharm Pharmacol 1999; 51: 193-200
6. Murch SJ, KrishnaRaj S, Saxena PK. Phytopharmaceuticals: Problems, limitations and solutions. Scientific Reviews of Alternate Medicine 2000; 4: 33-8
7. St. John's Wort Monograph. American Herbal Pharmacoepea and Theraputic Compendium HerbalGram. American Botanical Council, 1997; 40: 37-45
8. Tekel'ova D, Repcak M, Zemkova E, Toth J. Quantitative changes in dianthrones, hyperforin andflavonoids content in the flower ontogenesis of Hypericum perforatum. Planta Med 2000; 66: 778-80
9. Briskin DP, Gawienowski MG. Differential effects of light and nitrogen on production of hypericins and leaf glands in Hypericum perforatum. Plant Physiol Biochem 2001; 39: 1075-81
10. Southwell IA, Bourke CA. Seasonal variation in hypericin content of Hypericum perforatum L. (St. John's wort). Phytochemistry 2001; 56: 437-41
11. Murch SJ, KrishnaRaj S, Saxena PK. Phytopharmaceuticals: Mass-production, standardization and conservation. Scientific Reviews of Alternate Medicine 2000; 4: 39-43
12. Murch SJ, Choffe KL, Victor JMR, Slimmon TY, KrishnaRaj S, Saxena PK Thidiazuron-induced regeneration from hypocotyl cultures of St. John's wort (Hypericum perforatum cv. Anthos). Plant Cell Reports 2000; 19: 576-81
13. Murch SJ, KrishnaRaj S, Saxena PK. Tryptophan is a precursor for melatonin and serotonin biosynthesis in in vitro regenerated St. John's wort (Hypericum perforatum L. cv. Anthos) plants. Plant Cell Reports 2000; 19: 698-704
14. Murashige T, Skoog F. A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 1962; 15: 473-97
15. Gamborg OL, Miller RA, Ojima K. Nutrient requirement of suspension cultures of soybean root cells. Exp Cell Res 1968; 50; 150-8
16. Liu FF, Ang CYW, Springer D. Optimization of extraction conditions for active components in Hypericum perforatum using response surface methodology. J Agric Food Chem 2000; 48: 364-71
17. Gray DE, Rottinghaus GE, Garrett HEG, Pallardy G. Simultaneous determination of the predominant hyperforins and hypericins in St. John's Wort (Hypericum perforatum L.) by liquid chromatography. J AOAC Inter 2000; 83: 944-9
18. Pourtaraud A, Lobstein A, Girardin P, Weniger B. Improved procedure for the quality control of Hypericum perforatum L. Phytochem Anal 2001; 12: 355-62
19. Son SH, Paek KY. Large-scale production of medicinal plant species: The application of bioreactors for production of ginseng roots. In: Development of Plant Based Medicines: Conservation, Efficacy and Safety. P.K. Saxena (Ed.). Kluwer Academic Press, 2001: pp 139-50
20. Murch SJ, KrishnaRaj S, Saxena PK. Production of medicinal plant species in sterile controlled environments. In: Transplant Production in the 21st Century Kluwer Academic Pres, 2000: pp 160-5
21. Hahn E-J, Kin SJ, Paek KY, Lee YB. Growth and acclimatization of chrysanthemum plantlets using bioreactor and hydroponic culture techniques. Transplant Production in the 21st Century. Kluwer Academic Press, 2000: pp 274-8
22. Cooper A. The ABC of NFT: Nutrient Film Technique. Caspar Publications Pty Ltd. 1996: pp. xv, 134