Sanguinarine inhibits VEGF-induced Akt phosphorylation

Annals of the New York Academy of Sciences

Volumn 1095, Issue , 2007, Pages 371-376

  Basini, Giuseppina ^a   Santini, Sujen Eleonora ^a   Bussolati, Simona ^a   Grasselli, Francesca ^a  

^a UNIVERSITY OF PARMA   (Italy)

Author keywords

Akt; Angiogenesis; Granulosa cells; Sanguinarine; VEGF

Indexed keywords

PROTEIN KINASE B; SANGUINARINE; VASCULOTROPIN; ALKALOID; ANGIOGENESIS INHIBITOR; BENZOPHENANTHRIDINE DERIVATIVE; ISOQUINOLINE DERIVATIVE; VASCULOTROPIN A;

ANIMAL CELL; ANTIANGIOGENIC ACTIVITY; AORTA; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ISOLATION; DRUG SCREENING; ENDOTHELIUM CELL; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; NONHUMAN; SANGUINARIA; SANGUINARIA CANADENSIS; SWINE; ANIMAL; ARTICLE; CELL LINE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

SANGUINARIA CANADENSIS; SUS;

ALKALOIDS; ANGIOGENESIS INHIBITORS; ANIMALS; BENZOPHENANTHRIDINES; CELL LINE, TRANSFORMED; ENDOTHELIUM, VASCULAR; ISOQUINOLINES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SWINE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 34247895506     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1397.040     Document Type: Conference Paper

References (12)

1. DVORAK, H.F. 2005. Angiogenesis: update 2005. J. Thromb. Haemost. 3: 1835-1842.
2. BYRNE, A.M., D.J. BOUCHIER-HAYES & J.H. HARMEY. 2005. Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF). J. Cell. Mol. Med. 9: 777-794.
3. DIMMELER, S. & A.M. ZEIHER. 2000. Akt takes center stage in angiogenesis signaling. Circ. Res. 86: 4-5.
4. SHAMMA, M. & H. GUINAUDEAU. 1986. Anorphinoid alkaloids. Nat. Prod. Rep. 3: 345-351.
5. BIANCO, F., G. BASINI & F. GRASSELLI. 2006. The plant alkaloid Sanguinarine affects swine granulosa cell activity. Reprod. Toxicol. 10: 335-340.
6. EUN, J.P. & G.Y. KOH. 2004. Suppression of angiogenesis by the plant alkaloid, sanguinarine. Biochem. Biophys. Res. Commun. 317: 618-624.
7. CARRILLO, A., S. CHAMORRO, M. RODRIGUEZ- GAGO, et al. 2002. Isolation and characterization of immortalized porcine aortic endothelial cell lines. Vet. Immunol. Immunopathol. 89: 91-98.
8. FERRARA, N. & R.S. KERBEL. 2005. Angiogenesis as a therapeutic target. Nature 438: 967-974.
9. MUNOZ-CHAPULI, R., A.R. QUESADA & M. ANGEL MEDINA. 2004. Angiogenesis and signal transduction in endothelial cells. Cell. Mol. Life Sci. 61: 2224-2243.
10. ACKAH, E., J. YU, S. ZOELLNER, et al. 2005. Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. J. Clin. Invest. 115: 2119-2127.
11. DIMMELER, S. & A.M. ZEIHER. 2000. Akt takes center stage in angiogenesis signaling. Circ. Res. 86: 4-5.
12. SHIOJIMA, I. & K. WALSH. 2002. Role of Akt signaling in vascular homeostasis and angiogenesis. Circ. Res. 90: 1243-1250.