Influence of beta-amyloid protein and cholesterol on the pathological changes of Alzheimer's disease and expression of nicotinic acetylcholine receptors in rats

Chinese Journal of Pathology

Volumn 36, Issue 3, 2007, Pages 184-189

  Liu, Ru Yu ^a   Gu, Ran ^b   Qi, Xiao Lan ^b   Chen, Jia ^b   Liu, Jia Liu ^b   Guan, Zhi Zhong ^a  

^a GUIZHOU MEDICAL UNIVERSITY   (China)

^b NONE

Author keywords

Alzheimer disease; Amyloid beta protein; Animal testing alternatives; Hepercholesterolemia

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CHOLESTEROL; NICOTINIC RECEPTOR;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL DIET; CONTROLLED STUDY; HYPERCHOLESTEROLEMIA; IMMUNOHISTOCHEMISTRY; LEARNING; MEMORY; NEUROPATHOLOGY; NONHUMAN; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CEREBRAL CORTEX; CHOLESTEROL; DRUG SYNERGISM; FEMALE; HYPERCHOLESTEROLEMIA; LEARNING; MALE; PEPTIDE FRAGMENTS; RANDOM ALLOCATION; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; RNA, MESSENGER;

EID: 34247893790     PISSN: 05295807     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Puglielli L, Tanzi RE, Kovacs DM. Alzheimer's disease: the cholesterol connection. Nat Neurosci, 2003, 6(4): 345-351.
2. Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev, 2001, 81(2): 741-766.
3. RoherAE, Kuo YM, Kokjohn KM, et al. Amyloid and lipids in the pathology of Alzheimer disease. Amyloid, 1999, 6(2): 136-145.
4. Park IH, Hwang EM, Hong HS, et al. Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice. Neurobiol Aging, 2003, 24(5): 637-643.
5. Refolo LW, Malester B, LaFrancois J, et al. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis, 2000, 7(4): 321-331.
6. Shie FS, Jin LW, Cook DG, et al. Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice. Neuroreport, 2002, 13(4): 455-459.
7. Paterson D, Nordberg A. Neuronal nicotinic receptors in the human brain. Prog Neurobiol, 2000, 61(1): 75-111.
8. Guan ZZ, Zhang X, Ravid R, et al. Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer's disease. J Neurochem, 2000, 74 (1): 237-243.
9. Bodovitz S, Klein WL. Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein. J Biol Chem, 1996, 271(8) : 4436-4440.
10. Chinese source
11. Gonzalo-Ruiz A, Perez JL, Sanz JM, et al. Effects of lipids and aging on the neurotoxicity and neuronal loss caused by intracerebral injections of the amyloid-beta peptide in the rat. Exp Neurol, 2006, 197(1): 41-55.
12. Chinese source
13. Mansvelder HD, McGehee DS. Cellular and synaptic mechanisms of nicotine addiction. J Neurobiol, 2002, 53(4): 606-617.
14. Nordberg A. Nicotinic receptor abnormalities of Alzheimer's disease: therapeutic implications. Biol Psychiatry, 2001, 49(3): 200-210.
15. Court J, Martin-Ruiz C, Piggott M, et al. Nicotinic receptor abnormalities in Alzheimer's disease. Biol Psychiatry, 2001, 49(3): 175-184.