Amyloid-forming propensity of the hydrophobic non-natural amino acid on the fibril-forming core peptide of human tau

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 11, 2007, Pages 2971-2974

  Hirata, Akiyoshi ^a   Sugimoto, Kenji ^a   Konno, Takashi ^b   Morii, Takashi ^a,c  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF FUKUI   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Aggregates; Amyloid; Fibrils; Non natural amino acid; Pathogenic polypeptides; Peptide; Tau

Indexed keywords

AMINO ACID; AMYLOID; BIPHENYL; PHENYLALANINE; POLYPEPTIDE; TAU PROTEIN; TYROSINE;

ARTICLE; BETA SHEET; FIBER; FLUORESCENCE; HUMAN; HYDROPHOBICITY; MOLECULAR INTERACTION; PROTEIN AGGREGATION; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE;

AMINO ACIDS; AMINO ACIDS, AROMATIC; AMYLOID; HUMANS; HYDROPHOBICITY; MICROSCOPY, ELECTRON, TRANSMISSION; PEPTIDES; SOLUBILITY; TAU PROTEINS;

EID: 34247890074     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.03.071     Document Type: Article

References (9)

1. Gazit E. FASEB J. 16 (2002) 77
2. Goux W.J., Kopplin L., Nguyen A.D., Leak K., Rutkofsky M., Shanmuganandam V.D., Sharma D., Inouye H., and Kirschner D.A. J. Biol. Chem. 279 (2004) 26868
3. Azriel R., and Gazit E. J. Biol. Chem. 276 (2001) 34156
4. Petkova A.T., Ishii Y., Balbach J.J., Antzutkin O.N., Leapman R.D., Delaglio F., and Tycko R. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 16742
5. von Bergen M., Friedhoff P., Biernat J., Heberle J., Mandelkow E.-M., and Mandelkow E. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 5129
6. Rojas-Quijano F.A., Morrow D., Wise B.M., Brancia F.L., and Goux W. J. Biochemistry 45 (2006) 4638
7. Inouye H., Sharma D., Goux W.J., and Kirschner D.A. Biophys. J. 90 (2006) 1774
8. Crowther R.A. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 2288
9. LeVine III H. Protein Sci. 2 (1993) 404