The vascular phenotypes in hypertension: Relation with the natural history of hypertension

Journal of the American Society of Hypertension

Volumn 1, Issue 1, 2007, Pages 56-67

  Schiffrin, Ernesto L ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Arteries; endothelium; extracellular matrix; genes; remodeling; signaling; smooth muscle

Indexed keywords

ANGIOTENSIN RECEPTOR; C REACTIVE PROTEIN; FIBRONECTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; NORADRENALIN; PLASMINOGEN ACTIVATOR INHIBITOR 1;

AGING; AORTA; ARTERY COMPLIANCE; ARTERY MUSCLE; ARTICLE; BLOOD VESSEL DIAMETER; COHORT ANALYSIS; DIASTOLIC BLOOD PRESSURE; DISEASE COURSE; ELASTICITY; ENDOTHELIAL DYSFUNCTION; ESSENTIAL HYPERTENSION; HUMAN; HYPERTENSION; INFLAMMATION; MOLECULAR MECHANICS; NONHUMAN; PATHOLOGICAL ANATOMY; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RENOVASCULAR HYPERTENSION; SIGNAL TRANSDUCTION; SYSTOLIC BLOOD PRESSURE; TENSILE STRENGTH; VASCULAR DISEASE; VASCULAR ENDOTHELIUM; VASCULARIZATION;

EID: 34247882026     PISSN: 19331711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jash.2006.11.003     Document Type: Article

References (105)

1. Safar M.E., and Boudier H.S. Vascular development, pulse pressure, and the mechanisms of hypertension. Hypertension 46 (2005) 205-209
2. Najjar S.S., Scuteri A., and Lakatta E.G. Arterial aging: is it an immutable cardiovascular risk factor. Hypertension 46 (2005) 454-462
3. Safar M.E., Girerd X., and Laurent S. Structural changes of large conduit arteries in hypertension. J Hypertens 14 (1996) 545-555
4. Mitchell G.F., Lacourcière Y., Ouellet J.P., et al. Determinants of elevated pulse pressure in middle-aged and older subjects with uncomplicated systolic hypertension: the role of proximal aortic diameter and the aortic pressure-flow relationship. Circulation 108 (2003) 1592-1598
5. Safar M.E., Levy B.I., and Struijker-Boudier H. Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases. Circulation 107 (2003) 2864-2869
6. O'Rourke M.F., and Nichols W.W. Aortic diameter, aortic stiffness, and wave reflection increase with age and isolated systolic hypertension. Hypertension 45 (2005) 652-658
7. Schiffrin E.L. Vascular stiffening and arterial compliance: implications for systolic blood pressure. Am J Hypertens 17 (2004) 39S-48S
8. Laurent S., Boutouyrie P., Asmar R., et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37 (2001) 1236-1241
9. Cohn J.N. Arterial stiffness, vascular disease, and risk of cardiovascular events. Circulation 113 (2006) 601-603
10. Dernellis J., and Panaretou M. Aortic stiffness is an independent predictor of progression to hypertension in nonhypertensive subjects. Hypertension 45 (2005) 426-431
11. Liao D.P., Arnett D.K., Tyroler H.A., et al. Arterial stiffness and the development of hypertension: the ARIC Study. Hypertension 34 (1999) 201-206
12. Chobanian A. Adaptive and maladaptive responses of the arterial wall to hypertension. Hypertension 15 (1990) 666-674
13. Deanfield J., Donald A., Ferri C., et al. Endothelial function and dysfunction. Part I: methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension. J Hypertens 23 (2005) 7-17
14. Boumaza S., Arribas S.M., Osborne-Pellegrin M., et al. Fenestrations of the carotid internal elastic lamina and structural adaptation in stroke-prone spontaneously hypertensive rats. Hypertension 37 (2001) 1101-1107
15. Laurent S. Arterial wall hypertrophy and stiffness in essential hypertensive patients. Hypertension 26 (1995) 355-362
16. Laurent S., Boutouyrie P., and Lacolley P. Structural and genetic bases of arterial stiffness. Hypertension 45 (2005) 1050-1055
17. Mitchell G.F., DeStefano A.L., Larson M.G., et al. Heritability and a genome-wide linkage scan for arterial stiffness, wave reflection, and mean arterial pressure: the Framingham Heart Study. Circulation 112 (2005) 194-199
18. DeStefano A.L., Larson M.G., Mitchell G.F., et al. Genome-wide scan for pulse pressure in the National Heart, Lung, and Blood Institute's Framingham Heart Study. Hypertension 44 (2004) 152-155
19. 1166A/C gene polymorphisms and increase in aortic stiffness with age in hypertensive subjects. J Hypertens 19 (2001) 407-413
20. Aalkjaer C., Heagerty A.M., Petersen K.K., Swales J.D., and Mulvany M.J. Evidence for increased media thickness, increased neuronal amine uptake, and depressed excitation-contraction coupling in isolated resistance vessels from essential hypertensives. Circ Res 61 (1987) 181-186
21. Heagerty A.M., Aalkjaer C., Bund S.J., Korsgaard N., and Mulvany M.J. Small artery structure in hypertension: dual processes of remodeling and growth. Hypertension 21 (1993) 391-397
22. Mulvany M.J., Baumbach G.L., Aalkjaer C., et al. Vascular remodeling. Hypertension 28 (1996) 505-506
23. Schiffrin E.L., Deng L.Y., and Larochelle P. Morphology of resistance arteries and comparison of effects of vasoconstrictors in mild essential hypertensive patients. Clin Invest Med 16 (1993) 177-186
24. Schiffrin E.L. Remodeling of resistance arteries in essential hypertension and effects of antihypertensive treatment. Am J Hypertens 17 (2004) 1192-1200
25. Rizzoni D., Porteri E., Castellano M., et al. Vascular hypertrophy and remodeling in secondary hypertension. Hypertension 28 (1996) 785-790
26. Rizzoni D., Porteri E., Guelfi D., et al. Structural alterations in subcutaneous small arteries of normotensive and hypertensive patients with non-insulin-dependent diabetes mellitus. Circulation 103 (2001) 1238-1244
27. Endemann D., Pu Q., De Ciuceis C., et al. Persistent remodeling of resistance arteries in type 2 diabetic patients on antihypertensive treatment. Hypertension 43 (2004) 399-404
28. Rizzoni D., Porteri E., Giustina A., et al. Acromegalic patients show the presence of hypertrophic remodeling of subcutaneous small resistance arteries. Hypertension 43 (2004) 561-565
29. Amiri F., Virdis A., Neves M.F., et al. Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction. Circulation 110 (2004) 2233-2240
30. Schiffrin E.L., Larivière R., Li J.S., and Sventek P. Enhanced expression of the endothelin-1 gene in blood vessels of DOCA-salt hypertensive rats: correlation with vascular structure. J Vasc Res 33 (1996) 235-248
31. Li J.S., Larivière R., and Schiffrin E.L. Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats: evidence for a role of endothelin in vascular hypertrophy. Hypertension 24 (1994) 183-188
32. D'Uscio L.V., Barton M., Shaw S., Moreau P., and Lüscher T.F. Structure and function of small arteries in salt-induced hypertension: effects of chronic endothelin-subtype-A-receptor blockade. Hypertension 30 (1997) 905-911
33. Schiffrin E.L., and Touyz R.M. From bedside to bench to bedside: role of renin-angiotensin-aldosterone system in remodeling of resistance arteries in hypertension. Am J Physiol Heart Circ Physiol 287 (2004) H435-H446
34. Mulvany M.J., Baandrup U., and Gundersen H.J. Evidence for hyperplasia in mesenteric resistance vessels of spontaneously hypertensive rats using a three-dimensional disector. Circ Res 57 (1985) 794-800
35. Lee R.M.K.W., Garfield R.E., Forrest J.B., and Daniel E.E. Morphometric study of structural changes in the mesenteric blood vessels of spontaneously hypertensive rats. Blood Vessels 20 (1983) 57-71
36. Korsgaard N., Aalkjær C., Heagerty A.M., Izzard A.S., and Mulvany M.J. Histology of subcutaneous small arteries from patients with essential hypertension. Hypertension 22 (1993) 523-526
37. Rizzoni D., Porteri E., Guefi D., et al. Cellular hypertrophy in subcutaneous small arteries of patients with renovascular hypertension. Hypertension 35 (2000) 931-935
38. DeBlois D., Tea B.S., Dam T.V., Tremblay J., and Hamet P. Smooth muscle apoptosis during vascular regression in spontaneously hypertensive rats. Hypertension 29 (1997) 340-349
39. Dickhout J.G., and Lee R.M. Apoptosis in the muscular arteries from young spontaneously hypertensive rats. J Hypertens 17 (1999) 1413-1419
40. Intengan H.D., and Schiffrin E.L. Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis. Hypertension 38 (2001) 581-587
41. Intengan H.D., and Schiffrin E.L. Structure and mechanical properties of resistance arteries in hypertension: role of adhesion molecules and extracellular matrix determinants. Hypertension 36 (2000) 312-318
42. Intengan H.D., Deng L.Y., Li J.S., and Schiffrin E.L. Mechanics and composition of human subcutaneous resistance arteries in essential hypertension. Hypertension 33 (1999) 569-574
43. Intengan H.D., Thibault G., Li J.S., and Schiffrin E.L. Resistance artery mechanics, structure, and extracellular components in spontaneously hypertensive rats: effects of angiotensin receptor antagonism and converting enzyme inhibition. Circulation 100 (1999) 2267-2275
44. Baumbach G.L., and Hajdu M.A. Mechanics and composition of cerebral arterioles in renal and spontaneously hypertensive rats. Hypertension 21 (1993) 816-826
45. Pu Q., Neves M.F., Virdis A., Touyz R.M., and Schiffrin E.L. Endothelin antagonism onaldosterone-induced oxidative stress and vascular remodeling. Hypertension 42 (2003) 49-55
46. Neves M.F., Virdis A., and Schiffrin E.L. Resistance artery mechanics and composition in angiotensin II-infused rats: effects of aldosterone antagonism. J Hypertens 21 (2003) 189-198
47. Bakker E.N.T.P., Van der Meulen E.T., Van den Berg B.M., Everts V., Spaan J.A.E., and VanBavel E. Inward remodeling follows chronic vasoconstriction in isolated resistance arteries. J Vasc Res 39 (2002) 12-20
48. Bakker E.N.T.P., Buus C.L., VanBavel E., and Mulvany M.J. Activation of resistance arteries with endothelin-1: from vasoconstriction to functional adaptation and remodeling. J Vasc Res 41 (2004) 174-182
49. Brassard P., Amiri F., and Schiffrin E.L. Combined angiotensin II type 1 and type 2 receptor blockade on vascular remodeling and matrix metalloproteinases in resistance arteries. Hypertension 46 (2005) 598-606
50. Brassard P., Amiri F., Thibault G., and Schiffrin E.L. Role of angiotensin type-1 and angiotensin type-2 receptors in the expression of vascular integrins in angiotensin II-infused rats. Hypertension 47 (2006) 122-127
51. Bakker E.N.T.P., Buus C.L., Spaan J.A.E., et al. Small artery remodeling depends on tissue-type transglutaminase. Circ Res 96 (2005) 119-126
52. Langille B.L., and Dajnowiec D. Cross-linking vasomotor tone and vascular remodeling: a novel function for tissue transglutaminase?. Circ Res 96 (2005) 9-11
53. De Ciuceis C., Amiri F., Brassard P., Endemann D.H., Touyz R.M., and Schiffrin E.L. Reduced vascular remodeling, endothelial dysfunction, and oxidative stress in resistance arteries of angiotensin II-infused macrophage colony-stimulating factor-deficient mice: evidence for a role in inflammation in angiotensin-induced vascular injury. Arterioscler Thromb Vasc Biol 25 (2005) 2106-2113
54. Park J.B., and Schiffrin E.L. Small artery remodeling is the most prevalent (earliest) form of target organ damage in mild essential hypertension. J Hypertens 19 (2001) 921-930
55. Rizzoni D., Porteri E., Boari G.E., et al. Prognostic significance of small-artery structure in hypertension. Circulation 108 (2003) 2230-2235
56. Mulvany M.J., and Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 41 (1977) 19-26
57. Mulvany M.J., Hansen P.K., and Aalkjaer C. Direct evidence that the greater contractility of resistance vessels in spontaneously hypertensive rats is associated with a narrowed lumen, a thickened media, and in increased number of smooth muscle cell layers. Circ Res 43 (1978) 854-864
58. Folkow B., Hallback M., Lundgren Y., Sivertsson R., and Weiss L. Importance of adaptive changes in vascular design for establishment of primary hypertension, studied in man and in spontaneously hypertensive rats. Circ Res 32/33 suppl I (1973) I12-I16
59. Baubach G.L., and Heistad D.D. Remodeling of cerebral arterioles in chronic hypertension. Hypertension 13 (1989) 968-972
60. Izzard A.S., Bund S.J., and Heagerty A.M. Increased wall-lumen ratio of mesenteric vessels from the spontaneously hypertensive rat is not associated with increased contractility under isobaric conditions. Hypertension 28 (1996) 604-608
61. Izzard A.S., Heagerty A.M., and Leenen F.H.H. The amplifier hypothesis: permission to dissent?. J Hypertens 17 (1999) 1667-1669
62. Izzard A.S., Bund S.J., and Heagerty A.M. Myogenic tone in mesenteric arteries from spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 270 (1996) H1-H6
63. Izzard A.S., and Heagerty A.M. Impaired flow-dependent dilatation in distal mesenteric arteries from the spontaneously hypertensive rat. J Physiol 518 (1999) 239-245
64. Schofield I., Malik R., Izzard A., Austin C., and Heagerty A. Vascular structural and functional changes in type 2 diabetes mellitus: evidence for the roles of abnormal myogenic responsiveness and dyslipidemia. Circulation 106 (2002) 3037-3043
65. Matrougui K., Schiavi P., Guez D., and Henrion D. High sodium intake decreases pressure-induced (myogenic) tone and flow-induced dilation in resistance arteries from hypertensive rats. Hypertension 32 (1998) 176-179
66. Deng L.Y., Li J.S., and Schiffrin E.L. Endothelium-dependent relaxation of small arteries from essential hypertensive patients: mechanisms and comparison with normotensive subjects and with responses of vessels from spontaneously hypertensive rats. Clin Sci (Lond) 88 (1995) 611-622
67. Endemann D.H., and Schiffrin E.L. Endothelial dysfunction. J Am Soc Nephrol 15 (2004) 1983-1992
68. Schiffrin E.L. A critical review of the role of endothelial factors in the pathogenesis of hypertension. J Cardiovasc Pharmacol 38 (2001) S3-S6
69. Schiffrin E.L., Deng L.Y., Sventek P., and Day R. Enhanced expression of endothelin-1 gene in resistance arteries in severe human essential hypertension. J Hypertens 15 (1997) 57-63
70. Al Suwaidi J., Hamasaki S., Higano S.T., Nishimura R.A., Holmes Jr. D.R., and Lerman A. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 101 (2000) 948-954
71. Perticone F., Ceravolo R., Pujia A., et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation 104 (2001) 191-196
72. Britten M.B., Zeiher A.M., and Schächinger V. Microvascular dysfunction in angiographically normal or mildly diseased coronary arteries predicts adverse cardiovascular long-term outcome. Coronary Artery Dis 15 (2004) 259-264
73. Rizzoni D., Porteri E., Guelfi D., et al. Endothelial dysfunction in small resistance arteries of patients with non-insulin-dependent diabetes mellitus. J Hypertens 19 (2001) 913-919
74. DeBlois D., Lombardi D.M., Su E.J., Clowes A.W., Schwartz S.M., and Giachelli C.M. Angiotensin II induction of osteopontin expression and DNA replication in rat arteries. Hypertension 28 (1996) 1055-1063
75. Lin Z.H., Fukuda N., Jin X.Q., et al. Complement 3 is involved in the synthetic phenotype and exaggerated growth of vascular smooth muscle cells from spontaneously hypertensive rats. Hypertension 44 (2004) 42-47
76. Landmesser U., Dikalov S., Price S.R., et al. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest 111 (2003) 1201-1209
77. Callera G.E., Montezano A.C.I., Yogi A., et al. c-src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats. Hypertension 46 (2005) 1032-1038
78. Touyz R.M. Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance?. Hypertension 44 (2004) 248-252
79. Taniyama Y., and Griendling K.K. Reactive oxygen species in the vasculature: molecular and cellular mechanisms. Hypertension 42 (2003) 1075-1081
80. Cruzado M.C., Risler N.R., Miatello R.M., Yao G.Y., Schiffrin E.L., and Touyz R.M. Vascular smooth muscle cell NAD(P)H oxidase activity during the development of hypertension: effect of angiotensin II and role of insulinlike growth factor-1 receptor transactivation. Am J Hypertens 18 (2005) 81-87
81. Touyz R.M., Yao G., and Schiffrin E.L. c-src induces phosphorylation and translocation of p47phox: role in superoxide generation by angiotensin II in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 23 (2003) 981-987
82. Touyz R.M., Yao G., Quinn M.T., Pagano P.J., and Schiffrin E.L. p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: role in NAD(P)H oxidase regulation by angiotensin II. Arterioscler Thromb Vasc Biol 25 (2005) 512-518
83. phox in vascular oxidative stress and hypertension caused by angiotensin II. Hypertension 40 (2002) 511-515
84. phox in vascular smooth muscle. Am J Physiol Heart Circ Physiol 288 (2005) H37-H42
85. Dikalova A., Clempus R., Lassegue B., et al. Nox1 Overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice. Circulation 112 (2005) 2276-2668
86. Lee D.L., Webb R.C., and Jin L.M. Hypertension and RhoA/Rho-kinase signaling in the vasculature: highlights from the recent literature. Hypertension 44 (2004) 796-799
87. Seko T., Ito M., Kureishi Y., et al. Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. Circ Res 92 (2003) 411-418
88. Ohtsu H., Suzuki H., Nakashima H., et al. Angiotensin II signal transduction through small GTP-binding proteins: mechanism and significance in vascular smooth muscle cells. Hypertension 48 (2006) 534-540
89. Savoia C., Tabet F., Yao G.Y., Schiffrin E.L., and Touyz R.M. Negative regulation of RhoA/Rho kinase by angiotensin II type 2 receptor in vascular smooth muscle cells: role in angiotensin II-induced vasodilation in stroke-prone spontaneously hypertensive rats. J Hypertens 23 (2005) 1037-1045
90. Touyz R.M., He G., El Mabrouk M., and Schiffrin E.L. p38 MAP kinase regulates vascular smooth muscle cell collagen synthesis by angiotensin II in SHR but not in WKY. Hypertension 37 (2001) 574-580
91. El Mabrouk M., Diep Q.N., Benkirane K., Touyz R.M., and Schiffrin E.L. SAM68: a downstream target of angiotensin II signaling in vascular smooth muscle cells in genetic hypertension. Am J Physiol Heart Circ Physiol 286 (2004) H1954-H1962
92. Brewster L.M., Mairuhu G., Bindraban N.R., Koopmans R.P., Clark J.F., and van Montfrans G.A. Creatine kinase activity is associated with blood pressure. Circulation 114 (2006) 2034-2039
93. Wesselman J.P.M., Kuijs R., Hermans J.J.R., et al. Role of the Rhoa/Rho kinase system in flow-related remodeling of rat mesenteric small arteries in vivo. J Vasc Res 41 (2004) 277-290
94. De Mey J.G.R., Schiffers P.M., Hilgers R.H.P., and Sanders M.M.W. Toward functional genomics of flow-induced outward remodeling of resistance arteries. Am J Physiol Heart Circ Physiol 288 (2005) H1022-H1027
95. Durier S., Fassot C., Laurent S., et al. Physiological genomics of human arteries: quantitative relationship between gene expression and arterial stiffness. Circulation 108 (2003) 1845-1851
96. Rudnichi A., Safar M.E., Lajemi M., and Benetos A. Gene polymorphisms of the renin-angiotensin system and age-related changes in systolic and diastolic blood pressure in subjects with hypertension. Am J Hypertens 17 (2004) 321-327
97. Safar M.E., Lajemi M., Rudnichi A., Asmar R., and Benetos A. Angiotensin-converting enzyme D/I gene polymorphism and age-related changes in pulse pressure in subjects with hypertension. Arterioscler Thromb Vasc Biol 24 (2004) 782-786
98. Safar M.E., Cattan V., Lacolley P., et al. Aldosterone synthase gene polymorphism, stroke volume, and age-related changes in aortic pulse wave velocity in subjects with hypertension. J Hypertens 23 (2005) 1159-1166
99. Lajemi M., Gautier S., Poirier O., et al. Endothelin gene variants and aortic and cardiac structure in never-treated hypertensives. Am J Hypertens 14 (2001) 755-760
100. Franklin S.S., Pio J.R., Wong N.D., et al. Predictors of new-onset diastolic and systolic hypertension: the Framingham Heart Study. Circulation 111 (2005) 1121-1127
101. James M.A., Watt P.A.C., Potter J.F., Thurston H., and Swales J.D. Pulse pressure and resistance artery structure in the elderly. Hypertension 26 (1995) 301-306
102. Mitchell G.F., Vita J.A., Larson M.G., et al. Cross-sectional relations of peripheral microvascular function, cardiovascular disease risk factors, and aortic stiffness: the Framingham Heart Study. Circulation 112 (2005) 3722-3728
103. Mulvany M.J. Resistance vessel structure and the pathogenesis of hypertension. J Hypertens 11 suppl 5 (1993) S7-S12
104. Crowley S.D., Gurley S.B., Oliverio M.I., et al. Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. J Clin Invest 115 (2005) 1092-1099
105. Julius S., Nesbitt S.D., Egan B.M., et al. Feasibility of treating prehypertension with an angiotensin-receptor blocker. N Engl J Med 354 (2006) 1685-1697