Activating transcription factor 2 controls Bcl-2 promoter activity in growth plate chondrocytes

Journal of Cellular Biochemistry

Volumn 101, Issue 2, 2007, Pages 477-487

  Ma, Qin ^a,c   Li, Xinying ^a   Vale Cruz, Dustin ^a   Brown, Mark L ^a   Beier, Frank ^b   LuValle, Phyllis ^a,d  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^d Department of Anatomy and Cell Biology ^*  (United States)

Author keywords

ATF 2; BCL 2; ChIP; Chondrocytes; Cyclic AMP response element (CRE); Luciferase reporter assays; Promoter activity

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR; CYCLIC AMP; PROTEIN BCL 2;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DWARFISM; GENE IDENTIFICATION; GROWTH PLATE; HYPOCHONDROPLASIA; KYPHOSIS; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION;

ACTIVATING TRANSCRIPTION FACTOR 2; ANIMALS; CHONDROCYTES; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENE EXPRESSION REGULATION; GROWTH PLATE; MICE; MICE, KNOCKOUT; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-BCL-2;

MAMMALIA; MUS;

EID: 34247869654     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21198     Document Type: Article

References (45)

1. Adams JM, Cory S. 1998. The Bcl-2 family: Arbitrators of cell survival. Science 281:1322-1326.
2. Amling M, Neff L, Tanaka S, Inoue D, Kuida K, Weir E, Philbrick W, Broadus A, Baron R. 1997. Bcl-2 lies downstream of Parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J Cell Biol 136:205-213.
3. Beier F, Lee RJ, Taylor AC, Pestell RG, LuValle P. 1999. Identification of the cyclin D1 gene as a target for activating transcription factor 2 in chondrocytes. Proc Natl Acad Sci USA 96:1433-1438.
4. Beier F, Taylor AC, LuValle P. 2000. Activating transcription factor 2 is necessary for maximal activity and serum induction of the cyclin A promoter in chondrocytes. J Biol Chem 275:12948-12953.
5. Beier F, Ali Z, Mok D, Taylor A, Leask T, Albanese C, Pestell RG, LuValle P. 2001. TGFb and PTHrP control chondrocyte proliferation by activating cyclin D1 expression. Mol Biol Cell 12:3852-3863.
6. Bi W, Deng JM, Zhang Z, Behringer RR, de Crombrugghe B. 1999. Sox9 is required for cartilage formation. Nat Genet 22:85-89.
7. Bowlus CL, McQuillan JJ, Dean DC. 1991. Characterization of three different elements in the 5′ flanking region of the fibronectin gene which mediate transcriptional response to cAMP. J Biol Chem 266:1122-1127.
8. Cancedda R, Descalzi-Cancedda F, Castagnola P. 1995. Chondrocyte differentiation. Int Rev Cytol 159:265-358.
9. Craig AM, Denhardt D. 1991. The murine gene encoding secreted phosphoprotein 1 (osteopontin): Promoter structure, activity, and induction in vitro by estrogen and progesterone. Gene 100:163-171.
10. Duan H, Heckman CA, Boxer LM. 2005. Histone Deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas. Mol Cell Biol 25:1608-1619.
11. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G. 1997. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation. Cell 89:747-754.
12. Fisch T, Prywes R, Simon M, Roeder R. 1989. Multiple sequence elements in the c-fos promoter mediate induction by cAMP. Genes Dev 3:198-211.
13. Gil-Gomez G, Berns A, Brady H. 1998. A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis. EMBO J 17: 7209-7218.
14. Hai T, Curran T. 1991. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc Natl Acad Sci USA 88: 3720-3724.
15. Heckman C, Mehew J, Boxer LM. 2002. NFkB activates Bcl-2 expression in t(14;18) lymphoma cells. Oncogene 21:3898-3908.
16. Huang DCS, O'Reilly LA, Strasser A, Cory S. 1997. The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry. EMBO J 16:4628-4638.
17. Ito T, Deng X, Carr B, May WS. 1997. Bcl-2 phosphorylation required for anti-apoptosis function. J Biol Chem 272:11671-11673.
18. Jacenko O, Olsen BR, LuValle P. 1991. Organization and regulation of collagen genes. Grit Rev Eukaryot Gene Expr 1:327-353.
19. Kawasaki H, Schiltz L, Chiu R, Itakura K, Taira K, Nakatani Y, Yokoyama K. 2000. ATF-2 has intrinsic histone acetyl transferase activity which is modulated by phosphorylation. Nature 405:195-200.
20. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Shimizi Y, Bronson RT, Gao YH, Inada M, et al. 1997. Targeted disruption of Cbfa1 results in complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755-764.
21. Kwan AP, Cummings CE, Chapman JA, Grant ME. 1991. Macromolecular organization of chicken type X collagen in vitro. J Cell Biol 114:597-604.
22. Lanske B, Karaplis A, Lee K, Luz A, Vortkamp A, Pirro A, Karperien M, Defize L, Ho C, Mulligan R, Abou-Samra A-B, Juppner H, Segre GV, Kronenberg HM. 1996. PTH/ PTHrP receptor in early development and Indian hedgehog-related bone growth. Science 273:663-666.
23. Lefebvre V, Li P, de Crombrugghe B. 1998. A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are co-expressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J 17:5718-5733.
24. Lefevbre V, Garofalo S, Zhou G, Metsaranta M, Vuorio E, de Crombrugghe B. 1994. Characterization of primary cultures of chondrocytes from type II collagen/β-galactosidase transgenic mice. Matrix Biol 14:329-335.
25. Ling Y-H, Torno C, Persz-Soler R. 1998. Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis. J Biol Chem 273:18984-18991.
26. Long F, Schipani E, Asahara H, Kronenberg H, Montminy M. 2001. The CREB family of activators is required for endochondral bone development. Development 128:541-550.
27. Maekawa T, Bernier F, Sato M, Singh M, Reimold A, Glimcher L, Ishii S. 1999. Mouse ATF-2 null mutants display features of a severe type of meconium aspiration syndrome. J Biol Chem 274:17813-17819.
28. Matsuura S, Kishi F, Kajii T. 1990. Characterization of a 5′ flanking region of the human liver/bone/kidney alkaline phosphatase gene: Two kinds of mRNA from a single gene. Biochem Biophys Res Commun 168:993-1000.
29. Merry DE, Korsmeyer SJ. 1997. Bcl-2 gene family in the nervous system. Annu Rev Neurosci 20:245-267.
30. Mikhailov V, Mikhailova M, Pulkrabek DJ, Dong Z, Venkatachalam MA, Saikumar P. 2001. Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane. J Biol Chem 276:18361-18374.
31. Mundlos S, Olsen BR. 1997a. Heritable disease of the skeleton. Part 1: Molecular insights into skeletal development-transcription factors and signaling pathways. FASEB J 11:125-132.
32. Mundlos S, Olsen BR. 1997b. Heritable disease of the skeleton, Part II: Molecular insights into skeletal development-Matrix components and their homeostasis. FASEB J 11:227-233.
33. Murphy KM, Streips UN, Lock RB. 2000. Bcl-2 inhibits a Fas-induced conformational change in the Bax terminus and Bax mitochondrial translocation. J Biol Chem 275: 17225-17228.
34. Nilsson A, Ohlsson C, Isaksson OGP, Lindahl A, Isgaard J. 1994. Hormonal regulation of longitudinal bone growth. Eur J Clin Nutr 48:S150-S160.
35. Oltvai ZN, Milliman CL, Korsmeyer SJ. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619.
36. Park K, Choe J, Osifchin NE, Templeton DJ, Robbins PD, Kim S-J. 1994. The human retinoblastoma gene promoter is positively autoregulated by it's own product. J Biol Chem 269:6083-6088.
37. Reimold AM, Grusby MJ, Kosaras B, Fries JWU, Mori R, Maniwa S, Clauss IM, Colins T, Sidman RL, Glimcher MJ, Glimcher LH. 1996. Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice. Nature 379:262-265.
38. Rudolph D, Tafuri A, Gass P, Hammerling GJ, Arnold B, Schutz G. 1998. Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein. Proc Acad Sci USA 95:4481-4486.
39. Schule R, Umesono K, Mangelsdorf DJ, Bolado J, Pile JW, Evans RM. 1990. Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene. Cell 61:497-504.
40. Smits P, Li P, Mande J, Zhang Z, Deng J, Behringer R, de Crombrugghe B, Lefebvre V. 2001. The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. Dev Cell 1:277-290.
41. Struthers RS, Vale WW, Arias C, Sawchenko PE, Montminy MR. 1991. Somatotrophic hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant. Nature 350:622-624.
42. van Dam H, Wilhelm D, Herr I, Steffen A, Herrlich P, Angel P. 1995. ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J 14:1798-1811.
43. Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM, Tabin CJ. 1996. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 273:613-622.
44. Wilson BE, Mochon E, Boxer LM. 1996. Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis. Mol Cell Biol 16:5546-5556.
45. Wu X, McMurray CT. 2001. Calmodulin kinase II attenuation of gene transcription by preventing cAMP response element binding protein (CREB) dimerization and binding of the CREB binding protein. J Biol Chem 276:1735-1741.