Platelet-rich plasma: Growth factors and pro- and anti-inflammatory properties

Journal of Periodontology

Volumn 78, Issue 4, 2007, Pages 661-669

  El Sharkawy, Hesham ^a,b   Kantarci, Alpdogan ^a   Deady, Jennifer ^a   Hasturk, Hatice ^a   Liu, Hongsheng ^a   Alshahat, Mohammad ^b   Van Dyke, Thomas E ^a  

^a BOSTON UNIVERSITY   (United States)

^b Mansoura University   (Egypt)

Author keywords

Chemokines; Growth factors; Lipoxin; Monocytes; Platelet rich plasma

Indexed keywords

CYTOKINE; LIPOXIN; LIPOXIN A; RANTES; SIGNAL PEPTIDE;

ADULT; ARTICLE; BLOOD; CHEMISTRY; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; MONOCYTE; NEUTROPHIL CHEMOTAXIS; PHYSIOLOGY; SECRETION; THROMBOCYTE COUNT; THROMBOCYTE RICH PLASMA;

ADULT; CHEMOTAXIS, LEUKOCYTE; CYTOKINES; FEMALE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOXINS; MALE; MIDDLE AGED; MONOCYTES; PLATELET COUNT; PLATELET-RICH PLASMA; RANTES;

EID: 34247859019     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2007.060302     Document Type: Article

References (55)

1. Deodhar AK, Rana RE. Surgical physiology of wound healing: A review. J Postgrad Med 1997;43:52-56.
2. Weibrich G, Kleis WK, Hafner G, Hitzler WE. Growth factor levels in platelet-rich plasma and correlations with donor age, sex, and platelet count. J Craniomaxillofac Surg 2002;30:97-102.
3. Assoian RK, Grotendorst GR, Miller DM, Sporn MB. Cellular transformation by coordinated action of three peptide growth factors from human platelets. Nature 1984;309:804-806.
4. Antoniades HN, Galanopoulos T, Neville-Golden J, Kiritsy CP, Lynch SE. Expression of growth factor and receptor mRNAs in skin epithelial cells following acute cutaneous injury. Am J Pathol 1993;142:1099-1110.
5. Schilephake H. Bone growth factors in maxillofacial skeletal reconstruction. Int J Oral Maxillofac Surg 2002; 31:469-484.
6. Giannobile WV. Periodontal tissue engineering by growth factors. Bone 1996;19(1 Suppl.):23S-37S.
7. Tischler M. Platelet rich plasma. The use of autologous growth factors to enhance bone and soft tissue grafts. N Y State Dent J 2002;68:22-24.
8. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:638-646.
9. Sanchez AR, Sheridan PJ, Kupp LI. Is platelet-rich plasma the perfect enhancement factor? A current review. Int J Oral Maxillofac Implants 2003;18:93-103.
10. Aghaloo TL, Moy PK, Freymiller EG. Investigation of platelet-rich plasma in rabbit cranial defects: A pilot study. J Oral Maxillofac Surg 2002;60:1176-1181.
11. Kim SG, Chung CH, Kim YK, Park JC, Lim SC. Use of particulate dentin-plaster of Paris combination with/without platelet-rich plasma in the treatment of bone defects around implants. Int J Oral Maxillofac Implants 2002;17:86-94.
12. Kassolis JD, Rosen PS, Reynolds MA. Alveolar ridge and sinus augmentation utilizing platelet-rich plasma in combination with freeze-dried bone allograft: Case series. J Periodontol 2000;71:1654-1661.
13. Lekovic V, Camargo PM, Weinlaender M, Vasilic N, Aleksic Z, Kenney EB. Effectiveness of a combination of platelet-rich plasma, bovine porous bone mineral and guided tissue regeneration in the treatment of mandibular grade II molar furcations in humans. J Clin Periodontol 2003;30:746-751.
14. Camargo PM, Lekovic V, Weinlaender M, Vasilic N, Madzarevic M, Kenney EB. Platelet-rich plasma and bovine porous bone mineral combined with guided tissue regeneration in the treatment of intrabony defects in humans. J Periodontal Res 2002;37:300-306.
15. Hanna R, Trejo PM, Weltman RL. Treatment of intrabony defects with bovine-derived xenograft alone and in combination with platelet-rich plasma: A randomized clinical trial. J Periodontol 2004;75:1668-1677.
16. Roldan JC, Jepsen S, Miller J, et al. Bone formation in the presence of platelet-rich plasma vs. bone morphogenetic protein-7. Bone 2004;34:80-90.
17. Jensen TB, Rahbek O, Overgaard S, Soballe K. Platelet rich plasma and fresh frozen bone allograft as enhancement of implant fixation. An experimental study in dogs. J Orthop Res 2004;22:653-658.
18. Koch RM, Roche NS, Parks WT, Ashcroft GS, Letterio JJ, Roberts AB. Incisional wound healing in transforming growth factor-beta1 null mice. Wound Repair Regen 2000;8:179-191.
19. Pollard JW. Tumour-stromal interactions. Transforming growth factor-beta isoforms and hepatocyte growth factor/scatter factor in mammary gland ductal morphogenesis. Breast Cancer Res 2001;3:230-237.
20. Tilley SL, Coffman TM, Koller BH. Mixed messages: Modulation of inflammation and immune responses by prostaglandins and thromboxanes. J Clin Invest 2001; 108:15-23.
21. Huynh ML, Fadok VA, Henson PM. Phosphatidyl-serine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J Clin Invest 2002;109:41-50.
22. Lucas M, Stuart LM, Savill J, Lacy-Hulbert A. Apoptotic cells and innate immune stimuli combine to regulate macrophage cytokine secretion. J Immunol 2003; 171:2610-2615.
23. Kantarci A, Van Dyke TE. Resolution of inflammation in periodontitis. J Periodontol 2005;76(Suppl.): 2168-2174.
24. Van Dyke TE, Serhan CN. Resolution of inflammation: A new paradigm for the pathogenesis of periodontal diseases. J Dent Res 2003; 82:82-90.
25. Bannenberg GL, Chiang N, Ariel A, et al. Molecular circuits of resolution: Formation and actions of resolvins and protectins. J Immunol 2005;174:4345-4355.
26. Fiore S, Serhan CN. Lipoxin A4 receptor activation is distinct from that of the formyl peptide receptor in myeloid cells: Inhibition of CD11/18 expression by lipoxin A4-lipoxin A4 receptor interaction. Biochemistry 1995;34:16678-16686.
27. Aster RH, Jandl JH. Platelet sequestration in man. I. Methods. J Clin Invest 1964;43:843-855.
28. Weibrich G, Kleis WK, Hitzler WE, Hafner G. Comparison of the platelet concentrate collection system with the plasma-rich-in-growth-factors kit to produce platelet-rich plasma: A technical report. Int J Oral Maxillofac Implants 2005;20:118-123.
29. Man D, Plosker H, Winland-Brown JE. The use of autologous platelet-rich plasma (platelet gel) and autologous platelet-poor plasma (fibrin glue) in cosmetic surgery. Plast Reconstr Surg 2001;107:229-237.
30. Appel TR, Potzsch B, Muller J, von Lindern, JJ, Berge SJ, Reich RH. Comparison of three different preparations of platelet concentrates for growth factor enrichment. Clin Oral Implants Res 2002;13:522-528.
31. Kalmar JR, Arnold RR, Warbington ML, Gardner MK. Superior leukocyte separation with a discontinuous one-step Ficoll-Hypaque gradient for the isolation of human neutrophils. J Immunol Methods 1988;110: 275-281.
32. Maddox JF, Serhan CN. Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: Selective inactivation by dehydrogenation and reduction. J Exp Med 1996;183:137-146.
33. Levy BD, Bertram S, Tai HH, et al. Agonist-induced lipoxin A4 generation: Detection by a novel lipoxin A4-ELISA. Lipids 1993;28:1047-1053.
34. Fine JS, Byrnes HD, Zavodny PJ, Hipkin RW. Evaluation of signal transduction pathways in chemoattractant-induced human monocyte chemotaxis. Inflammation 2001;25:61-67.
35. Weibrich G, Kleis WK, Hafner G. Growth factor levels in the platelet-rich plasma produced by 2 different methods: Curasan-type PRP kit versus PCCS PRP system. Int J Oral Maxillofac Implants 2002;17:184-190.
36. Matsuda N, Lin WL, Kumar NM, Cho MI, Genco RJ. Mitogenic, chemotactic, and synthetic responses of rat periodontal ligament fibroblastic cells to polypeptide growth factors in vitro. J Periodontol 1992;63:515-525.
37. Bartold PM. Platelet-derived growth factor stimulates hyaluronate but not proteoglycan synthesis by human gingival fibroblasts in vitro. J Dent Res 1993;72:1473-1480.
38. Gamal AY, Mailhot JM. The effect of local delivery of PDGF-BB on attachment of human periodontal ligament fibroblasts to periodontitis-affected root surfaces in vitro. J Clin Periodontol 2000;27:347-353.
39. Bartold PM, Narayanan AS, Page RC. Platelet-derived growth factor reduces the inhibitory effects of lipopolysaccharide on gingival fibroblast proliferation. J Periodontal Res 1992;27:499-505.
40. Sporn MB, Roberts AB. Transforming growth factor-beta: Recent progress and new challenges. J Cell Biol 1992;119:1017-1021.
41. Blom S, Holmstrup P, Dabelsteen E. The effect of insulin-like growth factor-I and human growth hormone on periodontal ligament fibroblast morphology, growth pattern, DNA synthesis, and receptor binding. J Periodontol 1992;63:960-968.
42. McCarthy TL, Centrella M, Canalis E. Parathyroid hormone enhances the transcript and polypeptide levels of insulin-like growth factor I in osteoblast-enriched cultures from fetal rat bone. Endocrinology 1989;124:1247-1253.
43. Caffesse RG, Quinones CR. Polypeptide growth factors and attachment proteins in periodontal wound healing and regeneration. Periodontol 2000 1993;1:69-79.
44. Terranova VP, Odziemiec C, Tweden KS, Spadone DP. Repopulation of dentin surfaces by periodontal ligament cells and endothelial cells. Effect of basic fibroblast growth factor. J Periodontol 1989;60:293-301.
45. Takayama S, Murakami S, Miki Y, et al. Effects of basic fibroblast growth factor on human periodontal ligament cells. J Periodontal Res 1997;32:667-675.
46. Geiger F, Bertram H, Berger I, et al. Vascular endothelial growth factor gene-activated matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects. J Bone Miner Res 2005;20: 2028-2035.
47. Barry OP, Pratico D, Savani RC, FitzGerald GA. Modulation of monocyte-endothelial cell interactions by platelet microparticles. J Clin Invest 1998;102:136-144.
48. Appay V, Brown A, Cribbes S, Randle E, Czaplewski LG. Aggregation of RANTES is responsible for its inflammatory properties. Characterization of nonaggregating, noninflammatory RANTES mutants. J Biol Chem 1999;274:27505-27512.
49. Alam R, Forsythe PA, Lett-Brown MA, Grant JA. Interleukin-8 and RANTES inhibit basophil histamine release induced with monocyte chemotactic and activating factor/monocyte chemoattractant peptide-1 and histamine releasing factor. Am J Respir Cell Mol Biol 1992;7:427-433.
50. Holme PA, Muller F, Solum NO, Brosstad F, Froland SS, Aukrust P. Enhanced activation of platelets with abnormal release of RANTES in human immuno-deficiency virus type 1 infection. FASEB J 1998;12: 79-89.
51. Yoshimura T, Yuhki N, Moore SK, Appella E, Lerman MI, Leonard EJ. Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE. FEBS Lett 1989;244:487-493.
52. Rollins BJ, Walz A, Baggiolini M. Recombinant human MCP-1/JE induces chemotaxis, calcium flux, and the respiratory burst in human monocytes. Blood 1991; 78:1112-1116.
53. Locati M, Zhou D, Luini W, Evangelista V, Mantovani A, Sozzani S. Rapid induction of arachidonic acid release by monocyte chemotactic protein-1 and related chemokines. Role of Ca2+ influx, synergism with platelet-activating factor and significance for chemotaxis. J Biol Chem 1994;269:4746-4753.
54. Godson C, Mitchell S, Harvey K, Petasis NA, Hogg N, Brady HR. Cutting edge: Lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages. J Immunol 2000; 164:1663-1667.
55. Petrungaro PS. Using platelet-rich plasma to accelerate soft tissue maturation in esthetic periodontal surgery. Compend Contin Educ Dent 2001;22:729-732, 734, 736 passim; quiz 46.