Ameliorative effect of combined administration of inducible nitric oxide synthase inhibitor with cyclooxygenase-2 inhibitors in neuropathic pain in rats

European Journal of Pain

Volumn 11, Issue 5, 2007, Pages 528-534

  Dudhgaonkar, Shailesh P ^a   Tandan, Surendra K ^a   Kumar, Dinesh ^a   Naik, Ajit K ^a   Raviprakash, V ^a  

^a INDIAN VETERINARY RESEARCH INSTITUTE   (India)

Author keywords

Aminoguanidine hydrochloride; CCI; Meloxicam; Rats; Rofecoxib; Synergism

Indexed keywords

AMINOGUANIDINE; KETAMINE; MELOXICAM; ROFECOXIB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; HYPERALGESIA; MALE; MONOTHERAPY; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE;

ANIMALS; CYCLOOXYGENASE 2 INHIBITORS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG SYNERGISM; GUANIDINES; HYPERALGESIA; LACTONES; MALE; NEURALGIA; NEURONS, AFFERENT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NOCICEPTORS; PAIN THRESHOLD; PERIPHERAL NERVOUS SYSTEM DISEASES; PHYSICAL STIMULATION; RATS; REACTION TIME; SCIATIC NEUROPATHY; SULFONES; THIAZINES; THIAZOLES; TREATMENT OUTCOME;

EID: 34247645106     PISSN: 10903801     EISSN: 15322149     Source Type: Journal    
DOI: 10.1016/j.ejpain.2006.07.006     Document Type: Article

References (35)

1. Bennet G.J., and Xie Y.K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33 (1988) 87-107
2. Bingham S., Beswick P.J., Bountra C., Brown T., Campbell I.B., Chessell I.P., et al. The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization. J Pharmacol Exp Ther 312 (2005) 1161-1169
3. Broom D.C., Samad T.A., Kohno T., Tegeder I., Geisslinger G., and Woolf C.J. Cyclooxygenase 2 expression in the spared nerve injury model of neuropathic pain. Neuroscience 124 (2004) 891-900
4. Clatworthy A.L., Illich P.A., Castro G.A., and Walters E.T. Role of peri-axonal inflammation in the development of thermal hyperalgesia and guarding behaviour in a rat model of neuropathic pain. Neurosci Lett 184 (1995) 5-8
5. Craig A.D., Bushnell M.C., Zhang E.T., and Blomqvist A. A thalamic nucleus specific for pain and temperature sensation. Nature 372 (1994) 770-773
6. Cunha F.Q., Poole S., Lorenzetti B.B., and Ferreira S.H. The pivotal role of tumor necrosis factor α in the development of inflammatory hyperalgesia. Br J Phrmacol 107 (1992) 660-664
7. De Alba J., Clayton N.M., Collins S.D., Colthup P., Chessell I., and Knowles R.G. GW274150, a novel and highly selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), shows analgesic effects in rat models of inflammatory and neuropathic pain. Pain 120 (2006) 170-181
8. Frisen J., Risling M., and Fried K. Distribution and axonal relations of macrophages in a neuroma. Neuroscience 55 (1993) 1003-1013
9. Hargreaves K., Dubner R., Brown F., Flores C., and Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32 (1988) 77-88
10. Kawabata A., Manabe S., Manabe Y., and Takagi H. Effect of topical administration of Larginine on formalin-induced nociception in the mouse: a dual role of peripherally formed NO in pain modulation. Br J Pharmacol 112 (1994) 547-550
11. Kim S.F., Huri D.A., and Snyder S.H. Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science 310 (2005) 1966-1970
12. Labuda C.J., Koblish M., Tuthill P., Dolle R.E., and Little P.J. Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and post-operative pain. Eur J Pain 10 (2006) 505-512
13. Lee D.H., Singh J.P., and Lodge D. Experiments with nitric oxide synthase inhibitors in spinal nerve ligated rats provide no evidence of a role of mechanical allodynia. Neurosci Lett 385 (2005) 179-183
14. Levy D., Hoke A., and Zochodne D.W. Local expression of iNOS in an animal model of neuropathic pain. Neurosci Lett 260 (1999) 207-209
15. Levy D., and Zochodne D.W. Local nitric oxide synthase activity in a model of neuropathic pain. Eur J Neurosci 10 (1998) 1845-1855
16. Levine J.D., Coderre T.J., White D.M., Finkbeiner W.E., and Basbaum A.I. Denervation-induced inflammation in the rat. Neurosci Lett 119 (1990) 37-40
17. Ma W., and Eisenach J.C. Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury. Neuroscience 121 (2003) 691-704
18. Ma W., and Eisenach J.C. Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain. Eur J Neurosci 15 (2002) 1037-1047
19. Naik A.K., Tandan S.K., Kumar D., and Dudhgaonkar S.P. Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats. Eur J Pharmacol 530 (2006) 59-69
20. Nathan C.F. Secretory products of macrophages. J Clin Invest 79 (1987) 319-326
21. Oldfors A. Macrophages in peripheral nerves. An ultra structural and enzyme histochemical study on rats. Acta Neuropath 49 (1980) 43-49
22. Perry V.H., Brown M.C., and Gordon S. The macrophage response to central and peripheral nerve injury. J Exp Med 165 (1987) 1218-1223
23. Perry V.H. Macrophages and the nervous system (1994), RG Landes Company, CRC Press, Austin, TX
24. Randall L.O., and Selitto J.J. A method for measurement of analgesic activity on inflammed tissues. Arch Int Pharmacodyn 111 (1957) 409-419
25. Salvemini D., Misko T.P., Masferrer J.L., Seibrt K., Currie M.G., and Needleman P. Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci USA 190 (1993) 7240-7244
26. Schaible H.G., and Schmidt R.F. Excitation and sensitization of fine articular afferents from cat's knee joint by PGE2. J Physiol 403 (1988) 91-104
27. Seltzer Z., Dubner R., and Shir Y. A novel behavioural model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain 41 (1990) 205-218
28. Shim B., Kim D.W., Kim B.H., Nam T.S., Leem J.W., and Chung J.M. Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy. Neuroscience 132 (2005) 193-201
29. Shir Y., and Seltzer Z. A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats. Neurosci Lett 115 (1990) 62-67
30. Sung C.S., Wen Z.H., Chang W.K., Ho S.T., Tsai S.K., Chang Y.C., et al. Intrathecal interleukin-1beta administration induces thermal hyperalgesia by activating inducible nitric oxide synthase expression in the rat spinal cord. Brain Res 1015 (2004) 145-153
31. Suyama H., Kawamoto M., Gaus S., and Yuge O. Effect of etodolac, a COX-2 inhibitor on neuropathic pain in rat model. Brain Res 1010 (2004) 144-150
32. Syriatowicz J.P., Hu D., Walker J.H.S., and Tracey D.J. Hyperalgesia due to nerve injury: role of prostaglandin. Neurosci 94 (1999) 587-594
33. Takahashi M., Kawaguchi M., Shimada K., Nakashima T., and Furuya H. Systemic meloxicam reduces tactile allodynia development after L5 single spinal nerve injury in rats. Reg Anesth Pain Med 30 (2005) 351-355
34. Tracey D.J., and Walker J.S. Pain due to nerve damage: are inflammatory mediators involved?. Inflamm Res 44 (1995) 407-411
35. Winter C.A., Risley E.A., and Nuss G.W. Carrageenan-induced oedema in hind paw of rats as an assay for anti-inflammatory drugs. Proc Soc Biol Med 111 (1962) 544-546