Up-regulation of IL-10 expression in dendritic cells is involved in Trichosanthin-induced immunosuppression

Immunology Letters

Volumn 110, Issue 1, 2007, Pages 74-81

  Zhou, Xiaorong ^a,c   Yang, Neng ^a   Lu, Liming ^a,b   Ding, Qing ^a   Jiao, Zhijun ^a   Zhou, Yun ^a,b   Chou, Kuang Yen ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b E institutes of Shanghai   (China)

^c NANTONG MEDICAL COLLEGE   (China)

Author keywords

Dendritic cells; IL 10; Immunosuppression; Th1 Th2 cells; Trichosanthin

Indexed keywords

ALLOANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TRICHOSANTHIN;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG POTENCY; ENZYME ACTIVATION; IMMUNE RESPONSE; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; INHIBITION KINETICS; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; IMMUNOSUPPRESSIVE AGENTS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-2; INTERLEUKIN-4; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; TH1 CELLS; TRICHOSANTHIN; UP-REGULATION;

EID: 34247643933     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2007.03.008     Document Type: Article

References (39)

1. Shaw P.C., Lee K.M., and Wong K.B. Recent advances in trichosanthin, a ribosome-inactivating protein with multiple pharmacological properties. Toxicon 45 (2005) 683-689
2. Collins E.J., Robertus J.D., LoPresti M., Stone K.L., Williams K.R., Wu P., et al. Primary amino acid sequence of alpha-trichosanthin and molecular models for abrin A-chain and alpha-trichosanthin. J Biol Chem 265 (1990) 8665-8669
3. Chow T.P., Feldman R.A., Lovett M., and Piatak M. Isolation and DNA sequence of a gene encoding alpha-trichosanthin, a type I ribosome-inactivating protein. J Biol Chem 265 (1990) 8670-8674
4. Shaw P.C., Yung M.H., Zhu R.H., Ho W.K., Ng T.B., and Yeung H.W. Cloning of trichosanthin cDNA and its expression in Escherichia coli. Gene 97 (1991) 267-272
5. Ng T.B., Shaw P.C., and Chan W.Y. Importance of the Glu 160 and Glu 189 residues to the various biological activities of the ribosome inactivating protein trichosanthin. Life Sci 58 (1996) 2439-2446
6. Nie H., Cai X., He X., Xu L., Ke X., Ke Y., et al. Position 120-123, a potential active site of trichosanthin. Life Sci 62 (1998) 491-500
7. Zhang X.J., and Wang J.H. Homology of trichosanthin and ricin A chain. Nature 321 (1986) 477-478
8. Jin Y.C. Crystal trichosanthin protein intramuscular or intracervical injection for the termination of pregnancy at 10 to 14 weeks gestation: clinical analysis of 200 cases. Shengzhi Yu Biyun 10 (1990) 34-37
9. Chan W.Y., Huang H., and Tam S.C. Receptor-mediated endocytosis of trichosanthin in choriocarcinoma cells. Toxicology 186 (2003) 191-203
10. Wang Q.C., Ying W.B., Xie H., Zhang Z.C., Yang Z.H., and Ling L.Q. Trichosanthin-monoclonal antibody conjugate specifically cytotoxic to human hepatoma cells in vitro. Cancer Res 51 (1991) 3353-3355
11. McGrath M.S., Hwang K.M., Caldwell S.E., Gaston I., Luk K.C., Wu P., et al. GLQ223: an inhibitor of human immunodeficiency virus replication in acutely and chronically infected cells of lymphocyte and mononuclear phagocyte lineage. Proc Natl Acad Sci USA 86 (1989) 2844-2848
12. Byers V.S., Levin A.S., Waites L.A., Starrett B.A., Mayer R.A., Clegg J.A., et al. A phase I/II study of trichosanthin treatment of HIV disease. AIDS 4 (1990) 1189-1196
13. Chou K.Y., Chan M., and Bias W.B. Differential expression of the down-regulatory function of CD8 cells in trichosanthin-induced immunosuppression and its genetic control in humans. Eur J Immunogenet 23 (1996) 29-40
14. Zhou H., Jiao Z., Pan J., Hong J., Tao J., Li N., et al. Immune suppression via IL-4/IL-10-secreting T cells: A nontoxic property of anti-HIV agent Trichosanthin. Clin Immunol 122 (2007) 312-322
15. Chou K.Y., Fu S.L., Li N.L., Huang L.D., Wang F.Q., Lu P.H., et al. Cis-trans complementation of DQA1-DQB1 genes are modulated by DQ alleles: an immunogenetics analysis of DQ association with the down-regulatory function of CD8 cells in trichosanthin-induced immunosuppression. Eur J Immunogenet 26 (1999) 5-13
16. Li F., Mei Y., Wang Y., Chen C., Tu J., Xiao B., et al. Trichosanthin inhibits antigen-specific T cell expansion through nitric oxide-mediated apoptosis pathway. Cell Immunol 234 (2005) 23-30
17. Banchereau J., and Steinman R.M. Dendritic cells and the control of immunity. Nature 392 (1998) 245-252
18. Steinman R.M., and Hemmi H. Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol 311 (2006) 17-58
19. Lutz M.B., and Schuler G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?. Trends Immunol 23 (2002) 445-449
20. He Q., Moore T.T., Eko F.O., Lyn D., Ananaba G.A., Martin A., et al. Molecular basis for the potency of IL-10-deficient dendritic cells as a highly efficient APC system for activating Th1 response. J Immunol 174 (2005) 4860-4869
21. Huang L.Y., Reis e Sousa, Itoh Y., Inman J., and Scott D.E. IL-12 induction by a TH1-inducing adjuvant in vivo: dendritic cell subsets and regulation by IL-10. J Immunol 167 (2001) 1423-1430
22. Sai T., Milling S.W., and Mintz B. Freezing and thawing of bone marrow-derived murine dendritic cells with subsequent retention of immunophenotype and of antigen processing and presentation characteristics. J Immunol Methods 264 (2002) 153-162
23. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-408
24. Li G., Kim Y.J., and Broxmeyer H.E. Macrophage colony-stimulating factor drives cord blood monocyte differentiation into IL-10(high)IL-12absent dendritic cells with tolerogenic potential. J Immunol 174 (2005) 4706-4717
25. Corinti S., Albanesi C., la S.A., Pastore S., and Girolomoni G. Regulatory activity of autocrine IL-10 on dendritic cell functions. J Immunol 166 (2001) 4312-4318
26. Ding Q., Lu L., Wang B., Zhou Y., Jiang Y., Zhou X., et al. B7H1-Ig fusion protein activates the CD4+ IFN-gamma receptor+ type 1 T regulatory subset through IFN-gamma-secreting Th1 cells. J Immunol 177 (2006) 3606-3614
27. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3 (2003) 133-146
28. Yu Q., Kovacs C., Yue F.Y., and Ostrowski M.A. The role of the p38 mitogen-activated protein kinase, extracellular signal-regulated kinase, and phosphoinositide-3-OH kinase signal transduction pathways in CD40 ligand-induced dendritic cell activation and expansion of virus-specific CD8+ T cell memory responses. J Immunol 172 (2004) 6047-6056
29. Puig-Kroger A., Relloso M., Fernandez-Capetillo O., Zubiaga A., Silva A., Bernabeu C., et al. Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells. Blood 98 (2001) 2175-2182
30. Ouyang D.Y., Chan H., Wang Y.Y., Huang H., Tam S.C., and Zheng Y.T. An inhibitor of c-Jun N-terminal kinases (CEP-11004) counteracts the anti-HIV-1 action of trichosanthin. Biochem Biophys Res Commun 339 (2006) 25-29
31. Kahn J.O., Kaplan L.D., Gambertoglio J.G., Bredesen D., Arri C.J., Turin L., et al. The safety and pharmacokinetics of GLQ223 in subjects with AIDS and AIDS-related complex: a phase I study. AIDS 4 (1990) 1197-1204
32. Mayer R.A., Sergios P.A., Coonan K., and O'Brien L. Trichosanthin treatment of HIV-induced immune dysregulation. Eur J Clin Invest 22 (1992) 113-122
33. Lee-Huang S., Huang P.L., Kung H.F., Li B.Q., Huang P.L., Huang P., et al. TAP 29: an anti-human immunodeficiency virus protein from Trichosanthes kirilowii that is nontoxic to intact cells. Proc Natl Acad Sci USA 88 (1991) 6570-6574
34. Sun P., Celluzzi C.M., Marovich M., Subramanian H., Eller M., Widjaja S., et al. CD40 ligand enhances dengue viral infection of dendritic cells: a possible mechanism for T cell-mediated immunopathology. J Immunol 177 (2006) 6497-6503
35. Tsujimoto H., Efron P.A., Matsumoto T., Ungaro R.F., Abouhamze A., Ono S., et al. Maturation of murine bone marrow-derived dendritic cells with poly(I:C) produces altered TLR-9 expression and response to CpG DNA. Immunol Lett 107 (2006) 155-162
36. Wang Y.Y., Ouyang D.Y., Huang H., Chan H., Tam S.C., and Zheng Y.T. Enhanced apoptotic action of trichosanthin in HIV-1 infected cells. Biochem Biophys Res Commun 331 (2005) 1075-1080
37. Zhang C., Gong Y., Ma H., An C., Chen D., and Chen Z.L. Reactive oxygen species involved in trichosanthin-induced apoptosis of human choriocarcinoma cells. Biochem J 355 (2001) 653-661
38. Li J., Xia X., Nie H., Smith M.A., and Zhu X. PKC inhibition is involved in trichosanthin-induced apoptosis in human chronic myeloid leukemia cell line K562. Biochim Biophys Acta 1770 (2007) 63-70
39. Chan W.L., Zheng Y.T., Huang H., and Tam S.C. Relationship between trichosanthin cytotoxicity and its intracellular concentration. Toxicology 177 (2002) 245-251