Altered distribution of heat shock protein 60 (Hsp60) with dysregulated expression of DHX32

Experimental and Molecular Pathology

Volumn 82, Issue 3, 2007, Pages 256-261

  Chen, Yong ^a   Alli, Zaman ^a   Ackerley, Cameron ^a   Al Saud, Bandar ^a   Abdelhaleem, Mohamed ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

DHX32; Heat shock protein 60; Mitochondria

Indexed keywords

CYTOCHROME C; DHX32 ENZYME; HEAT SHOCK PROTEIN 60; LEUCINE; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL PROTEIN; PEROXIREDOXIN; RNA HELICASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; LEUKEMIA CELL LINE; LYMPHOCYTE ACTIVATION; MASS SPECTROMETER; MITOCHONDRIAL MEMBRANE; TWO DIMENSIONAL GEL ELECTROPHORESIS;

CHAPERONIN 60; CYTOPLASM; DEAD-BOX RNA HELICASES; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; JURKAT CELLS; MICROSCOPY, IMMUNOELECTRON; MITOCHONDRIA; PROTEIN TRANSPORT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 34247639529     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2006.11.002     Document Type: Article

References (17)

1. Abdelhaleem M. The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia. Leuk. Res. 26 (2002) 945-954
2. Abdelhaleem M. Do RNA helicases have a role in cancer?. Biochim. Biophys. Acta, Rev. Cancer 1704 (2004) 37-46
3. Abdelhaleem M. Over-expression of RNA helicases in cancer. Anticancer Res. 24 (2004) 3951-3954
4. Abdelhaleem M. RNA helicases: regulators of differentiation. Clin. Biochem. 38 (2005) 499-503
5. Abdelhaleem M., Maltais L., and Wain H. The human DDX and DHX gene families of putative RNA helicases. Genomics 81 (2003) 618-622
6. Abdelhaleem M., Sun T., and Ho M. DHX32 expression suggests a role in lymphocyte differentiation. Anticancer Res. 25 (2005) 2645-2648
7. Alli Z., Nam E.H., Beimnet K., and Abdelhaleem M. The activation-induced expression of DHX32 in Jurkat T cells is specific and involves calcium and nuclear factor of activated T cells. Cell. Immunol. 237 (2005) 141-146
8. Alli Z., Ho M., and Abdelhaleem M. Expression of DHX32 in lymphoid tissues. Exp. Mol. Pathol. 79 (2005) 219-223
9. Alli Z., Cameron A., Chen Y., Al-Saud B., and Abdelhaleem M. Nuclear and mitochondrial localization of the putative RNA helicase DHX32. Exp. Mol. Pathol. 81 (2006) 245-248
10. Bakau B., and Horwich A.L. The Hsp70 and Hsp60 chaperon machines. Cell 92 (1998) 351-366
11. Kitamura T., Onishi M., Kinoshita S., Shibuya A., Miyajima A., and Nolan G.P. Efficient screening of retroviral cDNA expression libraries. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 9146-9150
12. Parcellier A., Gurbuxani S., Schmitt E., Solary E., and Garrido C. Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways. Biochem. Biophys. Res. Commun. 304 (2003) 505-512
13. Samali A., Cai J., Zhivotovsky B., Jones D.P., and Orrenius S. Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells. EMBO J. 18 (1999) 2040-2048
14. Shan Y.X., Liu T.J., Su H.F., Samsamshariat A., Mestril R., and Wang P.H. Hsp10 and Hsp60 modulate Bcl-2 family and mitochondrial apoptosis signaling induced by doxorubicin in cardiac muscle cells. J. Mol. Cell. Cardiol. 35 (2003) 1135-1143
15. Soltys B.J., and Gupta R.S. Immunoelectron microscopic localization of the 60-kDa heat shock chaperonin protein (Hsp60) in mammalian cells. Exp. Cell Res. 222 (1996) 16-27
16. Thomas X., Campos L., Le Q.-H., and Guyotat D. Heat shock proteins and acute leukemias. Hematology 10 (2005) 225-235
17. Xanthoudakis S., Roy S., Rasper D., Hennessey T., Aubin Y., Cassady R., Tawa P., Ruel R., Rosen A., and Nicholson D.W. Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis. EMBO J. 18 (1999) 2049-2056