Lactulose feeding lowers cecal densities of clostridia in piglets

Journal of Parenteral and Enteral Nutrition

Volumn 31, Issue 3, 2007, Pages 194-198

  Kien, C Lawrence ^a,e   Blauwiekel, Ruth ^a   Williams, Carol H ^a,c   Bunn, Janice Yanushka ^b   Buddington, Randal K ^d  

^a UNIVERSITY OF VERMONT   (United States)

^b Mississippi State University ^*  (United States)

^c MISSISSIPPI STATE UNIVERSITY   (United States)

^d MISSISSIPPI STATE UNIVERSITY   (United States)

^e UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INULIN; LACTULOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL MILK; CARBOHYDRATE INTOLERANCE; CECUM; CLOSTRIDIUM; COLON FLORA; COLONY FORMING UNIT; CONTROLLED STUDY; DIARRHEA; ENTERIC FEEDING; NONHUMAN; PIGLET; PRIORITY JOURNAL;

ANIMALS; ANIMALS, NEWBORN; BUTYRATES; CECUM; CLOSTRIDIUM; COLONY COUNT, MICROBIAL; DIARRHEA; ENTERAL NUTRITION; GASTROINTESTINAL AGENTS; INULIN; LACTULOSE; MALABSORPTION SYNDROMES; ORGAN SIZE; PROBIOTICS; RANDOM ALLOCATION; STATISTICS, NONPARAMETRIC; SWINE;

CLOSTRIDIA;

EID: 34247571317     PISSN: 01486071     EISSN: None     Source Type: Journal    
DOI: 10.1177/0148607107031003194     Document Type: Article

References (39)

1. Kien CL, Murray RD, Qualman SJ, Marcon M. Lactulose feeding in piglets: a model for persistent diarrhea and colitis induced by severe sugar malabsorption. Dig Dis Sci. 1999;44:1476-1484.
2. Kien CL, Chang JC, Cooper JR, Frankel WL. Effects of prefeeding a prebiotic on diarrhea and colonic cell proliferation in piglets fed lactulose. JPEN J Parenter Enteral Nutr. 2004;28:22-26.
3. Kien CL, Schmitz-Brown M, Solley T, Sun D, Frankel WL. Increased colonic luminal synthesis of butyric acid is associated with lowered colonic cell proliferation in piglets. J Nutr. 2006;136:64-69.
4. Roy CC, Kien CL, Bouthillier L, Levy E. Short-chain fatty acids: ready for prime time? Nutr Clin Pract. 2006;21:351-366.
5. Sakata T. Stimulatory effect of short-chain fatty acids on epithelial cell proliferation in the rat intestine: a possible explanation for trophic effects of fermentable fibre, gut microbes and luminal tropic factors. Br J Nutr. 1987;58:95-103.
6. Frankel WL, Zhang W, Singh A, et al. Mediation of the trophic effects of short-chain fatty acids on the rat jejunum and colon. Gastroenterology. 1994;106:375-380.
7. Sakata T, Tamate H. Rumen epithelial cell proliferation accelerated by rapid increase in intraruminal butyrate. J Dairy Sci. 1978;61:1109-1113.
8. Flourie B, Briet F, Florent C, Pellier P, Maurel M, Rambaud JC. Can diarrhea induced by lactulose be reduced by prolonged ingestion of lactulose? Am J Clin Nutr. 1993;58:369-375.
9. Briet F, Achour L, Flourie B, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr. 1995;49:501-507.
10. Howard MD, Gordon DT, Pace LW, Garleg KA, Kerley MS. Effects of dietary supplementation with fructooligosaccharides on colonic microbiota populations and epithelial cell proliferation in neonatal pigs. J Pediatr Gastroenterol Nutr. 1995;21:297-303.
11. Kleessen B, Sykura B, Zunft H-J, Blaut M. Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons. Am J Clin Nutr. 1997;65:1397-1402.
12. Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr. 1995;125:1401-1412.
13. Butel MJ, Waligora-Dupriet AJ, Szylit O. Oligofructose and experimental model of neonatal necrotising enterocolitis. Br J Nutr. 2002;87(suppl 2):S213-S219.
14. Ito Y, Moriwaki H, Muto Y, Kato N, Watanabe K, Ueno K. Effect of lactulose on short-chain fatty acids and lactate production and on the growth of faecal flora, with special reference to Clostridium difficile. J Med Microbiol. 1997;46:80-84.
15. Kien CL, Ailabouni AH, Murray RD, Powers PA, McClead RE, Kepner J. Technical note: pig model for studying nutrient assimilation by the intestine and colon. J Anim Sci. 1997;75:2161-2164.
16. Kien CL, Chang JC, Cooper JR. Quantitation of colonic luminal synthesis of butyric acid in piglets. J Pediatr Gastroenterol Nutr. 2002;35:324-328.
17. Ebner S, Schoknecht P, Reeds P, Burrin D. Growth and metabolism of gastrointestinal and skeletal muscle tissues in protein-malnourished neonatal pigs. Am J Physiol. 1994;266:R1736-R1743.
18. Reeds PJ, Burrin DG, Jahoor F, Wykes L, Henry J, Frazer EM. Enteral glutamate is almost completely metabolized in first pass by the gastrointestinal tract of infant pigs. Am J Physiol. 1996;270:E413-E418.
19. Onderdonk AB, Allen SD. Clostridium. In: Balows A, Hausler WJ, Herrmann KL, Isenberg HD, Shadomy HJ, eds. Manual of Clinical Microbiology. Washington, DC: American Society for Microbiology; 1995:574-586.
20. Summanen P, Baron EJ, Citron DM, Strong CA, Wexler HA, Finegold SM. Wadsworth Anaerobic Bacteriology Manual. Belmont, CA: Star Publishing Co; 1993.
21. Biavati B, Sgorbati B, Scardovi V. The genus Bifidobacterium. In: Balows A, Triiper HG, Dworkin M, Harder W, Schleifer K-H, eds. The Prokaryotes: A Handbook on the Biology of Bacteria. New York, NY: Springer-Verlag; 1992:816-833.
22. Conover WJ, Iman RI. Rank transformations as a bridge between parametric and nonparametric statistics. Am Stat. 1981;35:124-128.
23. Stephen AM, Cummings JH. The microbial contribution to human faecal mass. J Med Microbiol. 1980;13:45-56.
24. Waligora-Dupriet AJ, Dugay A, Auzeil N, Huerre M, Butel MJ. Evidence for clostridial implication in necrotizing enterocolitis through bacterial fermentation in a gnotobiotic quail model. Pediatr Res. 2005;58:629-635.
25. Mevissen-Verhage EAE, Marcelis JH, De Vos MN, Harmsen-van Amerongen WCM, Verhoef J. Bifidobacterium, Bacteroides, and Closiridium spp. in fecal samples from breast-fed and bottle-fed infants with or without iron supplement. J Clin Microbiol. 1987;25:285-289.
26. Kosloske AM, Ball WS Jr, Umland E, Skipper B. Clostridial necrotizing enterocolitis. J Pediatr Surg. 1985;20:155-159.
27. Alfa MJ, Robson D, Davi M, Bernard K, Van Caeseele P, Harding GK. An outbreak of necrotizing enterocolitis associated with a novel clostridium species in a neonatal intensive care unit. Clin Infect Dis. 2002;35(Suppl 1):S101-S105.
28. Sangild PT, Siggers RH, Schmidt M, et al. Diet- and colonization- dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs. Gastroenterology. 2006;130:1776-1792.
29. Petrillo TM, Beck-Sague CM, Songer JG, et al. Enteritis necroticans (pigbel) in a diabetic child. N Engl J Med. 2000;342:1250-1253.
30. Kien CL. Colonic fermentation of carbohydrate in the premature infant: possible relevance to necrotizing enterocolitis. J Pediatr. 1990;117:S52-S58.
31. Butel MJ, Roland N, Hibert A, et al. Clostridial pathogenicity in experimental necrotising enterocolitis in gnotobiotic quails and protective role of bifidobacteria. J Med Microbiol. 1998;47:391-399.
32. Florent C, Flourie B, Leblond A, Rautureau M, Bernier J-J, Rambaud J-C. Influence of chronic lactulose ingestion on the colonic metabolism of lactulose in man (an in vivo study). J Clin Invest. 1985;75:608-613.
33. Kien CL, Sumners JE, Stetina JS, Heimler R, Grausz JP. A method for assessing carbohydrate energy absorption and its application to premature infants. Am J Clin Nutr. 1982;36:910-916.
34. Davie JR. Inhibition of histone deacetylase activity by butyrate. J Nutr. 2003;133(7 Suppl):2485S-2489S.
35. Backhed F, Ding H, Wang T, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A. 2004;101:15718-15723.
36. Whelan K, Judd PA, Preedy VR, Simmering R, Jann A, Taylor MA. Fructooligosaccharides and fiber partially prevent the alterations in fecal microbiota and short-chain fatty acid concentrations caused by standard enteral formula in healthy humans. J Nutr. 2005;135:1896-1902.
37. Langlands SJ, Hopkins MJ, Coleman N, Cummings JH. Prebiotic carbohydrates modify the mucosa associated microflora of the human large bowel. Gut. 2004;53:1610-1616.
38. Loh G, Eberhard M, Brunner RM, et al. Inulin alters the intestinal microbiota and short-chain fatty acid concentrations in growing pigs regardless of their basal diet. J Nutr. 2006;136:1198-1202.
39. Flickinger EA, Van Loo J, Fahey GC Jr. Nutritional responses to the presence of inulin and oligofructose in the diets of domesticated animals: a review. Crit Rev Food Sci Nutr. 2003;43:19-60.