Relationship between retinal glial cell activation in glaucoma and vascular dysregulation

Journal of Glaucoma

Volumn 16, Issue 2, 2007, Pages 215-219

  Grieshaber, Matthias C ^a   Orgul, Selim ^a   Schoetzau, Andreas ^a   Flammer, Josef ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Astrocytes; Glaucoma; Glial cells; Intraretinal gliosis; M ller cells; Neuronal tissue remodeling

Indexed keywords

AGED; ARTICLE; ASTROCYTE; CELL ACTIVATION; CONFIDENCE INTERVAL; CONTROLLED STUDY; CYTOLOGY; FEMALE; GLIA CELL; GLIOSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MUELLER CELL; OPEN ANGLE GLAUCOMA; PRIORITY JOURNAL; RETINA CELL; RISK ASSESSMENT; VASCULAR DISEASE; VISUAL DISORDER;

AGED; BLOOD FLOW VELOCITY; CHOROID; FEMALE; GLAUCOMA, OPEN-ANGLE; GLIOSIS; HUMANS; LASER-DOPPLER FLOWMETRY; MALE; NAILS; NEUROGLIA; PERIPHERAL VASCULAR DISEASES; PROSPECTIVE STUDIES; REGIONAL BLOOD FLOW; RETINA; VISUAL FIELDS;

EID: 34247552864     PISSN: 10570829     EISSN: None     Source Type: Journal    
DOI: 10.1097/IJG.0b013e31802d045a     Document Type: Article

References (38)

1. Flammer J, Orgul S, Costa VP, et al. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res. 2002;21:359-393.
2. Healey PR, Mitchell P, Smith W, et al. Optic disc hemorrhages in a population with and without signs of glaucoma. Ophthalmology. 1998;105:216-223.
3. Jonas JB. Clinical implications of peripapillary atrophy in glaucoma. Curr Opin Ophthalmol. 2005;16:84-88.
4. Graf T, Flammer J, Prünte C, et al. Gliosis-like retinal alterations in glaucoma patients. J Glaucoma. 1993;2:257-279.
5. Grieshaber MC, Flammer J. Clinical signs of retinal glial cell activation in glaucoma patients. SE Eur J Ophthalmol. 2006;1:1-6.
6. Newman E. Glia of the retina. In: Ryan SJ, ed. Retina. St Louis: Mosby; 2001:89-103.
7. Sarthy V, Ripps H. The Retinal Muller Cell. New York: Kluwer Academic/Plenum Publishers; 2001.
8. Schnitzer J. Astrocytes in the guinea pig, horse, and monkey retina: their occurrence coincides with the presence of blood vessels. Glia. 1988;1:74-89.
9. de Raad S, Szczesny PJ, Munz K, et al. Light damage in the rat retina: glial fibrillary acidic protein accumulates in Muller cells in correlation with photoreceptor damage. Ophthalmic Res. 1996;28:99-107.
10. Ekstrom P, Sanyal S, Narfstrom K, et al. Accumulation of glial fibrillary acidic protein in Muller radial glia during retinal degeneration. Invest Ophthalmol Vis Sci. 1988;29:1363-1371.
11. Yoshida A, Ishiguro S, Tamai M. Expression of glial fibrillary acidic protein in rabbit Muller cells after lensectomy-vitrectomy. Invest Ophthalmol Vis Sci. 1993;34:3154-3160.
12. Napper GA, Kalloniatis M. Neurochemical changes following postmortem ischemia in the rat retina. Vis Neurosci. 1999;16:1169-1180.
13. Wang X, Tay SS, Ng YK. An electron microscopic study of neuronal degeneration and glial cell reaction in the retina of glaucomatous rats. Histol Histopathol. 2002;17:1043-1052.
14. Wang L, Cioffi GA, Cull G, et al. Immunohistologic evidence for retinal glial cell changes in human glaucoma. Invest Ophthalmol Vis Sci. 2002;43:1088-1094.
15. Lam DY, Kaufman PL, Gabelt BT, et al. Neurochemical correlates of cortical plasticity after unilateral elevated intraocular pressure in a primate model of glaucoma. Invest Ophthalmol Vis Sci. 2003;44:2573-2581.
16. Flammer J, Haefliger IO, Orgul S, et al. Vascular dysregulation: a principal risk factor for glaucomatous damage? J Glaucoma. 1999;8:212-219.
17. Gherghel D, Orgul S, Dubler B, et al. Is vascular regulation in the central retinal artery altered in persons with vasospasm? Arch Ophthalmol. 1999;117:1359-1362.
18. Hasler PW, Orgul S, Gugleta K, et al. Vascular dysregulation in the choroid of subjects with acral vasospasm. Arch Ophthalmol. 2002;120:302-307.
19. Gugleta K, Orgul S, Hasler PW, et al. Choroidal vascular reaction to hand-grip stress in subjects with vasospasm and its relevance in glaucoma. Invest Ophthalmol Vis Sci. 2003;44:1573-1580.
20. Flammer J. The concept of visual field indices. Graefes Arch Clin Exp Ophthalmol. 1986;224:389-392.
21. Flammer J, Jenni A, Bebie H, et al. The Octopus glaucoma G1 program. Glaucoma. 1987;9:67-72.
22. Gasser P, Flammer J. Blood-cell velocity in the nailfold capillaries of patients with normal-tension and high-tension glaucoma. Am J Ophthalmol. 1991;111:585-588.
23. Khurana RK, Setty A. The value of the isometric hand-grip test - studies in various autonomic disorders. Clin Auton Res. 1996;6:211-218.
24. Geiser MH, Riva CE, Diermann U. Measuring choroid blood flow with a new confocal laser Doppler device. Klin Monatsbl Augenheilkd. 1999;214:285-287.
25. Riva CE, Cranstoun SD, Grunwald JE, et al. Choroidal blood flow in the foveal region of the human ocular fundus. Invest Ophthalmol Vis Sci. 1994;35:4273-4281.
26. Breslow N, Clayton D. Approximate inference in generalized linear models. J Am Stat Assoc. 1993;88:9-25.
27. Lin X, Breslow N. Bias correction in generalized linear mixed models with multiple components of dispersion. J Am Statistical Association. 1996;91:1007-1016.
28. Flammer J, Guthauser U, Mahler F. Do ocular vasospasms help cause low-tension glaucoma? Doc Ophthalmol Proc Series. 1987;49:397-399.
29. O'Brien C. Vasospasm and glaucoma. Br J Ophthalmol. 1998;82:855-856.
30. Broadway DC, Drance SM. Glaucoma and vasospasm. Br J Ophthalmol. 1998;82:862-870.
31. Arai-Gaun S, Katai N, Kikuchi T, et al. Heme oxygenase-1 induced in muller cells plays a protective role in retinal ischemia-reperfusion injury in rats. Invest Ophthalmol Vis Sci. 2004;45:4226-4232.
32. Osborne NN, Block F, Sontag KH. Reduction of ocular blood flow results in glial fibrillary acidic protein (GFAP) expression in rat retinal Muller cells. Vis Neurosci. 1991;7:637-639.
33. Schnitzer J. Retinal astrocytes: their restriction to vascularized parts of the mammalian retina. Neurosci Lett. 1987;78:29-34.
34. Schnitzer J. The development of astrocytes and blood vessels in the postnatal rabbit retina. J Neurocytol. 1988;17:433-449.
35. Eng LF, Ghirnikar RS, Lee YL. Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem Res. 2000;25:1439-1451.
36. Ueda H, Baba T, Terada N, et al. Immunolocalization of dystrobrevin in the astrocytic endfeet and endothelial cells in the rat cerebellum. Neurosci Lett. 2000;283:121-124.
37. Arend O, Remky A, Plange N, et al. Fluorescein leakage of the optic disc in glaucomatous optic neuropathy. Graefes Arch Clin Exp Ophthalmol. 2005;243:659-664.
38. Grieshaber MC, Terhorst T, Flammer J. The pathogenesis of optic disc splinter haemorrhages: a new hypothesis. Acta Ophthalmol Scand. 2006;84:62-68.