An electron microscopic study of neuronal degeneration and glial cell reaction in the retina of glaucomatous rats

Histology and Histopathology

Volumn 17, Issue 4, 2002, Pages 1043-1052

  Wang, X ^a   Tay, Samuel Sam Wah ^a   Ng, Y K ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Glaucoma; Microglia; M ller cells; Neurons; Ultrastructure

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; CAUTERIZATION; CELL ACTIVATION; CELL DEATH; CELL ULTRASTRUCTURE; CONTROLLED STUDY; CYTOPLASM; DENSE BODY; DISSECTION; EXPERIMENTAL MODEL; GLAUCOMA; GLIA CELL; HISTOPATHOLOGY; INTRAOCULAR PRESSURE; MACROPHAGE; MALE; MICROFILAMENT; MICROGLIA; MUELLER CELL; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NERVE ENDING; NERVE FIBER DEGENERATION; NONHUMAN; PATHOLOGICAL ANATOMY; POSTOPERATIVE PERIOD; PROTECTION; RAT; RETINA; RETINA BIPOLAR GANGLION CELL; RETINA GANGLION CELL; RETINA INNER PLEXIFORM LAYER; STRUCTURE ANALYSIS; TISSUE PREPARATION; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; CELL DEATH; GLAUCOMA; IN SITU NICK-END LABELING; INTRAOCULAR PRESSURE; MALE; MICROSCOPY, ELECTRON; NERVE DEGENERATION; NEUROGLIA; RATS; RATS, WISTAR; RETINA; TISSUE FIXATION;

ANIMALIA;

EID: 0036788697     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Battisti W.P., Wang J., Bozek K. and Murray M. (1995). Macrophages, microglia, and astrocytes are rapidly activated after crush injury of the goldfish optic nerve: a light and electron microscopic analysis. J. Comp. Neurol. 354, 306-320.
2. Dithmar S., Holz F.G. and Volcker H.E. (1997). Massive reactive gliosis of the retina. Klin. Monatsbl Augenheilkd 211, 338-341.
3. Eisenfeld A.J., Bunt-Milam A.H. and Sarthy P.V. (1984). Müller cell expression of glial fibrillary acidic protein after genetic and experimental photoreceptor degeneration in the rat retina. Invest. Ophthalmol. Vis. Sci. 25, 1321-1328.
4. Garcia-Valenzuela E., Shareef S., Walsh J. and Sharma S.C. (1995). Programmed cell death of retinal ganglion cells during experimental glaucoma. Exp. Eye Res. 61, 33-44.
5. Glovinsky Y., Quigley H.A. and Pease M.E. (1993). Foveal ganglion cell loss is size dependent in experimental glaucoma. Invest. Ophthalmol. Vis. Sci. 34, 395-400.
6. Hare W.A., Ton H., Ruiz G., Feldmann B., Wijono M. and WoldeMussie E. (2001). Characterization of retinal injury using ERG measures obtained with both conventional and multifocal methods in chronic ocular hypertensive primates. Invest. Ophthalmol. Vis. Sci. 42, 127-136.
7. Jordan F.L. and Thomas W.E. (1988). Brain macrophages: questions of origin and interrelationship. Brain Res. 472, 165-78.
8. Kendell K.R., Quigley H.A., Kerrigan L.A., Pease M.E. and Quigley E.N. (1995). Primary open-angle glaucoma is not associated with photoreceptor loss. Invest. Ophthalmol. Vis. Sci. 36, 200-205.
9. Kerrigan L.A., Zack D.J., Quiglay H.A., Smith S.D. and Pease M.E. (1997). TUNEL-positive ganglion cells in human primary open-angle glaucoma. Arch. Ophthalmol. 115, 1031-1035.
10. Korth M., Horn F., Storck B. and Jonas J. (1989). The pattern-evoked electroretinogram (PERG): age-related alterations and changes in glaucoma. Graefes Arch. Clin. Exp. Ophthalmol. 227, 123-130.
11. Kreutzberg G.W. (1995). Microglia, the first line of defence in brain pathologies. Arzneimittelforschung 45, 357-360.
12. Lam T.K., Chan W.Y., Kuang G.B., Wei H., Shum A.S. and Yew D.T. (1995). Differential expression of glial fibrillary acidic protein (GFAP) in the retinae and visual cortices of rats with experimental renal hypertension. Neurosci. Lett. 198, 165-168.
13. Laquis S., Chaudhary P. and Sharma S.C. (1998). The patterns of retinal ganglion cell death in hypertensive eyes. Brain Res. 784, 100-104.
14. Ling E.A. (1981). Ultrastructure and peroxidase cytochemistry of macrophages present in the retina of postnatal rats. Arch. Histol. Jpn. 44, 165-176.
15. Ling E.A., Tan C.K. and Tan C.B.C. (1996). Preface. In: Topical issues in microglia research. Ling E.A., Tan C.K. and Tan C.B.C. (eds) Singapore Neuroscience Association. Singapore. pp 318.
16. Merrill J.E. (1994). The role of microglial cells and astrocytes in pathology: introduction. Dev. Neurosci. 16, 113.
17. Nakajima K. and Kohsaka S. (1996) Functional implications of microglia-derived secretory proteases. In: Topical issues in microglia research. Ling E.A., Tan C.K. and Tan C.B.C. (eds). Singapore Neuroscience Association. Singapore pp. 203-218.
18. Ng Y.K. and Ling E.A. (1997). Induction of major histocompatibility class II antigen on microglial cells in postnatal and adult rats following intraperitoneal injections of lipopolysaccharide. Neurosci. Res. 28, 111-118.
19. Osborne, N.N., Ugarte M., Chao M., Chidlow G., Bae J.H., Wood J.P. and Nash M.S. (1999). Neuroprotection in relation to retinal ischemia and relevance to glaucoma. Surv. Ophthalmol. 43 (Suppl 1) 102-128.
20. Panda S. and Jonas J.B. (1992). Decreased photoreceptor count in human eyes with secondary angle-closure glaucoma. Invest. Ophthalmol. Visc. Sci. 33, 2532-2536.
21. Pearson H.E., Payne B.R. and Cunningham T.J. (1993). Microglial invasion and activation in response to naturally occurring neuronal degeneration in the ganglion cell layer of the postnatal cat retina. Dev. Brain Res. 76, 249-255.
22. Quigley H.A. and Green W.R. (1979). The histology of human glaucoma cupping and optic nerve damage: clinicopathologic correlation in 21 eyes. Opthalmol. 86, 1803-1830.
23. Quigley H.A., Addicks E.M., Green W.R. and Maumenee A.E. (1981). Optic nerve damage in human glaucoma: II. The site of injury and susceptibility to damage. Arch. Opthalmol. 99, 635-649.
24. Thale A.B., Gordes R.S., Rochesl R. and Tillmann B. (1996). Changes in extracellular matrix in the lamina cribosa of patients with secondary glaucoma. Ophthalmologe 93, 586-591.
25. Thomas J. and Liesegang M.D. (1996). Concise review for primary-care physicians. Glaucoma: changing concepts and future directions. Mayo Clin. Proc. 71, 689-694.
26. Trick G.L. (1987). Pattern reversal retinal potentials in ocular hypertensive at high and low risk of developing glaucoma. Doc. Ophthalmol. 65, 79-85.
27. Velten I.M., Korth M. and Horn F.K. (2001). The a-wave of the dark adapted electroretinogram in glaucomas: are photoreceptors affected. Br. J. Ophthalmol. 85, 397-402.
28. Wang X., Tay S.S.W. and Ng Y.K. (2000). An immunohistochemical study of neuronal and glial cell reactions in retinae of rats with experimental glaucoma, Exp. Brain Res. 132, 476-484.
29. Wygnanski T., Desatnik H., Quigley H.A. and Glovinsky Y. (1995). Comparison of ganglion cell loss and cone loss in experimental glaucoma. Am. J. Ophthalmol. 120, 184-189.
30. Zhang J., Wu G.S., Ishimot S.I., Pararajasegaram G. and Rao N.A. (1997). Expression of major histocompatibility complex molecules in rodent retina. Invest. Ophthalmol. Vis. Sci. 38, 1848-1857.