Updates on the Evaluation and Management of Caustic Exposures

Emergency Medicine Clinics of North America

Volumn 25, Issue 2, 2007, Pages 459-476

  Salzman, Matthew ^a   O'Malley, Rika N ^a  

^a ALBERT EINSTEIN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ALPHA TOCOPHEROL; AMMONIA; ANALGESIC AGENT; ANTIBIOTIC AGENT; BENZALKONIUM CHLORIDE; CALCIUM CHLORIDE; CAUSTIC AGENT; CORTICOSTEROID; ENEMA; GLUCONATE CALCIUM; HISTAMINE H2 RECEPTOR ANTAGONIST; HYDROCHLORIC ACID; HYDROFLUORIC ACID; KETOTIFEN; MAGNESIUM CHLORIDE; MAGNESIUM SULFATE; MESALAZINE; METHYLPREDNISOLONE; PHOSPHATIDYLCHOLINE; PHOSPHORIC ACID; POTASSIUM CARBONATE; POTASSIUM HYDROXIDE; PROTON PUMP INHIBITOR; SODIUM HYDROXIDE; SULFURIC ACID;

ACIDITY; ALKALINITY; CAUSTIC BURN; CLINICAL ASSESSMENT; CLINICAL TRIAL; DIAGNOSTIC PROCEDURE; DIGESTIVE SYSTEM INJURY; DRUG ACTIVITY; DRUG MEGADOSE; ESOPHAGUS BURN; ESOPHAGUS CANCER; ESOPHAGUS INJURY; ESOPHAGUS STRICTURE; EYE INJURY; FIBROSIS; FLUID THERAPY; HUMAN; HYPOCALCEMIA; INTESTINE INJURY; INTOXICATION; META ANALYSIS; NONHUMAN; PAIN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROGNOSIS; RESPIRATORY TRACT INJURY; REVIEW; SKIN INJURY; STOMACH INJURY; SYSTEMATIC REVIEW;

EID: 34247551791     PISSN: 07338627     EISSN: 07338627     Source Type: Journal    
DOI: 10.1016/j.emc.2007.02.007     Document Type: Review

References (91)

1. Watson W.A., Litovitz T.L., Rodgers Jr. G.C., et al. 2004 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 23 5 (2005) 589-666
2. Hoffman R.S., Howland M.A., Kamerow H.N., et al. Comparison of titratable acid/alkaline reserve and pH in potentially caustic household products. J Toxicol Clin Toxicol 27 4-5 (1989) 241-246
3. Mattos G.M., Lopes D.D., Mamede R.C., et al. Effects of time of contact and concentration of caustic agent on generation of injuries. Laryngoscope 116 3 (2006) 456-460
4. Havanond C. Is there a difference between the management of grade 2b and 3 corrosive gastric injuries?. J Med Assoc Thai 85 3 (2002) 340-344
5. Mamede R.C., and de Mello Filho F.V. Ingestion of caustic substances and its complications. Sao Paulo Med J 119 1 (2001) 10-15
6. Poley J.W., Steyerberg E.W., Kuipers E.J., et al. Ingestion of acid and alkaline agents: outcome and prognostic value of early upper endoscopy. Gastrointest Endosc 60 3 (2004) 372-377
7. Gunel E., Caglayan F., Caglayan O., et al. Reactive oxygen radical levels in caustic esophageal burns. J Pediatr Surg 34 3 (1999) 405-407
8. Satar S., Topal M., and Kozaci N. Ingestion of caustic substances by adults. Am J Ther 11 4 (2004) 258-261
9. Crain E.F., Gershel J.C., and Mezey A.P. Caustic ingestions. Symptoms as predictors of esophageal injury. Am J Dis Child 138 9 (1984) 863-865
10. Nuutinen M., Uhari M., Karvali T., et al. Consequences of caustic ingestions in children. Acta Paediatr 83 11 (1994) 1200-1205
11. Chen T.Y., Ko S.F., Chuang J.H., et al. Predictors of esophageal stricture in children with unintentional ingestion of caustic agents. Chang Gung Med J 26 4 (2003) 233-239
12. Gaudreault P., Parent M., McGuigan M.A., et al. Predictability of esophageal injury from signs and symptoms: a study of caustic ingestion in 378 children. Pediatrics 71 5 (1983) 767-770
13. Gorman R.L., Khin-Maung-Gyi M.T., Klein-Schwartz W., et al. Initial symptoms as predictors of esophageal injury in alkaline corrosive ingestions. Am J Emerg Med 10 3 (1992) 189-194
14. Previtera C., Giusti F., and Guglielmi M. Predictive value of visible lesions (cheeks, lips, oropharynx) in suspected caustic ingestion: may endoscopy reasonably be omitted in completely negative pediatric patients?. Pediatr Emerg Care 6 3 (1990) 176-178
15. Rigo G.P., Camellini L., Azzolini F., et al. What is the utility of selected clinical and endoscopic parameters in predicting the risk of death after caustic ingestion?. Endoscopy 34 4 (2002) 304-310
16. Katzka D.A. Caustic injury to the esophagus. Curr Treat Options Gastroenterol 4 1 (2001) 59-66
17. Brun J.G., Celerier M., Koskas F., et al. Blunt thorax oesophageal stripping: an emergency procedure for caustic ingestion. Br J Surg 71 9 (1984) 698-700
18. Cheng Y.J., and Kao E.L. Arterial blood gas analysis in acute caustic ingestion injuries. Surg Today 33 7 (2003) 483-485
19. Estrera A., Taylor W., Mills L.J., et al. Corrosive burns of the esophagus and stomach: a recommendation for an aggressive surgical approach. Ann Thorac Surg 41 3 (1986) 276-283
20. Cattan P., Munoz-Bongrand N., Berney T., et al. Extensive abdominal surgery after caustic ingestion. Ann Surg 231 4 (2000) 519-523
21. Erdogan E., Eroglu E., Tekant G., et al. Management of esophagogastric corrosive injuries in children. Eur J Pediatr Surg 13 5 (2003) 289-293
22. Zargar S.A., Kochhar R., Mehta S., et al. The role of fiberoptic endoscopy in the management of corrosive ingestion and modified endoscopic classification of burns. Gastrointest Endosc 37 2 (1991) 165-169
23. Baskin D., Urganci N., Abbasoglu L., et al. A standardised protocol for the acute management of corrosive ingestion in children. Pediatr Surg Int 20 11-12 (2004) 824-828
24. Squires Jr. R.H., and Colletti R.B. Indications for pediatric gastrointestinal endoscopy: a medical position statement of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr 23 2 (1996) 107-110
25. Gupta S.K., Croffie J.M., and Fitzgerald J.F. Is esophagogastroduodenoscopy necessary in all caustic ingestions?. J Pediatr Gastroenterol Nutr 32 1 (2001) 50-53
26. Aronow S.P., Aronow H.D., Blanchard T., et al. Hair relaxers: a benign caustic ingestion?. J Pediatr Gastroenterol Nutr 36 1 (2003) 120-125
27. Kamijo Y., Kondo I., Kokuto M., et al. Miniprobe ultrasonography for determining prognosis in corrosive esophagitis. Am J Gastroenterol 99 5 (2004) 851-854
28. Chiu H.M., Lin J.T., Huang S.P., et al. Prediction of bleeding and stricture formation after corrosive ingestion by EUS concurrent with upper endoscopy. Gastrointest Endosc 60 5 (2004) 827-833
29. Millar A.J., Numanoglu A., Mann M., et al. Detection of caustic oesophageal injury with technetium 99m-labelled sucralfate. J Pediatr Surg 36 2 (2001) 262-265
30. Homan C.S., Singer A.J., Henry M.C., et al. Thermal effects of neutralization therapy and water dilution for acute alkali exposure in canines. Acad Emerg Med 4 1 (1997) 27-32
31. Homan C.S., Singer A.J., Thomajan C., et al. Thermal characteristics of neutralization therapy and water dilution for strong acid ingestion: an in-vivo canine model. Acad Emerg Med 5 4 (1998) 286-292
32. Homan C.S., Maitra S.R., Lane B.P., et al. Histopathologic evaluation of the therapeutic efficacy of water and milk dilution for esophageal acid injury. Acad Emerg Med 2 7 (1995) 587-591
33. Homan C.S., Maitra S.R., Lane B.P., et al. Therapeutic effects of water and milk for acute alkali injury of the esophagus. Ann Emerg Med 24 1 (1994) 14-20
34. Tiryaki T., Livanelioglu Z., and Atayurt H. Early bougienage for relief of stricture formation following caustic esophageal burns. Pediatr Surg Int 21 2 (2005) 78-80
35. Jain A.L., Robertson G.J., and Rudis M.I. Surgical issues in the poisoned patient. Emerg Med Clin North Am 21 4 (2003) 1117-1144
36. Anderson K.D., Rouse T.M., and Randolph J.G. A controlled trial of corticosteroids in children with corrosive injury of the esophagus. N Engl J Med 323 10 (1990) 637-640
37. Boukthir S., Fetni I., Mrad S.M., et al. High doses of steroids in the management of caustic esophageal burns in children. [abstract]. Arch Pediatr 11 1 (2004) 13-17 [in French]
38. Rosenberg N., Kunderman P.J., Vroman L., et al. Prevention of experimental esophageal stricture by cortisone. II. Control of suppurative complications by penicillin. AMA Arch Surg 66 5 (1953) 593-598
39. Pelclova D., and Navratil T. Do corticosteroids prevent oesophageal stricture after corrosive ingestion?. Toxicol Rev 24 2 (2005) 125-129
40. Ulman I., and Mutaf O. A critique of systemic steroids in the management of caustic esophageal burns in children. Eur J Pediatr Surg 8 2 (1998) 71-74
41. Zwischenberger J.B., Savage C., and Bidani A. Surgical aspects of esophageal disease: perforation and caustic injury. Am J Respir Crit Care Med 165 8 (2002) 1037-1040
42. Gunel E., Caglayan F., Caglayan O., et al. Effect of antioxidant therapy on collagen synthesis in corrosive esophageal burns. Pediatr Surg Int 18 1 (2002) 24-27
43. Yukselen V., Karaoglu A.O., Ozutemiz O., et al. Ketotifen ameliorates development of fibrosis in alkali burns of the esophagus. Pediatr Surg Int 20 6 (2004) 429-433
44. Demirbilek S., Aydin G., Yucesan S., et al. Polyunsaturated phosphatidylcholine lowers collagen deposition in a rat model of corrosive esophageal burn. Eur J Pediatr Surg 12 1 (2002) 8-12
45. Berkovits R.N., Bos C.E., Wijburg F.A., et al. Caustic injury of the oesophagus. Sixteen years experience, and introduction of a new model oesophageal stent. J Laryngol Otol 110 11 (1996) 1041-1045
46. Zhou J.H., Jiang Y.G., Wang R.W., et al. Management of corrosive esophageal burns in 149 cases. J Thorac Cardiovasc Surg 130 2 (2005) 449-455
47. Wang R.W., Zhou J.H., Jiang Y.G., et al. Prevention of stricture with intraluminal stenting through laparotomy after corrosive esophageal burns. Eur J Cardiothorac Surg 30 2 (2006) 207-211
48. Bapat R.D., Bakhshi G.D., Kantharia C.V., et al. Self-bougienage: long-term relief of corrosive esophageal strictures. Indian J Gastroenterol 20 5 (2001) 180-182
49. Kochhar R., Ray J.D., Sriram P.V., et al. Intralesional steroids augment the effects of endoscopic dilation in corrosive esophageal strictures. Gastrointest Endosc 49 4 Pt 1 (1999) 509-513
50. Nwomeh B.C., Luketich J.D., and Kane T.D. Minimally invasive esophagectomy for caustic esophageal stricture in children. J Pediatr Surg 39 7 (2004) e1-e6
51. Diarra B., Roudie J., Ehua Somian F., et al. Caustic burns of rectum and colon in emergencies. Am J Surg 187 6 (2004) 785-789
52. da Fonseca J., Brito M.J., Freitas J., et al. Acute colitis caused by caustic products. Am J Gastroenterol 93 12 (1998) 2601-2602
53. Kawamata M., Fujita S., Mayumi T., et al. Acetic acid intoxication by rectal administration. J Toxicol Clin Toxicol 32 3 (1994) 333-336
54. Cappell M.S., and Simon T. Fulminant acute colitis following a self-administered hydrofluoric acid enema. Am J Gastroenterol 88 1 (1993) 122-126
55. Michopoulos S., Bouzakis H., Sotiropoulou M., et al. Colitis due to accidental alcohol enema: clinicopathological presentation and outcome. Dig Dis Sci 45 6 (2000) 1188-1191
56. Burd A. Hydrofluoric acid-revisited. Burns 30 7 (2004) 720-722
57. CDC chemical emergencies, facts about hydrogen fluoride. Available at: http://www.bt.cdc.gov/agent/hydrofluoricacid/basics/facts.asp. Accessed October 8, 2006.
58. Kirkpatrick J.J., Enion D.S., and Burd D.A. Hydrofluoric acid burns: a review. Burns 21 7 (1995) 483-493
59. Kao W.F., Dart R.C., Kuffner E., et al. Ingestion of low-concentration hydrofluoric acid: an insidious and potentially fatal poisoning. Ann Emerg Med 34 1 (1999) 35-41
60. Caravati E.M. Acute hydrofluoric acid exposure. Am J Emerg Med 6 2 (1988) 143-150
61. Agency for toxic substances and diseases registry: medical management guideline for hydrogen fluoride. Available at: http://www.atsdr.cdc.gov/MHMI/mmg11.htm. Accessed October 8, 2006.
62. Wing J.S., Brender J.D., Sanderson L.M., et al. Acute health effects in a community after a release of hydrofluoric acid. Arch Environ Health 46 3 (1991) 155-160
63. Dote T., Kono K., Usuda K., et al. Lethal inhalation exposure during maintenance operation of a hydrogen fluoride liquefying tank. Toxicol Ind Health 19 2-6 (2003) 51-54
64. Rao RB, Hoffman RS. Caustics and batteries. In: Goldfrank LR, NF, Lewis NA, editors. Goldfrank's toxicologic emergencies. 7th edition. New York: McGraw-Hill; 2002. p. 1323-45.
65. Strubelt O., Iven H., and Younes M. The pathophysiological profile of the acute cardiovascular toxicity of sodium fluoride. Toxicology 24 3-4 (1982) 313-323
66. Cummings C.C., and McIvor M.E. Fluoride-induced hyperkalemia: the role of Ca2+-dependent K+ channels. Am J Emerg Med 6 1 (1988) 1-3
67. Murano M. Studies of the treatment of hydrofluoric acid burn. Bull Osaka Med Coll 5 (1989) 39-48
68. Saady J.J., and Rose C.S. A case of nonfatal sodium fluoride ingestion. J Anal Toxicol 12 5 (1988) 270-271
69. Kirkpatrick J.J., and Burd D.A. An algorithmic approach to the treatment of hydrofluoric acid burns. Burns 21 7 (1995) 495-499
70. Burkhart K.K., Brent J., Kirk M.A., et al. Comparison of topical magnesium and calcium treatment for dermal hydrofluoric acid burns. Ann Emerg Med 24 1 (1994) 9-13
71. Dunn B.J., MacKinnon M.A., Knowlden N.F., et al. Topical treatments for hydrofluoric acid dermal burns. Further assessment of efficacy using an experimental piq model. J Occup Environ Med 38 5 (1996) 507-514
72. Soderberg K., Kuusinen P., Mathieu L., et al. An improved method for emergent decontamination of ocular and dermal hydrofluoric acid splashes. Vet Hum Toxicol 46 4 (2004) 216-218
73. Mathieu L., Nehles J., Blomet J., et al. Efficacy of hexafluorine for emergent decontamination of hydrofluoric acid eye and skin splashes. Vet Hum Toxicol 43 5 (2001) 263-265
74. Hulten P., Hojer J., Ludwigs U., et al. Hexafluorine vs. standard decontamination to reduce systemic toxicity after dermal exposure to hydrofluoric acid. J Toxicol Clin Toxicol 42 4 (2004) 355-361
75. Vance M.V., Curry S.C., Kunkel D.B., et al. Digital hydrofluoric acid burns: treatment with intraarterial calcium infusion. Ann Emerg Med 15 8 (1986) 890-896
76. Schiettecatte D., Mullie G., and Depoorter M. Treatment of hydrofluoric acid burns. Acta Chir Belg 103 4 (2003) 375-378
77. Kono K., Watanabe T., Dote T., et al. Successful treatments of lung injury and skin burn due to hydrofluoric acid exposure. Int Arch Occup Environ Health 73 Suppl (2000) S93-S97
78. Henry J.A., and Hla K.K. Intravenous regional calcium gluconate perfusion for hydrofluoric acid burns. J Toxicol Clin Toxicol 30 2 (1992) 203-207
79. Casey W. Intravenous regional anesthesia (Bier's block). Update in Anesthesia. Available at: http://www.nda.ox.ac.uk/wfsa/html/u01_003.htm. Accessed October 8, 2006.
80. Williams J.M., Hammad A., Cottington E.C., et al. Intravenous magnesium in the treatment of hydrofluoric acid burns in rats. Ann Emerg Med 23 3 (1994) 464-469
81. Heard K., Hill R.E., Cairns C.B., et al. Calcium neutralizes fluoride bioavailability in a lethal model of fluoride poisoning. J Toxicol Clin Toxicol 39 4 (2001) 349-353
82. Siegel D.C., and Heard J.M. Intra-arterial calcium infusion for hydrofluoric acid burns. Aviat Space Environ Med 63 3 (1992) 206-211
83. Dowbak G., Rose K., and Rohrich R.J. A biochemical and histologic rationale for the treatment of hydrofluoric acid burns with calcium gluconate. J Burn Care Rehabil 15 4 (1994) 323-327
84. Bjornhagen V., Hojer J., Karlson-Stiber C., et al. Hydrofluoric acid-induced burns and life-threatening systemic poisoning-favorable outcome after hemodialysis. J Toxicol Clin Toxicol 41 6 (2003) 855-860
85. Buckingham F.M. Surgery: a radical approach to severe hydrofluoric acid burns. A case report. J Occup Med 30 11 (1988) 873-874
86. Yang S.J., Zhang Y.H., Liu L.P., et al. Comparison of various methods of early management of hydrofluoric acid burn in rabbits. [abstract]. Zhonghua Shao Shang Za Zhi 21 1 (2005) 40-42 [in Chinese]
87. McCully J. Ocular hydrofluoric acid burns: animal model. Trans Am Ophthalmol Soc 88 (1990) 649-684
88. Recommended medical treatment for hydrofluoric acid exposure. [pamphlet] (2006), Honeywell International Inc.
89. Beiran I., Miller B., and Bentur Y. The efficacy of calcium gluconate in ocular hydrofluoric acid burns. Hum Exp Toxicol 16 4 (1997) 223-228
90. Bentur Y., Tannenbaum S., Yaffe Y., et al. The role of calcium gluconate in the treatment of hydrofluoric acid eye burn. Ann Emerg Med 22 9 (1993) 1488-1490
91. Rubinfeld R.S., Silbert D.I., Arentsen J.J., et al. Ocular hydrofluoric acid burns. Am J Ophthalmol 114 4 (1992) 420-423