Ketotifen ameliorates development of fibrosis in alkali burns of the esophagus

Pediatric Surgery International

Volumn 20, Issue 6, 2004, Pages 429-433

  Yukselen, Vahit ^a   Karaoglu, Ali Onder ^a   Ozutemiz, Omer ^b   Yenisey, Cigdem ^a   Tuncyurek, Muge ^b  

^a ADNAN MENDERES UNIVERSITY   (Turkey)

^b EGE UNIVERSITY   (Turkey)

Author keywords

Caustic burn; Corrosive esophagitis; Fibrosis; Ketotifen; Stricture

Indexed keywords

COLLAGEN; HISTAMINE H1 RECEPTOR ANTAGONIST; HYDROXYPROLINE; KETOTIFEN; SODIUM HYDROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAUSTIC BURN; CONTROLLED STUDY; DRUG EFFICACY; ESOPHAGUS BURN; ESOPHAGUS STENOSIS; ESOPHAGUS STRICTURE; FIBROSIS; HISTOPATHOLOGY; LAPAROTOMY; MAST CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 4143148437     PISSN: 01790358     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00383-004-1170-2     Document Type: Article

References (23)

1. Haller JA, Andrews HG, White JJ, Tamer MA, Cleceland WW (1971) Pathophysiology and management of acute corrosive burns of the esophagus. Results of treatment in 285 children. J Ped Surg 6:578-584
2. Bautista A, Tojo R, Varela R, Estevez E, Villanueva A, Cadranel S (1996) Effects of prednisolone and dexamethasone on alkali burns of the esophagus in rabbit. J Pediatr Gastroenterol Nutr 22:275-283
3. Tanyel FC, Büyükpamukcu N, Hiçsönmez A (1988) The place of steroids, antibiotics and early bougienage combination in the treatment of caustic esophageal burns in childhood. Turk J Pediatr 30:253-257
4. Mutaf O (1996) Treatment of corrosive esophageal strictures by long-term stenting. J Pediatr Surg 31:681-685
5. Galli SJ, Wershil BK, Bose R, Walker PA, Szabo S (1987) Ethanol-induced acute gastric injury in mast cell-deficient and congenic normal mice. Am J Pathol 128:131-140
6. Takeuchi K, Ohtsuki H, Okabe S (1986) Pathogenesis of compound 48/80-induced gastric lesions in rat. Dig Dis Sci 31:392-400
7. Berton A, Levi-Schaffer F, Emonard H, Garbuzenko E, Gillery P, Maquart FX (2000) Activation of fibroblasts in lattices by mast cell extract: a model of fibrosis. Clin Exp Allergy 30:485-492
8. Garbuzenko E, Nagler A, Pickholtz D, Cillery P, Reich R, Maquart FX, et al. (2002) Human mast cells stimulate fibroblast proliferation, collagen synthesis and lattice contraction: a direct role for mast cells in skin fibrosis. Clin Exp Allergy 32:237-246
9. Gehanno P, Guedon C (1981) Inhibition of experimental esophageal lye strictures by penicillamin. Arch Otolaryngol 107:145-147
10. Berthet B, DiCostanzo J, Arnaud C, Choux R, Assadourian R (1994) Influence of epidermal growth factor and Interferon γ on healing of oesophageal corrosive burns in the rat. Br J Surg 81:395-398
11. Demirbilek S, Bernay F, Rizalar R, Baris S, Gürses N (1994) Effects of estradiol and progesterone on the synthesis of collagen in corrosive esophageal burns in rats. J Pediatr Surg 29:1426-1428
12. Reddy GK, Enwemeka CS (1996) A simplified method for the analysis of hydroxyproline in biological tissues. Clin Biochem 29:225-229
13. Day DW (1989) Infective, physical and chemical oesophagitis. In: Whitehead R (ed) Gastrointestinal and oesophageal pathology. Churchill Livingstone, London, pp 377-383
14. Zahavi I, Weizen T, Marcus H, Karmeli F, Dinari G (1996) Ketotifen is protective against indomethacin-induced intestinal ulceration in the rat. Isr J Med Sci 32:312-315
15. Kalia N, Bardhan KD, Reed MWR, Jacob S, Brown NJ (2000) Mast cell stabilization prevents ethanol-induced rat gastric mucosal injury: mechanisms of protection. J Gastroenterol Hepatol 15:133-141
16. Eliakim R, Karmeli F, Okon E, Rachmilewitz D (1995) Ketotifen ameliorates capsaicin-augmented acetic acid-induced colitis. Dig Dis Sci 40:503-509
17. Yonetci N, Oruc N, Ozutemiz AO, Celik HA, Yuce G (2001) Effects of mast-cell stabilization in cerulein-induced acute pancreatitis in rats. Int J Pancreatol 29:163-171
18. Walker M, Harley R, LeRoy EC (1990) Ketotifen prevents skin fibrosis in the tight skin mouse. J Rheumatol 17:57-59
19. Greenberg G, Burnstock G (1983) A novel cell-to-cell interaction between mast cells and other cell types. Exp Cell Res 147:1-13
20. Gruber BL, Kew RR, Jelaska A, Marchese MJ, Garlick J, Ren S, et al. (1997) Human mast cells activate fibroblasts: tryptase is a fibrogenic factor stimulating collagen messenger ribonucleic acid synthesis and fibroblast chemotaxis. J Immunol 158:2310-2317
21. Cairns JA, Walls AF (1997) Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts. J Clin Invest 99:1313-1321
22. Abe M, Kurosawa M, Ishikawa O, Miyachi Y (2000) Effect of mast cell-derived mediators and mast cell-related neutral proteases on human dermal fibroblast proliferation and type I collagen production. J Allergy Clin Immunol 106:578-584
23. Levi-Schaffer F, Rubinchick E (1995) Activated mast cells are fibrogenic for 3T3 fibroblasts. J Invest Dermatol 104:999-1003