Sodium phenyl butyrate downregulates endothelin-1 expression in cultured human endothelial cells: Relevance to sickle-cell disease

American Journal of Hematology

Volumn 82, Issue 5, 2007, Pages 357-362

  Odièvre, Marie Hélène ^a,b   Brun, Manuel ^a,b   Krishnamoorthy, Rajagopal ^a,b   Lapouméroulie, Claudine ^a,b   Elion, Jacques ^a,b  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Endothelin 1; Endothelium; Sickle cell disease; Sodium phenyl butyrate

Indexed keywords

BUTYRIC ACID DERIVATIVE; ENDOTHELIN 1; HEMOGLOBIN F; HYDROXYUREA; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; SODIUM DERIVATIVE; SODIUM PHENYLBUTYRATE; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SICKLE CELL ANEMIA;

ANEMIA, SICKLE CELL; CELL LINE, TRANSFORMED; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; ENDOTHELIAL CELLS; ENDOTHELIN-1; GENE EXPRESSION REGULATION; HUMANS; HYDROXYUREA; INTERCELLULAR ADHESION MOLECULE-1; INTERFERON TYPE II; PHENYLBUTYRATES; RNA, MESSENGER; SOLUBILITY; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 34247543502     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.20709     Document Type: Article

References (27)

1. Elion JE, Brun M, Odievre MH, Lapoumeroulie CL, Krishnamoorthy R. Vaso-occlusion in sickle cell anemia: Role of interactions between blood cells and endothelium. Hematol J 2004;5 (Suppl 3):S195-S198.
2. Charache S, Terrin ML, Moore RD, et al. Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the multicenter study of hydroxyurea in sickle cell anemia. N Engl J Med 1995;332:1317-1322.
3. Perrine SP, Ginder GD, Faller DV, et al. A short-term trial of butyrate to stimulate fetal-globin-gene expression in the P-globin disorders. N Engl J Med 1993;328:81-86.
4. Sher GD, Ginder GD, Little J, Yang S, Dover GJ, Olivieri NF. Extended therapy with intravenous arginine butyrate in patients with β- hemoglobinopathies. N Engl J Med 1995;332:1606-1610.
5. Dover GJ, Brusilow S, Charache S. Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate. Blood 1994;84:339-343.
6. Resar LM, Segal JB, Fitzpatric LK, Friedmann A, Brusilow SW, Dover GJ. Induction of fetal hemoglobin synthesis in children with sickle cell anemia on low-dose oral sodium phenylbutyrate therapy. J Pediatr Hematol Oncol 2002;24:737-741.
7. Atweh GF, Sutton M, Nassif I, et al. Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease. Blood 1999;93:1790-1797.
8. Atweh GF, Loukopoulos D. Pharmacological induction of fetal hemoglobin in sickle cell disease and β-thalassemia. Semin Hematol 2001;38:367-373.
9. Pace BS, Chen YR, Thompson A, Goodman SR. Butyrate-inducible elements in the human γ-globin promoter. Exp Hematol 2000; 28:283-293.
10. Cokic VP, Smith RD, Beleslin-Cokic BB, et al. Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase. J Clin Invest 2003;111:231-239.
11. Brun M, Bourdoulous S, Couraud PO, Elion J, Krishnamoorthy R, Lapoumeroulie C. Hydroxyurea downregulates endothelin-1 gene expression and upregulates ICAM-1 gene expression in cultured human endothelial cells. Pharmacogenomics J 2003;3:215-226.
12. Makis AC, Hatzimichael EC, Kolios G, Bourantas KL. Circulating endothelin-3 levels in patients with sickle cell disease during hydroxyurea treatment. Haematologica 2004;89:360-361.
13. Zapolska-Downar D, Siennicka A, Kaczmarczyk M, Kolodziej B, Naruszewicz M. Butyrate inhibits cytokine-induced VCAM-1 and ICAM-1 expression in cultured endothelial cells: The role of NF-κB and PPARα. J Nutr Biochem 2004;15:220-228.
14. Menzel T, Luhrs H, Zirlik S, et al. Butyrate inhibits leukocyte adhesion to endothelial cells via modulation of VCAM-1. Inflamm Bowel Dis 2004;10:122-128.
15. Ogawa H, Rafiee P, Fisher PJ, Johnson NA, Otterson MF, Binion DG. Butyrate modulates gene and protein expression in human intestinal endothelial cells. Biochem Biophys Res Commun 2003; 309:512-519.
16. Maeda T, Towatari M, Kosugi H, Saito H. Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells. Blood 2000;96:3847-3856.
17. Schweitzer KM, Vicart P, Delouis C, et al. Characterization of a newly established human bone marrow endothelial cell line: Distinct adhesive properties for hematopoietic progenitors compared with human umbilical vein endothelial cells. Lab Invest 1997;76:25-36.
18. Makis AC, Hatzimichael EC, Bourantas KL. The role of cytokines in sickle cell disease. Ann Hematol 2000;79:407-413.
19. Ergul S, Brunson CY, Hutchinson J, et al. Vasoactive factors in sickle cell disease: In vitro evidence for endothelin-1-mediated vasoconstriction. Am J Hematol 2004;76:245-251.
20. Cines DB, Pollak ES, Buck CA, et al. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 1998;91:3527-3561.
21. Graido-Gonzalez E, Doherty JC, Bergreen EW, Organ G, Telfer M, McMillen MA. Plasma endothelin-1, cytokine, and prostaglandin E2 levels in sickle cell disease and acute vaso-occlusive sickle crisis. Blood 1998;92:2551-2555.
22. Hammerman SI, Kourembanas S, Conca TJ, Tucci M, Brauer M, Farber HW. Endothelin-1 production during the acute chest syndrome in sickle cell disease. Am J Respir Crit Care Med 1997; 156:280-285.
23. Lapoumeroulie C, Benkerrou M, Odievre MH, Ducrocq R, Brun M, Elion J. Decreased plasma endothelin-1 levels in children with sickle cell disease treated with hydroxyurea. Haematologica 2005; 90:401-403.
24. Kato GJ, Martyr S, Blackwelder WC, et al. Levels of soluble endothelium-derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality. Br J Haematol 2005;130:943-953.
25. 2 production of polymorphonuclear neutrophils from patients with sickle cell anemia. Blood 2002;99:2297-2303.
26. Saleh AW, Hillen HF, Duits AJ. Levels of endothelial, neutrophil and platelet-specific factors in sickle cell anemia patients during hydroxyurea therapy. Acta Haematol 1999;102:31-37.
27. 1-Integrin expression on sickle reticulocytes: Vascular cell adhesion molecule-1-dependent binding to endothelium. Blood 1993;82:1891-1899.