Are exhaled breath condensates useful in monitoring asthma?

Current Allergy and Asthma Reports

Volumn 7, Issue 1, 2007, Pages 65-71

  Ko, Fanny W S ^a   Leung, T F ^b   Hui, David S C ^b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

8 ISOPROSTANE; ALDEHYDE; BIOLOGICAL MARKER; CHEMOKINE; CORTICOSTEROID; CYTOKINE; FLUTICASONE PROPIONATE; GLUTATHIONE; GROWTH FACTOR; HYDROGEN PEROXIDE; ICOSANOID; LEUKOTRIENE B4; LEUKOTRIENE E4; MONTELUKAST; NITROGEN OXIDE; PEPTIDOLEUKOTRIENE; PROSTAGLANDIN; STEROID; THROMBOXANE A2;

ACIDIFICATION; ALLERGIC RHINITIS; ANTIINFLAMMATORY ACTIVITY; ASTHMA; CLINICAL ASSESSMENT TOOL; DISEASE MARKER; DISEASE SEVERITY; EXHALED BREATH CONDENSATE; HUMAN; LUNG FUNCTION; NON INVASIVE PROCEDURE; OXIDATIVE STRESS; PATHOGENESIS; PH; RESPIRATORY TRACT INFLAMMATION; REVIEW;

ASTHMA; BIOLOGICAL MARKERS; BREATH TESTS; CHEMOKINES; CYTOKINES; EICOSANOIDS; HUMANS; HYDROGEN PEROXIDE; HYDROGEN-ION CONCENTRATION; NITRIC OXIDE; OXIDATIVE STRESS;

EID: 34247540785     PISSN: 15297322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11882-007-0032-0     Document Type: Review

References (50)

1. Mutlu GM, Garey KW, Robbins RA, et al.: Collection and analysis of exhaled breath condensate in humans. Am J Respir Crit Care Med 2001, 164:731-737.
2. Silkoff PE, Erzurum SC, Lundberg JO, et al.: ATS workshop proceedings: exhaled nitric oxide and nitric oxide oxidative metabolism in exhaled breath condensate. Proc Am Thorac Soc 2006, 3:131-14S.
3. Carpagnano GE, Barnes PJ, Francis J, et al.: Breath condensate pH in children with cystic fibrosis and asthma: a new noninvasive marker of airway inflammation? Chest 2004, 125:2005-2010.
4. Kostikas K, Papatheodorou G, Ganas K, et al.: pH in expired breath condensate of patients with inflammatory airway diseases. Am J Respir Crit Care Med 2002, 165:1364-1370.
5. Leung TF, Li CY, Yung E, et al.: Clinical and technical factors affecting pH and other biomarkers in exhaled breath condensate. Pediatr Pulmonol 2006, 41:87-94.
6. Hunt JF, Fang K, Malik R, et al.: Endogenous airway acidification. Implications for asthma pathophysiology. Am J Respir Crit Care Med 2000, 161:694-699.
7. Effros RM, Casaburi R, Su J, et al.: The effects of volatile salivary acids and bases on exhaled breath condensate pH. Am J Respir Crit Care Med 2006, 173:386-392.
8. Hunt J, Yu Y, Burns J, et al.: Identification of acid reflux cough using serial assays of exhaled breath condensate pH. Cough 2006, 2:3-10.
9. Nicolaou NC, Lowe LA, Murray CS, et al.: Exhaled breath condensate pH and childhood asthma: unselected birth cohort study. Am J Respir Crit Care Med 2006, 174:254-259.
10. Busse WW: Leukotrienes and inflammation. Am J Respir Crit Care Med 1998, 157:S210-S213.
11. Hardy CC, Robinson C, Tattersfield AE, Holgate ST: The bronchoconstrictor effect of inhaled prostaglandin D2 in normal and asthmatic men. N Engl J Med 1984, 311:209-213.
12. Noveral JP, Grunstein MM: Role and mechanism of thromboxane-induced proliferation of cultured airway smooth muscle cells. Am J Physiol 1992, 263:L555-L561.
13. Csoma Z, Kharitonov SA, Balint B, et al.: Increased leukotrienes in exhaled breath condensate in childhood asthma. Am J Respir Crit Care Med 2002, 166:1345-1349.
14. Montuschi P, Barnes PJ: Exhaled leukotrienes and prostaglandins in asthma. J Allergy Clin Immunol 2002, 109:61S-620.
15. Leung TF, Wong GW, Ko FW, et al.: Clinical and atopic parameters and airway inflammatory markers in childhood asthma: a factor analysis. Thorax 2005, 60:822-826.
16. Antczak A, Montuschi P, Kharitonov S, et al.: Increased exhaled cysteinyl-leukotrienes and 8-isoprostane in aspirin-induced asthma. Am J Respir Crit Care Med 2002, 166:301-306.
17. Mondino C, Ciabattoni G, Koch P, et al.: Effects of inhaled corticosteroids on exhaled leukotrienes and prostanoids in asthmatic children. J Allergy Clin Immunol 2004, 114:761-767.
18. Failla M, Biondi G, Provvidenza Pistorio M, et al.: Intranasal steroid reduces exhaled bronchial cysteinyl leakotrienes in allergic patients. Clin Exp Allergy 2006, 36:325-330.
19. Lex C, Zacharasiewicz A, Payne DN, et al.: Exhaled breath condensate cysteinyl leukotrienes and airway remodeling in childhood asthma: a pilot study. Respir Res 2006, 7:63.
20. Baraldi E, Carraro S, Atinovi R, et al.: Cysteinyl leukotrienes and 8-isoprostane in exhaled breath condensate of children with asthma exacerbations. Thorax 2003, 58:505-509.
21. Jain B, Rubinstein I, Robbins RA, et al.: Modulation of airway epithelial cell ciliary beat frequency by nitric oxide. Biocbem Biopbys Res Commun 1993, 191:83-88.
22. Gaston B, Ratjen F, Vaughan JW, et al.: Nitrogen redox balance in the cystic fibrosis airway: effects of anti-pseudomonal therapy. Am J Respir Crit Care Med 2002, 165:387-390.
23. Corradi M, Pesci A, Casana R, et al.: Nitrate in exhaled breath condensate of patients with different airway diseases. Nitric Oxide 2003, 8:26-30.
24. Formanek W, Inci D, Lauener RP, et al.: Elevated nitrite in breath condensates of children with respiratory disease. Eur Respir J 2002, 19:487-491.
25. Hanazawa T, Kharitonov SA, Barnes PJ: Increased nitrotyrosine in exhaled breath condensate of patients with asthma. Am J Respir Crit Care Med 2000, 162:1273-1276.
26. Horvath I, Hunt J, Barnes PJ, et al.: Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J 2005, 26:523-548.
27. Chladkova J, Kremova I, Chladek J, et al.: Validation of nitrite and nitrate measurements in exhaled breath condensate. Respiration 2006, 73:173-179.
28. Ratnawati, Morton J, Henry RL, Thomas PS: Exhaled breath condensate nitrite/nitrate and pH in relation to pediatric asthma control and exhaled nitric oxide. Pediatr Pulmonol 2006, 41:929-936.
29. Smith AD, Cowan JO, Brassett KP, et al.: Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl J Med 2005, 352:2163-2173.
30. Morrow JD, Roberts LJ: The isoprostanes: unique hioactive products of lipid peroxidation. Prog Lipid Res 1997, 36:1-21.
31. Montuschi P, Corradi M, Ciabattoni G, et al.: Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients. Am J Respir Crit Care Med 1999, 160:216-220.
32. Shahid SK, Kharitonov SA, Wilson NM, et al.: Exhaled 8-isoprostane in childhood asthma. Respir Res 2005, 6:79.
33. Battaglia S, den Hertog H, Timmers MC, et al.: Small airways function and molecular markers in exhaled air in mild asthma. Thorax 2005, 60:639-644.
34. Montuschi P, Kharitonov SA, Ciabattoni G, et al.: Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis. Thorax 2000, 55:205-209.
35. Ko FW, Lau CY, Leung TF, et al.: Exhaled breath condensate levels of 8-isoprostane, growth related oncogene alpha and monocyte chemoattractant protein-1 in patients with chronic obstructive pulmonary disease. Respir Med 2006, 100:630-638.
36. Carpagnano GE, Kharitonov SA, Resta O, et al.: 8-Isoprostane, a marker of oxidative mess, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy. Chest 2003, 124:1386-1392.
37. Mates JM, Sanchez-Jimenez F: Antioxidant enzymes and their implications in pathophysiologic processes. Front Biosci 1999, 4:D339-D345.
38. Emelyanov A, Fedoseev G, Abulimity A, et al.: Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients. Chest 2001, 120:1136-1139.
39. Antczak A, Nowak D, Shariati B, et al.: Increased hydrogen peroxide and thiobarbituric acid-reactive products in expired breath condensate of asthmatic patients. Eur Respir J 1997, 10:1235-1241.
40. Schleiss MB, Holz O, Behnke M, et al.: The concentration of hydrogen peroxide in exhaled air depends on expiratory flow rate. Eur Respir J 2000, 16:1115-1118.
41. Corradi M, Folesani G, Andreoli R, et al.: Aldehydes and glutathione in exhaled breath condensate of children with asthma exacerbation. Am J Respir Crit Care Med 2003, 167:395-399.
42. Matsunaga K. Yanagisawa S, Ichikawa T, et al.: Airway cytokine expression measured by means of protein array in exhaled breath condensate: correlation with physiologic properties in asthmatic patients. J Allergy Clin Immunol 2006, 118:84-90.
43. Shahid SK, Kharitonov SA, Wilson NM, et al.: Increased interleukin-4 and decreased interferon-gamma in exhaled breath condensate of children with asthma. Am J Respir Crit Care Med 2002, 165:1290-1293.
44. Leung TF, Wong GW, Ko FW, et al.: Analysis of growth factors and inflammatory cytokines in exhaled breath condensate from asthmatic children. Int Arch Allergy Immunol 2005, 137:66-72.
45. Ko FW, Lau CY, Leung TF, et al.: Exhaled breath condensate levels of cotaxin and macrophage-derived chemokine in stable adult asthma patients. Clin Exp Allergy 2006, 36:44-51.
46. Leung TF, Wong GW, Ko FW, et al.: Increased macrophage-derived chemokine in exhaled breath condensate and plasma from children with asthma. Clin Exp Allergy 2004, 34:786-791.
47. Robrocks CM, Jobsis Q, Damoiseaux JG, et al.: Cytokines in exhaled breath condensate of children with asthma and cystic fibrosis. Ann Allergy Asthma Immunol 2006, 96:349-355.
48. Rosias PP, Dompeling E, Dentener MA, et al.: Childhood asthma: exhaled markers of airway inflammation, asthma control score, and lung function tests. Pediatr Pulmonol 2004, 38:107-114.
49. Effros RM, Dunning MB 3rd, Biller J, Shaker R: The promise and perils of exhaled breath condensates. Am J Physiol Lung Cell Mol Physiol 2004, 287:L1073-L1080.
50. Rosias PP, Robroeks CM, Niemarkt HJ, et al.: Breath condenser coatings affect measurement of biomarkers in exhaled breath condensate. Eur Respir J 2006, [Epub ahead of print].