Synthesis and cytotoxic evaluation of new (4,5,6,7-tetrahydro-indol-1-yl)-3-R-propionic acids and propionic acid ethyl esters generated by molecular mimicry

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 11, 2007, Pages 3912-3918

  Martínez, Roberto ^a   Clara Sosa, Angel ^a   Ramírez Apan, Ma Teresa ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Amino acids; Azepinones; Cytotoxic activity; Indolones; Microwave; Paal Knorr

Indexed keywords

2 (2,6,6 TRIMETHYL 4 OXO 4,5,6,7 TETRAHYDROINDOL 1 YL) 3 HYDROXYPROPIONIC ACID ETHYL ESTER; 2 (2,6,6 TRIMETHYL 4 OXO 4,5,6,7 TETRAHYDROINDOL 1 YL) 3 MERCAPTOPROPIONIC ACID; 2 (2,6,6 TRIMETHYL 4 OXO 4,5,6,7 TETRAHYDROINDOL 1 YL) 3 MERCAPTOPROPIONIC ACID ETHYL ESTER; 2 (2,6,6 TRIMETHYL 4 OXO 4,5,6,7 TETRAHYDROINDOL 1 YL) 3 PHENYLPROPIONIC ACID; 2 (2,6,6 TRIMETHYL 4 OXO 4,5,6,7 TETRAHYDROINDOL 1 YL)PROPIONIC ACID METHYL ESTER; 2 (6,6 DIMETHYL 4 OXO 2 PHENYL 4,5,6,7 TETRAHYDROINDOL 1 YL) 3 HYDROXYPROPIONIC ACID ETHYL ESTER; 2 (6,6 DIMETHYL 4 OXO 2 PHENYL 4,5,6,7 TETRAHYDROINDOL 1 YL) 3 MERCAPTOPROPIONIC ACID; 2 (6,6 DIMETHYL 4 OXO 2 PHENYL 4,5,6,7 TETRAHYDROINDOL 1 YL) 3 MERCAPTOPROPIONIC ACID ETHYL ESTER; 2 (6,6 DIMETHYL 4 OXO 2 PHENYL 4,5,6,7 TETRAHYDROINDOL 1 YL) 3 PHENYLPROPIONIC ACID; 2 (6,6 DIMETHYL 4 OXO 2 PHENYL 4,5,6,7 TETRAHYDROINDOL 1 YL)PROPIONIC ACID METHYL ESTER; 2 [6,6 DIMETHYL 2 (4 NITROPHENYL) 4 OXO 4,5,6,7 TETRAHYDROINDOL 1 YL] 3 MERCAPTOPROPIONIC ACID ETHYLESTER; 2 [6,6 DIMETHYL 2 (4 NITROPHENYL) 4 OXO 4,5,6,7 TETRAHYDROINDOL 1 YL]PROPIONIC ACID METHYLESTER; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN; CHIRALITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG INHIBITION; HUMAN; HUMAN CELL; MICROWAVE IRRADIATION; MOLECULAR MIMICRY; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; ESTERS; HUMANS; INDOLES; MOLECULAR MIMICRY; PROPIONIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34247531430     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.12.018     Document Type: Article

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