Differential fear conditioning in Asperger's syndrome: Implications for an amygdala theory of autism

Neuropsychologia

Volumn 45, Issue 9, 2007, Pages 2125-2134

  Gaigg, Sebastian B ^a   Bowler, Dermot M ^a  

^a CITY UNIVERSITY   (United Kingdom)

Author keywords

Autism spectrum disorder; Cortico amygdala connectivity; Emotional processes; Psychophysiological reactivity

Indexed keywords

ADULT; AMYGDALOID NUCLEUS; ARTICLE; ASPERGER SYNDROME; AUTISM; CLINICAL ARTICLE; CLINICAL FEATURE; COGNITION; CONTROLLED STUDY; EMOTIONAL DISORDER; EMOTIONALITY; FEAR; FEMALE; HUMAN; LIMBIC SYSTEM; MALE; SOCIAL ASPECT;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; ASPERGER SYNDROME; CASE-CONTROL STUDIES; CONDITIONING, CLASSICAL; DISCRIMINATION (PSYCHOLOGY); FEAR; FEMALE; GALVANIC SKIN RESPONSE; HUMANS; MALE;

EID: 34247512211     PISSN: 00283932     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropsychologia.2007.01.012     Document Type: Article

References (79)

1. ADInstruments. (1994-2004). PowerLab Data acquisition unit (ML845) with SCR amplifier (ML116). ADInstruments Pty Ltd.
2. ADInstruments. (1994-2004). Chart 5 v5.2 07. ADInstruments Pty Ltd.
3. Aggleton J.P. The amygdala: A functional analysis. 2nd ed. (2000), Oxford University Press, Oxford
4. Amaral D.G., Bauman M.D., and Mills Schumann C. The amygdala and autism: Implications from non-human primate studies. Genes Brain and Behaviour 2 (2003) 295-302
5. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (DSM-IV-TR). Washington, DC: American Psychiatric Association.
6. Bachevalier J. Medial temporal lobe structures and autism: A review of clinical and experimental findings. Neuropsychologia 32 (1994) 627-648
7. Bachevalier J. The amygdala, social behaviour, and autism. In: Aggleton J.B. (Ed). The amygdala. 2nd ed. (2000), Oxford University Press, Oxford 509-543
8. Baron-Cohen S., Leslie A.M., and Frith U. Does the autistic child have a 'theory of mind'?. Cognition 21 (1985) 37-46
9. Baron-Cohen S., Ring H.A., Bullmore E.T., Wheelwright S., Ashwin C., and Williams S.C. The amygdala theory of autism. Neuroscience and Biobehavioural Reviews 24 (2000) 355-364
10. Baron-Cohen S., Ring H.A., Wheelwright S., Bullmore E.T., Brammer M.J., Simmons A., et al. Social intelligence in the normal and autistic brain: An fMRI. European Journal of study Neuroscience 11 (1999) 1891-1898
11. Bechara A., Tranel D., Damasio H., Adolphs R., Rockland C., and Damasio A. Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science 269 (1995) 1115-1118
12. Belmonte M.K., Allen G., Beckel-Mitchener A., Boulanger L.M., Carper R.A., and Webb S.J. Autism and abnormal development of brain connectivity. Journal of Neuroscience 24 (2004) 9228-9231
13. Ben Shalom D. Autism: Emotions without feelings. Autism 4 (2000) 205-206
14. Ben Shalom D., Mostofsky S.H., Hazlett R.L., Goldberg M.C., McLeod D.R., and Hoehn-Saric R. Intact galvanic skin responses and impaired self-reports in response to emotional pictures in high-functioning autism. New York Academy of Sciences 985 (2003) 501-504
15. Bernier R., Dawson G., Panagiotides H., and Webb S. Individuals with autism spectrum disorder show normal responses to a fear potential startle paradigm. Journal of Autism and Developmental Disorders 16 (2005) 1-9 (Epub ahead of print)
16. Blair R.J.R. Psychophysiological responsiveness to the distress of others in children with autism. Personality and Individual Differences 26 (1999) 477-485
17. Bowler D.M., Briskman J., Gurvidi N., and Fornells-Ambrojo M. Understanding the mind or predicting signal-dependent action? Performance of children with and without autism on analogues of the false-belief task. Journal of cognition and development 6 (2005) 259-283
18. Brock J., Brown C.C., Boucher J., and Rippon G. The temporal binding deficit hypothesis of autism. Development and Psychopathology 14 (2002) 209-224
19. Büchel C., Dolan R.J., Armony J.L., and Friston K.J. Amygdala-hippocampal involvement in human aversive trace conditioning revealed through event-related functional magnetic resonance imaging. Journal of Neuroscience 19 (1999) 10869-10876
20. Büchel C., Morris J., Dolan R.J., and Friston K.J. Brain systems mediating aversive conditioning: An event-related fMRI study. Neuron 20 (1998) 947-957
21. Cannon, W. B. (1929). Bodily changes in pain, hunger, fear, and rage, Vol. 2. New York: Appleton (cited in LeDoux, J. E. (1998). The emotional brain. New York: Phoenix).
22. Castelli F., Frith C., Happé F., and Frith U. Autism Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes. Brain 125 (2002) 1839-1849
23. Cheng D.T., Knight D.C., Stein E.A., and Smith C.N. Functional MRI of human amygdala activity during Pavlovian fear conditioning: Stimulus processing versus response expression. Behavioral Neuroscience 117 (2003) 3-10
24. Dawson G., Hill D., Spencer A., Galpert L., and Watson L. Affective exchanges between young autistic children and their mothers. Journal of Abnormal Child Psychology 18 (1990) 335-345
25. Fotheringham J.B. Autism: Its primary psychological and neurological deficit. Canadian Journal of Psychiatry 36 (1991) 686-692
26. Frederikson M., Annas P., Georgiades A., Hursti T., and Tersman Z. Internal consistency and temporal stability of classically conditioned skin conductance responses. Biological Psychology 35 (1993) 153-163
27. Gaigg S.B., and Bowler D.M. The effects of arousal on learning and memory in Asperger's syndrome. Poster session presented at the international meeting for autism research. Montreal, Canada (June, 2006)
28. Gross T.F. Global-local precedence in the perception of facial age and emotional expressions by children with autism and other developmental disabilities. Journal of Autism and Developmental Disorder 35 (2005) 773-785
29. Happé F.G. The role of age and verbal ability in the theory of mind task performance of subjects with autism. Child Development 66 (1995) 843-855
30. Hillier A., Carpenter A., Smith R.M., Berntson G.G., and Beversdorf D.Q. Electrodermal responsiveness to affective stimuli among those on the autism spectrum. Poster session presented at the international meeting for autism research. Montreal, Canada (June, 2006)
31. Hobson R.P. The autistic child's appraisal of expressions of emotion. Journal of Child Psychology and Psychiatry 27 (1986) 321-342
32. Hobson R.P. The autistic child's appraisal of expressions of emotion: A further study. Journal of Child Psychology and Psychiatry 27 (1986) 671-680
33. Hobson R.P. Beyond cognition: A theory of autism. In: Dawson G. (Ed). Autism: Nature, diagnosis & treatment (1989), The Guilford Press, New York 22-48
34. Hobson R.P. Methodological issues for experiments on autistic individuals' perception and understanding of emotion. Journal of Child Psychology and Psychiatry 32 (1991) 1135-1158
35. Hobson R.P., Ouston J., and Lee A. Emotion recognition in autism: Coordinating faces and voices. Psychological Medicine 18 (1988) 911-923
36. Hobson R.P., Ouston J., and Lee A. What's in a face? The case of autism. British Journal of Psychology 79 (1988) 441-453
37. Howard M.A., Cowell P.E., Boucher J., Broks P., Mayes A., Farrant A., et al. Convergent neuroanatomical and behavioural evidence of an amygdala hypothesis of autism. Neuroreport 11 (2000) 2931-2935
38. James, W. (1984). What is an emotion? Mind, Vol. 9, 188-205 (cited in LeDoux, J. E. (1998). The emotional brain (pp. 42-45). New York: Phoenix.
39. Jarrell T.W., Gentile C.G., Romanski L.M., McCabe P.M., and Schneiderman N. Involvement of cortical and thalamic auditory regions in retention of differential bradycardia conditioning to acoustic conditioned stimuli in rabbits. Brain Research 412 (1987) 285-494
40. Joseph R.M., and Tanaka J. Holistic and part-based face recognition in children with autism. Journal of Child Psychology and Psychiatry 44 (2003) 529-542
41. Joseph R.M., Ehrman K., McNally R., and Tager-Flusberg H. Affective response to eye contact in children with autism. Poster session presented at the biennial meeting of the Society for Research in Child Development. Atlanta, GA (April, 2005)
42. Just, M. A., Cherkassky, V. L., Keller, T. A., Kana, R. K., & Minshew, N. J. (in press). Functional and anatomical cortical underconnectivity in autism: Evidence from an fMRI study of an executive function task and corpus callosum morphometry. Cerebral Cortex.
43. Just M.A., Cherkassky V.L., Keller T.A., and Minshew N.J. Cortical activation and synchronization during sentence comprehension in high-functioning autism: Evidence of underconnectivity. Brain 127 (2004) 1811-1821
44. Kanner L. Autistic disturbances of affective contact. Nervous Child 2 (1943) 217-250
45. Kasari C., Sigman M.D., Baumgartner P., and Stipek D.J. Pride and mastery in children with auism. Journal of Child Psychology and Psychiatry 34 (1993) 353-362
46. Kasari C., Sigman M., Mundy P., and Yirmiya N. Affective sharing in the context of joint attention interactions of normal, autistic, and mentally retarded children. Journal of Autism and Developmental Disorders 20 (1990) 87-100
47. Knight D.C., Smith C.N., Cheng D.T., Stein E.A., and Helmstetter F.J. Amygdala and hippocampal activity during acquisition and extinction of human fear conditioning. Cognitive, Affective and Behavioural Neuroscience 4 (2004) 317-325
48. Koshino H., Carpenter P.A., Minshew N.J., Cherkassky V.L., Keller T.A., and Just M.A. Functional connectivity in an fMRI working memory task in high-functioning autism. Neuroimage 24 (2005) 810-821
49. Kylliainen A., and Hietanen J.K. Skin conductance responses to another person's gaze in children with autism. Journal of Autism and Developmental disorders 36 (2006) 517-525
50. LaBar K.S., Gatenby J.C., Gore J.C., LeDoux J.E., and Phelps E.A. Human amygdala activation during conditioned fear acquisition and extinction: A mixed-trial fMRI study. Neuron 20 (1998) 937-945
51. LaBar K.S., LeDoux J.E., Spencer D.D., and Phelps E.A. Impaired fear conditioning following unilateral temporal lobectomy in humans. Journal of Neuroscience 15 (1995) 6846-6855
52. LeDoux J.E. Emotion: Clues from the brain. Annual Review of Psychology 46 (1995) 209-235
53. LeDoux J.E. Emotion, memory and the brain. Scientific American 270 (1994) 32-39
54. LeDoux J.E. The neural circuits underlying anxiety and fear. Biological Psychiatry 44 (1998) 1229-1238
55. LeDoux J.E. The amygdala and emotion: A view through fear. In: Aggleton J.P. (Ed). The amygdala. 2nd ed. (2000), Oxford University Press, Oxford 289-310
56. Lovaas O.I. Behavioural treatment and normal educational and intellectual functioning in young autistic children. Journal of Consutling and Clinical Psychology 55 (1987) 3-9
57. McAlonan G.M., Cheung V., Cheung C., Suckling J., Lam G.Y., Tai K.S., et al. Mapping the brain in autism. A voxel-based MRI study of volumetric differences and intercorrelations in autism. Brain 128 (2005) 268-276
58. Morgan M.A., Romanski L.M., and LeDoux J.E. Extinction of emotional learning: Contribution of medial prefrontal cortex. Neuroscience Letters 163 (1993) 109-113
59. Morgan M.A., Schulkin J., and LeDoux J.E. Ventral medial prefrontal cortex and emotional perseveration: The memory for prior extinction training. Behavioural Brain Research 146 (2003) 121-130
60. Morris J.S., Friston K.J., and Dolan R.J. Experience-dependent modulation of tonotopic neural responses in human auditory cortex. Proceedings of the Royal Society London, Series B: Biological Sciences 265 (1998) 649-657
61. Morris J.S., Friston K.J., and Dolan R.J. Neural responses to salient visual stimuli. Proceedings of the Royal Society London, Series B: Biological Sciences 264 (1997) 769-775
62. Morris J.S., Öhman A., and Dolan R.J. Conscious and unconscious emotional learning in the human amygdala. Nature 393 (1998) 467-474
63. Mundy P., and Sigman M. Specifying the nature of the social impairment in autism. In: Dawson G. (Ed). Autism: Nature diagnosis and treatment (1989), The Guildford Press, New York 3-21
64. Palmen S.J.M.C., van Engeland H., Hof P.R., and Schmitz C. Neuropathological findings in autism. Brain 127 (2004) 1-12
65. Partland J., Dawson G., Webb S.J., Panagiotides H., and Carver L.J. Event-related brain potentials reveal anomalies in temporal processing of faces in autism spectrum disorder. Journal of Child Psychology and Psychiatry 45 (2004) 1235-1245
66. Phelps E.A., Delgado M.R., Nearing K.I., and LeDoux J.E. Extinction learning in humans: Role of the amygdala and vmPFC. Neuron 43 (2004) 897-905
67. Phelps E.A., LaBar K.S., Anderson A.K., O'Connor K.J., Fulbright R.K., and Spencer D.D. Specifying the contributions of the human amygdala to emotional memory: A case study. Neurocase 4 (1998) 527-540
68. Quirk G.J., Russo G.K., Barron J.L., and Lebron K. The role of ventromedial prefrontal cortex in the recovery of extinguished fear. Journal of Neuroscience 20 (2000) 6225-6231
69. Rippon, G., Brock, J., Brown, C. C., & Boucher, J. (in press). Disordered connectivity in the autistic brain: Challenges for the 'new psychophysiology'. International Journal of Psychophysiology.
70. Salmond C.H., de Haan M., Friston K.J., Gadian D.G., and Vargha-Khadem F. Investigating individual differences in brain abnormalities in autism. Philosophical Transactions of the Royal Society of London. Series B. Biological Sciences 358 (2003) 405-413
71. Schultz R.T. Developmental deficits in social perception in autism: The role of the amygdala and fusiform face area. International Journal of Developmental Neuroscience 23 (2005) 125-141
72. Sigman M.D., Kasari C., Jung-Hye K., and Yirmiya N. Responses to the negative emotions of others by autistic, mentally retarded, and normal children. Child Development 63 (1992) 796-807
73. Spezio, M. L., Adolphs, R., Hurley, R. S. E., & Piven, J. (in press). Analysis of face gaze in autism using "Bubbles". Neuropsychologia.
74. Sweeten T.L., Posey D.J., Shekhar A., and McDougle C.J. The amygdala and related structures in the pathophysiology of autism. Pharmacology, Biochemistry and Behavior 71 (2002) 449-455
75. The Psychological Corporation. (2000). Wechsler adult intelligence scale III UK edition (WAIS IIIUK) (3rd ed). London: The Psychological Corporation.
76. Weeks S.J., and Hobson R.P. The salience of facial expression for autistic children. Journal of Child Psychology and Psychiatry 28 (1987) 137-152
77. World Health Organisation. (1992). Tenth revision of the international classification of disease (ICD-10). Geneva: World Health Organisation.
78. Yirmiya N., Kasari C., Sigman M., and Mundy P. Facial expressions of affect in autistic, mentally retarded and normal children. Journal of Child Psychology and Psychiatry 30 (1989) 725-735
79. Yirmiya N., Sigman M.D., Kasari C., and Mundy P. Empathy and cognition in high-functioning children with autism. Child Development 63 (1992) 150-160