An experimental animal model of spinal root compression syndrome: An analysis of morphological changes of myelinated axons during compression radiculopathy and after decompression

Experimental Brain Research

Volumn 179, Issue 1, 2007, Pages 111-119

  Jancalek, R ^a   Dubovy, P ^b  

^a ST ANNE S UNIVERSITY HOSPITAL   (Czech Republic)

^b MASARYK UNIVERSITY   (Czech Republic)

Author keywords

Compression; Morphometry; Spinal root; Treatment

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DECOMPRESSION SURGERY; DORSAL ROOT; FEMALE; HISTOGRAM; HISTOLOGY; MORPHOMETRICS; MYELINATED NERVE; NERVE COMPRESSION; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; RADICULOPATHY; RAT; SPINAL ROOT;

ANIMALS; CELL COUNT; DECOMPRESSION, SURGICAL; DISEASE MODELS, ANIMAL; FEMALE; LOW BACK PAIN; NERVE COMPRESSION SYNDROMES; NERVE FIBERS, MYELINATED; NERVE REGENERATION; RADICULOPATHY; RATS; RATS, WISTAR; SPINAL NERVE ROOTS; TIME FACTORS; WALLERIAN DEGENERATION;

EID: 34247501642     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00221-006-0771-5     Document Type: Article

References (23)

1. Avellino AM, Hart D, Dailey AT, MacKinnon M, Ellegala D, Kliot M (1995) Differential macrophage responses in the peripheral and central nervous system during wallerian degeneration of axons. Exp Neurol 136:183-198
2. Bruck W (1997) The role of macrophages in Wallerian degeneration. Brain Pathol 7:741-752
3. Cornefjord M, Sato K, Olmarker K, Rydevik B, Nordborg C (1997) A model for chronic nerve root compression studies. Presentation of a porcine model for controlled, slow-onset compression with analyses of anatomic aspects, compression onset rate, and morphologic and neurophysiologic effects. Spine 22:946-957
4. Fager CA (1994) Observations of spontaneous recovery form intervertebral disc herniation. Surg Neurol 42:282-286
5. Frymoyer J (1991) Epidemiology of spinal diseases. In: Mayer T, Mooney V, Gatchel RJ (eds) Contemporary conservative care for painful spinal disorders. Lea and Febiger, Philadelphia, pp 10-23
6. Habtemariam A, Gronblad M, Virri J, Seitsalo S, Karaharju E (1998) A comparative immunohistochemical study of inflammatory cells in acute-stage and chronic-stage disc herniations. Spine 23:2159-2165
7. Hou SX, Tang JG, Chen HS, Chen J (2003) Chronic inflammation and compression of the dorsal root contribute to sciatica induced by the intervertebral disc herniation in rats. Pain 105:255-264
8. Hu SJ, Xing JL (1998) An experimental model for chronic compression of dorsal root ganglion produced by intervertebral foramen stenosis in the rat. Pain 77:15-23
9. Kawakami M, Weinstein JN, Chatani K, Spratt KF, Meller ST, Gebhart GF (1994) Experimental lumbar radiculopathy. Behavioral and histologic changes in a model of radicular pain after spinal nerve root irritation with chromic gut ligatures in the rat. Spine 19:1795-1802
10. Kawakami M, Tamaki T, Weinstein JN, Hashizume H, Nishi H, Meller ST (1996) Pathomechanism of pain-related behavior produced by allografts of intervertebral disc in the rat. Spine 21:2101-2107
11. Kawakami M, Tamaki T, Hayashi N, Hashizume H, Nishi H (1998) Possible mechanism of painful radiculopathy in lumbar disc herniation. Clin Orthop Relat Res 351:241-251
12. Kawakami M (2005) Pathophysiology of radicular pain. Clin Calcium 15:377-382
13. Kobayashi S, Yoshizawa H, Yamada S (2004) Pathology of lumbar nerve root compression. Part 2: morphological and immunohistochemical changes of dorsal root ganglion. J Orthop Res 22:180-188
14. Novak Z, Krupa P, Zlatos J, Nadvornik P (2000) The function of the cerebrospinal fluid space and its expansion. Bratisl Lek Listy 101:594-597
15. Oblinger MM, Lasek RJ (1984) A conditioning lesion of the peripheral axons of dorsal root ganglion cells accelerates regeneration of only their peripheral axons. J Neurosci 4:1736-1744
16. Olmarker K, Holm S, Rosenqvist AL, Rydevik B (1991) Experimental nerve root compression. A model of acute, graded compression of the porcine cauda equina and an analysis of neural and vascular anatomy. Spine 16:61-69
17. Omarker K, Myers RR (1998) Pathogenesis of sciatic pain: role of herniated nucleus pulposus and deformation of spinal nerve root and dorsal root ganglion. Pain 78:99-105
18. Rothoerl RD, Woertgen C, Brawanski A (2002) When should conservative treatment for lumbar disc herniation be ceased and surgery considered? Neurosurg Rev 25:162-165
19. Suchomel P, Stastny F, Trojan S (1983) The effect of cortisol on intracranial pressure and asphyxic edema in the chick embryo. Bratisl Lek Listy 79:30-37
20. Tabo E, Jinks SL, Eisele JH Jr, Carstens E (1999) Behavioral manifestations of neuropathic pain and mechanical allodynia, and changes in spinal dorsal horn neurons, following L4-L6 dorsal root constriction in rats. Pain 80:503-520
21. Thomas PK, Berthold CH, Ochoa J (1993) Microscopic anatomy of the peripheral nervous system. Peripheral Neuropathy. W.B. Saunders Company, Philadelphia
22. Toh E, Mochida J (1997) Histologic analysis of the lumbosacral nerve roots after compression in young and aged rabbits. Spine 22:721-726
23. Yoshizawa H, Kobayashi S, Morita T (1995) Chronic nerve root compression. Pathophysiologic mechanism of nerve root dysfunction. Spine 20:397-407