메뉴 건너뛰기




Volumn 43, Issue 3, 2007, Pages 137-147

Lumiracoxib

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXY 5 CARBOXY LUMIRACOXIB; 4 HYDROXY LUMIRACOXIB; 5 CARBOXY LUMIRACOXIB; ACETYLSALICYLIC ACID; ALUMINUM HYDROXIDE; ANTACID AGENT; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; DRUG METABOLITE; ETORICOXIB; GLUCURONIDE; IBUPROFEN; LOCAL ANESTHETIC AGENT; LUMIRACOXIB; METHOTREXATE; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; ORAL CONTRACEPTIVE AGENT; PLACEBO; PROSTACYCLIN; ROFECOXIB; UNCLASSIFIED DRUG; WARFARIN;

EID: 34247493764     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2007.43.3.1062673     Document Type: Review
Times cited : (17)

References (61)
  • 1
    • 84878732700 scopus 로고    scopus 로고
    • Flowers, R., Moncada, S., Vane, J. Analgesic-anti-pyretics and anti-inflammatory agents: Drugs employed in the treatment of gout. In: Gilman, A., Goodman, L., Rall, T. et al. The Pharmacological Basis of Therapeutics (7 Ed.). Macmillan, New York 1985.
    • Flowers, R., Moncada, S., Vane, J. Analgesic-anti-pyretics and anti-inflammatory agents: Drugs employed in the treatment of gout. In: Gilman, A., Goodman, L., Rall, T. et al. The Pharmacological Basis of Therapeutics (7 Ed.). Macmillan, New York 1985.
  • 2
    • 84916006645 scopus 로고    scopus 로고
    • Von Euler, U.S. On the specific vasodilating and plain muscle stimulating substance from accessory genital glands in man and certain animals (prostaglandin and vestiglandin). J Physiol 1937, 88: 213-34.
    • Von Euler, U.S. On the specific vasodilating and plain muscle stimulating substance from accessory genital glands in man and certain animals (prostaglandin and vestiglandin). J Physiol 1937, 88: 213-34.
  • 3
    • 0036316688 scopus 로고    scopus 로고
    • Prostanoids and pain: Unraveling mechanisms and revealing therapeutic targets
    • Samad, T.A., Sapirstein, A., Woolf, C.J. Prostanoids and pain: Unraveling mechanisms and revealing therapeutic targets. Trends Mol Med 2002, 8: 390-6.
    • (2002) Trends Mol Med , vol.8 , pp. 390-396
    • Samad, T.A.1    Sapirstein, A.2    Woolf, C.J.3
  • 4
    • 0028888055 scopus 로고
    • Nonsteroidal anti-inflammatory drugs in perisurgical pain management: Mechanisms of action and rationale for optimum use
    • Cashman, J., McAnulty, G. Nonsteroidal anti-inflammatory drugs in perisurgical pain management: Mechanisms of action and rationale for optimum use. Drugs 1995, 49: 51-70.
    • (1995) Drugs , vol.49 , pp. 51-70
    • Cashman, J.1    McAnulty, G.2
  • 5
    • 0015505169 scopus 로고
    • Prostaglandins, aspirin-like drugs and analgesia
    • Ferreira, S.H. Prostaglandins, aspirin-like drugs and analgesia. Nature 1972, 240: 200-3.
    • (1972) Nature , vol.240 , pp. 200-203
    • Ferreira, S.H.1
  • 6
    • 0036882078 scopus 로고    scopus 로고
    • Origins of prostaglandins E2: Involvement of cyclooxygenase (COX)-1 and COX-2 in human and rat systems
    • Giuliano, F., Warner, T.D. Origins of prostaglandins E2: Involvement of cyclooxygenase (COX)-1 and COX-2 in human and rat systems. J Pharmacol Therp 2002, 102: 1001-6.
    • (2002) J Pharmacol Therp , vol.102 , pp. 1001-1006
    • Giuliano, F.1    Warner, T.D.2
  • 7
    • 0019174041 scopus 로고
    • Arachidonic acid metabolism, pain and hyperalgesia: The mode of action of non-steroid mild analgesics
    • Higgs, G.A. Arachidonic acid metabolism, pain and hyperalgesia: The mode of action of non-steroid mild analgesics. Br J Pharmacol 1980, 10; 233-5S.
    • (1980) Br J Pharmacol , vol.10
    • Higgs, G.A.1
  • 8
    • 0027282989 scopus 로고
    • Inflammation and hyperalgesia: The team effort
    • Dray, A., Bevan, S. Inflammation and hyperalgesia: The team effort. Trends Pharm Sci 1993, 14: 287-62.
    • (1993) Trends Pharm Sci , vol.14 , pp. 287-262
    • Dray, A.1    Bevan, S.2
  • 9
    • 0026322957 scopus 로고
    • A serum and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein
    • O'Banion, M.K., Sadowski, H.B., Winn, V. et al. A serum and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein. J Biol Chem 1991, 266: 23261-7.
    • (1991) J Biol Chem , vol.266 , pp. 23261-23267
    • O'Banion, M.K.1    Sadowski, H.B.2    Winn, V.3
  • 10
    • 0033791318 scopus 로고    scopus 로고
    • Cyclooxygenases: Structural, cellular biology
    • Smith, W.L., DeWitt, D.L., Garavito, R.M. et al. Cyclooxygenases: Structural, cellular biology. Annu Rev Biochem 2000, 69: 145-82.
    • (2000) Annu Rev Biochem , vol.69 , pp. 145-182
    • Smith, W.L.1    DeWitt, D.L.2    Garavito, R.M.3
  • 11
    • 0033802911 scopus 로고    scopus 로고
    • COX-2 specific inhibitors - the emergence of a new class of analgesic and anti-inflammatory drugs
    • Everts, B., Wahrborg, P., Hedner, T. et al. COX-2 specific inhibitors - the emergence of a new class of analgesic and anti-inflammatory drugs. Clin Rheumatol 2000, 19: 331-43.
    • (2000) Clin Rheumatol , vol.19 , pp. 331-343
    • Everts, B.1    Wahrborg, P.2    Hedner, T.3
  • 12
    • 0026588059 scopus 로고
    • Prostaglandin endoperoxide synthase gene structure: Identification of the transcriptional start site and 5′ flanking regulatory sequences
    • Kraemer, S.A., Meade, E.A., DeWitte, D.L. Prostaglandin endoperoxide synthase gene structure: Identification of the transcriptional start site and 5′ flanking regulatory sequences. Arch Biochem Biophys 1992, 293: 391-400.
    • (1992) Arch Biochem Biophys , vol.293 , pp. 391-400
    • Kraemer, S.A.1    Meade, E.A.2    DeWitte, D.L.3
  • 13
    • 4143124753 scopus 로고    scopus 로고
    • Signal transduction pathways regulating cyclooxygenase-2 expression: Potential molecular targets for chemoprevention
    • Chun, K.S., Surh, Y.J. Signal transduction pathways regulating cyclooxygenase-2 expression: Potential molecular targets for chemoprevention. Biochemical pharmacology 2004, 68: 1089-100.
    • (2004) Biochemical pharmacology , vol.68 , pp. 1089-1100
    • Chun, K.S.1    Surh, Y.J.2
  • 14
    • 0032896588 scopus 로고    scopus 로고
    • Cyclooxygenase-2: Molecular biology, pharmacology and neurobiology
    • O'Banion, M.K. Cyclooxygenase-2: Molecular biology, pharmacology and neurobiology. Crit Rev Neurobiol 1999, 13: 45-82.
    • (1999) Crit Rev Neurobiol , vol.13 , pp. 45-82
    • O'Banion, M.K.1
  • 15
    • 0035882262 scopus 로고    scopus 로고
    • The acute antihyperalgesic action of non-steroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1
    • Yaksh, T.L., Dirig, D.M., Conway, C.M. et al. The acute antihyperalgesic action of non-steroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1. J Neurosci 2001, 21: 5847-53.
    • (2001) J Neurosci , vol.21 , pp. 5847-5853
    • Yaksh, T.L.1    Dirig, D.M.2    Conway, C.M.3
  • 16
    • 0017199955 scopus 로고
    • The mode of action of aspirin and similar compounds
    • Vane, J.R. The mode of action of aspirin and similar compounds. J Allergy Clin Immunol 1976, 58: 691-712.
    • (1976) J Allergy Clin Immunol , vol.58 , pp. 691-712
    • Vane, J.R.1
  • 17
    • 0036744812 scopus 로고    scopus 로고
    • Cyclooyxgenase-2 (COX-2) inhibitor potentiates morphine antinociception at the spinal level in a post-operative pain model
    • Kroin, J.S., Buvanendran, A., McCarthy, R.J. et al. Cyclooyxgenase-2 (COX-2) inhibitor potentiates morphine antinociception at the spinal level in a post-operative pain model. Reg Anesth Pain Med 2002, 27: 451-5.
    • (2002) Reg Anesth Pain Med , vol.27 , pp. 451-455
    • Kroin, J.S.1    Buvanendran, A.2    McCarthy, R.J.3
  • 18
    • 33646246179 scopus 로고    scopus 로고
    • Triptolide inhibits COX-2 expression via NF-kappa B pathway in astrocytes
    • Dai, Y.Q., Jin, D.Z., Zhu, X.Z. et al. Triptolide inhibits COX-2 expression via NF-kappa B pathway in astrocytes. Neurosci 2006, 55: 154-60.
    • (2006) Neurosci , vol.55 , pp. 154-160
    • Dai, Y.Q.1    Jin, D.Z.2    Zhu, X.Z.3
  • 19
    • 0035932121 scopus 로고    scopus 로고
    • Interleukin-1beta mediated induction of COX-2 in the central nervous system contributes to inflammatory pain hypersensitivity
    • Samad, T.A., Moore, K.A., Sapirstein, A. et al. Interleukin-1beta mediated induction of COX-2 in the central nervous system contributes to inflammatory pain hypersensitivity. Nature 2001, 410: 471-5.
    • (2001) Nature , vol.410 , pp. 471-475
    • Samad, T.A.1    Moore, K.A.2    Sapirstein, A.3
  • 20
    • 33645502345 scopus 로고    scopus 로고
    • 2 and interleukins in the central nervous system and peripheral tissue during and after surgery in humans
    • 2 and interleukins in the central nervous system and peripheral tissue during and after surgery in humans. Anesthesiology 2006, 104: 403-10.
    • (2006) Anesthesiology , vol.104 , pp. 403-410
    • Buvanendran, A.1    Kroin, J.S.2    Berger, R.A.3
  • 21
    • 1642540162 scopus 로고    scopus 로고
    • Upregulation of spinal cyclooxygenase-2 in rats after surgical incision
    • Kroin, J.S., Ling, Z.D., Buvanendran, A. et al. Upregulation of spinal cyclooxygenase-2 in rats after surgical incision. Anesthesiology 2004, 100: 364-9.
    • (2004) Anesthesiology , vol.100 , pp. 364-369
    • Kroin, J.S.1    Ling, Z.D.2    Buvanendran, A.3
  • 22
    • 33645511269 scopus 로고    scopus 로고
    • Postoperative modulation of central nervous system prostaglandins E2 by cyclooxygenase inhibitors after vascular surgery
    • Reuben, S.S., Buvanendran, A., Kroin, J.S. et al. Postoperative modulation of central nervous system prostaglandins E2 by cyclooxygenase inhibitors after vascular surgery. Anesthesiology 2006, 104: 411-6.
    • (2006) Anesthesiology , vol.104 , pp. 411-416
    • Reuben, S.S.1    Buvanendran, A.2    Kroin, J.S.3
  • 23
    • 13244283391 scopus 로고    scopus 로고
    • Central nervous system concentration of cyclooxygenase-2 inhibitors in humans
    • Dembo, G., Park, S.B., Kharasch, E.D. Central nervous system concentration of cyclooxygenase-2 inhibitors in humans. Anesthesiology 2005, 102: 409-15.
    • (2005) Anesthesiology , vol.102 , pp. 409-415
    • Dembo, G.1    Park, S.B.2    Kharasch, E.D.3
  • 24
    • 17744387958 scopus 로고    scopus 로고
    • Cerebrospinal fluid and plasma pharmacokinetics of the cyclooxygenase 2 inhibitor rofecoxib in humans: Single and multiple oral drug administration
    • Buvanendran, A., Kroin, J.S., Tuman, K.J. et al. Cerebrospinal fluid and plasma pharmacokinetics of the cyclooxygenase 2 inhibitor rofecoxib in humans: Single and multiple oral drug administration. Anesth Analg 2005, 100: 1320-4.
    • (2005) Anesth Analg , vol.100 , pp. 1320-1324
    • Buvanendran, A.1    Kroin, J.S.2    Tuman, K.J.3
  • 25
    • 6044245845 scopus 로고    scopus 로고
    • Lyseng-Williamson, K.A., Curran, M.P. Lumiracoxib. Drugs 2004, 64: 2237-46.
    • Lyseng-Williamson, K.A., Curran, M.P. Lumiracoxib. Drugs 2004, 64: 2237-46.
  • 26
    • 0012762429 scopus 로고    scopus 로고
    • Steady state pharmacodynamics of COX 189 in healthy subjects
    • Scott, G., Rordorf, C., Blood, P. et al. Steady state pharmacodynamics of COX 189 in healthy subjects. Ann Rheum Dis 2002, 61 (Suppl. 1): 244.
    • (2002) Ann Rheum Dis , vol.61 , Issue.SUPPL. 1 , pp. 244
    • Scott, G.1    Rordorf, C.2    Blood, P.3
  • 27
    • 1542615524 scopus 로고    scopus 로고
    • Assessment of lumiracoxib bioavailability from targeted sites in the human intestine using remotely activated capsules and gamma scintigraphy
    • Wilding, I.R., Connor, A.L., Carpenter, P. et al. Assessment of lumiracoxib bioavailability from targeted sites in the human intestine using remotely activated capsules and gamma scintigraphy. Pharm Res 2004, 21: 443-6.
    • (2004) Pharm Res , vol.21 , pp. 443-446
    • Wilding, I.R.1    Connor, A.L.2    Carpenter, P.3
  • 28
    • 3242889081 scopus 로고    scopus 로고
    • Lumiracoxib: A new selective COX-2 inhibitor
    • Mysler, E. Lumiracoxib: A new selective COX-2 inhibitor. Int J Clin Pract 2004, 58: 606-11.
    • (2004) Int J Clin Pract , vol.58 , pp. 606-611
    • Mysler, E.1
  • 29
    • 2642556303 scopus 로고    scopus 로고
    • Pharmacokinetics of lumiracoxib in plasma and synovial fluid
    • Scott, G., Rordorf, C., Reynolds, C. et al. Pharmacokinetics of lumiracoxib in plasma and synovial fluid. Clin Pharmacokinet 2004, 43: 467-78.
    • (2004) Clin Pharmacokinet , vol.43 , pp. 467-478
    • Scott, G.1    Rordorf, C.2    Reynolds, C.3
  • 31
    • 20044381457 scopus 로고    scopus 로고
    • Esser, R. 2005, Bery, C., Du, Z. et al. Preclinical pharmacology of lumiracoxib: A novel selective inhibitor of cyclooxygenase-2. Br J Pharmacology 2005, 144: 538-50.
    • Esser, R. 2005, Bery, C., Du, Z. et al. Preclinical pharmacology of lumiracoxib: A novel selective inhibitor of cyclooxygenase-2. Br J Pharmacology 2005, 144: 538-50.
  • 32
    • 2042475404 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of lumiracoxib in healthy male subjects
    • Mangold, J.B., Gu, H., Rodriguez, L.C. et al. Pharmacokinetics and metabolism of lumiracoxib in healthy male subjects. Drug Metab Dispos 2004, 32: 566-71.
    • (2004) Drug Metab Dispos , vol.32 , pp. 566-571
    • Mangold, J.B.1    Gu, H.2    Rodriguez, L.C.3
  • 33
    • 29244433160 scopus 로고    scopus 로고
    • Clinical pharmacology of lumiracoxib: A selective cyclo-oxygenase-2 inhibitor
    • Rordorf, C.M., Choi, L., Marshall, P., Mangold, J.B. Clinical pharmacology of lumiracoxib: A selective cyclo-oxygenase-2 inhibitor. Clin Pharmacokinet 2005, 44: 1247-66.
    • (2005) Clin Pharmacokinet , vol.44 , pp. 1247-1266
    • Rordorf, C.M.1    Choi, L.2    Marshall, P.3    Mangold, J.B.4
  • 34
    • 2942618785 scopus 로고    scopus 로고
    • No influence of moderate hepatic impairment on the pharmacokinetics of lumiracoxib, an oral COX-2 selective inhibitor
    • Kalbag, J., Yeh, C.-M., Milosavljev, S. et al. No influence of moderate hepatic impairment on the pharmacokinetics of lumiracoxib, an oral COX-2 selective inhibitor. Pharmacol Res 2004, 50: 181-6.
    • (2004) Pharmacol Res , vol.50 , pp. 181-186
    • Kalbag, J.1    Yeh, C.-M.2    Milosavljev, S.3
  • 35
    • 4344661128 scopus 로고    scopus 로고
    • Comparison of lumiracoxib with naproxen and ibuprofen in the therapeutic arthritis research and gastrointestinal event trial (TARGET), reduction in ulcer complications: Randomized controlled trial
    • Schnitzer, T., Burmester, G.R., Mysler, E. et al. Comparison of lumiracoxib with naproxen and ibuprofen in the therapeutic arthritis research and gastrointestinal event trial (TARGET), reduction in ulcer complications: Randomized controlled trial. Lancet 2004, 364: 665-74.
    • (2004) Lancet , vol.364 , pp. 665-674
    • Schnitzer, T.1    Burmester, G.R.2    Mysler, E.3
  • 36
    • 14844336962 scopus 로고    scopus 로고
    • Efficacy and tolerability of lumiracoxib in the treatment of osteoarthritis of the knee: A 13-week, randomized, double-blind comparison with celecoxib and placebo
    • Sheldon, E., Beaulieu, A., Paster, Z. et al. Efficacy and tolerability of lumiracoxib in the treatment of osteoarthritis of the knee: A 13-week, randomized, double-blind comparison with celecoxib and placebo. Clin Ther 2005, 27: 64-77.
    • (2005) Clin Ther , vol.27 , pp. 64-77
    • Sheldon, E.1    Beaulieu, A.2    Paster, Z.3
  • 37
    • 4444239614 scopus 로고    scopus 로고
    • Gastroduodenal safety and tolerability of lumiracoxib compared with ibuprofen and celecoxib in patients with osteoarthritis
    • Hawkey, C.C., Svoboda, P., Fiedorowicz-Fabrycy, I.F. et al. Gastroduodenal safety and tolerability of lumiracoxib compared with ibuprofen and celecoxib in patients with osteoarthritis. J Rheumatol 2004, 31: 1804-10.
    • (2004) J Rheumatol , vol.31 , pp. 1804-1810
    • Hawkey, C.C.1    Svoboda, P.2    Fiedorowicz-Fabrycy, I.F.3
  • 38
    • 4344578073 scopus 로고    scopus 로고
    • Comparison of lumiracoxib with naproxen and ibuprofen in the therapeutic arthritis research and gastrointestinal event trial (TARGET), reduction in ulcer complications: Randomized controlled trial
    • Schnitzer, T., Burmester, G.R., Mysler, E. et al. Comparison of lumiracoxib with naproxen and ibuprofen in the therapeutic arthritis research and gastrointestinal event trial (TARGET), reduction in ulcer complications: Randomized controlled trial. Lancet 2004, 364: 675-84.
    • (2004) Lancet , vol.364 , pp. 675-684
    • Schnitzer, T.1    Burmester, G.R.2    Mysler, E.3
  • 39
    • 25844515649 scopus 로고    scopus 로고
    • Cardiovascular safety of lumiracoxib: A meta-analysis of all randomized controlled trials > 1 week and up to 1 year in duration of patients with osteoarthritis and rheumatorid arthritis
    • Matchaba, P., Gitton, X., Krammer, G. et al. Cardiovascular safety of lumiracoxib: A meta-analysis of all randomized controlled trials > 1 week and up to 1 year in duration of patients with osteoarthritis and rheumatorid arthritis. Clin Ther 2005, 27: 1196-24.
    • (2005) Clin Ther , vol.27 , pp. 1196-1124
    • Matchaba, P.1    Gitton, X.2    Krammer, G.3
  • 40
    • 19744380776 scopus 로고    scopus 로고
    • Adenomatous Polyp Prevention on Vioxx (APPROVE) Trial Investigators. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial
    • Bresalier, R.S., Sandler, R.S., Quan, H. et al.; Adenomatous Polyp Prevention on Vioxx (APPROVE) Trial Investigators. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med 2005, 352: 1092-102.
    • (2005) N Engl J Med , vol.352 , pp. 1092-1102
    • Bresalier, R.S.1    Sandler, R.S.2    Quan, H.3
  • 41
    • 0034707105 scopus 로고    scopus 로고
    • Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis
    • Bombardier, C., Laine, L., Reicin, A. et al. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. N Engl J Med 2000, 343: 1520-8.
    • (2000) N Engl J Med , vol.343 , pp. 1520-1528
    • Bombardier, C.1    Laine, L.2    Reicin, A.3
  • 42
    • 20144365496 scopus 로고    scopus 로고
    • Adenoma Prevention with Celecoxib (APC) Study investigators. Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention
    • Solomon, S.D., McMurray, J.V., Pfeffer, M.A. et al.; Adenoma Prevention with Celecoxib (APC) Study investigators. Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N Engl J Med 2005, 352: 1071-80.
    • (2005) N Engl J Med , vol.352 , pp. 1071-1080
    • Solomon, S.D.1    McMurray, J.V.2    Pfeffer, M.A.3
  • 43
    • 84878735504 scopus 로고    scopus 로고
    • Use of non-steroidal anti-inflammatory drugs suspended in large Alzheimer's disease prevention trial
    • National Institute of Health, Available at
    • National Institute of Health. Use of non-steroidal anti-inflammatory drugs suspended in large Alzheimer's disease prevention trial. FDA meeting, December 20, 2004. Available at: http://www.nih.gov/news/pr/dec2004/od20.htm.
    • (2004) FDA meeting, December 20
  • 44
    • 11144256197 scopus 로고    scopus 로고
    • Clinical trails. Halt of Celebrex study threatens drug's future and other trials
    • Couzin, J. Clinical trails. Halt of Celebrex study threatens drug's future and other trials. Science 2004, 306: 2170.
    • (2004) Science , vol.306 , pp. 2170
    • Couzin, J.1
  • 45
    • 33749868787 scopus 로고    scopus 로고
    • Selective COX-2 inhibitors and risk of thromboembolic events-regulatory aspects
    • Heim, H.K., Broich, K. Selective COX-2 inhibitors and risk of thromboembolic events-regulatory aspects. Thromb Haemost 2006, 96: 423-32.
    • (2006) Thromb Haemost , vol.96 , pp. 423-432
    • Heim, H.K.1    Broich, K.2
  • 46
    • 31044441042 scopus 로고    scopus 로고
    • Biological basis for the cardiovascular consequences of COX-2 inhibition: Therapeutic challenges and opportunities
    • Grosser, T., Fries, S., Fitzgerald, G.A. Biological basis for the cardiovascular consequences of COX-2 inhibition: Therapeutic challenges and opportunities. J Clin Invest 2006, 116: 4-15.
    • (2006) J Clin Invest , vol.116 , pp. 4-15
    • Grosser, T.1    Fries, S.2    Fitzgerald, G.A.3
  • 47
    • 4344578073 scopus 로고    scopus 로고
    • Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: Randomized controlled trial
    • Farkouh, M., Kirshner, H., Harrington, R.A. et al. Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: Randomized controlled trial. Lancet 2004, 364: 675-84.
    • (2004) Lancet , vol.364 , pp. 675-684
    • Farkouh, M.1    Kirshner, H.2    Harrington, R.A.3
  • 48
    • 25444446582 scopus 로고    scopus 로고
    • Lumiracoxib does not affect the ex vivo antiplatelet aggregation activity of low-dose asprin in healthy subjects
    • Jermany, J., Branson, J., Schmouder, R. et al. Lumiracoxib does not affect the ex vivo antiplatelet aggregation activity of low-dose asprin in healthy subjects. J Clin Pharmacol 2005, 45: 1172-8.
    • (2005) J Clin Pharmacol , vol.45 , pp. 1172-1178
    • Jermany, J.1    Branson, J.2    Schmouder, R.3
  • 49
    • 0012766468 scopus 로고    scopus 로고
    • Steady state pharmacokinetics, pharmacodynamics, safety and tolerability of COX 189 in healthy subjects
    • Rordorf, C., Scott, G., Milosavlljev, et al. Steady state pharmacokinetics, pharmacodynamics, safety and tolerability of COX 189 in healthy subjects. Ann Rheum Dis 2002, 61 (Suppl. 1): 420.
    • (2002) Ann Rheum Dis , vol.61 , Issue.SUPPL. 1 , pp. 420
    • Rordorf, C.1    Scott, G.2    Milosavlljev3
  • 50
    • 84878680016 scopus 로고    scopus 로고
    • Bonner, J., Branson, J., Milosavijev, S. et al. Co-administration of lumiracoxib and warfarin does not alter the pharmacokinetics profile of RorS warfarin. Ann Rheum Dis 2003, 62: 264 (Abst. FRI0225).
    • Bonner, J., Branson, J., Milosavijev, S. et al. Co-administration of lumiracoxib and warfarin does not alter the pharmacokinetics profile of RorS warfarin. Ann Rheum Dis 2003, 62: 264 (Abst. FRI0225).
  • 51
    • 2342432927 scopus 로고    scopus 로고
    • Analgesic efficacy of single oral doses of lumiracoxib and ibuprofen in patients with postoperative dental pain
    • Zelenakas, K., Fricke, J.R., Jayawardene, S., Kellstein, D. Analgesic efficacy of single oral doses of lumiracoxib and ibuprofen in patients with postoperative dental pain. Int J Clin Pract 2004, 58: 251-6.
    • (2004) Int J Clin Pract , vol.58 , pp. 251-256
    • Zelenakas, K.1    Fricke, J.R.2    Jayawardene, S.3    Kellstein, D.4
  • 52
    • 2342419009 scopus 로고    scopus 로고
    • Analgesic efficacy of single dose of lumiracoxib compared with rofecoxib, celecoxib and placebo in the treatment of postoperative dental pain
    • Kellstein, D., Ott, D., Jayawardene, S., Fricke, J. Analgesic efficacy of single dose of lumiracoxib compared with rofecoxib, celecoxib and placebo in the treatment of postoperative dental pain. Int J Clin Pract 2004, 58: 244-50.
    • (2004) Int J Clin Pract , vol.58 , pp. 244-250
    • Kellstein, D.1    Ott, D.2    Jayawardene, S.3    Fricke, J.4
  • 53
    • 2642552966 scopus 로고    scopus 로고
    • Efficacy and tolerability of lumiracoxib in the treatment of primary dysmenorrhea
    • Bitner, M., Kattenhorn, J., Hatfield, C. et al. Efficacy and tolerability of lumiracoxib in the treatment of primary dysmenorrhea. Int J Clin Pract 2004, 58: 340-5
    • (2004) Int J Clin Pract , vol.58 , pp. 340-345
    • Bitner, M.1    Kattenhorn, J.2    Hatfield, C.3
  • 54
    • 33644878002 scopus 로고    scopus 로고
    • Lumiracoxib is effective in the treatment of episodic tension type headache
    • Packman, E., Packman, B., Thurston, H. et al. Lumiracoxib is effective in the treatment of episodic tension type headache. Headache 2005, 45: 1163-70.
    • (2005) Headache , vol.45 , pp. 1163-1170
    • Packman, E.1    Packman, B.2    Thurston, H.3
  • 55
    • 84878683971 scopus 로고    scopus 로고
    • Efficacy and safety of four doses of lumiracoxib versus diclofenac in patients with knee or hip osteoarthritis: A phase II, four week multicenter, randomized, double-blind, placebo-controlled trial
    • Schnitzer, T.J., Beier, J., Geusens, P. et al. Efficacy and safety of four doses of lumiracoxib versus diclofenac in patients with knee or hip osteoarthritis: A phase II, four week multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2004, 15: 549-57.
    • (2004) Arthritis Rheum , vol.15 , pp. 549-557
    • Schnitzer, T.J.1    Beier, J.2    Geusens, P.3
  • 56
    • 33645734212 scopus 로고    scopus 로고
    • Lumiracoxib is effective in the treatment of osteoarthritis of the knee: A prospective, randomized, 13-week study versus placebo and celecoxib
    • Fleischmann, R., Sheldon, E., Maldonado-Cocco, J. et al. Lumiracoxib is effective in the treatment of osteoarthritis of the knee: A prospective, randomized, 13-week study versus placebo and celecoxib. Clin Rheumatol 2005, 25: 42-53.
    • (2005) Clin Rheumatol , vol.25 , pp. 42-53
    • Fleischmann, R.1    Sheldon, E.2    Maldonado-Cocco, J.3
  • 57
    • 4644320066 scopus 로고    scopus 로고
    • Efficacy and tolerability of lumiracoxib versus placebo in patients with osteoarthritis of the hand
    • Grifka, J.K., Zacher, J., Brown, J.P. et al. Efficacy and tolerability of lumiracoxib versus placebo in patients with osteoarthritis of the hand. Clin Exp Rheumatol 2004, 22: 589-96.
    • (2004) Clin Exp Rheumatol , vol.22 , pp. 589-596
    • Grifka, J.K.1    Zacher, J.2    Brown, J.P.3
  • 58
    • 13444256641 scopus 로고    scopus 로고
    • Efficacy of lumiracoxib in osteoarthritis: A review of nine studies
    • Berenbaum, F., Grifka, J., Brown, J.P. et al. Efficacy of lumiracoxib in osteoarthritis: A review of nine studies. J Int Med Res 2005, 33: 21-41.
    • (2005) J Int Med Res , vol.33 , pp. 21-41
    • Berenbaum, F.1    Grifka, J.2    Brown, J.P.3
  • 59
    • 84878709586 scopus 로고    scopus 로고
    • Efficacy, safety and tolerability of lumiracoxib in patients with rheumatoid arthritis
    • Geusens, P., Alten, R., Rovensky, J. et al. Efficacy, safety and tolerability of lumiracoxib in patients with rheumatoid arthritis. Arthritis Rheum 2005, 52: 582-91.
    • (2005) Arthritis Rheum , vol.52 , pp. 582-591
    • Geusens, P.1    Alten, R.2    Rovensky, J.3
  • 60
    • 10444252228 scopus 로고    scopus 로고
    • Lumaricoxib dose not affect methotrexate pharmacokinetics in rheumatoid arthritis patients
    • Hartmann, S., Rordorf, C.M., Milosavljev, S. et al. Lumaricoxib dose not affect methotrexate pharmacokinetics in rheumatoid arthritis patients. Ann Pharmacother 2004, 38: 1582-7.
    • (2004) Ann Pharmacother , vol.38 , pp. 1582-1587
    • Hartmann, S.1    Rordorf, C.M.2    Milosavljev, S.3
  • 61
    • 2442679180 scopus 로고    scopus 로고
    • Concomitant administration of lumiracoxib and a triphasic oral contraceptive does not affect contraceptive activity or pharmacokinetic profile
    • Kalbag, J., Elder, C., Scott, G. et al. Concomitant administration of lumiracoxib and a triphasic oral contraceptive does not affect contraceptive activity or pharmacokinetic profile. J Clin Pharmacol 2004, 44: 646-54.
    • (2004) J Clin Pharmacol , vol.44 , pp. 646-654
    • Kalbag, J.1    Elder, C.2    Scott, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.