Antitumor activity of Vilon dipeptide Lys-Glu

Chinese Pharmacological Bulletin

Volumn 23, Issue 2, 2007, Pages 233-236

  Tan, Chan Yuan ^a   Zhang, Xin ^a   Jiang, Yin Feng ^a   Zhang, Dong Mei ^a   Chen, Jun Hui ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Antitumor activity; Lys Glu; Solution phase peptide synthesis; Vilon

Indexed keywords

DIPEPTIDE; GLUTAMIC ACID; LYSINE; UNCLASSIFIED DRUG; VILON;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CELL; LEUKOCYTE COUNT; LIQUID PHASE MICROEXTRACTION; LIVER CELL CARCINOMA; MOLECULAR WEIGHT; NONHUMAN; TUMOR GROWTH;

EID: 34247491123     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Khavinson V K, Anisimov V N. A synthetic dipeptide vilon (L-Lys-L-Glu) inhibits growth of spontaneous tumors and increase life span of mice[J]. Dokl Biol Sci, 2000, 372(1-6):261-3.
2. Anisimov V N, Khavinson V K, Mikhalski A I, et al. Effect of synthtic thymic and pineal peptides on biomarkers of ageing survival and spontaneous tumor incidence in female CBA mice[J]. Mech Ageing Dev, 2001, 122(1):41-68.
3. Khavinson V K, Anisimov V N, Zavarizina N Y, et al. Effect of vilon on biological age and lifespan in mice[J]. Bull Exp Biol Med, 2000, 130(7):687-90.
4. Khavinson V K, Timofeeva N M, Malinin V V,et al. Effect of the dipeptide vilon on activity of digestive enzyme in rats of various ages[J]. Bull Exp Biol Med, 2001, 131(6):583-5.
5. Pliss G B, Mel'nikov A S, Malinin V V, et al. Effect of vilon and epithalone on induction and growth of induced bladder neoplasms in rats[J]. Vopr Onkol, 2001, 47(5):601-7.
6. Kniaz'kin I V, Poliakova VO. The effect of vilon on the thymus and spleen in a radiation modle of premature aging[J]. Adv Gerontol, 2002, 9:105-9.
7. Khavinson V K, Lezhava T A, Malinin V V. Effects of short peptides on lymphocyte chromatin in senile subjects[J]. Bull Exp Biol Med, 2004, 137(1):78-81.
8. Raikhlin N T, Bukaeva I A, Smirnova E A, et al. Expression of argyrophilic proteins in the nucleolar organizer regions of human thymocytes and thymic epitheliocytes under conditions of cocultureing with Vilon and epithalon peptides[J]. Bull Exp Biol Med, 2004, 137(6):24-6.
9. Kazakova T B, Barabanova S V, Novikova N S, et al. Synthesis of IL-2 mRNA in cells of rate hypothalamic structures after injection of short peptides[J]. Bull Exp Biol Med, 2005 June, 139(6):718 -20.
10. Xin H W, Zeng F D, Xie B J. The inhibitory effects on the growth of human hepatocellular carcinoma cell and its mechanism by theasinesin[J]. Chin Pharmacol Bull, 2001, 17(1):37-44.
11. Peng S P, Fang W Y, Jiang R C, et al. Prokaryotic expression of vascular basement membrane-derived multifunctional peptide and its anti-tumor activity assay[J]. Chin Pharmacol Bull, 2003, 19 (6):678-82.
12. Zhang W D, Cui Y Z, Yao C F, et al. Polypeptide extract from scorpion venom inhibits angiogenesis and angiogenesis-dependent tumor growth[J]. Chin Pharmacol Bull, 2005, 21(6):708-11.
13. Ma Y F, Chen J H, Zhang D M, et al. The antitumor activity of the extract from human urine[J]. Chin Pharmacol Bull, 2004, 20 (1):69-71.
14. Zhang D M, Chen J H, Li J, et al. The antitumor activity of ND 100 peptide[J]. Chin Pharmacol Bull, 2005, 21(1):114-6.