Prokaryotic expression of vascular basement membrane-derived multifunctional peptide and its anti-tumor activity assay

Chinese Pharmacological Bulletin

Volumn 19, Issue 6, 2003, Pages 678-682

  Peng, Shu Ping ^a   Fang, Wei Yi ^a   Jiang, Ri Cheng ^a   Zhou, Jian Guo ^a   Dong, Lin ^a   Cao, Jian Guo ^a  

^a UNIVERSITY OF SOUTH CHINA   (China)

Author keywords

Lewis lung carcinoma; Prokaryotic expression; Therapeutic action; Vascular basement membrane derived multifunctional peptide

Indexed keywords

GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE VASCULAR BASEMENT MEMBRANE DERIVED MULTIFUNCTIONAL FUSION PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN G3; PEPTIDE; PEPTIDE FRAGMENT; TUMSTATIN; UNCLASSIFIED DRUG; VASCULAR BASEMENT MEMBRANE DERIVED MULTIFUNCTIONAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASSAY; CANCER INHIBITION; CONTROLLED STUDY; DNA VECTOR; DRUG ACTIVITY; DRUG PURIFICATION; DRUG SYNTHESIS; ESCHERICHIA COLI; FUSION GENE; GENE CONSTRUCT; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSFORMATION; LEWIS CARCINOMA; METASTASIS INHIBITION; MOLECULAR CLONING; MOUSE; NONHUMAN; PROKARYOTE; PROKARYOTIC EXPRESSION VECTOR; PROTEIN PURIFICATION; RESTRICTION MAPPING; TUMOR GROWTH;

EID: 0042709321     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Timpl R, Wiedemann H, Delden VV et al. A network model for the organization of type IV collagen molecules in basement membranes. Eur J Biochem, 1981;120(2):203-11
2. Maeshima Y, Colorado PC, Torre A et al. Distinct antitumor properties of a type IV collagen domain derived from basement membrane. J Biol Chem, 2000;275(28):21340-8
3. 3 integrin and inhibits angiogenesis. J Biol Chem 2001;276(34):31959-68
4. Maeshima Y, Manfredi M, Reimer C et al. Identification of antiangiogenic site within vascular basement membrane-derived tumstatin. J Biol Chem, 2001;276(18):15240-6
5. 3 chain of type IV collagen on tumor cells. Cancer Res, 1999;59(18):4584-90
6. Maeshima Y, Colorado PC, Kalluri R. Two RGD-independent integrin binding sites on tumstatin regulates distinct antitumor properties. J Biol Chem. 2000;275(31):23745-50
7. Fawzi A, Robinet A, Monboisse JC et al. A peptide of the alpha 3 (IV) chain of type IV collagen modulates stimulated neutrophil function via activation of camp-dependent protein kinase and Ser/Thr protein phosphatase. Cell Signal, 2000;12(5):327-35
8. Rheinnecker M, Hardt C, Ilag LL et al. Multivalent antibody fragments with high functional affinity for a tumor-associated carbohydrate antigen. J Immunol, 1996;157(7):2989-97