Interleukin-18 induces apoptosis in human articular chondrocytes

Histology and Histopathology

Volumn 22, Issue 4-6, 2007, Pages 469-482

  John, Thilo ^a   Kohl, B ^a   Mobasheri, A ^b   Ertel, W ^a   Shakibaei, M ^c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

Apoptosis; Chondrocyte; COX 2; IL 18; MAPKinase; Matrix proteins; Osteoarthritis

Indexed keywords

BETA INTEGRIN; CASPASE 3; COLLAGEN TYPE 2; CYCLOOXYGENASE 2; FIBRIN; MATRIX PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN SHC; RECOMBINANT INTERLEUKIN 18; VINCULIN; CASP3 PROTEIN, HUMAN; FIBRONECTIN; INTERLEUKIN 18; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PTGS2 PROTEIN, HUMAN; UNCLASSIFIED DRUG; VCL PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CARTILAGE CELL; CATABOLISM; CELL CULTURE; CELL STIMULATION; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SYNTHESIS; FIBRIN DEPOSITION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; WESTERN BLOTTING; AGED; ARTICULAR CARTILAGE; CELL SHAPE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; FLUORESCENCE MICROSCOPY; METABOLISM; MIDDLE AGED; TIME; ULTRASTRUCTURE;

AGED; APOPTOSIS; BLOTTING, WESTERN; CARTILAGE, ARTICULAR; CASPASE 3; CELL SHAPE; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE II; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRONECTINS; HUMANS; INTEGRIN BETA CHAINS; INTERLEUKIN-18; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASES; TIME FACTORS; VINCULIN;

EID: 34247479045     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Aigner T., Hemmel M., Neureiter D., Gebhard PM., Zeiler G., Kirchner T. and McKenna L. (2001). Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritis human articular knee cartilage: a study of proliferation, programmed cell death (apoptosis), and viability of chondrocytes in normal and osteoarthritic human knee cartilage. Arthritis Rheum. 44, 1304-12.
2. Aigner T. and Kim HA. (2002). Apoptosis and cellular vitality: issues in osteoarthritic cartilage degeneration. Arthritis Rheum. 46, 1986- 1996.
3. Aizawa T., Kon T., Einhorn T.A. and Gerstenfeld L.C. (2001). Induction of apoptosis in chondrocytes by tumor necrosis factor-α. J. Orthop. Res. 19, 785-796.
4. Akira S. (2000). The role of IL-18 in innate immunity. Curr. Opin. Immunol. 12, 59-63
5. Akita K., Ohtsuki T., Nukada Y., Tanimoto T., Namba M., Okura T., Takakura-Yamamoto R., Torigoe K., Gu Y., Su MS., Fuji M., Satoh-Itoh M., Yamamoto K., Kohno K., Ikeda M. and Kurimoto M. (1997). Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin-18 in monocytic THP.1 cells. J. Biol. Chem. 272, 265595-265603.
6. Banda N.K., Vondracek A., Kraus D., Dinarello C.A., Kim S.H., Bendela A., Senaldi G. and Arend W.P. (2003). Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein. J. Immunol. 170, 2100-2105.
7. Barberis L., Wary K.K., Fiucci G., Liu F., Hirsch E., Brancaccio M., Altruda F., Tarone G. and Giancotti F.G. (2000). Distinct roles of the adaptor protein SHC and focal adhesion kinsae in integrin signaling to ERK. J. Biol. Chem. 47, 36532-36540.
8. Bessis N. and Boissier M.C. (2001). Novel pro-inflammatory interleukins: potential therapeutical targets in rheumatoid arthritis. Joint Bone Spine 68, 477-481.
9. Boileau C., Martel-Pelletier J., Moldovan F., Jouzeau J.Y., Netter P., Manning P.T. and Pelletier J.P. (2002). The in situ up-regulation of chondrocyte interleukin-l-converting enzyme and interleukin-18 level in experimental osteoarthritis is mediated by nitric oxide. Arthritis Rheum. 46, 2637-47.
10. Cao L., Lee V., Adams M.E., Kiani C., Zhang Y., Hu W. and Yang B.B. (1999). β1-integrin-collagen interaction reduces chondrocyte apoptosis. Matrix Biol. 18, 343-355.
11. Cohen G.M. (1997). Caspases: the executioners of apoptosis. Biochem. J. 326, 1-16.
12. Chandrasekar B., Vemula K., Surabhi R.M., Li-Weber M., Owen-Schaub L.B., Jensen L.E. and Mummidi S. (2004). Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death. J. Biol. Chem. 279, 20221-33.
13. Cornish J., Gillespie M.T., Callon K.E., Horwood N.J., Mosely J.M. and Reis I.R. (2003). Interleukin-18 is a novel mitogen of osteogenic and chondrogenic cells. Endocrinology 144, 1194-1201.
14. Dai S-M., Matsuno H., Nakamura H., Hishioka K. and Yudoh K. (2004). Interleukin-18 enhances monocyte tumor necrosis factor alpha and interleukin-1beta production induced by direct contact with T lymphocytes. Arthritis Rheum. 50, 432-443.
15. Dai S.M., Shan Z.Z., Nishioka K. and Yudoh K. (2005). Implication of interleukin 18 in production of matrix metalloproteinases in articular chondrocytes in arthritis: direct effect on chondrocytes may not be pivotal. Ann. Rheum. Dis. 64, 735-742.
16. Dinarello C.A. (2002). The IL-1 family and inflammatory diseases. Clin. Exp. Rheumatol. 20, S1-13.
17. Dieppe P.A. and Lohmander L.S. (2005). Pathogenesis and management of pain in osteoarthritis. Lancet 365, 965-973.
18. Dunne A. and O'Neill L.A. (2003). The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci STKE 171, re3.
19. Goggs R., Carter S.D., Schulze-Tanzil G., Shakibaei M. and Mobasheri A. (2003). Apoptosis and the loss of chondrocyte survival signals contribute to articular cartilage degradation in osteoarthritis. Vet. J. 166, 140-158.
20. Goldring M.B. (2000). The role of the chondrocyte in osteoarthritis. Arthritis Rheum. 43, 1916-1926.
21. Goldring S.R. and Goldring M.B. (2004). The role of cytokines in cartilage matrix degeneration in osteoarthritis. Clin. Orthop 427s, 27-36
22. Heraud F., Heraud A. and Harmand M.F. (2000). Apoptosis in normal and osteoarthritic human articular cartilage. Ann. Rheum. Dis 59, 959-965.
23. Hirsh M.S., Lunsford L.E., Trinkhaus-Randall V. and Svoboda K.K. (1997). Chondrocyte survival and differentiation in situ are integrin mediated. Dev. Dyn. 210, 249-263.
24. Homandberg G.A. (1999). Potential regulation of cartilage metabolism in osteoarthritis by fibronectin fragments. Front. Biosci. 4, 713- 730.
25. Jackson D.W., Simon T.M. and Aberman H.M. (2001). The articular cartilage repair dilemma: symptomatic articular cartilage degeneration. Clin. Orthop. Rel. Res. 391S, S14-S25.
26. Joosten L.A., van De Loo F.A., Lubberts E., Helsen M.M., Netea M.G., van Der Meer J.W., Dinarello C.A. and van Den Berg W.B. (2000). An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis. J. Immunol. 165, 6553-6558.
27. Joosten L.A., Smeets R.L., Koenders M.I., van den Bersselaar L.A., Helse M.M., Oppers-Walgreen B., Lubberts E., Iwakura Y., van de Loo F.A. and van den Berg W.B. (2004). Interleukin-18 promotes joint inflammation and induces interleukin-l-driven cartilage destruction. Am. J. Pathol. 165, 959-967.
28. Kasiwamura S., Ueda H. and Okamura H. (2002). Roles of Interleukin- 18 in tissue destruction and compensatory reactions. J. Immunother. 25, S4-11.
29. Kojima F., Naraba H., Miyamoto S., Beppu M., Aoki H. and Kawai S. (2004). Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis. Arthritis Res. Ther. 6, R355- R365.
30. Kolettas E., Muir H.I., Barrett J.C. and Hardingham T.E. (2001). Chondrocyte phenotype and cell survival are regulated by culture conditions and by specific cytokines through the expression of sox-9 transcription factor. Rheumatology 40, 1146-1156.
31. Kühn K., D'Lima D.D., Hashimoto S. and Lotz M. (2004). Cell death in cartilage. Osteoarthritis Cartilage 12, 1-16.
32. Lee J-K., Kim S-H., Lewis E-C., Azam T., Reznikov L-L. and Dinarello C.A. (2004). Differences in signaling pathways by IL-18 and IL-18. PNAS101, 8815-8820.
33. Lotz M.L. (2001). Cytokines in cartilage injury and repair. Clin. Orthop. Rel. Dis. 391S, S108-Sl15.
34. Lotz M., Hashimoto S. and Kühn K. (1999). Mechanisms of chondrocyte apoptosis. Osteoarthritis Cartilage 7, 389-391.
35. Marino E. and Cardier JE. (2003). Differential effect of IL-18 on endothelial cell apoptosis mediated by TNF-α and Fas (CD95). Cytokine 22, 142-148.
36. Matsui K., Tsutsui H. and Nakanishi K. (2003). Pathophysiological roles for IL-18 in inflammatory arthritis. Expert Opin. Ther. Targets 7, 701-724.
37. Meredith J.E., Fazeli B. and Schwartz M.A. (1993). The extracellular matrix as a cell survival factor. Mol. Biol. Cell 4, 953-961.
38. Moller B., Paulukat J., Nold M., Behrens M., Kukoc-Zivojnov N., Kaltwasser J.P., Pfeilschifter J. and Muhl H. (2003). Interferon- gamma induces expression of interleukin-18 binding protein in fibroblast-like synoviocytes. Rheumatology 42, 442-445.
39. Muratami S., Lefebvre V. and deCrombrugghe B. (2000). Potent inhibition of the master chondrogenic factor sox9 gene by interleukin-1 and tumor necrosis factor-α. J. Biol. Chem. 275, 3687-3692.
40. Olee T., Hashimoto S., Quach J. and Lotz M. (1999). IL-18 is produced by articular chondrocytes and induces pro-inflammatory and catabolic responses. J. Immunol. 162, 1096-1100.
41. Plater-Zyberk C., Joosten L.A., Helsen M.M., Sattonnet-Roche P., Siegfried C., Alouani S., van de Loo F.A., Graber P., Aloni S., Cirillo R., Lubberts E., Dinarello C.A., van den Berg W.B. and Chvatchko Y. (2001). Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis. J. Clin. Invest. 108, 1825-32
42. Roach H.I. and Clarke N.M. (2000). Physiological cell death of chondrocytes in vivo is not confined to apoptosis. New observations on the mammalian growth plate. J. Bone Joint Surg. Br. 82, 601- 613.
43. Robbins J.R., Thomas B.., Tan L., Choy B., Arbiser J.L., Berenbaum F. and Goldring M.B. (2000). Immortalized human adult articular chondrocytes maintain cartilage-specific phenotype and responses to interleukin-18. Arthritis Rheum. 43, 2189-2201.
44. Sandell LJ. and Aigner T. (2002). Articular cartilage and changes in arthritis: An introduction: Cell biology of osteoarthritis. Arthritis Res. 3, 107-113.
45. Schulze-Tanzil G., de Souza P., Villegas Castrejon H., John T., Merker H-J., Scheid A. and Shakibaei M. (2002). Redifferentiation of dedifferentiated human chondrocytes in high-density cultures. Cell Tis. Res. 308, 371-379.
46. Schulze-Tanzil G., Mobasheri A., Sendzik J., John J. and Shakibaei M. (2004). The effects of curcumin (diferuloylmethane) on NF-ÎB signalling in IL-1,-stimulated chondrocytes. Ann. NY Ok'd. Sci. 1030, 577-585.
47. Shakibaei M. and de Souza P. (1997). Differentiation of mesenchymal limb bud cells to chondrocytes in alginate beads. Cell Biol. Int. 21, 75-86.
48. Shakibaei M., John T., de Souza P., Rahmanzadeh R. and Merker H-J. (1999). Signal transduction by β1-integrin receptors in human chondrocytes in vitro: collaboration with the insulin-like growth factor-I receptor. Biochem. J. 342, 615-623.
49. Shakibaei M., Schulze-Tanzil G., de Souza P., John T., Rahmanzadeh M., Rahmanzadeh R. and Merker H-J. (2001). Inhibition of mitogen- activated protein kinase induces apoptosis of human chondrocytes. J. Biol. Chem. 276, 13289-13294.
50. Smeets R.L., van de Loo F.A., Arntz O.J., Bennink M.B., Joosten L.A. and van den Berg W.B. (2003). Adenoviral delivery of IL-18 binding protein C ameliorates collagen-induced arthritis in mice. Gene Ther. 10, 1004-1011.
51. Van der Kraan P.M. and van den Berg WB. (2003). Anabolic and desrtuctive mediators in osteoarthritis. Curr. Opin. Clin. Nutr. Metab. Care 3, 205-211
52. Van de Loo F.A.J., Joosten L.A. van Lent P.L., Arntz O.J. and van den Berg W.B. (1995). Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteo-glycanmetabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis. Arthritis Rheum. 38, 64-72.
53. Vervoordeldonk M.J. and Tak P.P. (2002). Cytokines in rheumatoid arthritis. Curr. Rheumatol. Rep. 4, 208-217.
54. Yang C., Li S-W., Helminen H.J., Khillan J.S., Bao Y. and Prockop D.J. (1997). Apoptosis of chondrocytes in transgenic mice lacking collagen II. Exp. Cell Res. 235, 370-373.