Lack of potassium channel induces proliferation and survival causing increased neurogenesis and two-fold hippocampus enlargement

Hippocampus

Volumn 17, Issue 4, 2007, Pages 292-304

  Almgren, Malin ^a,c   Persson, Ann Sophie ^a   Fenghua, Chen ^b   Witgen, Brent M ^b   Schalling, Martin ^a   Nyengaard, Jens R ^b   Lavebratt, Catharina ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b AARHUS UNIVERSITY   (Denmark)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Apoptosis; Epilepsy; Hyperplasia; Kv1.1; Megalencephaly

Indexed keywords

BROXURIDINE; KI 67 ANTIGEN; POTASSIUM CHANNEL KV1.1; SHAKER POTASSIUM CHANNEL;

ALEXANDER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN SIZE; CELL COUNT; CELL HYPERPLASIA; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DENTATE GYRUS; EPILEPSY; HIPPOCAMPUS; MOUSE; MUTATION; NERVOUS SYSTEM DEVELOPMENT; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; SEIZURE; SURVIVAL RATE;

ANIMALS; ANIMALS, NEWBORN; BROMODEOXYURIDINE; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; HIPPOCAMPUS; IN SITU NICK-END LABELING; KI-67 ANTIGEN; KV1.1 POTASSIUM CHANNEL; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, MUTANT STRAINS; NEURONS; STEREOTAXIC TECHNIQUES;

EID: 34247470685     PISSN: 10509631     EISSN: 10981063     Source Type: Journal    
DOI: 10.1002/hipo.20268     Document Type: Article

References (35)

1. Abrous DN, Koehl M, Le Moal M. 2005. Adult neurogenesis: from precursors to network and physiology. Physiol Rev 85:523-569.
2. Altman J, Das GD. 1965. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Comp Neurol 124:319-335.
3. Cameron HA, Woolley CS, McEwen BS, Gould E. 1993. Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat. Neuroscience 56:337-344.
4. Diez M, Schweinhardt P, Petersson S, Wang FH, Lavebratt C, Schalling M, Hokfelt T, Spenger C. 2003. MRI and in situ hybridization reveal early disturbances in brain size and gene expression in the megencephalic (mceph/mceph) mouse. Eur J Neurosci 18: 3218-3230.
5. Donahue LR, Cook SA, Johnson KR, Bronson RT, Davisson MT. 1996. Megencephaly: A new mouse mutation on chromosome 6 that causes hypertrophy of the brain. Mamm Genome 7:871-876.
6. Dorph-Petersen KA, Nyengaard JR, Gundersen HJ. 2001. Tissue shrinkage and unbiased stereological estimation of particle number and size. J Microsc 204 (Part 3):232-246.
7. Ekhterae D, Platoshyn O, Krick S, Yu Y, McDaniel SS, Yuan JX. 2001. Bcl-2 decreases voltage-gated K+ channel activity and enhances survival in vascular smooth muscle cells. Am J Physiol Cell Physiol 281:057-065.
8. Gundersen HJ. 1988. The nucleator. J Microsc 151 (Part 1):3-21.
9. Gundersen HJ, Bagger P, Bendtsen TF, Evans SM, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, Pakkenberg B. 1988. The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 96:857-881.
10. Gundersen HJ, Jensen EB. 1987. The efficiency of systematic sampling in stereology and its prediction. J Microsc 147:229-263.
11. Hallows JL, Tempel BL. 1998. Expression of Kv1.1, a Shaker-like potassium channel, is temporally regulated in embryonic neurons and glia. J Neurosci 18:5682-5691.
12. Hille B. 2001. Ion Channels of Excitable Membranes. Sunderland, Mass: Sinauer Associates.
13. Hinds JW. 1968. Autoradiographic study of histogenesis in the mouse olfactory bulb. I. Time of origin of neurons and neuroglia. J Comp Neurol 134:287-304.
14. Humphrey WM, Dong H, Csernansky CA, Csernansky JG. 2002. Immediate and delayed hippocampal neuronal loss induced by kainic acid during early postnatal development in the rat. Brain Res Dev Brain Res 137:1-12.
15. Jessberger S, Romer B, Babu H, Kempermann G. 2005. Seizures induce proliferation and dispersion of doublecortin-positive hippocampal progenitor cells. Exp Neurol 196:342-351.
16. Kaplan MS, Hinds JW. 1977. Neurogenesis in the adult rat: Electron microscopic analysis of light radioautographs. Science 197:1092-1094.
17. Kempermann G, Gast D, Kronenberg G, Yamaguchi M, Gage FH. 2003. Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. Development 130:391-399.
18. Lavebratt C, Trifunovski A, Persson AS, Wang FH, Klason T, Ohman I, Josephsson A, Olson L, Spenger C, Schalling M. 2006. Carbamazepine protects against megencephaly and abnormal expression of BDNF and Nogo signaling components in the mceph/mceph mouse. Neurobiol Dis 24:374-383.
19. Lee AL, Dumas TC, Tarapore PE, Webster BR, Ho DY, Kaufer D, Sapolsky RM. 2003. Potassium channel gene therapy can prevent neuron death resulting from necrotic and apoptotic insults. J Neurochem 86:1079-1088.
20. Lee J, Duan W, Mattson MP. 2002. Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem 82:1367-1375.
21. Lie DC, Song H, Colamarino SA, Ming GL, Gage FH. 2004. Neurogenesis in the adult brain: New strategies for central nervous system diseases. Annu Rev Pharmacol Toxicol 44:399-421.
22. Lois C, Alvarez-Buylla A. 1993. Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia. Proc Nad Acad Sci USA 90:2074-2077.
23. Misonou H, Trimmer JS. 2004. Determinants of voltage-gated potassium channel surface expression and localization in Mammalian neurons. Crit Rev Biochem Mol Biol 39:125-145.
24. Ouadid-Ahidouch H, Chaussade F, Roudbaraki M, Slomianny C, Dewailly E, Delcourt P, Prevarskaya N. 2000. KV1.1 K(+) channels identification in human breast carcinoma cells: Involvement in cell proliferation. Biochem Biophys Res Commun 278:272-277.
25. Palmer TD, Willhoite AR, Gage FH. 2000. Vascular niche for adult hippocampal neurogenesis. J Comp Neurol 425:479-494.
26. Parent JM, Janumpalli S, McNamara JO, Lowenstein DH. 1998. Increased dentate granule cell neurogenesis following amygdala kindling in the adult rat. Neurosci Lett 247:9-12.
27. Parent JM, Lowenstein DH. 2002. Seizure-induced neurogenesis: Are more new neurons good for an adult brain? Prog Brain Res 135:121-131.
28. Parent JM, Yu TW, Leibowitz RT, Geschwind DH, Sloviter RS, Lowenstein DH. 1997. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J Neurosci 17:3727-3738.
29. Persson AS, Klement G, Almgren M, Sahlholm K, Nilsson J, Petersson S, Arhem P, Schalling M, Lavebratt C. 2005. A truncated Kv1.1 protein in the brain of the megencephaly mouse, expression and interaction. BMC Neurosci 6:65.
30. Petersson S, Lavebratt C, Schalling M, Hokfelt T. 2000. Expression of cholecystokinin, enkephalin, galanin and neuropeptide Y is markedly changed in the brain of the megencephaly mouse. Neuroscience 100:297-317.
31. Petersson S, Persson AS, Johansen JE, Ingvar M, Nilsson J, Klement G, Arhem P, Schalling M, Lavebratt C. 2003. Truncation of the Shaker-like voltage-gated potassium channel, Kv1.1, causes megencephaly. Eur J Neurosci 18:3231-3240.
32. Petersson S, Sandberg Nordqvist A, Schalling M, Lavebratt C. 1999. The megencephaly mouse has disturbances in the insulin-like growth factor (IGF) system. Brain Res Mol Brain Res 72:80-88.
33. Sun FY, Guo X. 2005. Molecular and cellular mechanisms of neuroprotection by vascular endothelial growth factor. J Neurosci Res 79:180-184.
34. West MJ. 1993. Regionally specific loss of neurons in the aging human hippocampus. Neurobiol Aging 14:287-293.
35. Yuan J, Yankner BA. 2000. Apoptosis in the nervous system. Nature 407:802-809.