Immediate and delayed hippocampal neuronal loss induced by kainic acid during early postnatal development in the rat

Developmental Brain Research

Volumn 137, Issue 1, 2002, Pages 1-12

  Humphrey, William M ^a   Dong, HongXin ^a   Csernansky, Cynthia A ^a   Csernansky, John G ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Development; Electron microscopy; Excitotoxicity; Hippocampus; HSP 70; Kainic acid; Neuronal loss; Nissl; Schizophrenia; TUNEL

Indexed keywords

HEAT SHOCK PROTEIN 70; KAINIC ACID; THIONINE;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CONTROLLED STUDY; DOSE RESPONSE; ELECTRON MICROSCOPY; FEMALE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NERVE CELL DIFFERENTIATION; NERVE CELL NECROSIS; NEWBORN; NICK END LABELING; NONHUMAN; PERINATAL PERIOD; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PUBERTY; RAT;

AGE FACTORS; ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; CELL COUNT; EXCITATORY AMINO ACID AGONISTS; FEMALE; HIPPOCAMPUS; IN SITU NICK-END LABELING; KAINIC ACID; MICROSCOPY, ELECTRON; MICROTOMY; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; SCHIZOPHRENIA;

EID: 0037199340     PISSN: 01653806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-3806(02)00344-9     Document Type: Article

References (32)

1. Kainic acid-induced seizures: A developmental study
2. Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia
3. Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical hippocampal interactions
4. Kainic acid decreases hippocampal neuronal number and increases dopamine receptor binding in the nucleus accumbens: An animal model of schizophrenia
5. Myelination of a key relay zone in the hippocampal formation occurs in the human brain during childhood, adolescence, and adulthood
6. Advancing a neurodevelopmental origin for schizophrenia
7. Ontogenetic development of kainate neurotoxicity: Correlates with glutamatergic innervation
8. Intrahippocampal injection of kainic acid produces significant pyramidal cell loss in neonatal rats
9. Schizophrenia as an anomaly of development of cerebral asymmetry: A postmortem study and a proposal concerning the genetic basis of the disease
10. Limbic-cortical neuronal damage and the pathophysiology of schizophrenia
11. Neuronal degeneration after intracerebroventricular kainic acid administration in rats: Implications for neurodegeneration in schizophrenia?
12. Naturally occurring cell death in the subiculur complex and hippocampus in the rat during development
13. DNA fragmentation in rat brain after intraperitoneal administration of kainite
14. Distinguishing excitotoxic from apoptotic neurodegeneration in the developing rat brain
15. Prenatal developmental disturbances in the limbic allocortex in schizophrenics
16. Neuronal apoptosis: Current understanding of molecular mechanisms and potential role in ischemic brain injury
17. Temporal lobe sulco-gyral pattern anomalies in schizophrenia: An in vivo MR three-dimensional surface rendering study
18. Neuron loss, mossy fiber sprouting, and interictal spikes after intrahippocampal kainite in developing rats
19. The heat shock response
20. Induction of c-fos mRNA expression in an in vitro hippocampal slice model of adult rats after kainate but not γ-aminobutyric acid or bicuculline treatment
21. A study of apoptosis in normal and pathologic nervous system tissue after in situ end-labeling of DNA strand breaks
22. Delayed neuronal loss after administration of intracerebroventricular kainic acid to preweanling rats
23. Preferential vulnerability of hippocampus to intraventricular kainic acid
24. Kainate-induced apoptotic cell death in hippocampal neurons
25. Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: Further evidence for an apoptosis-necrosis continuum
26. Kindling is associated with the formation of novel mossy fiber synapses in the CA3 region
27. An immature mossy fiber innervation of hilar neurons may explain their resistance to kainate-induced cell death in 15 day-old rats
28. Implications of normal brain development for the pathogenesis of schizophrenia
29. Three-dimensional counting: An accurate and direct method to estimate numbers of cells in sectioned material
30. Kainate and glutamate neurotoxicity is dependent on the postnatal development with specific reference to hippocampal neurons
31. Size, shape and orientation of neurons in the left and right hippocampus: Investigation of normal asymmetries and alterations in schizophrenia