No association between ADRA2A polymorphisms and schizophrenia

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 144, Issue 3, 2007, Pages 341-343

  Clark, D A ^a   Mata, I ^b   Kerwin, R W ^a   Munro, J ^a   Arranz, M J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b Fundacion Argibide   (Spain)

Author keywords

Alpha2A adrenergic receptor; Genetics; Promoter; Psychosis

Indexed keywords

ADENINE; ALPHA 2A ADRENERGIC RECEPTOR; CYTOSINE; GUANINE; THYMINE;

ADRA2A GENE; ADULT; ARTICLE; BIOINFORMATICS; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RECEPTOR GENE; REGULATORY SEQUENCE; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; LINKAGE (GENETICS); MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ADRENERGIC, ALPHA-2; SCHIZOPHRENIA;

EID: 34247382411     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30355     Document Type: Article

References (16)

1. Ahmed I, Takeshita J. 1996. Clonidine: A critical review of its role in the treatment of psychiatric disorders. CNS Drugs 6:53-70.
2. Arnsten AFT. 2004. Adrenergic targets for the treatment of cognitive deficits in schizophrenia. Psychopharmacology 174:25-31.
3. Arnsten AFT, Goldman-Rakic PS. 1985. Alpha-2 adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates. Science 230:1273-1276.
4. Bertranpetit J, Cavalli-Sforza LL. 1991. A genetic reconstruction of the history of the population of the Iberian Peninsula. Ann of Hum Genet 55(1):51-67.
5. Bolonna AA, Arranz MJ, Munro J, Osbourne S, Petouni M, Martinez M, Kerwin RW. 2000. No influence of adrenergic receptor polymorphisms on schizophrenia and antipsychotic response. Neurosci Lett 280:65-68.
6. Calderón R, Carrion M, Pérez-Miranda AM, Pena JA, Dugoujon JM, Crouau-Roy B. 2003. Allele variation of DYS19 and Y-Alu insertion (YAP) polymorphisms in Basques: An insight into the peoplingof Europe and the Mediterranean region. Hum Biol 75(1):117-127.
7. Clark DA, Arranz MJ, Mata I, Lopéz-Ilundain J, Pérez-Neivas F, Kerwin RW. 2005. Polymorphisms in the promoter region of the alpha1A-adrenoceptor gene are associated with schizophrenia/schizoaffective disorder in a Spanish isolate population. Biol Psychiatry 58(6):435-439.
8. Coull JT. 1994. Pharmacological manipulations of the alpha2-noradrenergic system. Effects on cognition. Drugs Aging 5:116-126.
9. Fields RB, van Kammen DP, Peters J, Rosen JL, van Kammen WB, Nugent A, Stipetic M, Linnoila M. 1988. Clonidine improves memory function in schizophrenia independently from change in psychosis. Schizophr Res 1:417-423.
10. Franowicz JCS, Kessler L, Dailey-Borja CM, Kobilka BK, Limbird LE, Arnsten AFT. 2002. Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine. J Neurosci 22:8771-8777.
11. Handy DE, Gavras H. 1992. Promoter region of the human alpha2A adrenergic receptor gene. J Biol Chem 267(33):24017-24022.
12. Lahdesmaki J, Sallinen J, MacDonald E, Scheinin M. 2004. Alpha2A-adrenoceptors are important modulators of the effects of D-amphetamine on startle reactivity and brain monoamines. Neuropsychopharmacology 29:1282-1293.
13. Leysen JE. 2002. Atypical antipsychotics. In: Borrelli E, Di Chiara D, editors. Handbook of experimental pharmacology, vol 154(II). Berlin: Springer Verlag. pp 473-489.
14. Pérez-Miranda AM, Alfonso-Sánchez MA, Pena JA, Calderón R. 2003. HLA-DQA1 polymorphism in autochthonous Basques from Navarre (Spain): Genetic position within European and Mediterranean scopes. Tissue Antigens 61:465-474.
15. Tsai SJ, Wang Y, Younger Y, Lin C, Yang K, Hong CJ. 2001. Association analysis of polymorphism in the promoter region of the alpha2A-adrenoceptor gene with schizophrenia and clozapine response. Schizophr Res 49:53-58.
16. Weiss KM, Terwilliger JD. 2000. How many diseases does it take to map a gene with SNPs? Nature Genetics 26(2):151-157.