Insights into the molecular biology of adrenocortical tumors

Experimental and Clinical Endocrinology and Diabetes

Volumn 115, Issue 3, 2007, Pages 175-178

  Groussin, L ^a   Bertherat, J ^a   Gicquel, C ^a   Le Bouc, Y ^a   Bertagna, X ^a,b  

^a INSTITUT COCHIN   (France)

^b Hôpital Cochin ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; CYCLIC AMP; MEMBRANE RECEPTOR; PROTEIN P53; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; THYROTROPIN RECEPTOR; TUMOR MARKER;

ACROMEGALY; ADRENAL CORTEX ADENOMA; ADRENAL CORTEX CARCINOMA; ADRENAL CORTEX TUMOR; ALBRIGHT SYNDROME; BECKWITH WIEDEMANN SYNDROME; CARNEY COMPLEX; CHROMOSOME 11P; CHROMOSOME 17P; CHROMOSOME 2P; CUSHING SYNDROME; DISEASE COURSE; FAMILIAL CANCER; GENE LOCUS; GENE MUTATION; GENE OVEREXPRESSION; HEART MYXOMA; HETEROZYGOSITY LOSS; HORMONE RELEASE; HUMAN; LENTIGINOSIS; MOLECULAR CLONING; MULTIPLE ENDOCRINE NEOPLASIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; TESTIS TUMOR; THYROID ADENOMA; TUMOR SUPPRESSOR GENE;

ADRENAL CORTEX NEOPLASMS; CARCINOMA; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN; CYCLIC AMP; HUMANS; MOLECULAR BIOLOGY; MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; MUTATION;

EID: 34247374234     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-970411     Document Type: Review

References (27)

1. Allolio B, Hahner S, Weismann D, Fassnacht M: Management of adrenocortical carcinoma. Clin Endocrinol 2004; 60: 273-287
2. Bertherat J: Protein kinase A in Carney Complex: a new example of cAMP pathway alteration in endocrine tumors. Eur J Endocrinol 2001; 144: 209-211
3. Bertherat J, Gicquel C, Le Bouc Y, Bertagna X: Molecular genetics of adrenal tumours. In: John AH Wass and Stephen M Shalet, (eds). Oxford textbook of Endocrinology and Diabetes. Oxford: Oxford University Press, 2002; 831-842
4. Bertherat J, Groussin L, Sandrini F, Matyakhina L, Bei T, Stergiopoulos S, Papageorgiou T, Bourdeau I, Kirschner LS, Vincent-Dejean C, Perlemoine K, Gicquel C, Bertagna X, Stratakis CA: Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity. Cancer Res 2003; 63: 5308-5319
5. Bertherat J, Contesse V, Louiset E, Barrande G, Duparc C, Groussin L, Emy P, Bertagna X, Kuhn JM, Vaudry H, Lefebvre H: In vivo and in vitro Screening for illegitimate receptors in AIMAH causing Cushing's syndrome: Identification of two cases of gonadotropin/GIP-dependent hypercortisolism. J Clin Endocrinol Metab 2005; 90: 1302-1310
6. Beuschlein F, Reincke M, Karl M, Travis WD, Jaursch-Hancke C, Abdel hamid S, Chrousos GP, Allolio B: Clonal composition of human adrenocortical neoplasms. Cancer Res 1994; 54: 4927-4932
7. Bornstein SR, Stratakis CA, Chrousos GP: Adrenocortical tumors: recent advances in basic concepts and clinical management. Ann Intern Med 1999; 130: 759-771
8. Carney JA, Gordon H, Carpenter PC, Shenoy BV, Go VL: The complex of myxomas, spotty pigmentation, and endocrine overactivity. Medicine (Baltimore) 1985; 64: 270-283
9. De Fraipont F, El Atifi M, Le Moigne G, Defaye G, Houlgatte R, Bertherat J, Bertagna X, Plouin PF, Baudin E, Berger F, Gicquel C, Chabre O, Feige JJ: Gene expression profiling of human adrenocortical tumors using complementary cDNA micro-arrays identifies several candidate genes as markers of malignancy. J Clin Endocrinol Metab 2005; 90: 1819-1829
10. Gicquel C, Leblond-Francillard M, Bertagna X, Louvel A, Chapuis Y, Luton JP, Girard F, Le Bouc Y: Clonal analysis of human adrenocortical carcinomas and secreting-adenomas. Clin Endocrinol (Oxf) 1994; 40: 465-477
11. Gicquel C, Raffin-Sanson ML, Gaston V, Bertagna X, Plouin PF, Schlum berger M, Louvel A, Luton JP, Le Bouc Y: Structural and functional abnormalities at 11p15 are associated with the malignant phenotype in sporadic adrenocortical tumors. Study on a series of 82 tumors. J Clin Endocrinol Metab 1997; 87: 2559-2565
12. Cicquel C, Bertagna X, Gaston V, Coste J, Louvel A, Baudin E, Bertherat J, Chapuis Y, Duelos JM, Schlumberger M, Plouin PF, Luton JP, Le Bouc Y: Molecular markers and long-term recurrences in a large cohort of patients with sporadic adrenocortical tumors. Cancer Res 2001; 61: 6762-6767
13. Giordano TJ, Thomas DG, Kuick R, Lizyness M, Misek DE, Smith AL, Sand ers D, Aljundi RT, Gauger PG, Thompson NW, Taylor JM, Hanash SM: Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis. Am J Pathol 2003; 162: 521-531
14. Groussin L, Kirschner LS, Vincent-Dejean C, Perlemoine K, Jullian E, Delemer B, Zacharieva S, Pignatelli D, Carney JA, Luton JP, Bertagna X, Stratakis CA, Bertherat J: Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit IA (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD. Am J Hum Genet 2002; 71: 1433-1442
15. Groussin L, Jullian E, Perlemoine K, Louvel A, Leheup B, Luton JP, Bertagna X, Bertherat J: Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease. J Clin Endocrinol Metab 2002; 87: 4324-4329
16. Kirschner LS, Carney JA, Pack SD, Taymans SE, Giatzakis C, Cho YS, Cho-Chung YS, Stratakis CA: Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. Nat Genet 2000; 26: 89-92
17. Kirschner LS, Sandrini F, Monbo J, Lin JP, Carney JA, Stratakis CA: Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the Carney complex. Hum Mol Genet 2000; 9: 3037-3046
18. Kjellman M, Roshani L, Teh BT, Kallioniemi OP, Hoog A, Gray S, Farnebo LO, Holst M, Backdahl M, Larsson C: Genotyping of adrenocortical tumors: very frequent deletions of the MEN1 locus in 11q13 and of a 1-centimorgan region in 2p16. J Clin Endocrinol Metab 1999; 84: 730-735
19. Lacroix A, Bolte E, Tremblay J, Dupre J, Poitras P, Fournier H, Garon J, Ganel D, Bayard F, Taillefer R et al: Gastric inhibitory polypeptide-dependent cortisol hypersecretion - a new cause of Cushing's syndrome. N Engl J Med 1992; 327: 974-980
20. Lacroix A, Ndiaye N, Tremblay J, Hamet P: Ectopic and abnormal hormone receptors in adrenal Cushing's syndrome. Endocrinol Rev 2001; 22: 75-110
21. Latronico AC, Chrousos G: Extensive personal experience: adrenocortical tumors. J Clin Endocrinol Metab 1997; 85: 1317-1324
22. Logié A, Boulie N, Gaston V, Perin L, Boudou P, Le Bouc Y, Gicquel C: Autocrine role of IGF-II in proliferation of human adrenocortical carcinoma NCI H295R cell line. J Mol Endocrinol 1999; 23: 23-32
23. Luton JP, Cerdas S, Billaud L, Thomas G, Guilhaume B, Bertagna X, Laudat MH, Louvel A, Chapuis Y, Blondeau P, Bricaire H: Clinical features of adrenocortical carcinoma, prognostic factors, and the effect of mitotane therapy. N Engl J Med 1990; 322: 1195-1201
24. Pilon C, Pistorello M, Moscon A, Altavilla G, Pagotto U, Boscaro M, Fallo F: Inactivation of the p16 tumor suppressor gene in adrenocortical tumors. J Clin Endocrinol Metab 1999; 84: 2776-2779
25. Reineke M, Beuschlein F, Slawik M, Borm K: Molecular adrenocortical tumourigenesis. Eur J Clin Invest 2000; 30: 63-68
26. Reznik Y, Allali-Zerah V, Chayvialle A, Leroyer R, Leymarie P, Travert G, Lebrethon MC, Budi I, Balliere AM, Mahoudeau J: Food-dependent Cushing's syndrome mediated by aberrant adrenocortical sensitivity to gastric inhibitory polypeptide. N Engl J Med 1992; 327: 981-986
27. Weinstein LS, Shenker A, Gejman PV, Merino MJ, Friedman E, Spiegel AM: Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. N Engl J Med 1991; 325: 1688-1716