Genotyping of adrenocortical tumors: Very frequent deletions of the MEN1 locus in 11q13 and of a 1-centimorgan region in 2p16

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 2, 1999, Pages 730-735

  Kjellman, Magnus ^a   Roshani, Leyla ^a   Bin Tean, Teh ^a   Kallioniemi, Olli Pekka ^b   Höög, Anders ^a   Gray, Steven ^a   Farnebo, Lars Ove ^a   Holst, Mikael ^a   Bäckdahl, Martin ^a   Larsson, Catharina ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF TAMPERE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ADRENAL TUMOR; ARTICLE; CARNEY COMPLEX; CHROMOSOME 11Q; CHROMOSOME 2P; DNA SEQUENCE; FAMILIAL CANCER; GENE LOCUS; GENE MAPPING; GENOTYPE; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MULTIPLE ENDOCRINE NEOPLASIA; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADENOMA; ADRENAL CORTEX NEOPLASMS; ADULT; AGED; CARCINOMA; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 2; DNA MUTATIONAL ANALYSIS; FEMALE; GENE DELETION; GENES, TUMOR SUPPRESSOR; GENOTYPE; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MULTIPLE ENDOCRINE NEOPLASIA TYPE 1;

EID: 0032979047     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.2.730     Document Type: Article

References (23)

1. 1. Teh B. 1998 Recent advances in multiple endocrine neoplasia type 1. Curr Opin Endocrinol Diabetes. 5:35-39.
2. 2. Ballard H, Frame B, Hartsock R. 1964 Familial multiple endocrine adenomapeptic ulcer complex. Medicine. 43:494-525.
3. 3. Skogseid B, Larsson C, Lindgren F, et al. 1992 Clinical and genetic features of adrenocortical lesions in multiple endocrine neoplasia type 1. J Clin Endocrinol Metab. 75:76-81.
4. 4. Burgess J, Harle R, Tucker P, et al. 1996 Adrenal lesions in a large kindred with multiple endocrine neoplasia type 1. Arch Surg. 131:699-702.
5. 5. Larsson C, Skogseid B, Öberg K, Nakamura Y, Nordenskjöld M. 1988 Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature. 332:85-87.
6. 6. Chandrasekharappa S, Guru S, Manickam P, et al. 1997 Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science. 276:404-407.
7. 7. The European Consortium on MEN. 1 1997 Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. Hum Mol Genet. 6:1177-1183.
8. 8. Stratakis C, Carney J, Lin J, et al. 1996 Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2. J Clin Invest. 97:699-705.
9. 9. Kjellman M, Kallioniemi O-P, Karhu R, et al. 1996 Genetic aberrations in adrenocortical tumors detected using comparative genomic hybridization correlate with tumor size and malignancy. Cancer Res. 56:4219-4223.
10. 10. Sameshima Y, Tsunematsu Y, Watanabe S, et al. 1992 Detection of novel germ-line p53 mutations in diverse-cancer-prone families identified by selecting patients with childhood adrenocortical carcinoma. J Natl Cancer Inst. 84:703-707.
11. 11. Ohgaki H, Kleihues P, Heitz P. 1993 p53 mutations in sporadic adrenocortical tumors. Int J Cancer. 54:408-410.
12. 12. Iida S, Fujii H, Moriwaki K. 1997 A somatic mutation of the p21(Waf1/Cip1) gene in a human adrenocortical adenoma. Anticancer Res. 17:633-636.
13. 13. Reincke M, Mora P, Beuschlein F, Arlt W, Chrousos G, Allolio B. 1997 Deletion of the adrenocorticotropin receptor gene in human adrenocortical tumors: implications for tumorigenesis. J Clin Endocrinol Metab. 82: 3054-3058.
14. 14. Gray S, Kjellman M, Larsson C, Ekström T. 1997 Allelic expression imbalance and preferential splicing of IGF2 in adrenocortical tumors. Biochem Biophys Res Commun. 239:878-883.
15. 15. Beuschlein F, Schultze E, Mora P, et al. 1998 Steroid 21-hydroxylase mutations and 21-hydroxylase messenger ribonuceic acid expression in human adrenocortical tumors. J Clin Endocrinol Metab. 83:2585-2588.
16. 16. Gicquel C, Raffin-Sanson M, Gaston V, et al. 1997 Structural and functional abnormalities at 11p15 are associated with the malignant phenotype in sporadic adrenocortical tumors: study on a series of 82 tumors. J Clin Endocrinol Metab. 82:2559-2565.
17. 16a. Kjellman, M., et al. No overrepresentation of congenital adrenal hyperplasia in Swedish patients with adrenocortical tumors. Clin Endocrinol (Oxf). In press.
18. 17. Shibata D. 1994 Extraction of DNA from paraffin-embedded tissue for analysis by polymerase chain reaction: new tricks from an old friend. Hum Pathol. 25:561-563.
19. 18. Hazan J, Dubay C, Pankowiak M, Becuwe N, Weissenbach J. 1992 A genetic linkage map of human chromosome 20 composed entirely of microsatellite markers. Genomics. 12:183-189.
20. 19. Hedeland H, Östberg G, Hökfelt B. 1968 On the prevalence of adrenocortical adenomas in an autopsy material in relation to hypertension and diabetes. Acta Med Scand. 184:211-214.
21. 20. Beckers A, Abs R, Willems P, et al. 1992 Aldosterone-secreting adrenal adenoma as part of multiple endocrine neoplasia type 1 (MEN1): loss of heterozygosity for polymorphic chromosome 11 deoxyribonucleic acid markers, including the MEN1 locus. J Clin Endocrinol Metab. 75:564-570.
22. 21. Iida A, Blake K, Tunny T, et al. 1995 Allelic losses on chromosome band 11q13 in aldosterone-producing adrenal tumors. Gene Chromosome Cancer. 12:73-75.
23. 22. Stratakis CA, Jenkins RB, Pras E, et al. 1996 Cytogenetic and microsatellite alterations in rumors from patients with the syndrome of myxomas, spotty skin pigmentation, and endocrine overactivity. J Clin Endocrinol Metab. 81:3607-3614.