Blood, serum glucose and renal parameters in lead-loaded albino rats and treatment with some chelating agents and natural oils

Turkish Journal of Biology

Volumn 31, Issue 1, 2007, Pages 25-34

  Ashour, Abd El Rahiem A ^a   Yassin, Maged M ^b   Abu Aasi, Nahed M ^c   Ali, Rokaya M ^d  

^a AL AQSA UNIVERSITY   (Palestine)

^b ISLAMIC UNIVERSITY OF GAZA   (Palestine)

^c Ministry of Health Palestine   (Palestine)

^d Ain Shams University   (Egypt)

Author keywords

Albino rats; Blood; Chelating agents; Kidney; Lead acetate; Natural oils; Therapy

Indexed keywords

ALLIUM SATIVUM; RATTUS;

EID: 34247372969     PISSN: 13000152     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. nd ed. Boston: Little Brown; 1992: pp. 735-758.
2. Auf der Heide AC, Wittmers LE Jr. Selected aspects of the spatial distribution of lead in bone. Neurotoxicol 13: 809-820, 1992.
3. Gerhardsson L, Endlyst V, Lundstrom N. Lead in tissues of deceased lead smelter workers. J Trace Elem Med Biol 9: 136-143, 1995.
4. Al-Saleh I. Biochemical and clinical consequences of lead poisoning. Med Res Rev 14: 415-486, 1994.
5. Ghorbe F, Boujelbene M, Makni-Ayadi F et al. Effect of chronic lead exposure on kidney function in male and female rats, determination of lead exposure biomarker. Arch Physiol Biochem 109:457-463, 2001.
6. Lavicoli I, Carelli G, Stanek EJ et al. Effects of low doses of dietary lead on red blood cell production in male and female mice. Toxicol Lett 137: 193-199, 2003.
7. Terayama K. Effects of lead on electrophoretic mobility, membrane sialic acid, deformability and survival of rat erythrocytes. Ind Health 31: 113-126, 1993.
8. El-Missiry MA. Prophylactic effect of melatonin on lead-induced inhibition of heme biosynthesis and deterioration of antioxidant systems in male rats. J Biochem Mol Toxicol 14: 57-62, 2000.
9. Kim Y, Yoo CI, Lee CR et al. Evaluation of activity of erythrocyte 5-nucleotidase (P5N) in lead exposure workers, with focus on the effect on hemoglobin. Ind Health 40: 23-27, 2002.
10. Bersenyi A, Fekete S, Szoes Z et al. Effect of ingested heavy metals (Cd, Pb and Hg) on haematology and serum biochemistry in rabbits. Acta Vet Hung 51: 297-304, 2003.
11. Ahrens FA. Effects of lead on glucose metabolism, ion flux, and collagen synthesis in cerebral capillaries of calves. Am J Vet Res 54: 808-812, 1993.
12. Yokoyama K, Araki S, Akabayashi A et al. Alteration of glucose metabolism in the spinal cord of experimental lead poisoning rats: microdetermination of glucose utilization rate and distribution volume. Ind Health 38: 221-223, 2000.
13. Ashour A. Can garlic lobes, olive oil or black seed oil offer protection for some serum biochemical constituents against lead toxicity in rabbits? Al-Aqsa Univ J 6: 74-95, 2002.
14. Schraishuhn J, Kaufer-Weiss I, Weiss E. Light and electron subtoxic lead levels. Berl Munch Tieraztl Wochenschr 105: 290-293, 1992.
15. El-Ashmawy IM, El-Nahas AF, Salama OM. Protective effect of volatile oil, alcoholic and aqueous extracts of Origanum majorana on lead acetate toxicity in mice. Basic Clin Pharmacol Toxicol 97: 238-243, 2005.
16. Flora GJ, Seth PK, Prakash AO et al. Therapeutic efficacy of combined meso 2,3-dimercaptosuccinic acid and calcium disodium edetate treatment during acute lead intoxication in rats. Hum Exp Toxicol 14: 410-413, 1995.
17. Yokoyama K, Araki S, Aono H et al. Calcium disodium ethylenediaminetetraacetate-chelated lead as a predictor for subclinical lead neurotoxicity: follow-up study on gun-metal foundry workers. Int Arch Occup Environ Health 71: 459-464, 1998.
18. Marija Varnai V, Piasek M, Blanusa M et al. Succimer treatment and calcium supplementation reduce tissue lead in suckling rats. J Appl Toxicol 24: 123-128, 2004.
19. Yassin MM. Prophylactic efficacy of crushed garlic lobes, black seed or olive oils on cholinesterase activity in central nervous system parts and serum of lead intoxicated rabbits. Turk J Biol 29: 173-180, 2005.
20. Reinholz MM, Bertics PJ, Miletic V. Chronic exposure to lead acetate affects the development of protein kinase C activity and the distribution of the PKC gamma isozyme in the rat hippocampus. Neurotoxicol 20: 609-617, 1999.
21. Tandon S, Prasad S, Singh S et al. Influence of age on lead-induced oxidative stress in rat. Biol Trace Elem Res 88: 59-69, 2002.
22. Gong Z, Evans HL. Effect of chelation with DMSA before and after the appearance of lead-induced neurotoxicity in the rats. Toxicol Appl Pharmacol 144: 205-214, 1997.
23. 2EDTA on brain lead mobilization in rodents determined using a stable lead isotope tracer. Toxicol Appl Pharmacol 159: 153-160, 1999.
24. Trinder P. Glucose GOD-PAP method enzymatic colorimetric method. Ann Clin Biochem 6: 24, 1969.
25. Fawcett JK, Scott JE. A rapid and precise method for the determination of urea. J Clin Path 13: 156-159, 1960.
26. Fossatti P, Prencipe L, Berti G. Use of 3,5-dichloro-2-hydroxy- benzenesulfonic acid/4-aminophenazone chromogenic system in direct enzymic assay of uric acid in serum and urine. Clin Chem 26: 227-231, 1980.
27. Bartels H, Bohmer M, Heierli C. Serum creatinine determination without protein precipitation. Clin Chim Acta 37: 193-197, 1972.
28. Yassin MM, Ashour AA, Abu Aasi NM et al. Therapeutic effect of some chelating agents and natural oils on lead-induced liver enzymes alterations in albino rats. 2006 [in press].
29. Solliway BM, Schaffer A, Pratt H et al. Effects of exposure to lead on selected biochemical and haematological variables. Pharmacol Toxicol 78: 18-22, 1996.
30. Terayama K, Maehara N, Muratsugu M et al. Effect of lead on electrophoretic mobility of rat erythrocytes. Toxicol 40: 259-265, 1986.
31. Gurer H, Ozgunes H, Neal R et al. Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats. Toxicol 128: 181-189, 1998.
32. Redig PT, Lawler EM, Schwartz S et al. Effects of chronic exposure to sublethal concentrations of lead acetate on heme synthesis and immune function in red-tailed hawks. Arch Environ Contam Toxicol 21: 72-77, 1991.
33. Hu H, Watanabe H, Payton M et al. The relationship between bone lead and hemoglobin. JAMA 272: 1512-1517, 1994.
34. Environmental Protection Agency. Determination of reportable quantities for hazardous substances. Code of Federal Regulations. 40 CFR 117, US EPA, 1986.
35. Masci O, Carelli G, Vinci F et al. Blood lead concentration and biological effects in workers exposed to very low lead levels. J Occup Environ Med 40: 886-894, 1998.
36. Baranowska-Bosiacka I, Hlynczak AJ, Machalinski B. The impact of lead ions on metabolism of erythrocytes. Med Pr 51: 59-65, 2000.
37. Attia MH, Ali SH. Natural sulfur compounds as anti lead active substances. Egypt J Med Sci 14: 327-334, 1993.
38. Baccarelli A. Occupational agents and endocrine function: an update of the experimental and human evidence. Med Lav 90: 650-670, 1999.
39. Khalil MF, Gonick HC, Cohen A et al. Experimental model of lead nephropathy, effect of removal from lead exposure and chelation treatment with DMSA. Environ Res 58: 35-54, 1992.
40. Ankrah NA, Kamiya Y. Appiah-Opong R et al. Lead levels and related biochemical findings occurring in Ghanaian subjects occupationally exposed to lead. East Afr Med J 73: 375-379, 1996.
41. McBride MB, Rigden S, Haycock GB et al. Presymptomatic detection of familial juvenile hyperuricaemic nephropathy in children. Pediatr Nephrol 12: 357-364, 1998.
42. Wolf PL, Williams D, Tsudaka T et al. Methods and Techniques in Clinical Chemistry. New York: Wiley-Interscience a division of John Wiley and Sons; 1972.
43. Atef M, Youssef SA, Ramadan A et al. Interaction between lead toxicity and some sulphonamides in rabbits: effect on certain blood constituents and serum enzymes. Dtsch Tierarztl Wochenschr 101: 187-190, 1994.
44. Kaptan A, Szabo LL. Clinical Chemistry: Interpretation and Techniques. New York: Lea and Febiger; 1983.
45. Oberley TD, Friedman AL, Moser R et al. Effect of lead administration on developing rat kidney. II. Functional, morphological and immunohistochemical studies. Toxicol Appl Pharmacol 131: 94-107, 1995.
46. Wang FI, Kuo ML, Shun CT et al. Chronic toxicity of a mixture of chlorinated alkanes and alkenes in ICR mice. J Toxicol Environ Health 65: 279-291, 2002.
47. Weaver VM, Lee BK, Ahn KD et al. Associations of lead biomarkers with renal function in Korean lead workers. Occup Environ Med 60: 551-562, 2003.