FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: Evidence that benzodiazepine inverse agonists reduce food palatability

Neuropsychopharmacology

Volumn 32, Issue 5, 2007, Pages 1069-1081

  Cottone, Pietro ^a,b   Sabino, Valentina ^a   Steardo, Luca ^b   Zorrilla, Eric P ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Benzodiazepine receptor; Food intake or feeding; GABA; Meal pattern or microstructure; Obesity; Palatability

Indexed keywords

BENZODIAZEPINE; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; FLUMAZENIL; N METHYL BETA CARBOLINE 3 CARBOXAMIDE;

ANIMAL EXPERIMENT; ANOREXIA; ARTICLE; DIESTRUS; DOSE RESPONSE; DRUG MECHANISM; FEEDING BEHAVIOR; FEMALE; FOOD INTAKE; NONHUMAN; PRIORITY JOURNAL; RAT; SATIETY; TREATMENT DURATION;

ANIMALS; ANOREXIA; ANXIETY DISORDERS; APPETITE; APPETITE DEPRESSANTS; APPETITE REGULATION; BRAIN; CARBOLINES; CIRCADIAN RHYTHM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEEDING BEHAVIOR; FEMALE; FLUMAZENIL; GABA ANTAGONISTS; GABA MODULATORS; RATS; RATS, WISTAR; RECEPTORS, GABA-A; STRESS, PSYCHOLOGICAL;

EID: 34247363317     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1301229     Document Type: Article

References (50)

1. Bernard PS, Pastor G, Liebman JM (1986). CGS 8216, a benzodiazepine antagonist, reduces food intake in food-deprived rats. Pharmacol Biochem Behav 24: 1703-1706.
2. Carrillo CA, Zorrilla EP, Koob GF (2001). The effects of naltrexone, a non-selective opiate receptor antagonist, on the consumption of sweetened food and solutions. AAAS Annual Meeting & Science Innovation Exposition, San Francisco, 167, abstr# A85.
3. Chan A, Dudley CA, Moss RL (1984). Hormonal and chemical modulation of ventromedial hypothalamic neurons responsive to vaginocervical stimulation. Neuroendocrinology 38: 328-336.
4. Chen SW, Davies MF, Loew GH (1995). Food palatability and hunger modulated effects of CGS 9896 and CGS 8216 on food intake. Pharmacol Biochem Behav 51: 499-503.
5. Chouinard G (2004). Issues in the clinical use of benzodiazepines: potency, withdrawal, and rebound. J Clin Psychiatry 65(Suppl 5): 7-12.
6. Clifton PG, Cooper SJ (1996). The benzodiazepine partial receptor agonist, bretazenil, provokes a strong hyperphagic response: a meal pattern analysis in free feeding rats. Behav Pharmacol 7: 454-461.
7. Cooper SJ (1986). Hyperphagic and anorectic effects of beta-carbolines in a palatable food consumption test: comparisons with triazolam and quazepam. Eur J Pharmacol 120: 257-265.
8. Cooper SJ (2005). Palatability-dependent appetite and benzodiazepines: new directions from the pharmacology of GABA(A) receptor subtypes. Appetite 44: 133-150.
9. Cooper SJ, Barber DJ, Gilbert DB, Moores WR (1985). Benzodiazepine receptor ligands and the consumption of a highly palatable diet in non-deprived male rats. Psychopharmacology (Berlin) 86: 348-355.
10. Cooper SJ, Bowyer DM, Van der Hoek G (1989). Effects of the imidazobenzodiazepine Ro 15-4513 on saccharin choice and acceptance, and on food intake, in the rat. Brain Res 494: 172-176.
11. Cooper SJ, Estall LB (1985). Behavioural pharmacology of food, water and salt intake in relation to drug actions at benzodiazepine receptors. Neurosci Biobehav Rev 9: 5-19.
12. Cooper SJ, Kirkham TC (1993). Opioid mechanisms in the control of food consumption and taste preferences. In: Herz A (ed). Handbook of Experimental Pharmacology: II. Opioids II, Vol. 104. Springer-Verlag: Berlin. pp 239-262.
13. Cooper SJ, Moores WR (1985). Chlordiazepoxide-induced hyperphagia in non-food-deprived rats: effects of Ro15-1788, CGS 8216 and ZK 93 426. Eur J Pharmacol 112: 39-45.
14. Cooper SJ, Yerbury RE (1986a). Midazolam-induced hyperphagia and FG 7142-induced anorexia: behavioural characteristics in the rat. Pharmacol Biochem Behav 25: 99-106.
15. Cooper SJ, Yerbury RE (1986b). Benzodiazepine-induced hyperphagia: stereospecificity and antagonism by pyrazoloquinolines, CGS 9895 and CGS 9896. Psychopharmacology (Berlin) 89: 462-466.
16. Cruz AP, Frei F, Graeff FG (1994). Ethopharmacological analysis of rat behavior on the elevated plus-maze. Pharmacol Biochem Behav 49: 171-176.
17. Dawson GR, Maubach KA, Collinson N, Cobain M, Everitt B, Macleod A et al (2005). An inverse agonist selective for {alpha}5 subunit-containing GABAA receptors enhances cognition. J Pharmacol Exp Ther 316: 1335-1345.
18. Dekhuijzen AJ, Bagust J (1996). Analysis of neural bursting: nonrhythmic and rhythmic activity in isolated spinal cord. J Neurosci Methods 67: 141-147.
19. Fernandes C, File SE (1996). The influence of open arm ledges and maze experience in the elevated plus-maze. Pharmacol Biochem Behav 54: 31-40.
20. Higgs S, Cooper SJ (1996). Effects of the benzodiazepine receptor inverse agonist Ro 15-4513 on the ingestion of sucrose and sodium saccharin solutions: a microstructural analysis of licking behavior. Behav Neurosci 110: 559-566.
21. Higgs S, Cooper SJ (1998). Effects of benzodiazepine receptor ligands on the ingestion of sucrose, intralipid, and maltodextrin: an investigation using a microstructural analysis of licking behavior in a brief contact test. Behav Neurosci 112: 447-457.
22. Hinton EC, Parkinson JA, Holland AJ, Arana FS, Roberts AC, Owen AM (2004). Neural contributions to the motivational control of appetite in humans. Eur J Neurosci 20: 1411-1418.
23. Hunt T, Poulos CX, Cappell H (1988). Benzodiazepine-induced hyperphagia: a test of the hunger-mimetic model. Pharmacol Biochem Behav 30: 515-518.
24. Kelley AE, Bakshi VP, Fleming S, Holahan MR (2000). A pharmacological analysis of the substrates underlying conditioned feeding induced by repeated opioid stimulation of the nucleus accumbens. Neuropsychopharmacology 23: 455-467.
25. Kelley AE, Baldo BA, Pratt WE, Will MJ (2005). Corticostriatal- hypothalamic circuitry and food motivation: integration of energy, action and reward. Physiol Behav 86: 773-795.
26. Li CS, Davis BJ, Smith DV (2003). Opioid modulation of taste responses in the nucleus of the solitary tract. Brain Res 965: 21-34.
27. Li JS, Huston JP (2002). Non-linear dynamics of operant behavior: a new approach via the extended return map. Rev Neurosci 13: 31-57.
28. Lowe MR, Levine AS (2005). Eating motives and the controversy over dieting: eating less than needed versus less than wanted. Obes Res 13: 797-806.
29. Mittleman G, Jones GH, Robbins TW (1988). Effects of diazepam, FG-7142, and Ro-15-1788 on schedule-induced-polydipsia and the temporal control of behavior. Psychopharmacology 94: 103-109.
30. Morgan CA, Emmans GC, Tolkamp BJ, Kyriazakis I (2000). Analysis of the feeding behavior of pigs using different models. Physiol Behav 68: 395-403.
31. O'Brien CP (2005). Benzodiazepine use, abuse, and dependence. J Clin Psychiatry 66(Suppl 2): 28-33.
32. O'hare E, Kim EM, Tierney KJ (2006). An operant determination of the behavioral mechanism of benzodiazepine enhancement of food intake. Psychopharmacology (Berlin) 187: 138-142.
33. Patel SM, Ebenezer IS (2002). The effects of the benzodiazepine receptor ligand 3-(methoxycarbonyl) amino-beta-carboline on food and water intake in rats. Methods Find Exp Clin Pharmacol 24: 681-683.
34. Pfaus JG, Smith WJ, Byrne N, Stephens G (2000). Appetitive and consummatory sexual behaviors of female rats in bilevel chambers. II. Patterns of estrus termination following vagino-cervical stimulation. Horm Behav 37: 96-107.
35. Randall LO (1960). Pharmacology of methaminodiazepoxide. Dis Nerv Syst 21(Suppl 3): 7-10.
36. Randall LO, Schallek W, Heise GA, Keith EF, Badgon RE (1960). The psychosedative properties of methaminodiazepoxide. J Pharmacol Exp Ther 129: 163-171.
37. Richardson DK, Reynolds SM, Cooper SJ, Berridge KC (2005). Endogenous opioids are necessary for benzodiazepine palatability enhancement: naltrexone blocks diazepam-induced increase of sucrose-'liking'. Pharmacol Biochem Behav 81: 657-663.
38. Richardson HN, Zorrilla EP, Mandyam CD, Rivier CL (2006). Exposure to repetitive versus varied stress during prenatal development generates two distinct anxiogenic and neuroendocrine profiles in adulthood. Endocrinology 147: 2506-2517.
39. Rivier C, Vale W (1990). Cytokines act within the brain to inhibit luteinizing hormone secretion and ovulation in the rat. Endocrinology 127: 849-856.
40. Rivier J, Amoss M, Rivier C, Vale W (1974). Synthetic luteinizing hormone releasing factor. Short chain analogs. J Med Chem 17: 230-233.
41. Rudolph U, Möhler H (2004). Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics. Annu Rev Pharmacol Toxicol 44: 475-498.
42. Sanchez Gomez PP, Troop NA, Treasure JL (2002). Psychophysiology and eating disorders. In: D'Haenen H, den Boer JA, Willner P (eds). Biological Psychiatry. John Wiley & Sons, Ltd: Chichester. pp 1159-1165.
43. Shannon CE, Weaver W (1949). The Mathematical Theory of Communication. University of Illinois Press: Urbana.
44. Sharp J, Zammit T, Azar T, Lawson D (2003). Stress-like responses to common procedures in individually and group-housed female rats. Contemp Top Lab Anim Sci 42: 9-18.
45. Sieghart W, Sperk G (2002). Subunit composition, distribution and function of GABA(A) receptor subtypes. Curr Top Med Chem 2: 795-816.
46. Szücs A, Pinto RD, Rabinovich MI, Abarbanel HD, Selverston AI (2003). Synaptic modulation of the interspike interval signatures of bursting pyloric neurons. J Neurophysiol 89: 1363-1377.
47. Tolkamp BJ, Schweitzer DPN, Kyriazakis I (2000). The biologically relevant unit for the analysis of short-term feeding behavior of dairy cows. J Dairy Sci 83: 2057-2068.
48. Yerbury RE, Cooper SJ (1987). The benzodiazepine partial agonists, Ro16-6028 and Ro17-1812, increase palatable food consumption in nondeprived rats. Pharmacol Biochem Behav 28: 427-431.
49. Zorrilla EP, Inoue K, Fekete EM, Tabarin A, Valdez GR, Koob GF (2005a). Measuring meals: structure of prandial food and water intake of rats. Am J Physiol Regul Integr Comp Physiol 288: R1450-R1467.
50. Zorrilla EP, Inoue K, Valdez GR, Tabarin A, Koob GF (2005b). Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat. Psychopharmacology 177: 324-335.