R-Isomers of Arg-Gly-Asp (RGD) mimics as potent αvβ3 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 11, 2007, Pages 3783-3800

  Nagarajan, Srinivasan R ^a   Devadas, Balekudru ^a   Malecha, James W ^a   Lu, Hwang Fun ^a   Ruminski, Peter G ^a   Rico, Joseph G ^a   Rogers, Thomas E ^a   Marrufo, Laura D ^a   Collins, Joe T ^a   Kleine, H Peter ^a   Lantz, Melissa K ^a   Zhu, Jun ^a   Green, Nawasa F ^a   Russell, Mark A ^a   Landis, Bryan H ^a   Miller, Lawrence M ^a   Meyer, Debra M ^a   Duffin, Tiffany D ^a   Engleman, V Wayne ^a   Finn, Mary B ^a   Freeman, Sandra K ^a   Griggs, David W ^a   Williams, Melanie L ^a   Nickols, Maureen A ^a   Pegg, Jodi A ^a   Shannon, Kristen E ^a   Steininger, Christina ^a   Westlin, Marisa M ^a   Nickols, G Alan ^a   Keene, Jeffery L ^a   more..

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

v 3; Angiogenesis; Integrin antagonists; RGD mimics

Indexed keywords

3 BROMO 5 CHLORO 2 HYDROXY BETA [[2 [[[3 HYDROXY 5 [(1,4,5,6 TETRAHYDROPYRIMIDIN 2 YL)AMINO]PHENYL]CARBONYL]AMINO]ACETYL]AMINO]BENZENE PROPIONIC ACID; 3 BROMO 5 CHLORO BETA [[[[3 [(5 FLUORO 1,4,5,6 TETRAHYDRO 2 PYRIMIDINYL)AMINO]BENZOYL]AMINO]ACETYL]AMINO] 2 HYDROXYBENZENEPROPIONIC ACID; 3 BROMO 5 CHLORO BETA [[[[[(5 FLUORO 1,4,5,6 TETRAHYDRO 2 PYRIMIDINYL)AMINO] 5 HYDROXYBENZOYL]AMINO]ACETYL]AMINO] 2 HYDROXYBENZENEPROPIONIC ACID; 3,5 DIBROMO BETA [[[[3 [(5 FLUORO 1,4,5,6 TETRAHYDRO 2 PYRIMIDINYL)AMINO] 5 HYDROXYBENZOYL]AMINO]ACETYL]AMINO]BENZENEPROPIONIC ACID; 3,5 DICHLORO BETA [[[[3 [(5 HYDROXY 1,4,5,6 TETRAHYDRO 2 PYRIMIDINYL)HYDROXY]BENZOYL]AMINO]ACETYL]AMINO] 2 HYDROXYBENZENEPROPIONIC ACID; ARGINYLGLYCYLASPARTIC ACID; BETA AMINO ACID; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ARTICLE; CANCER INHIBITION; COLON TUMOR; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; EMBRYO; FEMALE; HUMAN; HUMAN CELL; HYPERCALCEMIA; MALE; MELANOMA; MOUSE; NONHUMAN; TUMOR VOLUME;

AMINO ACIDS; ANIMALS; ANTINEOPLASTIC AGENTS; COLONIC NEOPLASMS; HYPERCALCEMIA; INTEGRIN ALPHAVBETA3; ISOMERISM; MELANOMA; MICE; MICE, INBRED STRAINS; MOLECULAR MIMICRY; OLIGOPEPTIDES; SKIN NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ANIMALIA; MUS;

EID: 34247359551     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.03.034     Document Type: Article

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