The use of N-acetylcysteine for the prevention of hypertension in the reduced uterine perfusion pressure model for preeclampsia in Sprague-Dawley rats

American Journal of Obstetrics and Gynecology

Volumn 193, Issue 3 SUPPL., 2005, Pages 952-956

  Chang, Eugene Y ^a   Barbosa, Ernest ^a   Paintlia, M K ^a   Singh, Avtar ^b   Singh, Inderjit ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b RALPH H JOHNSON VA MEDICAL CENTER   (United States)

Author keywords

Animal model; Antioxidants; Nuclear factor kappa B; Preeclampsia

Indexed keywords

ACETYLCYSTEINE;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BRAIN WEIGHT; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; HYPERTENSION; INTRAUTERINE PRESSURE; MEAN ARTERIAL PRESSURE; NONHUMAN; PREECLAMPSIA; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ACETYLCYSTEINE; ANIMALS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; FEMALE; FETAL WEIGHT; HYPERTENSION; PRE-ECLAMPSIA; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; UTERUS;

EID: 24644434962     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2005.05.083     Document Type: Conference Paper

References (25)

1. J.M. Roberts, and C.A. Hubel Is oxidative stress the link in the two-stage model of pre-eclampsia? Lancet 354 1999 788 789
2. M.T. Raijmakers, R. Dechend, and L. Poston Oxidative stress and preeclampsia: rationale for antioxidant clinical trials Hypertension 44 2004 374 380
3. Y. Yamamoto, and R.B. Gaynor Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer J Clin Invest 107 2001 135 142
4. I.M. Verma Nuclear factor (NF)-kappaB proteins: therapeutic targets Ann Rheum Dis 63 Suppl 2 2004 ii57 ii61
5. O.I. Aruoma, B. Halliwell, B.M. Hoey, and J. Butler The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid Free Radic Biol Med 6 1989 593 597
6. S. Cuzzocrea, G. Costantino, and A.P. Caputi Protective effect of N-acetylcysteine on cellular energy depletion in a non-septic shock model induced by zymosan in the rat Shock 11 1999 143 148
7. T. Oda, J. Iwaoka, N. Komatsu, and T. Muramatsu Involvement of N-acetylcysteine-sensitive pathways in ricin-induced apoptotic cell death in U937 cells Biosci Biotechnol Biochem 63 1999 341 348
8. T.M. Bisseling, E. Maria Roes, M.T. Raijmakers, E.A. Steegers, W.H. Peters, and P. Smits N-acetylcysteine restores nitric oxide-mediated effects in the fetoplacental circulation of preeclamptic patients Am J Obstet Gynecol 191 2004 328 333
9. P. Takacs, S.W. Kauma, M.M. Sholley, S.W. Walsh, M.J. Dinsmoor, and K. Green Increased circulating lipid peroxides in severe preeclampsia activate NF-kappaB and upregulate ICAM-1 in vascular endothelial cells FASEB J 15 2001 279 281
10. D.J. Eder, and M. McDonald A role for brain angiotensin II in experimental pregnancy-induced hypertension in laboratory rats Clin Exp Hypertens Pregnancy 88 1987 431 451
11. B.T. Alexander, S.E. Kassab, M.T. Miller, S.R. Abram, J.F. Reckelhoff, and W.A. Bennett Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide Hypertension 37 2001 1191 1195
12. J. Vanderlelie, K. Venardos, V.L. Clifton, N.M. Gude, F.M. Clarke, and A.V. Perkins Increased biological oxidation and reduced anti-oxidant enzyme activity in pre-eclamptic placentae Placenta 26 2005 53 58
13. M.S. Mikhail, A. Anyaegbunam, D. Garfinkel, P.R. Palan, J. Basu, and S.L. Romney Preeclampsia and antioxidant nutrients: decreased plasma levels of reduced ascorbic acid, alpha-tocopherol, and beta-carotene in women with preeclampsia Am J Obstet Gynecol 171 1994 150 157
14. S. Kharb Low whole blood glutathione levels in pregnancies complicated by preeclampsia and diabetes Clin Chim Acta 294 2000 179 183
15. L.C. Chappell, P.T. Seed, A.L. Briley, F.J. Kelly, R. Lee, and B.J. Hunt Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial Lancet 354 1999 810 816
16. M. Aban, L. Cinel, M. Arslan, U. Dilek, M. Kaplanoglu, and R. Arpaci Expression of nuclear factor-kappa B and placental apoptosis in pregnancies complicated with intrauterine growth restriction and preeclampsia: an immunohistochemical study Tohoku J Exp Med 204 2004 195 202
17. S.E. Maynard, J.Y. Min, J. Merchan, K.H. Lim, J. Li, and S. Mondal Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia J Clin Invest 111 2003 649 658
18. R.J. Levine, S.E. Maynard, C. Qian, K.H. Lim, L.J. England, and K.F. Yu Circulating angiogenic factors and the risk of preeclampsia N Engl J Med 350 2004 672 683
19. R.J. Levine, R. Thadhani, C. Qian, C. Lam, K.H. Lim, and K.F. Yu Urinary placental growth factor and risk of preeclampsia JAMA 293 2005 77 85
20. J.R. Horowitz, A. Rivard, R. van der Zee, M. Hariawala, D.D. Sheriff, and D.D. Esakof Vascular endothelial growth factor/vascular permeability factor produces nitric oxide-dependent hypotension. Evidence for a maintenance role in quiescent adult endothelium Arterioscler Thromb Vasc Biol 17 1997 2793 2800
21. C. Wheeler-Jones, R. Abu-Ghazaleh, R. Cospedal, R.A. Houliston, J. Martin, and I. Zachary Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase FEBS Lett 420 1997 28 32
22. I. Zachary Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor Am J Physiol Cell Physiol 280 2001 C1375 C1386
23. M.R. Abid, I.G. Schoots, K.C. Spokes, S.Q. Wu, C. Mawhinney, and W.C. Aird Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB J Biol Chem 279 2004 44030 44038
24. S. Oka, H. Kamata, K. Kamata, H. Yagisawa, and H. Hirata N-acetylcysteine suppresses TNF-induced NF-kappaB activation through inhibition of IkappaB kinases FEBS Lett 472 2000 196 202
25. M.M. Abitbol, C.L. Pirani, W.B. Ober, S.G. Driscoll, and M.W. Cohen Production of experimental toxemia in the pregnant dog Obstet Gynecol 48 1976 537 548