Evaluation of ocular surface changes in a rabbit dry eye model using a modified impression cytology technique

Current Eye Research

Volumn 32, Issue 4, 2007, Pages 301-307

  Altinors, Dilek Dursun ^a   Bozbeyoglu, Simge ^a   Karabay, Gulten ^a   Akova, Yonca A ^a  

^a BASKENT UNIVERSITY   (Turkey)

Author keywords

Dry eye; Impression cytology; Ocular goblet cells; Rabbit

Indexed keywords

ATROPINE; FLUORESCEIN; MUCIN; PYROXYLIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOLOGY; DATA ANALYSIS; DRY EYE; GOBLET CELL; HISTOPATHOLOGY; NONHUMAN; PERIODIC ACID SCHIFF STAIN; PRIORITY JOURNAL; RABBIT; SCANNING ELECTRON MICROSCOPY; SCHIRMER TEST; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; CONJUNCTIVA; CYTOLOGICAL TECHNIQUES; DIAGNOSTIC TECHNIQUES, OPHTHALMOLOGICAL; DRY EYE SYNDROMES; FLUORESCEIN; FLUORESCENT DYES; GOBLET CELLS; MICROSCOPY, ELECTRON; MICROSCOPY, ELECTRON, SCANNING; RABBITS;

EID: 34247344475     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.1080/02713680701198742     Document Type: Article

References (20)

1. Pflugfelder SC. Dry eye and ocular surface disorders. In: Pflugfelder SC, Beuerman R, Stern ME, eds. Dry Eye: The Problem. 1st ed. New York: Marcel Dekker; 2004:1-10.
2. Bron AJ. The Doyne Lecture. Reflections on the tears. Eye. 1997;11:583-602.
3. Toshida H, Beuerman, RW. Effects of preganglionic parasympathetic denervation on the rabbit lacrimation. Adv Exp Med Biol. 2002;506:225-229.
4. Nelson JD, Wright JC. Conjunctival goblet cell densities in ocular surface disease. Arch Ophthalmol. 1984;102:1049-1052.
5. Gipson IK, Arg̈ueso P. Role of mucins in the function of the corneal and conjunctival epithelia. Int Rev Cytol. 2003;23:1-49.
6. Gipson I. Distribution of mucins at the ocular surface. Exp Eye Res. 2004;78:379-388.
7. Inatomi T, Spurr-Michaud S, Tisdale AS, et al. Expression of secretory mucin genes by human conjunctival epithelia. Invest Ophthalmol Vis Sci. 1996;37:1684-1692.
8. Rios JD, Zoukhri D, Rawe IM, et al. Immunolocalization of muscarinic and VIP receptor subtypes and their role in stimulation of goblet cell secretion. Invest Ophthalmol Vis Sci. 1999;40:1102-1111.
9. Corfield AP, Carrington SD, Hicks SJ, et al. Ocular mucins: purification, metabolism and functions. Prog Ret Eye Res. 1997;16(4):627-656.
10. Pflugfelder SC, Jones D, Ji Z, et al. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca. Curr Eye Res. 1999;19:201-211.
11. Hicks SJ, Corfield AP, Kaswan RL, et al. Biochemical analysis of ocular surface mucin abnormalities in dry eye: the canine model. Exp Eye Res. 1998;67:709-718.
12. Jumblatt MM, Mc Kenzie RW, Steele PS, et al. MUC 7 expression in the human lacrimal gland and conjunctiva. Cornea. 2003;22:41-5.
13. Gipson I. Distribution of mucins at the ocular surface. Exp Eye Res. 2004;78:379-388.
14. Nakamura T, Nishida K, Dota A, et al. Elevated expression of transglutaminase 1 and keratinization-related proteins in conjunctiva in severe ocular surface disease. Invest Ophthalmol Vis Sci. 2001;42:549-556.
15. Thoft RA, Friend J, Kinoshita S, et al. Ocular cicatricial pemphigoid associated with hyperproliferation of the conjunctival epithelium. Am J Ophthalmol. 1984;98:37-42.
16. Murube J, Rivas L. Biopsy of the conjunctiva in dry eye patients establishes a correlation between squamous metaplasia and dry eye clinical severity. Eur J Ophthalmol. 2003;13(3):246-256.
17. Fujihara T, Murakami T, Nagano T, et al. INS365 suppresses loss of corneal epithelial integrity by secretion of mucin-like glycoprotein in a rabbit short-term dry eye model. J Ocul Pharmacol Ther. 2002;18(4):363-370.
18. Doughty MJ, Bergmanson JPG. Heterogeneity in the ultrastructure of the mucous (goblet) cells of the rabbit palpebral conjunctiva. Clin Exp Optom. 2004;87(6):377-385.
19. Calonge M, Diebold Y, Saez V, et al. Impression cytology of the ocular surface: a review. Exp Eye Res. 2004;78(3):457-472.
20. Martinez AJ, Mills MB, Jaceldo KB, et al. Standardization of conjunctival impression cytology. Cornea. 1995;14(5):515-522.