Biopsy of the conjunctiva in dry eye patients establishes a correlation between squamous metaplasia and dry eye clinical severity

European Journal of Ophthalmology

Volumn 13, Issue 3, 2003, Pages 246-256

  Murube, Juan ^a,b   Rivas, L ^b  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

Biopsy; Cellular morphology; Conjunctiva; Dry eye; Ghrading system; Squamous metaplasia

Indexed keywords

ADULT; ARTICLE; BLOOD VESSEL; CELL STRUCTURE; CONJUNCTIVAL BIOPSY; CONTROLLED STUDY; DISEASE ASSOCIATION; DRY EYE; FEMALE; HUMAN; HUMAN TISSUE; HYPERPLASIA; HYPERTROPHY; LYMPH VESSEL; MAJOR CLINICAL STUDY; MALE; MICROSCOPY; MORPHOMETRICS; PRIORITY JOURNAL; SQUAMOUS CELL METAPLASIA; BIOPSY; COMPARATIVE STUDY; CONJUNCTIVA; EPITHELIUM CELL; GOBLET CELL; METAPLASIA; MIDDLE AGED; PATHOLOGY;

BIOPSY; CONJUNCTIVA; DRY EYE SYNDROMES; EPITHELIAL CELLS; FEMALE; GOBLET CELLS; HUMANS; HYPERTROPHY; MALE; METAPLASIA; MIDDLE AGED;

EID: 0042132044     PISSN: 11206721     EISSN: None     Source Type: Journal    
DOI: 10.1177/112067210301300302     Document Type: Article

References (18)

1. Murube J. Clasificación clínica del ojo seco. In: Murube J, ed. Ojo Seco-Dry Eye. Tecnimedia Editorial. Madrid, 1997; 39-44.
2. Oroza MA. Estudio inmunohistoquímico y morfológico en ojos de pacientes con síndrome de Sjögren. Doctoral Thesis. University Complutense of Madrid. June 2000. (Quoted in: Rivas L, Murube J. Utilización de la citología de impresión en el diagnóstico de las enfermedades de la superficie ocular. Novartis Ophthalmics. Barcelona. Spain, 2001: 1-33.
3. Nelson JD, Wright JC. Conjunctival goblet cell densities in ocular surface disease. Arch Ophthalmol 1984; 102: 1049-51.
4. Rivas L, Oroza MA, Pérez-Esteban A, Murube J. Topographical distribution of ocular surface cells by the use of impression cytology. Acta Ophthalmol 1991; 69: 371-6.
5. Steulh KP. Ultrastructure of the conjunctival epithelium. In: Straub W, ed. Developments in Ophthalmology. Basel: Karger 1989; 19: 1-104.
6. Lemp MA, Marquardt R. Morfología funcional de la conjuntiva. El Ojo seco. Barcelona: Springer-Verlag Ibérica 1994; 2: 35-61.
7. Tseng SCG. Topical tretinoin treatment for dry-eye disorders. Int Ophthalmol Clin 1987; 27: 47-53.
8. Roberts DK. Keratoconjunctivitis sicca. J Am Optom Assoc 1991; 62: 187-99.
9. Rivas L, Álvarez MI, Rodríguez JJ, Murube J. Ophthalmological tests in patients with and without association of primary Sjögren's syndrome. Ger J Ophthalmol 1995; 4: 306-10.
10. Rivas L, Toledano A, Álvarez MI, Sanz AI, Oroza MI, Murube J. Ultrastructural study of the conjunctiva in patients with keratoconjunctivitis sicca not associated with systemic disorders. Eur J Ophthalmol 1998; 8: 131-6.
11. Rivas L. Pruebas histológicas en el ojo seco. In: Murube J, ed. Ojo seco-Dry eye. Madrid: Tecnimedia Editorial SL, 1997: 159-67.
12. Murube J, Rivas L. Impression cytology on conjunctiva and cornea in dry eye patients establishes a correlation between squamous metaplasia and dry eye clinical severity. Eur J Ophthalmol 2003; 13: 115-27.
13. Murube del Castillo J, Cortés Rodrigo MD. Eye parameters for the diagnosis of xerophthalmos. Clin Exp Rheumatol 1989; 7: 145-50.
14. Van Bijsterveld OP. Diagnostic tests in the sicca syndrome. Arch Ophthalmol 1969; 82: 10-4.
15. Seamone CD, Jakson WB. Sjögren's syndrome. In: Tasman W, ed. Immunology of the external eye. Duane's Clinical Ophthalmology. Philadelphia: Lippincott-Raven Publishers; 1997. Vol. IV, chapter 2.
16. Wilson RW, Sexton RR. Laboratory aids in diagnosis. In: Tasman W, ed. Duane's Clinical Ophthalmology. Philadelphia: Lippincott Raven Publishers;1996. Vol IV, chapter 1.
17. Rivas L, Oroza, Pérez-Esteban A, Murube J. Topographical distribution of ocular surface cells by the use of impression cytology. Acta Ophthalmol 1991; 69: 371-6.
18. Nelson JD. Diagnostico de la keratoconjuntivitis sicca. In: Friedlaender M, ed. International Ophthalmology Clinics. Ojo seco. Buelach: Little, Brown and Company Inc. CibaVision SA, 1995: 37-56.