INS365 suppresses loss of corneal epithelial integrity by secretion of mucin-like glycoprotein in a rabbit short-term dry eye model

Journal of Ocular Pharmacology and Therapeutics

Volumn 18, Issue 4, 2002, Pages 363-370

  Fujihara, Tsutomu ^a   Murakami, Tadahiro ^a   Nagano, Takashi ^a   Nakamura, Masatsugu ^a   Nakata, Katsuhiko ^a  

^a SANTEN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; DIQUAFOSOL; GLYCOPROTEIN; PURINE P2Y RECEPTOR; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE; EYE DROPS; MUCIN; POLYPHOSPHATE; PURINE P2 RECEPTOR; PYRIMIDINE NUCLEOTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONJUNCTIVA; CONTROLLED STUDY; CORNEA DISEASE; CYTOLOGY; DOSE RESPONSE; DRY EYE; GOBLET CELL; MALE; NONHUMAN; PERIODIC ACID SCHIFF STAIN; TEAR FILM; ANIMAL; COMPARATIVE STUDY; CORNEA EPITHELIUM; DESICCATION; DRUG EFFECT; DRUG POTENTIATION; PATHOLOGY; PATHOPHYSIOLOGY; RABBIT; SECRETION; STAINING;

ANIMALS; DESICCATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRY EYE SYNDROMES; EPITHELIUM, CORNEAL; MALE; MUCINS; OPHTHALMIC SOLUTIONS; POLYPHOSPHATES; RABBITS; RECEPTORS, PURINERGIC P2; STAINING AND LABELING; URACIL NUCLEOTIDES;

EID: 0036668790     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/10807680260218524     Document Type: Article

References (36)

1. Basic principle and classification of dry eye disorder
2. Ocular fatigue is the major symptom of dry eye
3. A new punctum plug
4. New approaches to dry-eye therapy
5. Spectacle side panels and moist inserts for the treatment of dry-eye patients
6. Synthesis and P2Y receptor activity of a series of uridine dinucleotide 5′-polyphosphates
7. Effect of extracellular ATP and UTP on fluid transport by human nasal epithelial cell in culture
8. Secretory effects of ATP on non-transformed dog pancreatic epithelial cells
9. 2+ signaling in cultured rat aortic smooth muscle cells
10. Extracellular ATP activates receptor-operated cation channels in mouse lacrimal acinar cells to promote calcium influx in the absence of phosphoinositide metabolism
11. P2 purinoceptor regulation of mucin release by airway goblet cells in primary culture
12. Nucleotide-induced mucin release from primary hamster tracheal surface epithelial cells involves the P2U receptor
13. Nucleotide regulation of goblet cells in human airway epithelial explant
14. ATP and UTP increase secretion of bronchial inhibitor by human tracheal gland cells in culture
15. Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis
16. Altered fluid transport across airway epithelium in cystic fibrosis
17. Regulation of transepithelial ion transport and extracellular ATP in human normal and cystic fibrosis airway epithelium
18. 2 receptor stimulation increases mucin-like glycoprotein secretion from rabbit conjunctival goblet cells in vivo
19. Detection and quantification of conjunctival mucins
20. Establishment of a rabbit short-term dry eye model
21. Lactoferrin suppresses loss of corneal epithelial integrity in a rabbit short-term dry eye model
22. 2 nucleotide receptors in rabbit and human conjunctiva
23. Vasoactive intestinal peptide-stimulated glycoconjugate secretion from conjunctival goblet cells
24. Neural stimulation of conjunctival goblet cell mucous secretion in rats
25. Studies on the ocular pharmacology of prostaglandin D2
26. Functional biology of intestinal goblet cells
27. Tear film instability induced by rigid contact lenses
28. Tear functions in patients with pinguecula
29. Gefarnate stimulates secretion of mucin-like glycoproteins by corneal epithelium in vitro and protects corneal epithelium form desiccation in vivo
30. Dry eye treatment with eye drops that stimulate mucin production
31. Gefarnate increases PAS positive cell density in rabbit conjunctiva
32. 2 agonist INS 365 in a rat dry eye model
33. 2 receptor stimulation increases tear fluid secretion in rabbits
34. 2 receptor agonists stimulate chloride and fluid secretion
35. 2 receptor agonist increases Schirmer scores in albino rabbits
36. Therapeutic use of nucleotides in respiratory and ophthalmic diseases