Just the right amount of JNK: How nuclear factor-κB and downstream mediators prevent burn-induced intestinal injury

Critical Care Medicine

Volumn 35, Issue 5, 2007, Pages 1433-1434

  Clark, Jessica A ^a   Coopersmith, Craig M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Burn; c Jun N terminal kinase; Intestine; Nuclear factor B; Permeability; Thermal injury

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CHEMOKINE; CYTOKINE; FLICE INHIBITORY PROTEIN; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL XL; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR;

BURN; CELL DEATH; CELL SURVIVAL; CYTOSOL; EDITORIAL; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; IMMUNE RESPONSE; INFLAMMATION; INTENSIVE CARE; INTESTINE EPITHELIUM; INTESTINE INJURY; INTESTINE MUCOSA PERMEABILITY; MOUSE STRAIN; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BURNS; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; I-KAPPA B KINASE; INTESTINAL MUCOSA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICE, KNOCKOUT; NF-KAPPA B; PERMEABILITY; SIGNAL TRANSDUCTION;

EID: 34247329078     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000262392.95282.D1     Document Type: Editorial

References (15)

1. Karin M, Lin A: NF-kappaB at the crossroads of life and death. Nat Immunol 2002;3:221-227
2. Abraham E: NF-kappaB activation. Crit Care Med 2000; 28:N100-N104
3. Hacker H, Karin M: Regulation and function of IKK and IKK-related kinases. Sci STKE 2006; 357:13
4. Li ZW, Chu W, Hu Y, et al: The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med 1999; 189: 1839-1845
5. Tang G, Minemoto Y, Dibling B, et al: Inhibition of JNK activation through NF-kappaB target genes. Nature 2001; 414:313-317
6. Papa S, Bubici C, Zazzeroni F, et al: The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease. Cell Death Differ 2006; 13:712-729
7. Deng Y, Ren X, Yang L, et al: A JNK-dependent pathway is required for TNFalpha-induced apoptosis. Cell 2003; 115:61-70
8. Ventura JJ, Cogswell P, Flavell RA, et al: JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev 2004; 18:2905-2915
9. 2-terminal kinase activation. Crit Care Med 2007; 35:1332-1340
10. Chang L, Kamata H, Solinas G, et al: The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 2006; 124:601-613
11. Spies M, Chappell VL, Dasu MR, et al: Role of TNF-alpha in gut mucosal changes after severe burn. Am J Physiol Gastrointest Liver Physiol 2002; 283:G703-G708
12. Yasuda T, Takeyama Y, Ueda T, et al: Breakdown of intestinal mucosa via accelerated apoptosis increases intestinal permeability in experimental severe acute pancreatitis. J Surg Res 2006; 135:18-26
13. Abreu MT, Palladino AA, Arnold ET, et al: Modulation of barrier function during Fasmediated apoptosis in human intestinal epithelial cells. Gastroenterology 2000; 119:1524-1536
14. Coopersmith CM, Chang KC, Swanson PE, et al: Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice. Crit Care Med 2002; 30:195-201
15. Chen LW, Egan L, Li ZW, et al: The two faces of IKK and NF-kappaB inhibition: Prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 2003; 9:575-581