Serum from mice immunized in the context of Treg inhibition identifies DEK as a neuroblastoma tumor antigen

BMC Immunology

Volumn 8, Issue , 2007, Pages

  Zheng, Jin ^a   Kohler, M Eric ^a   Chen, Qingrong ^b   Weber, James ^a   Khan, Javed ^b   Johnson, Bryon D ^a   Orentas, Rimas J ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; ONCOPROTEIN; PROTEIN DEK; TUMOR ANTIGEN; UNCLASSIFIED DRUG; B7 ANTIGEN; CANCER VACCINE; CD86 ANTIGEN; DEK PROTEIN, MOUSE; DNA BINDING PROTEIN; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIGEN EXPRESSION; ARTICLE; BLOOD SAMPLING; CELLULAR IMMUNITY; CONTROLLED STUDY; DNA LIBRARY; GENE EXPRESSION; GENETIC SCREENING; LYMPHOCYTE FUNCTION; MOUSE; NEUROBLASTOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; PROTEIN ANALYSIS; PROTEIN TARGETING; REGULATORY T LYMPHOCYTE; SEROLOGY; TUMOR CELL LINE; ANIMAL; BLOOD; CD4+ T LYMPHOCYTE; DNA MICROARRAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENE LIBRARY; GENETICS; IMMUNIZATION; IMMUNOLOGY; METABOLISM; PATHOLOGY; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD80; ANTIGENS, CD86; ANTIGENS, NEOPLASM; BLOTTING, WESTERN; CANCER VACCINES; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENE LIBRARY; IMMUNITY, CELLULAR; IMMUNIZATION; MICE; NEUROBLASTOMA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONCOGENE PROTEINS; T-LYMPHOCYTES, REGULATORY;

EID: 34247279752     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-8-4     Document Type: Article

References (43)

1. Evans AE Hummeler K The significance of primitive cells in marrow aspirates of children with neuroblastoma Cancer 1973 32 906-912 10.1002/ 1097-0142(197310)32:4<906::AID-CNCR2820320423>3.0.CO;2-6 4751921
2. Bill AH The implications of immune reactions to neuroblastoma Surgery 1969 66 2 415-418 5797230
3. Hellstrom I Hellstrom KE Pierce GE Bill AH Demonstration of cell-bound and humoral immunity against neuroblastoma cells ProcNatlAcadSciUSA 1968 60 1231-1238
4. Matthay KK Villablanca JG Seeger RC Stram DO Harris RE Ramsay NK Swift P Shimada H Black CT Brodeur GM Gerbing RB Reynolds CP Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid New England Journal of Medicine 1999 341 16 1165-1173 10.1056/ NEJM199910143411601 10519894
5. Katsanis E Orchard PJ Bausero MA Gorden KB McIvor RS Blazar BR Interleukin-2 gene transfer into murine neuroblastoma decreases tumorigenicity and enhances systemic immunity causing regression of preestablished retroperitoneal tumors Journal of Immunotherapy 1994 15 81-90 10.1097/00002371-199402000-00001 8136949
6. Hock RA Reynolds BD Tucker-McClung CL Kwok WW Human class II major histocompatibility complex gene transfer into murine neuroblastoma leads to loss of tumorigenicity, immunity against subsequent tumor challenge, and elimination of microscopic preestablished tumors Journal of Immunotherapy 1995 17 12-18 10.1097/00002371-199501000-00002 7728302
7. Katsanis E Bausero MA Xu H Orchard PJ Xu Z McIvor RS Brian AA Blazar BR Transfection of the mouse ICAM-1 gene into murine neuroblastoma enhances susceptibility to lysis, reduces in vivo tumorigenicity and decreases ICAM-2-dependent killing Cancer Immunol Immunother 1994 38 135-141 7905790
8. Johnson BD Yan X Schauer DW Orentas RJ Dual expression of CD80 and CD86 produces a tumor vaccine superior to single expression of either molecule Cellular Immunology 2003 222 15-26 10.1016/ S0008-8749(03)00079-0 12798304
9. Johnson BD Gershan JA Natalia N Zujewski H Weber JJ Yan X Orentas RJ Neuroblastoma cells transiently transfected to simultaneously express the co-stimulatory molecules CD54, CD80, CD86, and CD137L generate antitumor immunity in mice Journal of Immunotherapy 2005 28 449-460 10.1097/01.cji.0000171313.93299.74 16113601
10. Rousseau RF Haight AE Hirschmann-Jax C Yvon ES Rill DR Mei Z Smith SC Inman S Cooper K Alcoser P Grilley B Gee A Popek E Davidoff A Bowman LC Brenner MK Strother D Local and systemic effects of an allogeneic tumor cell vaccine combining human lymphotactin with interleukin-2 in patients with advanced or refractory neuroblastoma Blood 2003 101 5 1718-1726 10.1182/blood-2002-08-2493 12406881
11. Rousseau RF Brenner MK Vaccine therapies for pediatric malignacies The Cancer Journal 2005 11 4 331-339 16197723
12. Dudley ME Wunderlich J Robbins PF Yang JC Hwu P Schwartsentruber DJ Topalian S Sherry R Restifo NP Hubicki AM Robinson MR Raffeld M Duray P Seipp CA Rogers-Freezer L Morton KE Mavroukakis SA White DE Rosenberg SA Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes Science 2002 298 850-854 1764179 12242449 10.1126/science.1076514
13. Sakaguchi S Sakaguchi N Shimizu J Yamazaki S Sakihama T Itoh M Huniyasu Y Nomura T Toda M Takahashi T Immunologic tolerance maintained by CD25+CD4+ regualtory T cells: Their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance Immunological Reviews 2001 182 18-23 10.1034/j.1600-065X.2001.1820102.x 11722621
14. Golgher D Jones E Powrie F Elliot T Gallimore A Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens EurJImmunol 2002 32 3267-3275
15. Miklos DB Kim HT Zorn E Hochberg EP Guo L Mattes-Ritz A Viatte S Soiffer RJ Antin JH Ritz J Antibody response to DBY minor histocompatibility antigen is induced after allogeneic stem cell transplantation and in healthy female donors Blood 2004 103 353-359 1350983 14512314 10.1182/ blood-2003-03-0984
16. Zorn E Miklos DB Floyd BH Mattes-Ritz A Gua L Soiffer RJ Antin JH Ritz J Minor histocompatibility antigen DBY elicits a coordinated B and T cell response after allogeneic stem cell transplantation JExpMed 2004 199 8 1133-1142
17. Sahin U Tureci O Schmitt H Cochlovius B Johannes T Schmits R Stenner F Luo G Schobert I Pfreundshuh M Human neoplasms elicit multiple specific immune responses in the autologous host ProcNatlAcadSciUSA 1995 92 11810-11813
18. Sahin U Tureci O Pfreundshuh M Serological identification of human tumor antigens Current Opinion in Immunology 1997 9 709-716 10.1016/ S0952-7915(97)80053-2 9368781
19. Chen YT Scanlan MJ Obata Y Old LJ Rosenberg SA Identification of Human Tumor Antigens by Serological Expression Cloning Prinicples and Practice of Biological Therapy of Cnacer Philadelphia, Lippincott Williams & Williams 2000 Third 557
20. Nishikawa H Jäger.E. Ritter G Old LJ Gnjatic S CD4+ CD25+ regulatoy T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients Blood 2005 106 1008 1011 10.1182/ blood-2005-02-0607 15840697
21. Danke NA Koelle DM Yee C Beharay S Kwok WW Autoreactive T cells in healthy individuals Journal of Immunology 2004 172 5967-5972
22. Grasemann K Gratias S Stephan H Schuler A Schramm A Klein-Hitpass L Rieder H Schneider S Kappes F Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma Oncogene 2005 24 6441-6449 16007192
23. Hoglund M Gisselsson D Hansen GB White VA Sall T Mitelman F Horsman D Dissectingg karyotypic paterns in malignant melanomas: Temporal clustering of losses and gains in melanoma karyotypic evolution International Journal of Cancer 2004 108 57-65 10.1002/ijc.11558
24. Koon N Zaika A Moskaluk CA Frierson HF Knuutila S Powell SA El-Rifai W Clustering of molecular alterations in gastroesophageal carcinomas Neoplasia 2004 6 2 143-149 1502088 15140403 10.1593/neo.03385
25. Lau CC Harris CP Lu XY Perlaky L Gogineli S Murali C Hicks J Johnson ME Davino NA Huvos AG Meyers PA Healy JH Gorlick R Rao PH Frequent amplification and rearrangement of chromosomal bands 6p12-021 and 17p11.12 in osteosarcoma Genes, Chromosomes and Cancer 2003 39 1 11-21 10.1002/gcc.10291
26. Wu Q Hoffmann MJ Hartmann FH Schulz WA Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer Molecular Cancer 2005 4 1 16 1131921 15876350 10.1186/1476-4598-4-16
27. von Lindern M Fornerod M van Baal S Jaegle M de Witt T Buijis A Grosveld G The translocation (6;9) assocaited with a specific subtype of acute myeloid leukemia, results in the fusion of two genes DEK and CAN, and the expression of a chimeric, leukemia-specific dek-can mRNA Molecular and Cellular Biology 1992 12 4 1687-1697
28. Fu GK Grosveld G Markovitz DM DEK, an autoantigen involoved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer ProcNatlAcadSciUSA 1997 94 1811-1815
29. Kappes F Damoc C Knippers R Przbylski M Pinna LA Gruss C Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK Molecular and Cellular Biology 2004 24 13 6011-6020 10.1128/MCB.24.13.6011-6020.2004
30. Kappes F Scholten I Richter N Gruss N Waldmann T Functional domains of the ubiquitous chromatin protein DEK Molecular and Cellular Biology 2004 24 13 6000-6010 10.1128/MCB.24.13.6000-6010.2004
31. Soares LMM Zanier K Mackereth C Sattler M Valcarcel J Intron removal requires proofreading of U2AF/3′ splice site recognition by DEK Science 2006 312 1961-1965 10.1126/science.1128659 16809543
32. Waldmann T Scholten I Kappes F Hu HG Knippers R The DEK protein-an abundant and ubiquitoous constituent of mammalian chromatin Gene 2004 343 1-9 10.1016/j.gene.2004.08.029 15563827
33. Meyn MS Lu-Kuo JM Herxzing LBK Expression cloning of multiple human cDNAs that complement the phenotypic defects of ataxia-telangiectasia group D fibroblasts Am J Hum Genet 1993 53 1206-1216 1682482 7504406
34. Krithivas A Fujimuro M Weidner M Young DB Hayward SD Protein interactions targeting the latency-associaited nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes Jounral of Virology 2002 76 22 11596-11604 10.1128/JVI.76.22.11596-11604.2002
35. Wise-Drapper TM Allen HV Thobe MN Jones EE Habash KB Munger K Wells SI The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7 Journal of Virology 2005 79 22 14309-14317 1280217 16254365 10.1128/ JVI.79.22.14309-14317.2005
36. Garcon L Libura M Delabesse E Valensi F Asnafi V Berger C Schmitt C Leblanc T Buzyn A Macintyre E DEK-CAN molecular monitoring of myeloid malignancies could aid therapeutic stratification Leukemia 2005 19 1338-1344 10.1038/sj.leu.2403835 15973457
37. Dong X Wang J Kabir FN Shaw M Reed AM Stein L Andrade LEC Trevisani VFM Miller ML Fuji T Akizuki M Pachman LM Satoh M Reeves WH Autoantibodies to DEK oncoprotein in human inflammatory disease Arthritis and Rheumatism 2000 43 1 85-93 10.1002/ 1529-0131(200001)43:1<85::AID-ANR11>3.0.CO;2-D
38. Makita M Azuma T Hamaguchi H Niiya H Kojima K Fujuta S Tanimoto M Harada M Yasukawa M Leukemia-associated fusion proteins, dek-can and bcr-abl, represetn immunogenic HLA-DR-restricted epitopes recognized by fusion peptide-specific CD4+ T lymphocytes Leukemia 2002 16 2400-2407 10.1038/ sj.leu.2402742 12454745
39. Kitano S Kageyama S Nagata Y Miyahara Y Hiasa A Naota H Okumura S Imai H Shiraishi T Masuya M Nishikawa M Sunamoto J Akiyoshi K Kanematsu T Scott AM Murphy R Hoffman EW Old LJ Shiku H HER2-specific T-cell immune responses in patients vaccinated with truncated HER2 protein complexes with nanogels of cholesteryl pullulan Clin Cancer Res 2006 12 24 7937-7945 10.1158/1078-0432.CCR-06-1546
40. Nishikawa H Kato T Tawara I Takemitsu T Saito K Wang L Ikarashi Y Wakasugi H Nakayama T Taniguchi M Kuribayashi K Old LJ Shiku H Accelerated chemically induced tumor development mediated by CD4+CD25+ regulatory T cells in wild-type hosts ProcNatlAcadSciUSA 2005 102 26 9253-9257
41. Nishikawa H Kato T Hiasa A Tawara I Ikeda H Ikarashi Y Wakasugi H Kronenberg M Nakayama T Tanigichi M Kuribayashi K Old LJ Shiku H CD4+ CD25+ T cells responding to serologically defined autoantigens suppress antitumor immune responses ProcNatlAcadSciUSA 2003 100 19 10902-10906
42. Rozen S Skaletsky H Primer3 on the WWW for general users and for biologist programmers Bioinformatics Methods and Protocols:MEthods in Molecular Biology Totowa, NJ, Humana Press Krawetz S, Misener S 2000 365-386
43. Wei JS Greer BT Westerman F Steinberg SM Son CG Chen QR Whiteford CC Bilke S Krasnoselsky AL Cenacchi N Catchpoole D Berthold F Schwab M Khan J Prediction of Cinical Outcome Using Gene Expression Profiling and Artifical Neural Networks for Patients with Neuroblastoma Cancer Research 2004 64 6883-6891 1298184 15466177 10.1158/0008-5472.CAN-04-0695